Molecular Physiological Analysis of the Two Plastidic ATP/ADP
... Arabidopsis (Arabidopsis thaliana) possesses two isoforms of plastidic ATP/ADP transporters (AtNTT1 and AtNTT2) exhibiting similar biochemical properties. To analyze the function of both isoforms on the molecular level, we examined the expression pattern of both genes by northern-blot analysis and p ...
... Arabidopsis (Arabidopsis thaliana) possesses two isoforms of plastidic ATP/ADP transporters (AtNTT1 and AtNTT2) exhibiting similar biochemical properties. To analyze the function of both isoforms on the molecular level, we examined the expression pattern of both genes by northern-blot analysis and p ...
Inhibition of the p53 tumor suppressor by MDM2
... ubiquitin proteins are loaded into the E3 complex to signal protein degradtion in order to deactivate the transcription of p53 proteins by the cell (Bartel, 2002). ...
... ubiquitin proteins are loaded into the E3 complex to signal protein degradtion in order to deactivate the transcription of p53 proteins by the cell (Bartel, 2002). ...
Advances in Genetics, Proteomics, and Metabolomics
... supports the collective data that, like homozygous HCM patients, double heterozygous patients display more clinically severe disease in HCM compared with single heterozygous patients. Compound Heterozygous FHC Mutations Most reports of multiple mutation carriers in HCM to date have involved compound ...
... supports the collective data that, like homozygous HCM patients, double heterozygous patients display more clinically severe disease in HCM compared with single heterozygous patients. Compound Heterozygous FHC Mutations Most reports of multiple mutation carriers in HCM to date have involved compound ...
Marfan syndrome
... spectrum of overlapping diseases. Presently no genotype/phenotype correlations have been ...
... spectrum of overlapping diseases. Presently no genotype/phenotype correlations have been ...
The viriosphere, diversity, and genetic exchange within phage
... genetic variation in natural virus communities. In particular, advances in techniques and the identification of suitable targets have propelled us into an era in which genomic approaches for interrogating viral communities are becoming routine [18]. Pulse field gel electrophoresis is a culture-indep ...
... genetic variation in natural virus communities. In particular, advances in techniques and the identification of suitable targets have propelled us into an era in which genomic approaches for interrogating viral communities are becoming routine [18]. Pulse field gel electrophoresis is a culture-indep ...
PopGen2: Linkage Disequilibrium
... An alternative to the family study is a population based approach called LINKAGE DISEQUILIBRIUM MAPPING (or LD MAPPING), and sometimes called an ALLELIC ASSOCIATION STUDY, and it is applied to a population rather than a family pedigree. LD mapping is based on the fact that the mutation in the gene t ...
... An alternative to the family study is a population based approach called LINKAGE DISEQUILIBRIUM MAPPING (or LD MAPPING), and sometimes called an ALLELIC ASSOCIATION STUDY, and it is applied to a population rather than a family pedigree. LD mapping is based on the fact that the mutation in the gene t ...
Chapter 6 Pichia pastoris
... (Saccharomyces cerevisiae and Pichia pastoris), mammalian cells, amphibian oocytes (Xenopus laevis), insect cells and bacteria (Escherichia coli). Plant cells are useful as hosts if mutants are available (Holton et al., 1993), but in many cases the distinction from resident activities may present a ...
... (Saccharomyces cerevisiae and Pichia pastoris), mammalian cells, amphibian oocytes (Xenopus laevis), insect cells and bacteria (Escherichia coli). Plant cells are useful as hosts if mutants are available (Holton et al., 1993), but in many cases the distinction from resident activities may present a ...
Searching in Applications Containing Bio-Sequences
... Insert: the query matches a gap to a database residue Delete: the query matches a residue with a gap in the database sequence The path leading to the highest score can be of any length, and, by definition of a local alignment, doesn’t have to start at the beginning or end at the end of both sequence ...
... Insert: the query matches a gap to a database residue Delete: the query matches a residue with a gap in the database sequence The path leading to the highest score can be of any length, and, by definition of a local alignment, doesn’t have to start at the beginning or end at the end of both sequence ...
Imperial College London
... Computational assignment of gene function is not 100% accurate! It will always be important to examine and refine initial automated metabolic reconstructions carefully before attempting to analyse the resulting network. Comparative genomics can be a powerful tool in network curation. By comparing ge ...
... Computational assignment of gene function is not 100% accurate! It will always be important to examine and refine initial automated metabolic reconstructions carefully before attempting to analyse the resulting network. Comparative genomics can be a powerful tool in network curation. By comparing ge ...
The methylcitric acid pathway in Ralstonia eutropha
... growth on propionic acid and levulinic acid. From the molecular, physiological and enzymic analysis of these mutants it was concluded that in this bacterium propionic acid is metabolized via the methylcitric acid pathway. The genes encoding enzymes of this pathway are organized in a cluster in the o ...
... growth on propionic acid and levulinic acid. From the molecular, physiological and enzymic analysis of these mutants it was concluded that in this bacterium propionic acid is metabolized via the methylcitric acid pathway. The genes encoding enzymes of this pathway are organized in a cluster in the o ...
frequency distribution of antimalarial drug
... drugs were administered and, to a lesser extent, on in vitro drug sensitivity assays. The limitations of these methods for studying drug-resistant malaria and elucidating molecular mechanisms of resistance to some antimalarial drugs have stimulated the use of a third approach based on molecular mark ...
... drugs were administered and, to a lesser extent, on in vitro drug sensitivity assays. The limitations of these methods for studying drug-resistant malaria and elucidating molecular mechanisms of resistance to some antimalarial drugs have stimulated the use of a third approach based on molecular mark ...
A recurrent deletion syndrome at chromosome bands 2p11
... European Journal of Human Genetics (2015) 23, 543–546; doi:10.1038/ejhg.2014.124; published online 2 July 2014 ...
... European Journal of Human Genetics (2015) 23, 543–546; doi:10.1038/ejhg.2014.124; published online 2 July 2014 ...
the genome of herpes simplex virus: structure, replication and
... near the centre of U l (Kaerner et al. 1979; Vlazny & Frenkel, 1981; Spaete & Frenkel, 1982). It was also shown that when monomer units from either class of defective were introduced into cells in the presence of wild-type virus, these could serve as ‘seeds’ for regeneration of tandemly repeated def ...
... near the centre of U l (Kaerner et al. 1979; Vlazny & Frenkel, 1981; Spaete & Frenkel, 1982). It was also shown that when monomer units from either class of defective were introduced into cells in the presence of wild-type virus, these could serve as ‘seeds’ for regeneration of tandemly repeated def ...
Comparative genomic analysis of carbon and nitrogen assimilation
... Background The employment of microorganisms for metal recovery from low-grade ores and mineral concentrates and secondary materials, has developed into a successful and expanding area of biotechnology. In association with this interest, microbial communities of extreme acidophilic prokaryotes from ...
... Background The employment of microorganisms for metal recovery from low-grade ores and mineral concentrates and secondary materials, has developed into a successful and expanding area of biotechnology. In association with this interest, microbial communities of extreme acidophilic prokaryotes from ...
Crossing Over…Markov Meets Mendel
... of independence). The same analysis applies for the assortment Ab, leading to an overall recombination probability of 1=4z1=4~1=2. However, it has been observed that some pairs of genes show a correlation in their alleles, e.g., their probability of recombination is less than 1=2. In this case, ther ...
... of independence). The same analysis applies for the assortment Ab, leading to an overall recombination probability of 1=4z1=4~1=2. However, it has been observed that some pairs of genes show a correlation in their alleles, e.g., their probability of recombination is less than 1=2. In this case, ther ...
Phylogenetic Relationships between the Western Aster Yellows
... dodecyl sulfate, and the DNA was bound to the filters by alkaline hydrolysis and baking. Nitrocellulose filters containing recombinant phage generated from the EcoRI fragment transformation were hybridized with the 5’ 18-mer. After clones that hybridized with the 18-mer were identified, the bound pr ...
... dodecyl sulfate, and the DNA was bound to the filters by alkaline hydrolysis and baking. Nitrocellulose filters containing recombinant phage generated from the EcoRI fragment transformation were hybridized with the 5’ 18-mer. After clones that hybridized with the 18-mer were identified, the bound pr ...
Sno/Ski Proto-Oncogene Family - The Newfeld Lab
... mouse developed spontaneous lymphomas, suggesting that Sno could function as a tumor suppressor gene. Two other Sno knockout mice, generated with a similar strategy, did not develop lymphoma but rather displayed developmental defects in T-cell proliferation. Studies utilizing small interfer ing RNA ...
... mouse developed spontaneous lymphomas, suggesting that Sno could function as a tumor suppressor gene. Two other Sno knockout mice, generated with a similar strategy, did not develop lymphoma but rather displayed developmental defects in T-cell proliferation. Studies utilizing small interfer ing RNA ...
Genetic Approaches to Studying Genome Function
... genetics and biochemistry • The validity of Pardee’s conclusion is unequivocally dependent on a biochemical phenomenon (total inhibition of protein synthesis by 5-methyltryptophan) • It turns out that not all protein synthesis in E. coli is inhibited by 5-me-T… ...
... genetics and biochemistry • The validity of Pardee’s conclusion is unequivocally dependent on a biochemical phenomenon (total inhibition of protein synthesis by 5-methyltryptophan) • It turns out that not all protein synthesis in E. coli is inhibited by 5-me-T… ...
Comparative Analysis of Parallel Gene Transfer Operators in the
... Three modified gene transfer operators were suggested in [9]. All of them are the derivatives of the original version with slight modifications. “Original gene transfer with auxiliary population” (BEA Aux., Fig. 3) also keeps a record of superior and inferior bacteria based on the objective values. ...
... Three modified gene transfer operators were suggested in [9]. All of them are the derivatives of the original version with slight modifications. “Original gene transfer with auxiliary population” (BEA Aux., Fig. 3) also keeps a record of superior and inferior bacteria based on the objective values. ...
What are major histocompatibility complex genes and why are they
... HLA and Infectious Disease In humans, there is evidence that the inheritance of particular MHC (aka HLA) alleles confers resistance to certain pathogens HLA-B53 and HLA-DRB1*1302 are found in individuals who are resistant to Plasmodium falciparum malaria ...
... HLA and Infectious Disease In humans, there is evidence that the inheritance of particular MHC (aka HLA) alleles confers resistance to certain pathogens HLA-B53 and HLA-DRB1*1302 are found in individuals who are resistant to Plasmodium falciparum malaria ...
jxb.oxfordjournals.org - Oxford Academic
... endosperm. Moreover, amylose content is one of the key factors used for evaluating rice grain quality (Fitzgerald et al., 2009; Jeon et al., 2010). However, how these genes are regulated during rice seed development remains poorly understood. The rice Wx gene encodes the OsGBSSI, a key enzyme for ...
... endosperm. Moreover, amylose content is one of the key factors used for evaluating rice grain quality (Fitzgerald et al., 2009; Jeon et al., 2010). However, how these genes are regulated during rice seed development remains poorly understood. The rice Wx gene encodes the OsGBSSI, a key enzyme for ...
Supplementary Table S1
... NCCN consensus that the intervention is appropriate.”) CAP: “ALK molecular testing should be used to select patients for ALK-targeted TKI therapy, and patients with lung adenocarcinoma should not be excluded from testing on the basis of clinical characteristics.” (Evidence Grade: ALK: B - “Body of e ...
... NCCN consensus that the intervention is appropriate.”) CAP: “ALK molecular testing should be used to select patients for ALK-targeted TKI therapy, and patients with lung adenocarcinoma should not be excluded from testing on the basis of clinical characteristics.” (Evidence Grade: ALK: B - “Body of e ...
human genome research
... triplet, with each trio of bases in DNA coding for a single amino acid (the basic building blocks of proteins). By 1966, scientists had worked out what each of the 64 possible triplet combinations coded for. • Developing the basic tools of biotechnology in the 1970s and early 80s. These include the ...
... triplet, with each trio of bases in DNA coding for a single amino acid (the basic building blocks of proteins). By 1966, scientists had worked out what each of the 64 possible triplet combinations coded for. • Developing the basic tools of biotechnology in the 1970s and early 80s. These include the ...
Introduction to Angelfish Genetics
... Platinum appears to be a recessive trait that modifies a gold angelfish to be a striking iridescent white color. As the angelfish matures, it shows a lot of blue iridescence. ...
... Platinum appears to be a recessive trait that modifies a gold angelfish to be a striking iridescent white color. As the angelfish matures, it shows a lot of blue iridescence. ...
RNA-Seq
RNA-seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), is a technology that uses the capabilities of next-generation sequencing to reveal a snapshot of RNA presence and quantity from a genome at a given moment in time.