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charlietalk
charlietalk

... • Cell is a dynamical system • Somewhat modularized (into pathways) • Given pathway elements, how do they communicate? – Protein modification – Gene expression changes ...
Genetic Disorders
Genetic Disorders

...  Gene mutations can be either inherited from a parent or acquired. A hereditary mutation is a mistake that is present in the DNA of virtually all body cells. Hereditary mutations are also called germ line mutations because the gene change exists in the reproductive cells and can be passed from gene ...
Chapter 11 Protein Characterization
Chapter 11 Protein Characterization

... The above picture shows Actin cytoskeletons of human endothelial cells which glow green in this immunofluorescent micrograph. DNA stained with DAPI is blue in color. DAPI is a fluorescent stain widely used to visualize DNA.The actin filaments has linked them into a highly triangular structure resemb ...
Genetics
Genetics

... Crossing over: Draw a picture of metaphase in mitosis and metaphase 1 in meiosis (They are different!) ...
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Section 8.2

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DNA Deoxyribonucleic Acid
DNA Deoxyribonucleic Acid

...  Codon – 3 bases on the mRNA that code for an amino acid.  Anticodon – 3 bases on the tRNA that code for an amino acid – follow base pairing rules for the codon. Translation Steps ...
dilemmas regarding clinical obligation
dilemmas regarding clinical obligation

... detection in heterozygous cases such as these, conveying of this information, and how it is done requires careful education and explanation. We believe these three examples are likely to be representative of multiple additional genes where clinical interpretation of aCGH results needs to be carefull ...
The History of Molecular Genetics
The History of Molecular Genetics

... – DNA composition varies between different species – In a given species, the four nitrogen bases are present in a predictable ratio ...
Twenty-five years of the nucleosome Kornberg and Lorch 1998, Cell
Twenty-five years of the nucleosome Kornberg and Lorch 1998, Cell

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... promoter region of the srfA gene was cloned through several PCR and reverse-PCR reactions. The nucleotide sequence of this DNA fragment was compared to that of several cDNA clones containing 5’-untranslated regions (5’-UTR) of srfA mRNAs, obtained from the public Japanese cDNA data bank or by rapid ...
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Exam 2 practice questions organized by lecture topic

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Oct 23, 2006 Handout
Oct 23, 2006 Handout

... a. If it is in a non-coding region, usually nothing. If it is in a coding region it will cause a frameshift: because codons are made of three nucleotides, deleting one base pair disrupts the “reading frame” or division of the sequence into threes. Frameshifts occur if the number of base pairs insert ...
An artifact in studies of gene regulation using β
An artifact in studies of gene regulation using β

... inserted at a site that did not disrupt the a-peptide could subsequently give rise to an increase in b-gal activity when it was used in experiments with E. coli strains carrying intact lacZ [15]. In conclusion, based on our data, an artifact can arise in gene regulation assays in which an empty plas ...
Chapter 8 Microbial Genetics
Chapter 8 Microbial Genetics

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AIMS Review Packet
AIMS Review Packet

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Chapter 12: Nucleotides and Nucleic Acids
Chapter 12: Nucleotides and Nucleic Acids

... determined that all the basic rules of protein and nucleic acid structure and synthesis are the same in Oz as they are on earth, with only two apparent exceptions. First, in Oz, only 12 different amino acids could be detected in protein samples (Gly, Pro, Leu, Lys, Arg, Phe, Tyr, Glu, Ser, Cys, Gln, ...
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Designing Molecular Machines·

... itself into a three-stranded polymer-a triple helix! This was an interesting anomaly but no one knew if it was really important. It was just a laboratory curiosity-an amusing chemical oddity-so it was duly written up. Nobody knew how the three strands bound togetherthey had no high-tech instruments ...
Viruses, Jumping Genes and Other Unusual Genes
Viruses, Jumping Genes and Other Unusual Genes

... • Up to 1% of DNA in a cell may be mitochondrial DNA • Mitochondrial DNA is circular • In plants, chloroplast DNA may make up 15% of the cell’s DNA • Also have complete systems for transcription and translation that resemble bacteria ...
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The characterization of floral organ identity gene homologues in

... scales all show conical type which is similar to that on the epidermal cells of ordinary bright petals. The results suggest that the perianths of Trochodendron are very likely reduced during evolution instead of being a pleiomorphic character, and the attracting agent has been replaced by whole flow ...
Exemplar exam questions – Chapter 7
Exemplar exam questions – Chapter 7

... This response is quite short but there are only 4 marks on this section so the candidate has chosen wisely to spend more time on the other sections. Three points have been made correctly and the candidate has said why they are important and so has ‘discussed’ them. Marks awarded for any four of the ...
Exemplar exam questions – Chapter 7, Nucleic acids and proteins
Exemplar exam questions – Chapter 7, Nucleic acids and proteins

powerpoint
powerpoint

... The components of the telomere repeat binding factor 1 (TRF1) (Ca) and 2 (TRF2) (Cb) complexes and are shown. ...
Sequencing the Human Genome
Sequencing the Human Genome

... apart into random pieces. 3. Put the mixture into a separator material (gel) and let the pieces sink. 4. Smaller molecules sink faster, so the molecules separate by length. 5. Find the glowing molecules at each level, and analyze their amino acid content. 6. Put the protein back together amino acid ...
2054, Chap. 13, page 1 I. Microbial Recombination and Plasmids
2054, Chap. 13, page 1 I. Microbial Recombination and Plasmids

... 7. transposons have been observed in eukaryotes, bacteria, Archaea, yeast, maize, Drosophila, and humans 8. transposons contribute to genetic diversity D. conjugation = transfer of DNA between bacteria in direct contact 1. depends on plasmids (free or integrated) 2. Lederberg and Tatum mixed multipl ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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