Histopathology of bronchiectasis
... the distribution of changes may provide a clue to the underlying aetiology. Post-infective bronchiectasis is traditionally the most common underlying cause, is most often basal and may be confined to a single lobe. However, nonobstructive bronchiectasis may occur in association with a number of othe ...
... the distribution of changes may provide a clue to the underlying aetiology. Post-infective bronchiectasis is traditionally the most common underlying cause, is most often basal and may be confined to a single lobe. However, nonobstructive bronchiectasis may occur in association with a number of othe ...
Scientific Research Summary
... lymphoma assay. This test has been shown to detect missing classes of mutations that are not capable of detection in the bacterial reverse mutation assay. Mouse lymphoma cell lines were exposed to varying concentrations of EpiCor, both in the presence and absence of an exogenous metabolic activation ...
... lymphoma assay. This test has been shown to detect missing classes of mutations that are not capable of detection in the bacterial reverse mutation assay. Mouse lymphoma cell lines were exposed to varying concentrations of EpiCor, both in the presence and absence of an exogenous metabolic activation ...
HIV-1 Envelope gp41 Is a Potent Inhibitor of Chemoattractant
... receptor superfamily have been identified as essential cofactors for HIV-1 entry (5), and HIV-1 cell-type tropism seems to be dictated by chemokine receptor usage. After the binding of the envelope gp120 to CD4, the chemokine receptors, CXCR4 for T lymphotropic and CCR5 for monotropic HIV-1, may eit ...
... receptor superfamily have been identified as essential cofactors for HIV-1 entry (5), and HIV-1 cell-type tropism seems to be dictated by chemokine receptor usage. After the binding of the envelope gp120 to CD4, the chemokine receptors, CXCR4 for T lymphotropic and CCR5 for monotropic HIV-1, may eit ...
MINIREVIEW Mounting Evidence for Vitamin D - Direct-MS
... affect the prevalence of autoimmune diseases were largely based on anecdotal evidence (9). For example, MS and IBD are diseases prevalent in Canada, the northern parts of the United States, and Europe. The underlying hypothesis would be that the availability of the vitamin D ligand in the environmen ...
... affect the prevalence of autoimmune diseases were largely based on anecdotal evidence (9). For example, MS and IBD are diseases prevalent in Canada, the northern parts of the United States, and Europe. The underlying hypothesis would be that the availability of the vitamin D ligand in the environmen ...
Granulomas in Infectious and Non
... in parallel with the meeting on “Host Response in Tuberculosis” and brings together researchers, clinicians and members of the pharmaceutical industry to discuss the basic mechanics of granuloma formation, elucidate common pathogenic mechanisms and identify novel areas of therapeutic intervention fo ...
... in parallel with the meeting on “Host Response in Tuberculosis” and brings together researchers, clinicians and members of the pharmaceutical industry to discuss the basic mechanics of granuloma formation, elucidate common pathogenic mechanisms and identify novel areas of therapeutic intervention fo ...
Transferrin and the Transferrin Receptor: Of Magic Bullets
... precursors and placenta cells [44, 45, reviewed in 46]. Trf receptor is also present in other tissues like the endocrine pancreas, liver, muscle cells, kidney, testis and pituitary glands [44, 47, reviewed in 48]. In general, proliferating cells express Trf receptor contrasting with resting cells in ...
... precursors and placenta cells [44, 45, reviewed in 46]. Trf receptor is also present in other tissues like the endocrine pancreas, liver, muscle cells, kidney, testis and pituitary glands [44, 47, reviewed in 48]. In general, proliferating cells express Trf receptor contrasting with resting cells in ...
Preparation of polyclonal antibody against porcine - Funpec-RP
... mortality of infected pigs. Therefore, it is important to find new antimicrobial treatments for use in these diseases. Studies showed pBD2 to have high antimicrobial activity against bacteria, including multidrug-resistant bacteria isolated from sick fowl (Veldhuizen et al., 2008; Li et al., 2013a), ...
... mortality of infected pigs. Therefore, it is important to find new antimicrobial treatments for use in these diseases. Studies showed pBD2 to have high antimicrobial activity against bacteria, including multidrug-resistant bacteria isolated from sick fowl (Veldhuizen et al., 2008; Li et al., 2013a), ...
ABSTRACT Title of Document: INTERFERON
... location of the two cysteines present in N-terminal portion of the chemokine protein sequence. The four families include the C, CC, CXC, and CX3C chemokines. They mediate their proinflammatory effects by binding to a variety of specific receptors, belonging to the G protein-coupled superfamily of se ...
... location of the two cysteines present in N-terminal portion of the chemokine protein sequence. The four families include the C, CC, CXC, and CX3C chemokines. They mediate their proinflammatory effects by binding to a variety of specific receptors, belonging to the G protein-coupled superfamily of se ...
Lessening Malaria Parasite Burden with Yogurt
... testing is not realistic or when experimental trials are still in earlier stages. Mice have similar disease progressions as humans, are small and simple to house, and are easily genetically manipulated. Over 85% of the mouse genome is similar to that of a human, which gives researchers confidence th ...
... testing is not realistic or when experimental trials are still in earlier stages. Mice have similar disease progressions as humans, are small and simple to house, and are easily genetically manipulated. Over 85% of the mouse genome is similar to that of a human, which gives researchers confidence th ...
Curriculum Vitae - Institute of Experimental Immunology
... 3. Reinhard Obst, Christian Münz, Stefan Stevanović and Hans-Georg Rammensee, "Generation of allo- and self-restricted cytotoxic T lymphocytes against a peptide library: evidence for a functionally diverse allo-restricted T cell repertoire", European Journal of Immunology (1998), 28:2432-2443. 4. Jo ...
... 3. Reinhard Obst, Christian Münz, Stefan Stevanović and Hans-Georg Rammensee, "Generation of allo- and self-restricted cytotoxic T lymphocytes against a peptide library: evidence for a functionally diverse allo-restricted T cell repertoire", European Journal of Immunology (1998), 28:2432-2443. 4. Jo ...
Vascular Endothelial Growth Factors In Eye Diseases
... risk of complications including endophthalmitis, cataract and haemorrhages increases. The optimal method for the delivery of therapeutic agents to the retina and choroidea has not yet been developed. Gene therapy offers an alternative in which the therapeutic protein or proteins are induced in the t ...
... risk of complications including endophthalmitis, cataract and haemorrhages increases. The optimal method for the delivery of therapeutic agents to the retina and choroidea has not yet been developed. Gene therapy offers an alternative in which the therapeutic protein or proteins are induced in the t ...
... has caused or is causing an allergic reaction in the first place. We might suspect certain culprits, however, there could be a variety and a combination of substances involved. Over the last twenty years or more there have been huge changes in food technology. The advent of genetic modification, the ...
Gene Therapy Using Adeno-Associated Virus Vectors
... Herpesvirus aids in AAV gene expression by providing viral DNA polymerase and helicase as well as the early functions necessary for HSV transcription. Although adenovirus and herpesvirus provide different sets of genes for helper function, they both regulate cellular gene expression, providing a per ...
... Herpesvirus aids in AAV gene expression by providing viral DNA polymerase and helicase as well as the early functions necessary for HSV transcription. Although adenovirus and herpesvirus provide different sets of genes for helper function, they both regulate cellular gene expression, providing a per ...
Development of a non-invasive murine infection model for acute
... elevated throughout the course of infection. Importantly, levels in PBS-inoculated mice were below the detection limit at 1.5, 48 and 96 h post-inoculation and marginal at 144 h post-inoculation (TNF-a, 14.5 pg ml21; IL-1b, 24.4 pg ml21). The levels of TNF-a and IL-1b in the middle ear at 48 h and 9 ...
... elevated throughout the course of infection. Importantly, levels in PBS-inoculated mice were below the detection limit at 1.5, 48 and 96 h post-inoculation and marginal at 144 h post-inoculation (TNF-a, 14.5 pg ml21; IL-1b, 24.4 pg ml21). The levels of TNF-a and IL-1b in the middle ear at 48 h and 9 ...
Drug Targeting to Particular Organs
... normally leaky or fenestrated or “ having loose junctions”. ...
... normally leaky or fenestrated or “ having loose junctions”. ...
Protein aggregation complicates the development of baculovirus-expressed African horsesickness
... & Taylor 1991 ). Nevertheless, all the remaining neurotropic cell culture-produced vaccine strains were subsequently replaced with fully cell culture-attenuated vaccine strains. Ever since, there have been problems with some of the AHSV vaccine strains. In 1990, a newly-attenuated serotype 5 vaccine ...
... & Taylor 1991 ). Nevertheless, all the remaining neurotropic cell culture-produced vaccine strains were subsequently replaced with fully cell culture-attenuated vaccine strains. Ever since, there have been problems with some of the AHSV vaccine strains. In 1990, a newly-attenuated serotype 5 vaccine ...
Contributions of the immune system to the
... Following brain injury, microglia extend their processes towards the damaged area as shown in vivo after laser or microelectrode injury (Davalos et al., 2005), or ex vivo on organotropic hippocampal slice cultures following MCAo (Neumann et al., 2008; Figure 1). Microglia morphologically become more ...
... Following brain injury, microglia extend their processes towards the damaged area as shown in vivo after laser or microelectrode injury (Davalos et al., 2005), or ex vivo on organotropic hippocampal slice cultures following MCAo (Neumann et al., 2008; Figure 1). Microglia morphologically become more ...
Clinical Synopsis A 32year old female presented with a four year
... The pathologic mechanism of vitiligo is not clearly known. Complex factors involving cellular and humoral immunity, toxic metabolites and genetic factors partly contribute to its pathogenesis. Ciuet al5 demonstrated that antibodies to melanocytes were present in both vitiligo and melanoma patients w ...
... The pathologic mechanism of vitiligo is not clearly known. Complex factors involving cellular and humoral immunity, toxic metabolites and genetic factors partly contribute to its pathogenesis. Ciuet al5 demonstrated that antibodies to melanocytes were present in both vitiligo and melanoma patients w ...
Chapter 8: Lactate Dehydrogenase
... In vivo, ___ ____________ is produced at high levels about ___ hours after LDV infection, and it may be involved in bringing about the decline in ________ viral titers that begins about ___ hours after infection. T or F: LDV-induced g-interferon does not control the replication of the virus. What ar ...
... In vivo, ___ ____________ is produced at high levels about ___ hours after LDV infection, and it may be involved in bringing about the decline in ________ viral titers that begins about ___ hours after infection. T or F: LDV-induced g-interferon does not control the replication of the virus. What ar ...
Antimicrobial peptides in lung transplant recipients with bronchiolitis obliterans syndrome
... found in human airways include a human cathelicidin (hCAP)18/LL-37, a- and b-defensins, and the proteinase inhibitors secretory leukoprotease inhibitor (SLPI) and elafin [12, 13]. Their release is stimulated by inflammatory cytokines and microbial products and they act directly as endogenous antibio ...
... found in human airways include a human cathelicidin (hCAP)18/LL-37, a- and b-defensins, and the proteinase inhibitors secretory leukoprotease inhibitor (SLPI) and elafin [12, 13]. Their release is stimulated by inflammatory cytokines and microbial products and they act directly as endogenous antibio ...
Lectins, Mitogens and Agglutinins
... control the damaging effects of terrorist attacks, Alibek has placed strong emphasis on stimulating nonspecific immunities of victims mainly with interleukins and other cytokines. A more productive alternative would be giving mitogens such as PHA and PWM to reinforce vaccine and antibiotic actions, ...
... control the damaging effects of terrorist attacks, Alibek has placed strong emphasis on stimulating nonspecific immunities of victims mainly with interleukins and other cytokines. A more productive alternative would be giving mitogens such as PHA and PWM to reinforce vaccine and antibiotic actions, ...
Lymph formation, composition and circulation
... Online, together with an indication of the study and the organism on which the study was performed. In this view, it is worth noting that protein hits reported in these studies may sometimes have resulted from searches on proteomics databases of orthogonal species (e.g. such as in the case of Bos Ta ...
... Online, together with an indication of the study and the organism on which the study was performed. In this view, it is worth noting that protein hits reported in these studies may sometimes have resulted from searches on proteomics databases of orthogonal species (e.g. such as in the case of Bos Ta ...
Unmasking tuberculosis in the era of antiretroviral treatment PERSPECTIVE
... Other authors refer to ‘‘unmasked TB’’ as a wide spectrum of TB clinical presentations, triggered by cART-induced immune recovery [5]. In a recent review, MANABE et al. [7] proposed a new way of classifying the different forms of TB occurring during cART. According to the authors, ‘‘primary TB’’ is ...
... Other authors refer to ‘‘unmasked TB’’ as a wide spectrum of TB clinical presentations, triggered by cART-induced immune recovery [5]. In a recent review, MANABE et al. [7] proposed a new way of classifying the different forms of TB occurring during cART. According to the authors, ‘‘primary TB’’ is ...