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apch19.ppt
apch19.ppt

... Lymphocytes – named for the type of cellular receptors they have. ...
(white blood cells).
(white blood cells).

... Figure 1-4 part 1 of 3 • The least common of the granulocytes • Representing about 0.01% to 0.3% of circulating leukocytes (white blood cells). • The name comes from the fact that these are basophilic • Basophils contain large cytoplasmic granules which obscure the cell nucleus under the microscope ...
Ch46
Ch46

... Antigen segments form complex with the class I MHC protein. Macrophages displays MHC-antigen complex on its cell surface. Helper T cells recognize the foreign antigen-MHC complex and secrete IL-2. These cytokines can activate T cells. Competent T cells are in turn activated, increase in size and div ...
Lecture Outline 7
Lecture Outline 7

... 7. stimulation of B-cell growth and differentiation to form plasma cells and antibodies 8. activation of the macrophage system a. slow or stop migration of the macrophages out of inflamed area b. activated macrophage phagocytosis B. cytotoxic T cells ...
The Immune System
The Immune System

... swallowed and then digested – Tears, sweat and saliva all contain lysozyme, an enzyme that can break down the cell wall of some bacteria. ...
The immune response to infection
The immune response to infection

... inflamed tissue. Their development is promoted by the cytokine IL-12. Their pathway of migration is distinct from Th2 cells in that they migrate via the blood and recognise receptors on inflamed endothelium, hence gaining access to infected tissue. There they activate macrophages via IFNg and by rel ...
Immunology - Mosaiced.org
Immunology - Mosaiced.org

... and macrophages) of neutrophils, lymphocytes, monocytes. Histamine secreted by mast cell *(see diagram in notes) Phagocytosis by activated macrophages Opsonisation of bacteria by complement (complement released) ...
Immunology PPT - Old Saybrook Public Schools
Immunology PPT - Old Saybrook Public Schools

... • protects an organism against potential pathogens (viral, bacterial, fungal, protists) ...
9.AM Shiv Pillai Cells of the Immune System and Innate Immunity
9.AM Shiv Pillai Cells of the Immune System and Innate Immunity

... We have already considered B and T lymphocytes in a general way. These lymphocytes have clonal receptors and can recognize an extraordinary range of distinct shapes. While lymphocytes are, by and large, components of the adaptive immune system, we will consider later in the course how, once lymphocy ...
Immunity Answers
Immunity Answers

Chapter 2
Chapter 2

... - Surrounded by capsule and divided into lobules - Outer part of lobule is cortex, inner is medulla - Network of epithelial cells, dendritic cells, and macrophages ○ Thymus will induce death of those T cells that ...
NK cells - University of Pittsburgh School of Medicine
NK cells - University of Pittsburgh School of Medicine

... question of whether TLRs are important in immune responses Toll was found to be important in activating Drosophila sp. non-adaptive immunity, i.e. production of anti-fungal and anti-bacterial peptides At least 10 TLRs in man [estimated to be between 10 and 15 in most mammals, TLRs TLRs 11-13 defined ...
blood - Dr Magrann
blood - Dr Magrann

Specific Host Defense IMMUNOLOGY
Specific Host Defense IMMUNOLOGY

... 1. Active: Ab produced the body, long: A. Natural: Infections; protective Ab B. Artificial: Vaccination ...
No Slide Title
No Slide Title

... Approx. 140 genes, ~70 of these are involved in immune responses. • HLA: Human Leukocyte Antigens. Is the name of the MHC in humans = interchangeable. ...
AQA Immunity Booklet Answers
AQA Immunity Booklet Answers

... When an antigen is recognised by a type of white blood cell known as a lymphocyte, the resulting process is known as immunity, the ability of our body to protect itself from a disease that we have already experienced. There are two interlinked types of immunity; Cell mediated immunity and humoural i ...
Unit 3 - Nervous and Immune Systems Study Guide
Unit 3 - Nervous and Immune Systems Study Guide

... List several basic defenses that are considered innate. Phagocytes are also considered an innate defense. o What are macrophages? o What are monocytes o How do these WBCs play a role in the immune system? ...
Exam 4 review key - Iowa State University
Exam 4 review key - Iowa State University

... B cells and T cells are cells capable of phagocytosing a pathogen into a vesicle, which will fuse with a lysosome and be degraded by enzymes. False, B cells and T cells are not phagocytic cells. WBC’s such as neutrophils and macrophages are phagocytic. ...
Autoimmune - Treg 2012
Autoimmune - Treg 2012

GI Pathology in Innate and Acquired Immunodeficiency
GI Pathology in Innate and Acquired Immunodeficiency

... • Absence of T&NK cells,normal number-dysfunctional B cells ...
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... • Action similar to Tc (CD8+) cells • Role: destroys tumor cells and virus-infected cells • Recognition due to altered expression of MHC-I and ADCC (Ab-dependent cell cytotoxicity) • NK1-T cell: T cell and NK cell. Expresses TCR, TCR interacts with CD1 (similar to MHC-1), express CD16, and cell kill ...
Document
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... plague which was caused by a bacterial pathogen carried by the fleas on rats. • Around 1850, a British surgeon named Joseph Lister, wondered if pathogens were being transferred from surgeons hands and medical equipment to patients. After surgeons started to clean their hands, scalpels etc. the death ...
The Immune System - SD43 Teacher Sites
The Immune System - SD43 Teacher Sites

... plague which was caused by a bacterial pathogen carried by the fleas on rats. • Around 1850, a British surgeon named Joseph Lister, wondered if pathogens were being transferred from surgeons hands and medical equipment to patients. After surgeons started to clean their hands, scalpels etc. the death ...
Blood Typing
Blood Typing

... cells and anti-B antibodies in the plasma. • Type B blood has the B antigen on the red blood cells and the anti-A antibodies in the plasma • Type AB blood has both antigens on the red blood cells and no antibodies in the plasma. • Type O blood has no has neither A nor B antigens on the cells and has ...
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... • Chronic mucosal inflammation, at least in part, leads to „airway remodeling”. ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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