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DNA Structure and Replication

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... • Genes with bivalent chromatin are thought to remain in a “poised” state until……. • ……the stem cell receives cues to differentiate down a defined lineage. Chromatin is then modified to a fully active state at lineage-specific genes (H3K4me, H3K9ac) or is fully repressed at genes required for other ...
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Vectors in gene therapy

Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods, summarized below. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
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