Epistemic goal as aspect of meaning
... namely, the explanation of the production of gene products. At the same time, this generic epistemic goal can be fleshed out differently in different research contexts. For instance, as some parts of molecular biology focus on RNAs as the primary gene product while others focus on proteins as the se ...
... namely, the explanation of the production of gene products. At the same time, this generic epistemic goal can be fleshed out differently in different research contexts. For instance, as some parts of molecular biology focus on RNAs as the primary gene product while others focus on proteins as the se ...
Leukaemia Section 12p abnormalities in myeloid malignancies Atlas of Genetics and Cytogenetics
... better prognosis than patients with 12p abnormalities in general and a lower tendency to additional chromosomal rearrangements; submicroscopic deletions of 12p are much more common in lymphoid than in myeloid malignancies; a minimal interstitial deletion region is described, involving ETV6 and CDKN1 ...
... better prognosis than patients with 12p abnormalities in general and a lower tendency to additional chromosomal rearrangements; submicroscopic deletions of 12p are much more common in lymphoid than in myeloid malignancies; a minimal interstitial deletion region is described, involving ETV6 and CDKN1 ...
Widespread expression of the bovine Agouti gene results from at
... expression pattern. We found no evidence of coding-region sequence variation within and between eight breeds representing a large panel of coat colour phenotypes. We detected by northern hybridization two Agouti mRNA isoforms in brain, heart, lung, liver, kidney, spleen and a third in skin. We chara ...
... expression pattern. We found no evidence of coding-region sequence variation within and between eight breeds representing a large panel of coat colour phenotypes. We detected by northern hybridization two Agouti mRNA isoforms in brain, heart, lung, liver, kidney, spleen and a third in skin. We chara ...
Commonly Asked Questions
... and the calculation of a suitable statistic such as a moderated t-statistic or a b-statistic which ranks each gene to indicate whether a gene has significantly changed in expression or not. The ordinary t-statistic is not ideal because a large t-statistic can be driven by an unrealistically small st ...
... and the calculation of a suitable statistic such as a moderated t-statistic or a b-statistic which ranks each gene to indicate whether a gene has significantly changed in expression or not. The ordinary t-statistic is not ideal because a large t-statistic can be driven by an unrealistically small st ...
IMSR File Format
... distributed from the provider’s site, and the “states” in which these strains or stocks are held. The list of valid states supported by the IMSR can be found in Table 3. The definition of the columns that should be provided in the tab-delimited IMSR load files can be found in Table 1, below. A singl ...
... distributed from the provider’s site, and the “states” in which these strains or stocks are held. The list of valid states supported by the IMSR can be found in Table 3. The definition of the columns that should be provided in the tab-delimited IMSR load files can be found in Table 1, below. A singl ...
The hybrid origins of three perennial Medicago species
... negatively, also disrupting for too long might destroy the DNA. Adding buffer AP1 and RNase A into the tube and incubate at 65°C for 10 min, will result in lysing the cell without affecting the DNA. Cell lysis breaks up the cell membrane and releases the macromolecules, such as protein and DNA. The ...
... negatively, also disrupting for too long might destroy the DNA. Adding buffer AP1 and RNase A into the tube and incubate at 65°C for 10 min, will result in lysing the cell without affecting the DNA. Cell lysis breaks up the cell membrane and releases the macromolecules, such as protein and DNA. The ...
Pierce Genetics: A Conceptual Approach 3e
... • Not well understood but gene dosage is main suspect • Interactions of many gene products influence development • Or novel functions • Human globin genes • Segmental duplications on one chromosome (intrachromosmal) or on different chromosomes (interchromosomal) ...
... • Not well understood but gene dosage is main suspect • Interactions of many gene products influence development • Or novel functions • Human globin genes • Segmental duplications on one chromosome (intrachromosmal) or on different chromosomes (interchromosomal) ...
Chromosome Band 1p36 Contains a Putative Tumor
... The p18INK4c gene is located on 1p32 and it is regarded as a tumor suppressor gene.24 Homozygous deletions of the p16INK4a gene, which is a homolog of the p18INK4c gene, were reported in lymphoid BC of CML.6 While the common region of LOH in the present study was more distal (1p36), 9 of the 14 samp ...
... The p18INK4c gene is located on 1p32 and it is regarded as a tumor suppressor gene.24 Homozygous deletions of the p16INK4a gene, which is a homolog of the p18INK4c gene, were reported in lymphoid BC of CML.6 While the common region of LOH in the present study was more distal (1p36), 9 of the 14 samp ...
A Yale geneticist and a Chinese lab are creating the Amazon.com of
... Humans and mice share about which has funded part of Xu’s research. The project 99 percent of their genes. is also funding other scientists to knock out 8,500 genes in mouse stem cells using more-conventional with a disabled gene simply by mating two specially technologies; its goal is to make a com ...
... Humans and mice share about which has funded part of Xu’s research. The project 99 percent of their genes. is also funding other scientists to knock out 8,500 genes in mouse stem cells using more-conventional with a disabled gene simply by mating two specially technologies; its goal is to make a com ...
Printable version
... get passed from cell to cell during cell division, and from one generation to the next during eukaryotic life cycles. Since chromosomes contain the genetic information, the study of chromosomes provides a key to understanding how the genetic information is transmitted from one generation to the ne ...
... get passed from cell to cell during cell division, and from one generation to the next during eukaryotic life cycles. Since chromosomes contain the genetic information, the study of chromosomes provides a key to understanding how the genetic information is transmitted from one generation to the ne ...
Six3, a murine homologue of the sine oculis gene, demarcates the
... Materials and Methods). Sequence analysis showed that this cDNA codes for a new gene belonging to the Six/sine oculis subclass of homeobox genes therefore, we named it Six3 (Fig. 1A). Northern blot analysis (Fig. 1B) of E10.5 poly(A) mRNA showed that Six3 produces two transcripts of approximately 3. ...
... Materials and Methods). Sequence analysis showed that this cDNA codes for a new gene belonging to the Six/sine oculis subclass of homeobox genes therefore, we named it Six3 (Fig. 1A). Northern blot analysis (Fig. 1B) of E10.5 poly(A) mRNA showed that Six3 produces two transcripts of approximately 3. ...
Leukaemia Section inv(3)(q21q26)x2 Atlas of Genetics and Cytogenetics in Oncology and Haematology
... Inv(3)(q21q26) is recognized as a distinctive entity of acute myeloid leukemia (AML) with recurrent genetic abnormalities of prognostic significance. The molecular consequence is the juxtaposition of the ribophorin I (RPN1) gene (located in band 3q21) with the ecotropic viral integration site 1 (EVI ...
... Inv(3)(q21q26) is recognized as a distinctive entity of acute myeloid leukemia (AML) with recurrent genetic abnormalities of prognostic significance. The molecular consequence is the juxtaposition of the ribophorin I (RPN1) gene (located in band 3q21) with the ecotropic viral integration site 1 (EVI ...
An Evolutionary Approach Towards Time Preferences∗
... evolutionary argument to explain altruistic behavior. Most of the papers on the evolution of preferences focused on attitude towards risk, altruism, and information processing. Excellent overviews of the theories on the relationship between biology and economic behavior can be found in Robson (2001 ...
... evolutionary argument to explain altruistic behavior. Most of the papers on the evolution of preferences focused on attitude towards risk, altruism, and information processing. Excellent overviews of the theories on the relationship between biology and economic behavior can be found in Robson (2001 ...
Slide 1
... If the first T and the second –P were deleted, the relative position of T and –P would change. ...
... If the first T and the second –P were deleted, the relative position of T and –P would change. ...
Mutations in the Anopheles gambiae Pink
... males and XY males. We also hoped to resolve some of the apparent conflicts in the literature regarding the sex-linked eye-color complementation groups and epistatic interactions with collarless* in A. gambiae. We show in the present report that five new induced mutations fall into two complementat ...
... males and XY males. We also hoped to resolve some of the apparent conflicts in the literature regarding the sex-linked eye-color complementation groups and epistatic interactions with collarless* in A. gambiae. We show in the present report that five new induced mutations fall into two complementat ...
Systematic analysis of gene properties influencing organ system
... organ system damage. For that, we performed a systematic analysis of the phenotypic impact of three perturbation scenarios, namely human drug treatment, human diseases and functional disruption of single genes in mice on 18 mammalian organ systems. For the three types of perturbations, we analyzed a ...
... organ system damage. For that, we performed a systematic analysis of the phenotypic impact of three perturbation scenarios, namely human drug treatment, human diseases and functional disruption of single genes in mice on 18 mammalian organ systems. For the three types of perturbations, we analyzed a ...
Author`s personal copy
... If a highly efficient method for mutant construction is developed, a genome-wide analysis of gene function is possible (Hammelmann and Soppa, 2008). It would not only accelerate the genome-wide identification of the genes responsible for PHA biosynthesis, but may also be used to genetically engineer ...
... If a highly efficient method for mutant construction is developed, a genome-wide analysis of gene function is possible (Hammelmann and Soppa, 2008). It would not only accelerate the genome-wide identification of the genes responsible for PHA biosynthesis, but may also be used to genetically engineer ...
Abstract - BioPublisher
... Genomic imprinting is an important mechanism of epigenetic regulation. It only expresses the genetic information one of the parent, the other part is silence. Numerous studies have shown that Imprinted Genes play an important role in regulating the growth and development of mammals, and its abnormal ...
... Genomic imprinting is an important mechanism of epigenetic regulation. It only expresses the genetic information one of the parent, the other part is silence. Numerous studies have shown that Imprinted Genes play an important role in regulating the growth and development of mammals, and its abnormal ...
Clustering Gene Expression Data: The Good, The Bad, and The
... within gene expression data • Hierarchical clustering dendrograms allow us to visualize gene expression data. • These methods allow us to hypothesize about relationships between genes and classes. • We should use these methods for visualization, hypothesis generation, selection of genes for further ...
... within gene expression data • Hierarchical clustering dendrograms allow us to visualize gene expression data. • These methods allow us to hypothesize about relationships between genes and classes. • We should use these methods for visualization, hypothesis generation, selection of genes for further ...
Evolution of genes, evolution of species: the case of aminoacyl
... their case will be discussed later. The pyramidal classification of the phenylalanyltRNA synthetases is shown in figure 1a and clearly shows two groups built by the a and b chains, respectively. PheRS is normally a heterotetramer with an a2b2 quaternary structure. In any given PheRS, the short (a) a ...
... their case will be discussed later. The pyramidal classification of the phenylalanyltRNA synthetases is shown in figure 1a and clearly shows two groups built by the a and b chains, respectively. PheRS is normally a heterotetramer with an a2b2 quaternary structure. In any given PheRS, the short (a) a ...
Extraction of Gene/Protein Interaction from Text
... continue to publish their discoveries on new gene/protein interactions and modified interactions of previous ones on various domains in scientific papers without submitting their results to specific public databases [3]. As a result, we can infer that most gene/protein interaction information still ...
... continue to publish their discoveries on new gene/protein interactions and modified interactions of previous ones on various domains in scientific papers without submitting their results to specific public databases [3]. As a result, we can infer that most gene/protein interaction information still ...
Human Sex Determination
... with mutations in SRY do not display any phenotypes that could be associated with a more general role for SRY. Comparison of human SRY and mouse Sry protein shows conservation of the HMG box but no homology outside this region. Striking differences between mouse and human SRY protein exist, particul ...
... with mutations in SRY do not display any phenotypes that could be associated with a more general role for SRY. Comparison of human SRY and mouse Sry protein shows conservation of the HMG box but no homology outside this region. Striking differences between mouse and human SRY protein exist, particul ...
Author`s personal copy
... organisms that are phylogenetically related. However, to infer a robust phylogenetic relationship of the organisms based only on their functional genes for denitrification is currently not possible, since horizontal gene transfer is likely to have occurred for denitrification genes [39,41]. Hence, cul ...
... organisms that are phylogenetically related. However, to infer a robust phylogenetic relationship of the organisms based only on their functional genes for denitrification is currently not possible, since horizontal gene transfer is likely to have occurred for denitrification genes [39,41]. Hence, cul ...