Regulatory sequences
... and Y sequences conserved in all MHC-II, Ii, and HLA-DM promoters. RFX, X2BP, NF-Y, and an as yet undefined W-binding protein bind cooperatively to these sequences and assemble into a stable higher order nucleoprotein complex referred to here as the MHC-II enhanceosome. CIITA is tethered to the enha ...
... and Y sequences conserved in all MHC-II, Ii, and HLA-DM promoters. RFX, X2BP, NF-Y, and an as yet undefined W-binding protein bind cooperatively to these sequences and assemble into a stable higher order nucleoprotein complex referred to here as the MHC-II enhanceosome. CIITA is tethered to the enha ...
Chapter 11: Gene Expression PPT
... – Within each homeotic gene, a specific DNA sequence known as the homeobox regulates patterns of development. – The homeoboxes of many eukaryotic organisms appear to be very similar. ...
... – Within each homeotic gene, a specific DNA sequence known as the homeobox regulates patterns of development. – The homeoboxes of many eukaryotic organisms appear to be very similar. ...
Talk4EmpiricalEvaluationHorvath
... – e.g. nervous system development (Bonferroni corrected pvalue =2.1e-6), – neuron differentiation (p=7.6e-5), – anatomical structure development (p=0.00013), – cell development (p=0.00024), – generation of neurons (p=0.00038), – neurogenesis (p=0.00052), cell differentiation (p=0.00057). ...
... – e.g. nervous system development (Bonferroni corrected pvalue =2.1e-6), – neuron differentiation (p=7.6e-5), – anatomical structure development (p=0.00013), – cell development (p=0.00024), – generation of neurons (p=0.00038), – neurogenesis (p=0.00052), cell differentiation (p=0.00057). ...
HNF-1B specifically regulates the transcription of the
... Hypomagnesemia, although not deeply investigated, is often reported in patients carrying HNF1B defects [11,12]. Interestingly, Adalat et al. described five cases of HNF1B whole-gene deletions, two splice site mutations and one frame-shift mutation being associated with renal malformations and hypomag ...
... Hypomagnesemia, although not deeply investigated, is often reported in patients carrying HNF1B defects [11,12]. Interestingly, Adalat et al. described five cases of HNF1B whole-gene deletions, two splice site mutations and one frame-shift mutation being associated with renal malformations and hypomag ...
Chapter 26 - RNA Metabolism
... • Pause sites - regions of the gene where the rate of elongation slows down (10 to 100-fold) or stops temporarily • Transcription termination often occurs here • G-C- rich regions are more difficult to separate than A-T rich regions and may be pause sites • Pause is exaggerated when newly transcribe ...
... • Pause sites - regions of the gene where the rate of elongation slows down (10 to 100-fold) or stops temporarily • Transcription termination often occurs here • G-C- rich regions are more difficult to separate than A-T rich regions and may be pause sites • Pause is exaggerated when newly transcribe ...
Neural plasticity and recovery of function
... effects of lesions on rats’ across the cortex. maze learning. • The larger the amount of cortex damaged, the more errors the rats made. ...
... effects of lesions on rats’ across the cortex. maze learning. • The larger the amount of cortex damaged, the more errors the rats made. ...
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... • Professor (Chair) of Microbiology, Trinity College Dublin (TCD) since 1994 • Head of the School of Genetics and Microbiology TCD 2008-‐2011; 2014-‐ • Chair of Publications, Microbiology Society, London 2015- ...
... • Professor (Chair) of Microbiology, Trinity College Dublin (TCD) since 1994 • Head of the School of Genetics and Microbiology TCD 2008-‐2011; 2014-‐ • Chair of Publications, Microbiology Society, London 2015- ...
Gene Section FOXC1 (forkhead box C1) Atlas of Genetics and Cytogenetics
... expression of FOXO1A. The promoter region of FOXO1A contains consensus FOXC1 binding site (GTAAACAAA). FOXO1A is responsible for regulation of cellular homeostasis and cell survival during ocular development, its functioning depends on function of FOXC1. Other targets of FOXC1 in transcriptional reg ...
... expression of FOXO1A. The promoter region of FOXO1A contains consensus FOXC1 binding site (GTAAACAAA). FOXO1A is responsible for regulation of cellular homeostasis and cell survival during ocular development, its functioning depends on function of FOXC1. Other targets of FOXC1 in transcriptional reg ...
Synthetic Zinc Finger Transcription Factor Action at
... and that modification of histone-DNA interactions through nucleosome repositioning (18, 19), histone depletion (20, 21), and removal of the histone tails (22, 23) can promote TFIIIA binding to a nucleosomal infrastructure. Accumulation of histone H1 in chromatin can specifically interfere with TFIII ...
... and that modification of histone-DNA interactions through nucleosome repositioning (18, 19), histone depletion (20, 21), and removal of the histone tails (22, 23) can promote TFIIIA binding to a nucleosomal infrastructure. Accumulation of histone H1 in chromatin can specifically interfere with TFIII ...
Kevin Ann Hunt Term paper
... loss of function allele of Grhl2 (Grhl2GT) was generated that also contained a reporter gene (βgeo). Heterozygous loss of function mutants (Grhl2GT/+) were stained and the location of expression was found to be comparable to expression seen from in situ hybridization and added branchial arches, nasa ...
... loss of function allele of Grhl2 (Grhl2GT) was generated that also contained a reporter gene (βgeo). Heterozygous loss of function mutants (Grhl2GT/+) were stained and the location of expression was found to be comparable to expression seen from in situ hybridization and added branchial arches, nasa ...
Cell-Specific Expression of Genes of the Lipid Transfer Protein
... of 85-92% (Soufleri et al. 1996). However, when these transcripts were compared to yet another B. napus LTP the tapetum-specific E2, they showed significantly lower identity, less than 50%. In addition, the N-terminal amino acid sequences of two Arabidopsis (ecotype Columbia) LTP are different from ...
... of 85-92% (Soufleri et al. 1996). However, when these transcripts were compared to yet another B. napus LTP the tapetum-specific E2, they showed significantly lower identity, less than 50%. In addition, the N-terminal amino acid sequences of two Arabidopsis (ecotype Columbia) LTP are different from ...
Genomic structure and promoter analysis of pathogen-induced genes from
... positions and junction-flanking sequences for both genes are highly conserved, including the location of an intron in the 5′-untranslated region with the donor sequence immediately before the start ATG codon (Fig. 1B, Table 2). The similarity in the genomic structure of repat1 and repat2 may indicat ...
... positions and junction-flanking sequences for both genes are highly conserved, including the location of an intron in the 5′-untranslated region with the donor sequence immediately before the start ATG codon (Fig. 1B, Table 2). The similarity in the genomic structure of repat1 and repat2 may indicat ...
Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning
... on these observations, it has been hypothesized that a subset of activity-regulated mRNAs is actively transported to synapses after synaptic activity, and localized translation of these has been proposed as a basic cellular mechanism required for synaptic plasticity (Rodriguez et al. 2008; Vuppalanc ...
... on these observations, it has been hypothesized that a subset of activity-regulated mRNAs is actively transported to synapses after synaptic activity, and localized translation of these has been proposed as a basic cellular mechanism required for synaptic plasticity (Rodriguez et al. 2008; Vuppalanc ...
Haoyang Zeng, Michela Meister, Subarna Sinha, David L. Dill
... This work confirmed many findings from previous work, including: Ø Genes associated with the four subtypes of GBM Ø Important genes in GBM, including RB1, CDKN2A and PTEN. Ø The role of IDH1 in hyper-methylation Ø Significant deletion in chromosome 7 and amplification in chromosome 10 and th ...
... This work confirmed many findings from previous work, including: Ø Genes associated with the four subtypes of GBM Ø Important genes in GBM, including RB1, CDKN2A and PTEN. Ø The role of IDH1 in hyper-methylation Ø Significant deletion in chromosome 7 and amplification in chromosome 10 and th ...
B - Computational Systems Biology Group
... ways of finding differentially expressed genes False Discovery Rate (FDR), controls the expected number of false rejections among the rejected hypotheses (differentially expressed genes), instead of the more conservative FWER, that controls the probability that one of more of the rejected hypotheses ...
... ways of finding differentially expressed genes False Discovery Rate (FDR), controls the expected number of false rejections among the rejected hypotheses (differentially expressed genes), instead of the more conservative FWER, that controls the probability that one of more of the rejected hypotheses ...
GENE TECHNOLOGY - mf011
... genes for practical purposes DNA technology has revolutionized biotechnology, the manipulation of organisms or their genetic components to make useful products An example of DNA technology is the microarray, a measurement of gene expression of thousands of different genes ...
... genes for practical purposes DNA technology has revolutionized biotechnology, the manipulation of organisms or their genetic components to make useful products An example of DNA technology is the microarray, a measurement of gene expression of thousands of different genes ...
Biochemistry
... expression of genetic information must be cued to extrinsic signals and respond only when necessary. Mammalian cells possess about 1000 times more genetic information than does the bacterium Escherichia coli. Much of this additional genetic information is probably involved in regulation of gene expr ...
... expression of genetic information must be cued to extrinsic signals and respond only when necessary. Mammalian cells possess about 1000 times more genetic information than does the bacterium Escherichia coli. Much of this additional genetic information is probably involved in regulation of gene expr ...
Chapter 4: DNA and Chromosomes
... Chromatin region extending 5,000 bp from chromo ends resistant to gene expression Many diff proteins required for special folding Mutations in silent information regulator proteins (SIR) prevent silencing of genes near telomeres ► Cooperative binding of SIRs occurs to facilitate modifications ...
... Chromatin region extending 5,000 bp from chromo ends resistant to gene expression Many diff proteins required for special folding Mutations in silent information regulator proteins (SIR) prevent silencing of genes near telomeres ► Cooperative binding of SIRs occurs to facilitate modifications ...
Document
... Multiple genes involved, and interaction of two dominant alleles (R & P) produce factors that modify comb shape from a simple (rose/pea) to more complex form (walnut). ...
... Multiple genes involved, and interaction of two dominant alleles (R & P) produce factors that modify comb shape from a simple (rose/pea) to more complex form (walnut). ...
Section 2 Gene Expression in Development and Cell Division
... – Within each homeotic gene, a specific DNA sequence known as the homeobox regulates patterns of development. – The homeoboxes of many eukaryotic organisms appear to be very similar. ...
... – Within each homeotic gene, a specific DNA sequence known as the homeobox regulates patterns of development. – The homeoboxes of many eukaryotic organisms appear to be very similar. ...
The honeybee as a model for understanding the basis of cognition
... Because these relatively complex behaviours are controlled by a brain consisting of only 1 million or so neurons, honeybees offer an opportunity to study the relationship between behaviour and cognition in neural networks that are limited in size and complexity. Most recently, the honeybee has been ...
... Because these relatively complex behaviours are controlled by a brain consisting of only 1 million or so neurons, honeybees offer an opportunity to study the relationship between behaviour and cognition in neural networks that are limited in size and complexity. Most recently, the honeybee has been ...
Gene Set Testing
... check whether the reduction of the RSS is significant. This tells us, for each gene set, whether there is association between its expression and the tumor stage. ...
... check whether the reduction of the RSS is significant. This tells us, for each gene set, whether there is association between its expression and the tumor stage. ...
Recombination and Repair
... Gene conversions are “not” associated with crossing over. Occur at Yeast mating-type switching at Bacterial genetic exchange via transduction or conjugation at eukaryote homologous recombination in meiosis ...
... Gene conversions are “not” associated with crossing over. Occur at Yeast mating-type switching at Bacterial genetic exchange via transduction or conjugation at eukaryote homologous recombination in meiosis ...
New Brain Cells Go to Work
... time. As it turned out, its hippocampus had as many newborn neurons as that of the more learned mice, but its memory gene, c-fos, was not switched on any more than it was in control animals that had not been trained. The memory gene’s activation seemed to be what made the learning possible. The rese ...
... time. As it turned out, its hippocampus had as many newborn neurons as that of the more learned mice, but its memory gene, c-fos, was not switched on any more than it was in control animals that had not been trained. The memory gene’s activation seemed to be what made the learning possible. The rese ...
Genome-based bioprospecting of microbes for new
... time consuming. A number of genomic-based techniques are currently being employed to increase titers. One is based on the fact that secondary metabolite gene clusters almost always contain regulatory genes, which control expression of structural biosynthetic genes. These pathway-specific regulators ...
... time consuming. A number of genomic-based techniques are currently being employed to increase titers. One is based on the fact that secondary metabolite gene clusters almost always contain regulatory genes, which control expression of structural biosynthetic genes. These pathway-specific regulators ...