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et al - International Journal of Systematic and Evolutionary
et al - International Journal of Systematic and Evolutionary

... these proteins was previously available from only a limited number of actinobacteria, whose genomes have been sequenced. One possible signature for actinobacteria, consisting of a large insert in the 23S rRNA, has previously been described (Roller et al., 1992). However, the validity and specificity ...
Chromatin dynamics during cellular differentiation in the female
Chromatin dynamics during cellular differentiation in the female

... most animals. Instead, the meiotic precursor cells, or spore mother cells (SMCs), differentiate de novo in very young flower buds in female and male floral organs: the ovule and anther primordia, respectively (left). In most flowering plants, only one female SMC (also called megaspore mother cell) i ...
Gene Section ALK (anaplastic lymphoma kinase) Atlas of Genetics and Cytogenetics
Gene Section ALK (anaplastic lymphoma kinase) Atlas of Genetics and Cytogenetics

... Hidden translocation is frequently found; either t(X;2)(q11;p23), or t(1;2)(q25;p23), or inv(2)(p23q35), or t(2;3)(p23;q21), or t(2;22)(p23;q11.2). Hybrid/Mutated gene 5' MSN, TPM3, ATIC, TFG, or CLTCL1 - 3' ALK. Abnormal protein N-term amino acids from the partner gene fused to the 562 C-term amino ...
change in `ploidy`
change in `ploidy`

... Duplicated A ...
Guidance on the Use of Biochemical and Molecular Markers
Guidance on the Use of Biochemical and Molecular Markers

... 1.1 A key feature of the process of eliminating varieties of common knowledge prior to the DUS growing trial is that the threshold for deciding which varieties can be safely excluded (i.e. are distinct on the basis of descriptions), can be set with a suitable margin of safety, because those varietie ...
Nucleolar caspase-2: Protecting us from DNA damage
Nucleolar caspase-2: Protecting us from DNA damage

... delineate two pathways of caspase-2 activation and show that, in response to DNA damage, caspase-2 forms a complex with the PIDDosome and NPM1 within the nucleolus. Caspase-2 is a critical component of the cellular machinery designed to remove damaged cells, preventing disease. Consistent with a fun ...
Gene Section MLL (myeloid/lymphoid or
Gene Section MLL (myeloid/lymphoid or

... Transcriptional regulatory factor, maintenance of Hox gene expression. ...
Existence Logic - ORION Active Structure
Existence Logic - ORION Active Structure

Replication studies in longevity: puzzling findings in Danish
Replication studies in longevity: puzzling findings in Danish

... older people (Williams, 1957 ; De Benedictis et al. 1998 a ; Yashin et al. 1999). These alleles will be lost from the genetic pool as the population ages and survival selection occurs, until the gene pool will arrive at a structure compatible with survival at old age. However, if the structure of th ...
Gene Section HFE (hemochromatosis) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Gene Section HFE (hemochromatosis) Atlas of Genetics and Cytogenetics in Oncology and Haematology

... other cancers. In South Wales (U.K.), C282Y mutation is associated with increased risk to childhood acute lympho-blastic leukemia in boys only. This association has not been noted in other studies in Finland, Spain and Mexico. In Italy, adult leukemia shows an association with H63D mutation. ...
Lecture 8
Lecture 8

... Identifying orthologous and paralogous genes * Use genome similarity matrix to distinguish between paralogs and orthologs * remember: homologs are genes that have a common ancestor, orthologs arise as homologs evolve in sisterspecies; paralogs arise from duplication and subsequent specialisation * R ...
Sperm Cell in ART
Sperm Cell in ART

... recombination of genetic information and the haploid spermatid production (Picture 2.). The aim of the process is to produce a highly specialized mature sperm cell which can bind to the oocyte. The paternal inherited centrosome is essential for normal fertilization, chromatin packaging and early emb ...
Coexpression of Linked Genes in Mammalian
Coexpression of Linked Genes in Mammalian

... of linked yeast genes (Lercher and Hurst 2006), the adaptive model implies that the gene order in the yeast genome must be highly organized. However, the high plasticity of yeast gene order revealed from a comparison of 11 species (Fischer et al. 2006) argues against this view. In addition, it is we ...
Involvement of respiratory chain in biofilm formation in - HAL
Involvement of respiratory chain in biofilm formation in - HAL

... genes lanking the mutation. The mutations had no effect on bacterial growth in anaerobic condition as expected. However, these genes may be involved in bacterial growth under variable nutrients or in the presence of few quantity of oxygen. Thus future experiment will be performed in different condit ...
The Advantage and Application of Genetically Humanized Mouse
The Advantage and Application of Genetically Humanized Mouse

... Genetically Humanized Mouse Models of Drug Metabolism and Disposition Model systems that accurately predict the fate of a drug in humans are essential in pharmaceutical research. Due to significant species differences in the proteins utilized for drug metabolism and disposition, genetically humanize ...
Allele Mining Strategies: Principles and Utilisation for Blast
Allele Mining Strategies: Principles and Utilisation for Blast

... An important goal of modern crop science is to use nucleotide sequence variation to improve crops. Variation can either be natural, from divergent populations, or induced through treatment with mutagens (Till et al., 2007a). Mutation, among the fundamental forces of development, is usually a sudden ...
Yeast as a Model Genetic Organism
Yeast as a Model Genetic Organism

... When diploid budding yeast are starved of nutrients, they can undergo meiosis to generate four haploid spores (Figures 1 and 2). Spores are more resistant to the environment than are vegetatively dividing cells. The four spores of a single meiosis are held together in an ascus, or tetrad, surrounded ...
Supplementary Discussion References
Supplementary Discussion References

... The differentially expressed gene list was obtained by meeting criteria: 1) intersection of both bipolar disorder and schizophrenia for significant genes, 2) passed ANCOVAs for restricted pH > 6.57 and 3) gene passed unrestricted ANCOVA for all pH. The list of genes that were found to be significant ...
KAIE LOKK Comparative genome-wide DNA methylation
KAIE LOKK Comparative genome-wide DNA methylation

... and transcription remain unclear. Several studies have linked methylation events in promoter-CpG islands with gene expression regulation. Despite these correlations, tissue-specific differentially methylated regions have been increasingly found among intragenic regions, such as in gene bodies or eve ...
MS-SCI-LS-Unit 2 -- Chapter 5- Genetics-The
MS-SCI-LS-Unit 2 -- Chapter 5- Genetics-The

... 5 7.1 All living organisms are composed of cells, from just one to many trillions, whose details usually are visible only through a microscope. As a basis for understanding this concept: ...
2.5.6 Genetic Inheritance 2.5.7 Causes of Variation 2.5.8 Evolution
2.5.6 Genetic Inheritance 2.5.7 Causes of Variation 2.5.8 Evolution

... Q. Human males and females differ in one of their twenty three pairs of chromosomes. What name is given to this pair of chromosomes? Allele only expressed in the homozygous condition ...
Stage-specific expressions of four different ribonuclease H genes in
Stage-specific expressions of four different ribonuclease H genes in

... are incurable in the chronic stage and often the disease is not detectable at the initial stages of infection using the currently available methods. Current drug treatments are effective only for the initial infection and have substantial toxicity. The available drugs are very costly and unaffordabl ...
Galactosemia screening when?
Galactosemia screening when?

... galactosemia known as type III or galactose epimerase deficiency. ...
Genome duplications and accelerated evolution of
Genome duplications and accelerated evolution of

... SYNOPSIS. The early origin of four vertebrate Hox gene clusters during the evolution of gnathostomes was likely caused by two consecutive duplications of the entire genome and the subsequent loss of individual genes. The presumed conserved and important roles of these genes in tetrapods during devel ...
The 10 autosomal recessive limb-girdle muscular - Genoma
The 10 autosomal recessive limb-girdle muscular - Genoma

... 10 genes responsible for the autosomal recessive forms, which account for more than 90% of the cases, had their product identified. This review will focus on the most recent data on autosomal recessive-limb-girdle muscular dystrophy and on our own experience of more than 300 patients studied from 12 ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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