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Brief Rapid Communications
Brief Rapid Communications

... therapy. First, this vector can only accept transgenes less than '4.5 kb in length. Second, current techniques do not allow the convenient production of large amounts of rAAV. Finally, although our studies have demonstrated efficient transduction of cardiomyocytes after 15 minutes of coronary artery ...
Simple Inheritance: Who`s queen bee?
Simple Inheritance: Who`s queen bee?

... life. Genes are the units of inheritance that allow all living things, from microbes to humans, to pass on features – known as traits –  to their descendants. Sometimes just a single gene can have a huge effect on an organism, like the Ivory gene that controls whether a bee’s eyes are black or white ...
Amplified fragment length polymorphism (AFLP)
Amplified fragment length polymorphism (AFLP)

... new sources of resistance genes to replace those that are no longer effective and to properly deploy existing genes in order to increase their durability. Molecular markers are becoming essential tools in plant breeding (Staub et al., 1996; Mohan et al., 1997; Gupta et al., 1999) and have several ad ...
Ch15-Computational_Approaches_in_Comparative_Genomics
Ch15-Computational_Approaches_in_Comparative_Genomics

... ⇒ Phylogenetic footprinting methods  Particularly well suited for  Identifying transcription factor binding sites  Cis-regulatory regions  Other overrepresented patterns ...
lecture - Haloarchaea
lecture - Haloarchaea

... E.coli O157:H7 - K12 genome comparison  The specific DNA segments for each strain were named ‘O islands’ , ie O157:H7-specific DNA segments, or ‘K islands’  Backbone of 4.1 Mb common sequence. Not identical (eg 75% of proteins differ by one aa).  O-islands total 1.34 Mb (about 26% of genes !)  ...
From DNA sequence to application: possibilities and
From DNA sequence to application: possibilities and

Determination of obesity associated gene variants related
Determination of obesity associated gene variants related

... scores equal to or below these thresholds were filtered out and not included for further analyses. For our analysis, we used a cut-off of at least 23% coverage on each DNA strand. Candidate SNPs also had to be detected in both the obese and control population. The filtering approach described above wa ...
Genetic predisposition to sarcoidosis: another brick in the wall EDITORIAL
Genetic predisposition to sarcoidosis: another brick in the wall EDITORIAL

... affect susceptibility to complex diseases [7, 8]. In just 5 years, the GWAS methodology has moved from extraordinary to commonplace. This hypothesis-free and unbiased approach is based on the data produced by the Human HapMap Project and the fact that genetic variance at one locus can predict with h ...
Chapter 1 - Online Open Genetics
Chapter 1 - Online Open Genetics

Guidance on the Use of Biochemical and Molecular Markers
Guidance on the Use of Biochemical and Molecular Markers

... Use of molecular data that are not susceptible to the environment; the set of markers and the laboratory protocol are well defined; Use of only phenotypic characteristics with a good robustness and possibility to use descriptions coming from different origins under close cooperation (The maize datab ...
It`s All In The Genes - American Maine
It`s All In The Genes - American Maine

... from this mating have a 50% chance of being heterozygous black (Bb - a black calf with one black and one red allele) and a 50% chance of being born red (bb). For the recessive gene to be displayed in the phenotype (i.e. for you to see it), the calf must inherit this gene from both parents. The same ...
studies on human x-chromosomal disorder
studies on human x-chromosomal disorder

... Conditions caused by a change in the number or structure of chromosomes are known as chromosomal disorders. There are over 3000 chromosomal disorders which make a major contribution to human morbidity and mortality. A very high number of both Mendelian and other diseases (some of which are incurable ...
Creation/Evolution
Creation/Evolution

... Any gene with two or more alleles is said to have multiple alleles Mendel worked with only two allele systems, but variations from the kind of results he obtained occur when more than two alleles are involved Note that while individuals cannot have more than two alleles for a given gene, populations ...
C. Errors and Exceptions in Chromosomal
C. Errors and Exceptions in Chromosomal

... fruit fly genes, body color (b), wing size (vg), and eye color (cn).  The recombination frequency between cn and b is 9%.  The recombination frequency between cn and vg is 9.5%.  The recombination frequency between b and vg is 17%.  The only possible arrangement of these three genes places the e ...
Genetic Characteristic of the Usual Form of the Polydactyl Gene in
Genetic Characteristic of the Usual Form of the Polydactyl Gene in

... one form of polydactyly is lethal when homozygous the possibility that polydactyly in the cat is also lethal naturally suggest itself, but the following considerations lend no support to such assumption. If we were indeed dealing with a gene, which is lethal when homozygous, its effect should appear ...
Genes, Phenes and the Baldwin Effect
Genes, Phenes and the Baldwin Effect

... Recall that the probability that a given agent will learn the Good Phene is determined by how far the agent is from the Good Gene (Figure 1). The graph in Figure 3 shows the evolution of a population in which learning of the Good Phene is occurring. The top line shows the total population. The middl ...
Discussion paper - Office of the Gene Technology Regulator
Discussion paper - Office of the Gene Technology Regulator

... The primary aim of this review is to provide clarity about whether organisms developed using a range of new technologies are subject to regulation as genetically modified organisms (GMOs) and ensure that new technologies are regulated in a manner commensurate with the risks they pose. The technical ...
Genomic Gene Clustering Analysis of Pathways
Genomic Gene Clustering Analysis of Pathways

... genes were found in uber-operons as well. Lathe et al. (2000) showed that uber-operons can be used to correctly predict function of ‘hypothetical’ proteins. Operons that have been detected in eukaryotes differ from those in prokaryotes in that eukaryotic polycistronic mRNAs are not translatable dire ...
Genome sequence of Aspergillus luchuensis
Genome sequence of Aspergillus luchuensis

Identification and quantification of mycotoxigenic fungi
Identification and quantification of mycotoxigenic fungi

... segment of DNA which can be referred to as a probe, is targeted to anneal with the piece of DNA of interest (the target). This is extended to equal the number of kb of the product to be amplified and to yield doubled DNA. The process is cycled approximately 40 times to give the desired quantity of D ...
Nucleotide sequence of a segment of Drosophila mitochondrial DNA
Nucleotide sequence of a segment of Drosophila mitochondrial DNA

... from platyhelminth worms to man, is in the form of a circular molecule of approximately 16.5 kb (1). Mitochondrial DNA (mtDNA) molecules from different Drosophila species range in size from 15.7 to 19.5 kb, but this variability can be accounted for by differences in size of the A+T-rich region which ...
Matthew Kwong - GEP Community Server
Matthew Kwong - GEP Community Server

... model of ey in contig 10. These sites indicate the beginning and end of the intronic regions that separate the exons. Donor sites have a characteristic GT nucleotide sequence and acceptor sites have a characteristic AG sequence. The criteria is that the corresonding donor and acceptor sites have a p ...
Quantitative and Single-Gene Perspectives on the Study of Behavior
Quantitative and Single-Gene Perspectives on the Study of Behavior

... locus that contains alleles with differential effects on the expression of a continuously distributed phenotypic trait. Usually it is detected by means of a DNA polymorphism, often not actually part of the gene in question, that shows association with quantitative variation in a particular phenotypi ...
Initiation of recombination suppression and PAR formation during
Initiation of recombination suppression and PAR formation during

... species in the genus Tokudaia that has maintained the Y chromosome, probably through fusion with an autosome [16, 18]. The short and long arms of their X chromosome (Xp and Xq) consisted of autosome (neo-X) and ancestral X, respectively, and the X chromosome had a large centromeric heterochromatin ...
Differential gene expression in ES/PNET with type 1 vs type 2 EWS
Differential gene expression in ES/PNET with type 1 vs type 2 EWS

... Performance of microarray-based predictor 136/137 sarcomas were accurately predicted Model Prediction ...
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