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Bioinformatics/Computational Biological Applications of
Bioinformatics/Computational Biological Applications of

... • Can lead to novel problems: (1) Many techniques assume n <= p e.g. LDA cannot be applied directly as covariance matrix is under-determined and can not be estimated, so feature selection is required. (Even where a method e.g. SVMs can handle the high dimensionality, feature selection is still usefu ...
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Recombinant DNA and Genetic Engineering

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Victor YU - National University of Singapore

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Gene Section EIF4A2 (eukaryotic translation initiation factor 4A, isoform 2)

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Identification and Chromosome Assignment of a Human Gene

... We identified a novel phosphatidylinositol (PI) 3-kinase by screening human brain cDNA libraries with probes designed from the conserved kinase-domain sequence. Analysis of cDNAs indicated that two different forms of transcripts are present: one is the full-length form composed of 1,044 amino acid r ...
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Vectors in gene therapy

Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
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