Slide 1
... • For CRM data, the best combination of five clustered transcription factor binding sites – in all human-mouse conserved non-coding sequences (up to 10 kb upstream of transcription start site) of the training genes – is determined using a genetic algorithm. ...
... • For CRM data, the best combination of five clustered transcription factor binding sites – in all human-mouse conserved non-coding sequences (up to 10 kb upstream of transcription start site) of the training genes – is determined using a genetic algorithm. ...
DNA sequence of the control region of phage D108: the N
... for the repressor gene, ner gene, and the 5' part of the A^ gene (which codes for transposase) are found in the sequence. The genetic organization of this region of phage D108 is quite similar to that of phage Mu in spite of considerable divergence, both in the nucleotide sequence and in the amino a ...
... for the repressor gene, ner gene, and the 5' part of the A^ gene (which codes for transposase) are found in the sequence. The genetic organization of this region of phage D108 is quite similar to that of phage Mu in spite of considerable divergence, both in the nucleotide sequence and in the amino a ...
Inferring gene-to-phenotype and gene-to
... Results: Using this algorithm derived gene-to-phenotype and gene-to-disease annotations were created for 16,000 and 2100 mouse markers, respectively, starting from over 57,900 and 4800 genotypes with at least one phenotype and disease annotation, respectively. Conclusions: Implementation of this alg ...
... Results: Using this algorithm derived gene-to-phenotype and gene-to-disease annotations were created for 16,000 and 2100 mouse markers, respectively, starting from over 57,900 and 4800 genotypes with at least one phenotype and disease annotation, respectively. Conclusions: Implementation of this alg ...
Gene Section CDK4 (cyclin-dependent kinase 4) Atlas of Genetics and Cytogenetics
... This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence. © 2007 Atlas of Genetics and Cytogenetics in Oncology and Haematology ...
... This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence. © 2007 Atlas of Genetics and Cytogenetics in Oncology and Haematology ...
The Jumping SHOX Gene—Crossover in the Pseudoautosomal
... pseudoautosomal. The SHOX gene in the normal situation is present in two functional copies. In fact, one might consider PAR1 as a very small extra pair of autosomes (11), except that segregation in autosomes is independent of sex. Here we describe three families in which an abnormality in PAR1 segre ...
... pseudoautosomal. The SHOX gene in the normal situation is present in two functional copies. In fact, one might consider PAR1 as a very small extra pair of autosomes (11), except that segregation in autosomes is independent of sex. Here we describe three families in which an abnormality in PAR1 segre ...
Horizontal gene transfer and microbial evolution: Is the Tree-of
... Paralogs: “deepest” bifurcation in molecular tree reflects gene duplication. The study of paralogs and their distribution in genomes provides clues on the way genomes evolved. Gen and genome duplication have emerged as the most important pathway to molecular innovation, including the evolution of de ...
... Paralogs: “deepest” bifurcation in molecular tree reflects gene duplication. The study of paralogs and their distribution in genomes provides clues on the way genomes evolved. Gen and genome duplication have emerged as the most important pathway to molecular innovation, including the evolution of de ...
NIHMS88703-supplement-2
... Overlap between liver signature genes from mouse models and a macrophage-enriched metabolic network (MEMN) Based on the co-expression networks constructed from liver and adipose tissues collected from a mouse cross between C57BL/6J (B6) and C3H/HeJ on an apolipoprotein E null background (BXH/apoE), ...
... Overlap between liver signature genes from mouse models and a macrophage-enriched metabolic network (MEMN) Based on the co-expression networks constructed from liver and adipose tissues collected from a mouse cross between C57BL/6J (B6) and C3H/HeJ on an apolipoprotein E null background (BXH/apoE), ...
Rapid divergence and diversification of mammalian duplicate gene
... While small Ne is also thought to result in a higher prevalence of subfunctionalization [34], this process does not appear to play a major role in the retention of duplicate genes in either lineage. One possible reason for this observation is that subfunctionalization may be more common in duplicate ...
... While small Ne is also thought to result in a higher prevalence of subfunctionalization [34], this process does not appear to play a major role in the retention of duplicate genes in either lineage. One possible reason for this observation is that subfunctionalization may be more common in duplicate ...
the contribution of gene movement to the two rules of speciation
... well accepted that Haldane’s rule likely results from the combined effect of hemizygosity in the heterogametic sex and the frequent recessivity of hybrid incompatibility loci; that is, their greatest effect is observed when homozygous or hemizygous loci from one species are exposed in the background ...
... well accepted that Haldane’s rule likely results from the combined effect of hemizygosity in the heterogametic sex and the frequent recessivity of hybrid incompatibility loci; that is, their greatest effect is observed when homozygous or hemizygous loci from one species are exposed in the background ...
Problem set questions from Exam 3 – Eukaryotic Gene Regulation
... (f) In light of the experiments from parts (a) – (e), propose a specific function for any cisacting segment that has a clear regulatory role as defined by these deletion constructs. (g) What two conclusions can you draw from the fact that deletions #3 - #5 show normal regulation of Prad66–LacZ? ...
... (f) In light of the experiments from parts (a) – (e), propose a specific function for any cisacting segment that has a clear regulatory role as defined by these deletion constructs. (g) What two conclusions can you draw from the fact that deletions #3 - #5 show normal regulation of Prad66–LacZ? ...
8 MITOCHONDRIAL INHERITANCE — Complex Patterns of
... Some of the estimated 20,000 genes in the human genome are located in small compartments in the cell called the mitochonria, rather than on chromosomes in the cell’s nucleus. Some cells contain many hundreds of mitochondria The genes found within the mitochondria contain the information that codes f ...
... Some of the estimated 20,000 genes in the human genome are located in small compartments in the cell called the mitochonria, rather than on chromosomes in the cell’s nucleus. Some cells contain many hundreds of mitochondria The genes found within the mitochondria contain the information that codes f ...
Genetics basics bell ringer
... 3. If your grandparents are the parental generation, what term would refer to your parents? 4. What type of pollination occurs when pollen from the stamen on one flower is transferred to the pistil on the same flower or to the pistil of a different flower on the same plant? 5. Identify each gene pai ...
... 3. If your grandparents are the parental generation, what term would refer to your parents? 4. What type of pollination occurs when pollen from the stamen on one flower is transferred to the pistil on the same flower or to the pistil of a different flower on the same plant? 5. Identify each gene pai ...
Effects of turmeric (Curcuma longa) on the expression
... system (Applied Biosystems) using factory default conditions (50°C, 2 min; 95°C, 10 min; and 40 cycles at 95°C, 15 s; 60°C, 1 min). Each gene was measured in triplicate and the formation of single PCR products was confirmed using melting curves. Negative controls, which consisted of all of the compo ...
... system (Applied Biosystems) using factory default conditions (50°C, 2 min; 95°C, 10 min; and 40 cycles at 95°C, 15 s; 60°C, 1 min). Each gene was measured in triplicate and the formation of single PCR products was confirmed using melting curves. Negative controls, which consisted of all of the compo ...
Leukaemia Section t(3;8)(q26;q24) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... Note: Aberrant EVI1 expression usually occurs in AML, MDS or CML-BC as a result of translocation involving 3q26. The most common ones are inv(3)(q21q26), t(3;3) and t(3;21)(q26;q22). The partner genes of EVI1 are identified as Ribophorin I in inv(3)(q21q26) and t(3;3), AML/ MDS1 /EAP in t(3;21), and ...
... Note: Aberrant EVI1 expression usually occurs in AML, MDS or CML-BC as a result of translocation involving 3q26. The most common ones are inv(3)(q21q26), t(3;3) and t(3;21)(q26;q22). The partner genes of EVI1 are identified as Ribophorin I in inv(3)(q21q26) and t(3;3), AML/ MDS1 /EAP in t(3;21), and ...
Molecular markers located on the DGAT1, CAST, and - Funpec-RP
... Rouge, Louisiana, were utilized for the current study. All female Holstein were maintained on a dry mixed diet and were managed and evaluated at the above location. Lactating females were milked twice daily during their lactation cycle and milk production traits were collected and recorded for each ...
... Rouge, Louisiana, were utilized for the current study. All female Holstein were maintained on a dry mixed diet and were managed and evaluated at the above location. Lactating females were milked twice daily during their lactation cycle and milk production traits were collected and recorded for each ...
Genes Involved in the Seminoma Testicular Cancer
... were discarded due to having missing, “null”, or p-value > 0,05, which means that they were expressed in a similar manner along the microarray and, therefore, their behavior patterns do not have capacity to discriminate between classes. In this way, it was possible to reduce the dimensionality of th ...
... were discarded due to having missing, “null”, or p-value > 0,05, which means that they were expressed in a similar manner along the microarray and, therefore, their behavior patterns do not have capacity to discriminate between classes. In this way, it was possible to reduce the dimensionality of th ...
tAIg = w
... them to have a threefold difference in translation rate (21.6 and 6.4 codons per second, respectively). Remarkably, the wi of these codons, which is based on the tRNA pool and affinity of codon-anti-codon coupling and is the basis for the tAI calculation, captures the ratio of translation rate betwe ...
... them to have a threefold difference in translation rate (21.6 and 6.4 codons per second, respectively). Remarkably, the wi of these codons, which is based on the tRNA pool and affinity of codon-anti-codon coupling and is the basis for the tAI calculation, captures the ratio of translation rate betwe ...
Journal of Molecular Biology
... 1980). The phoM gene product acts as an activator that can partially replace tIhe activator function of the phoR gene product’ (Wanner & Latterell, 1980). In addition, mutations in any of the genes phoS, ph,oT or pst result in t,he constibut)ivc synthesis of the PhoE protein (Tommassen 8: Lugtenberg ...
... 1980). The phoM gene product acts as an activator that can partially replace tIhe activator function of the phoR gene product’ (Wanner & Latterell, 1980). In addition, mutations in any of the genes phoS, ph,oT or pst result in t,he constibut)ivc synthesis of the PhoE protein (Tommassen 8: Lugtenberg ...
Conflicting patterns of mitochondrial and nuclear DNA diversity in
... locus, whether there was a homogenous rate of molecular evolution along all branches (Felsenstein 1981). Trees were constructed in paup* 4.0 (Swofford 1998) as described above. Because of computational limitations, we excluded all but the five most divergent willow warbler haplotypes, but included a ...
... locus, whether there was a homogenous rate of molecular evolution along all branches (Felsenstein 1981). Trees were constructed in paup* 4.0 (Swofford 1998) as described above. Because of computational limitations, we excluded all but the five most divergent willow warbler haplotypes, but included a ...
Nkx5 genes in inner ear development and genome evolution
... and Brenner, S. (1995) Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes. Proc. Natl. Acad. Sci. USA 92: 1684-1688 Aparicio, S. (2000) Vertebrate evolution: recent perspectives from fish. Trends Genet. 16: 546 Avraham, K. B., Hasson, T., Steel, ...
... and Brenner, S. (1995) Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes. Proc. Natl. Acad. Sci. USA 92: 1684-1688 Aparicio, S. (2000) Vertebrate evolution: recent perspectives from fish. Trends Genet. 16: 546 Avraham, K. B., Hasson, T., Steel, ...
Mechanistic Models of Cancer in the Space of Pathways
... Took previous analysis a step further by discovering the specific pathways implicated in tumorigenesis. – Previous work identified single genes which were relevant in progression and grouped them together to form important concepts. ...
... Took previous analysis a step further by discovering the specific pathways implicated in tumorigenesis. – Previous work identified single genes which were relevant in progression and grouped them together to form important concepts. ...
What is a functional genetic polymorphism?
... Apart from yielding mechanistic information on the underlying basis of disease for the design of more effective treatment strategies, functional polymorphisms may provide information for a more function-targeted approach that can be used to refine pathway analysis of genome-wide association studies, ...
... Apart from yielding mechanistic information on the underlying basis of disease for the design of more effective treatment strategies, functional polymorphisms may provide information for a more function-targeted approach that can be used to refine pathway analysis of genome-wide association studies, ...
Copy number variants and genetic traits: closer to the resolution of
... and association studies for polygenic complex traits. This list is not exhaustive, and the literature is continuously expanding with elegant experimental uses of genetic variation. To date, SNPs are the variant type of choice for association studies in common diseases and complex traits. The results ...
... and association studies for polygenic complex traits. This list is not exhaustive, and the literature is continuously expanding with elegant experimental uses of genetic variation. To date, SNPs are the variant type of choice for association studies in common diseases and complex traits. The results ...
Justification of Size Estimates for Tomato Genome Sequencing
... genetic map and spaced along chromosome 2. As such, they still have few and short contigs. Nevertheless, based on the physical distances between mapped marker sequences found in their sequenced BACs, they have estimated that the BACs sequenced to date represent approximately 20% of the genetic map f ...
... genetic map and spaced along chromosome 2. As such, they still have few and short contigs. Nevertheless, based on the physical distances between mapped marker sequences found in their sequenced BACs, they have estimated that the BACs sequenced to date represent approximately 20% of the genetic map f ...