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Chapter 9
Chapter 9

... Histones play major role in gene expression - Expose DNA when and where it is to be transcribed and shield it when it is to be silenced The three major types of small molecules that bind to histones are: - Methyl groups—no transcription OFF - Acetyl group—allow transcription  ON - Phosphate groups ...
Using bioinformatics for better understanding of genes amplify
Using bioinformatics for better understanding of genes amplify

... How this project using DOGMA will help me teaching my genetics course The next time I teach the part of genomes and proteomes in my genetics course, in the explanation of comparative genomics, I can show similarities between different genomes and introduce them the evolutionary relationships betwee ...
Gene Expression - Pleasantville High School
Gene Expression - Pleasantville High School

... •Example: Gene for blue eyes is “expressed” only in the iris of the eye. ...
Dr Anthony Isles
Dr Anthony Isles

... – histone modifications • Modifications of residues in the histone ‘tails’ • >40 possible modifications • Modification alter 3-D structure and make DNA more, or less, accessible • Acetylation found in regions of increased gene expression DNA-methylation and chromatin interact – differential recruitm ...
poster SIBBM 2016
poster SIBBM 2016

... Background: DNA is under persevering attack from both endogenous byproducts of cellular metabolism (e.g., reactive oxygen species) and exogenous sources of environmental stress (e.g., ultraviolet light). These genotoxic agents create DNA breaks and adducts that, if left unresolved, can be deleteriou ...
nature v. nurture
nature v. nurture

... one person may be struck by cancer, for example, while another is spared, even though neither's DNA harbors a cancer-causing mutation. "This is how the environment talks to the genome," said Rudolf Jaenisch, a geneticist at the Whitehead Institute for Biomedical Research in Cambridge, Mass., who was ...
Learning & Memory
Learning & Memory

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Final Jeopardy 2
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Models in Genetics - Cherokee High School
Models in Genetics - Cherokee High School

... be expressed  Knockout mice are valuable tools for discovering the function(s) of genes for which ...
TRANSPONSONS or TRANSPOSABLE ELEMENTS
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Supplementary information about the five
Supplementary information about the five

... (iii) the oscillatory state (O). The five-gene model also showed differentiation from the oscillatory state (Fig. S4). The attractor depended on the parameters Kij for each edge, while most effective regulations to determine the type of attractors were related to gene x1 , as in the four-gene model. I ...
Metabolitics Structural Genomic Protein States
Metabolitics Structural Genomic Protein States

... What genes went up or down under an experimental condition? The bigger picture Are cells or tissues related based on the genes they express? For an experimental cell model, are there conditions that are similar based on changes in gene expression? For certain experimental conditions, are there genes ...
Discovery and analysis of inflammatory disease-related
Discovery and analysis of inflammatory disease-related

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Chromosomes
Chromosomes

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Mechanisms of Learning and Memory
Mechanisms of Learning and Memory

... It’s discovered the nervous substrate of long-term memory is mostly cerebral cortex. The most important regions are temporal lobes, prefrontal area and hippocampus. Experimental researches revealed that some thalamic nuclei and reticular formation take part in memory function. Reticular formation gi ...
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41040-2-12118

... controlled, experimental conditions. By observing consequences of such an intervention scientists can verify existing hypothesis and form new ones about the role of that particular gene, both in terms of phenotype and the expression levels of other genes. Although very advantageous, gene silencing h ...
Exercise week 10, with answers File
Exercise week 10, with answers File

... reporter in specific tissues. This approach cannot directly prove a function for Gata1 in these cells, although it may provide indirect supporting evidence 4) Feed-forward loops in gene regulatory networks a. describe the behavior e.g. of AP-1 complexes or myogenic TFs such as MyoD to amplify their ...
Transcription – Part II
Transcription – Part II

... Transcriptional Regulation - Eukaryotes 8. Regulation of gene expression in eukaryotes is considered much more complex than in prokaryotes. Why do you think that is? 9. What is the role of enhancers and silencers in transcriptional regulation? 10. Describe the three different DNA binding motifs asso ...
DNA Function: Information Transmission
DNA Function: Information Transmission

... ● a small fraction of the non-protein coding DNA consists of genes for rRNAs and tRNAs ● until recently, researchers assumed that most of the remaining DNA was untranscribed…”junk” DNA ● however, new research suggests that a significant amount of the genome may be transcribed into non-proteincoding ...
DNA Jeopardy Review
DNA Jeopardy Review

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Genetics Science Learning Center
Genetics Science Learning Center

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Slide 1
Slide 1

... 1. Associate a hsp70 with a PKA-inhibitor gene in fruit fly 2. Heat flies • PKA-inhibitor expression increases within 1h • Learning is disrupted 1. Associate a hsp70 with a mutated (dysfunctional) PKA-inhibitor gene in fruit fly 2. Heat flies • Dysfunctional PKA-inhibitor expression increases • Lear ...
Ghost in Your Genes Response
Ghost in Your Genes Response

... 2. Why do scientists expect that something other than genes alone are at play in the making of an organism? ...
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Eukaryotic Gene Expression
Eukaryotic Gene Expression

... Eukaryotic mRNA can last hours or even weeks Length of time before degraded by cellular enzymes is related to quantity of protein synthesis they can direct Translation of mRNA can be delayed until control signal initiates it Initiation factors may be required for translation Polypeptides are extensi ...
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Epigenetics in learning and memory

While the cellular and molecular mechanisms of learning and memory have long been a central focus of neuroscience, it is only in recent years that attention has turned to the epigenetic mechanisms behind the dynamic changes in gene transcription responsible for memory formation and maintenance. Epigenetic gene regulation often involves the physical marking (chemical modification) of DNA or associated proteins to cause or allow long-lasting changes in gene activity. Epigenetic mechanisms such as DNA methylation and histone modifications (methylation, acetylation, and deacetylation) have been shown to play an important role in learning and memory.
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