The superbugs are coming!
... Unstable to acidic conditions thus can not be given in oral form. Simple mutations in bacteria can give rise to penicillin resistant strains. Can cause allergic reactions in some people (1-4% cases) which can be very serious. Fatality rates however are low 0.001%. Dr S. Cobb/ Durham University ...
... Unstable to acidic conditions thus can not be given in oral form. Simple mutations in bacteria can give rise to penicillin resistant strains. Can cause allergic reactions in some people (1-4% cases) which can be very serious. Fatality rates however are low 0.001%. Dr S. Cobb/ Durham University ...
a mathematical simulation of the inflammatory response to anthrax
... The major toxins of B. anthracis are protective antigen, lethal factor, and edema factor. These three exotoxins are synthesized, and each forms heterodimers that result in bioactive molecules: edema toxin is a heterodimer of protective antigen and edema factor, and lethal toxin consists of protectiv ...
... The major toxins of B. anthracis are protective antigen, lethal factor, and edema factor. These three exotoxins are synthesized, and each forms heterodimers that result in bioactive molecules: edema toxin is a heterodimer of protective antigen and edema factor, and lethal toxin consists of protectiv ...
Licentiate thesis from the Department of Immunology,
... cases are recorded each year. Although BCG vaccination triggers protective immune responses in the neonates, it confers protection against only certain forms of childhood TB. Protection mediated by BCG, against pulmonary TB, is controversial as reported with variable efficacy ranging from 0-80%. In ...
... cases are recorded each year. Although BCG vaccination triggers protective immune responses in the neonates, it confers protection against only certain forms of childhood TB. Protection mediated by BCG, against pulmonary TB, is controversial as reported with variable efficacy ranging from 0-80%. In ...
Characterization of extracellular and surface bound adherence
... The gene mecA is located in a mobile genetic element called the SCC mec (staphylococcal Cassette Chromosome mec). The mecA gene and the trans membrane β-lactam sensing signal transducer mecR1 are regulated by a repressor gene mec1. When exposed to beta-lactam antibiotics, mecR1 is auto-catalytically ...
... The gene mecA is located in a mobile genetic element called the SCC mec (staphylococcal Cassette Chromosome mec). The mecA gene and the trans membrane β-lactam sensing signal transducer mecR1 are regulated by a repressor gene mec1. When exposed to beta-lactam antibiotics, mecR1 is auto-catalytically ...
Immunological Studies in Malignant Melanoma: Importance of TNF and the Thioredoxin System
... macroscopically, as an irregularly growing, pigmented lesion that after a long time (even decades) of inactivity can debut with symptoms such as accelerated growth, itching and bleeding. Pathologists have called malignant melanoma the “great pretender”. When morphological characteristics of a lesion ...
... macroscopically, as an irregularly growing, pigmented lesion that after a long time (even decades) of inactivity can debut with symptoms such as accelerated growth, itching and bleeding. Pathologists have called malignant melanoma the “great pretender”. When morphological characteristics of a lesion ...
Printable Issue
... skin called a fibroblast. Collagen is one of the main components of the extracellular matrix — a threedimensional web that supports and stabilizes the cells in the skin. Now Longaker and stem cell expert Irving Weissman, MD, and colleagues have identified the cell type in mice that is responsible fo ...
... skin called a fibroblast. Collagen is one of the main components of the extracellular matrix — a threedimensional web that supports and stabilizes the cells in the skin. Now Longaker and stem cell expert Irving Weissman, MD, and colleagues have identified the cell type in mice that is responsible fo ...
Our focus is on vaccines
... Chimigen® HBV Therapeutic Vaccine Summary • Binds to immature DCs – CD32 & CD206 • Appropriate antigen processing and presentation – Efficacy in Normal and HBV carriers, ex vivo in DC/T cell antigen presentation assays • Induces activation and proliferation of CD8+ and CD4+ T cells • Production of ...
... Chimigen® HBV Therapeutic Vaccine Summary • Binds to immature DCs – CD32 & CD206 • Appropriate antigen processing and presentation – Efficacy in Normal and HBV carriers, ex vivo in DC/T cell antigen presentation assays • Induces activation and proliferation of CD8+ and CD4+ T cells • Production of ...
Inflammation Aggravates Disease Severity in Marfan Syndrome Patients
... markers in blood would correlate to aortic phenotype in MFS patients. TGF-b, C-Reactive Protein (CRP; a well established aspecific marker of systemic inflammation) and several prominent cytokines were measured in plasma of our MFS patient group (Table S1). The tested cytokines are pro- or anti-infla ...
... markers in blood would correlate to aortic phenotype in MFS patients. TGF-b, C-Reactive Protein (CRP; a well established aspecific marker of systemic inflammation) and several prominent cytokines were measured in plasma of our MFS patient group (Table S1). The tested cytokines are pro- or anti-infla ...
References
... Maartens, G., Wilkinson, R.J., Tuberculosis. Lancet, 2010. 370: p. 2030–43. Barry 3rd, C.E., New horizons in the treatment of tuberculosis. Biochem Pharmacol, 1997. 54(11): p. 1165-1172. Ramsden, J.J., What is nanotechnology? . Nanotechnology Perceptions, 2005. 1: p. 3-17. Wagner, V., Dullaart, A., ...
... Maartens, G., Wilkinson, R.J., Tuberculosis. Lancet, 2010. 370: p. 2030–43. Barry 3rd, C.E., New horizons in the treatment of tuberculosis. Biochem Pharmacol, 1997. 54(11): p. 1165-1172. Ramsden, J.J., What is nanotechnology? . Nanotechnology Perceptions, 2005. 1: p. 3-17. Wagner, V., Dullaart, A., ...
(pdf version)
... the latest scientific literature describing these important pathogenic interactions. Therapeutic treatments and preventive methods will also be covered. (3-0) T BIOL 6337 Regulation of Gene Expression (3 semester hours) An in depth look at how the cell makes use of its genetic information, with a pr ...
... the latest scientific literature describing these important pathogenic interactions. Therapeutic treatments and preventive methods will also be covered. (3-0) T BIOL 6337 Regulation of Gene Expression (3 semester hours) An in depth look at how the cell makes use of its genetic information, with a pr ...
Relative ability of ovine follicle stimulating hormone and
... (figure 4). Discussion The primary objective of the current study was to understand whether antibodies capable of sequestering FSH circulating in vivo are also able to inhibit FSH response in vitro and if so the mechanism by which this is achieved. All studies carried out hitherto on bioneutralizati ...
... (figure 4). Discussion The primary objective of the current study was to understand whether antibodies capable of sequestering FSH circulating in vivo are also able to inhibit FSH response in vitro and if so the mechanism by which this is achieved. All studies carried out hitherto on bioneutralizati ...
REVIEW: THE ROLE OF INFLAMMATION IN DEPRESSION
... The innate immune system is thought to play an integral role in depression and it determines the type of adaptive immune response involving T helper (Th) 1 or Th2 lymphocytes. In Th1 response, macrophages release pro-inflammatory cytokines such as interferon gamma (INF-γ), tumour necrosis factor alp ...
... The innate immune system is thought to play an integral role in depression and it determines the type of adaptive immune response involving T helper (Th) 1 or Th2 lymphocytes. In Th1 response, macrophages release pro-inflammatory cytokines such as interferon gamma (INF-γ), tumour necrosis factor alp ...
How is the STAT3 pathway activated?
... Summary STAT3 is a cytokine and growth factor activated transcription factor STAT3 has a wide range of functions, both anti and pro inflammatory depending on the tissue and physiological context STAT3 is also involved in disease states, such as asthma, colitis, and cancer STAT3 can suppress an ...
... Summary STAT3 is a cytokine and growth factor activated transcription factor STAT3 has a wide range of functions, both anti and pro inflammatory depending on the tissue and physiological context STAT3 is also involved in disease states, such as asthma, colitis, and cancer STAT3 can suppress an ...
Food Allergies in Children
... protein when it enters via the oral route – called oral tolerance Contrasts with the active immune responses needed to protect the gut against continual bombardment by invading pathogens and their products (toxins, etc) Also contrasts with the reduced responsiveness to the millions of microorganisms ...
... protein when it enters via the oral route – called oral tolerance Contrasts with the active immune responses needed to protect the gut against continual bombardment by invading pathogens and their products (toxins, etc) Also contrasts with the reduced responsiveness to the millions of microorganisms ...
BIOH122
... o Lymph Ducts: Lymph passes from lymph trunks into two main channels, the thoracic duct and the right lymphatic duct, and then drains into venous blood. o The thoracic duct: • is the main collecting duct of the lymphatic system • begins as a dilation called the cisterna chyli. • receives lymph from ...
... o Lymph Ducts: Lymph passes from lymph trunks into two main channels, the thoracic duct and the right lymphatic duct, and then drains into venous blood. o The thoracic duct: • is the main collecting duct of the lymphatic system • begins as a dilation called the cisterna chyli. • receives lymph from ...
A Functional Study of the Drosophila Host Defense
... ymmärtämään paremmin myös ihmisen synnynnäistä immuunivastetta johtuen ...
... ymmärtämään paremmin myös ihmisen synnynnäistä immuunivastetta johtuen ...
Nonalcoholic Fatty Liver Disease and Insulin Resistance: New
... Abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders worldwide. It is associated with clinical states such as obesity, insulin resistance, and type 2 diabetes, and covers a wide range of liver changes, ranging from simple steatosis to non-alcoholic ste ...
... Abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders worldwide. It is associated with clinical states such as obesity, insulin resistance, and type 2 diabetes, and covers a wide range of liver changes, ranging from simple steatosis to non-alcoholic ste ...
Licentiate thesis from the Department of Immunology,
... pathogen associated molecular patterns (PAMPs) on pathogens. The germ line encoded Toll-like receptors (TLRs) allow the direct recognition of distinct microbial structures that are shared by microorganisms, such as lipopolysaccharide (LPS), lipoteichoic acid (LTA), flagellin and bacterial DNA. Toll- ...
... pathogen associated molecular patterns (PAMPs) on pathogens. The germ line encoded Toll-like receptors (TLRs) allow the direct recognition of distinct microbial structures that are shared by microorganisms, such as lipopolysaccharide (LPS), lipoteichoic acid (LTA), flagellin and bacterial DNA. Toll- ...
Immune System Responses to Diseases/Disorders in the Dairy
... (linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid) fatty acids, on the cells and compounds involved in immune preservation primarily of bovine. Immune System Overview Edward Jenner is considered to be the founding scientist of immunology. In 1796 he discovered that if cowpox (called v ...
... (linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid) fatty acids, on the cells and compounds involved in immune preservation primarily of bovine. Immune System Overview Edward Jenner is considered to be the founding scientist of immunology. In 1796 he discovered that if cowpox (called v ...
carbamazepine in a patient with severe serum
... Another question is: why are so few people allergic to carbamazepine? We used mouse serum as the antigen, which was obtained by bleeding from mice that had been given a large amount of carbamazepine. Though large numbers of immune complexes were predicted from the clinical picture and laboratory fin ...
... Another question is: why are so few people allergic to carbamazepine? We used mouse serum as the antigen, which was obtained by bleeding from mice that had been given a large amount of carbamazepine. Though large numbers of immune complexes were predicted from the clinical picture and laboratory fin ...
4 results 28.06.13
... increased (P <0.05) ROS generation at 1.0 and 3.0 mg/kg while compound 2 significantly increased (P <0.01) the oxidative burst at 3.0 mg/kg dose. Compound 5 however, caused highly significant (P <0.001) oxidative burst at both 1.0 and 3.0 mg/kg doses. Treatment with compounds 3 and 4 did not lead to ...
... increased (P <0.05) ROS generation at 1.0 and 3.0 mg/kg while compound 2 significantly increased (P <0.01) the oxidative burst at 3.0 mg/kg dose. Compound 5 however, caused highly significant (P <0.001) oxidative burst at both 1.0 and 3.0 mg/kg doses. Treatment with compounds 3 and 4 did not lead to ...
toxic plant booklet
... exposed skin cells. Affected proteins interfere with the immune system's ability to recognize these cells as normal parts of the body, causing a T-‐ cell-‐mediated immune response.[2] This immune response is ...
... exposed skin cells. Affected proteins interfere with the immune system's ability to recognize these cells as normal parts of the body, causing a T-‐ cell-‐mediated immune response.[2] This immune response is ...
Parasite resistance and the adaptive significance of sleep The
... A wide range of hypotheses have been proposed to explain why this seemingly vulnerable and unproductive state has evolved, including suggestions that sleep conserves energy when alternative activities would bring little advantage [7], is required for the consolidation of memories and learning [8], o ...
... A wide range of hypotheses have been proposed to explain why this seemingly vulnerable and unproductive state has evolved, including suggestions that sleep conserves energy when alternative activities would bring little advantage [7], is required for the consolidation of memories and learning [8], o ...