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Introduction to high-‐throughput experiments and data analysis
Introduction to high-‐throughput experiments and data analysis

... – alternative  splicing:  different  splicing  pattern  for  the  same   pre-­‐mRNA.  For  example,  mRNA  could  be  from  exons  1  and   2  or  exons  1  and  3.  Those  are  different  “transcript”  of  the   same  gene. ...
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... • Charles Darwin published On the Origin of Species by Means of Natural Selection in 1859 • Darwin made two main points: – Species showed “descent with modification” from common ancestors – Natural selection is the mechanism ...
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... Gene Therapy  Gene therapy is lagging behind genetic testing • For example, gene for cystic fibrosis was identified in 1989 • Scientists have been testing ways to insert copies of the normal gene into cells of the respiratory tract  It is difficult to get the gene inserted into the tissue so that ...
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Transcription and translation

Cell Specialisation - NCEA Level 2 Biology
Cell Specialisation - NCEA Level 2 Biology

TF binding
TF binding

... Gene Expression • Methylation at CpG islands often repress nearby gene expression • Many highly expressed genes have CpG methylation on their exons Some genes could be imprinted, so maternal and paternal copies have different DNA methylation From Ting Wang, Wash U ...
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Vectors in gene therapy

Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
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