Principal Investigator/Program Director (Last, First, Middle): Halonen
... Major Goal: To identify astrocyte host cell proteins and host targets of parasites kinases and phosphatases that are differentially regulated during parasite infection and explore how these host cell changes are altered by the parasites of distinct virulent phenotypes. Model of Cerebral Toxoplasmosi ...
... Major Goal: To identify astrocyte host cell proteins and host targets of parasites kinases and phosphatases that are differentially regulated during parasite infection and explore how these host cell changes are altered by the parasites of distinct virulent phenotypes. Model of Cerebral Toxoplasmosi ...
Endogenous MMTV Proviruses Induce Susceptibility to Both Viral
... layer to invade the underlying lymphoid tissue [10]. B lymphocytes and dendritic cells are the initial targets of MMTV infection [11]. These infected antigen-presenting cells (APCs) express virus-encoded superantigen (Sag), a type II transmembrane glycoprotein, at the cell surface in association wit ...
... layer to invade the underlying lymphoid tissue [10]. B lymphocytes and dendritic cells are the initial targets of MMTV infection [11]. These infected antigen-presenting cells (APCs) express virus-encoded superantigen (Sag), a type II transmembrane glycoprotein, at the cell surface in association wit ...
Dissociating Siv Env And Cd4: Consequenes For Virus And Host
... variants of HIV and SIV have been described that can utilize coreceptors CCR5 or CXCR4 in the absence of CD4, these viruses typically retain their CD4 binding sites and can still interact with CD4. In this thesis, I present the characterization and evaluation, both in vitro and in vivo, of a novel C ...
... variants of HIV and SIV have been described that can utilize coreceptors CCR5 or CXCR4 in the absence of CD4, these viruses typically retain their CD4 binding sites and can still interact with CD4. In this thesis, I present the characterization and evaluation, both in vitro and in vivo, of a novel C ...
Archives of Microbiology
... thick and short roots (Tsr) on Vicia sativa (Van Brussel et al. 1982). Recent results have indicated that nod genes are required for the induction of the Tsr phenotype (Van Brussel et al. 1984). In R. Ieguminosarum strain 248 the symbiotic functions are located on the self-transmissible plasmid p R ...
... thick and short roots (Tsr) on Vicia sativa (Van Brussel et al. 1982). Recent results have indicated that nod genes are required for the induction of the Tsr phenotype (Van Brussel et al. 1984). In R. Ieguminosarum strain 248 the symbiotic functions are located on the self-transmissible plasmid p R ...
and Adaptive Immunity Structure and Function
... HSP-peptide interactions have been studied using environmentally sensitive fluorescent peptides (31), fluorescence anisotropy (32, 33), radiolabeled peptides (34), and tryptophan fluorescence (35). These techniques have been used to quantify Ag delivery by HSPs, although the extremely hydrophobic na ...
... HSP-peptide interactions have been studied using environmentally sensitive fluorescent peptides (31), fluorescence anisotropy (32, 33), radiolabeled peptides (34), and tryptophan fluorescence (35). These techniques have been used to quantify Ag delivery by HSPs, although the extremely hydrophobic na ...
Lyme Disease? - Nutri-Spec
... disappears spontaneously (with no antibiotics) after several months to several years. One of the less than conventional Lyme specialists uses CD57 as an indicator of the presence of Lyme, even in the absence of positive antibody titre. Activation of invariant natural killer cells is indeed a critica ...
... disappears spontaneously (with no antibiotics) after several months to several years. One of the less than conventional Lyme specialists uses CD57 as an indicator of the presence of Lyme, even in the absence of positive antibody titre. Activation of invariant natural killer cells is indeed a critica ...
Monoclonal Antibody Pharmacokinetics and
... cell-mediated cytotoxicity by mononuclear cells is more efficient for IgG1 and IgG3 than for IgG2 and IgG4. On the other hand, IgG4 is much more active in recruiting the alternative complement pathway than are the other three IgG subclasses.1 Antibody drugs typically possess several desirable pharma ...
... cell-mediated cytotoxicity by mononuclear cells is more efficient for IgG1 and IgG3 than for IgG2 and IgG4. On the other hand, IgG4 is much more active in recruiting the alternative complement pathway than are the other three IgG subclasses.1 Antibody drugs typically possess several desirable pharma ...
Vaccinia virus protein A46R targets multiple Toll-like
... mice (2–5). Many but not all of these receptors have been assigned a role in the initial detection of, and response to, specific pathogen-associated molecules (PAMs). In macrophages and neutrophils, this drives innate immune responses, such as inflammation and induction of microbicidal activity, whe ...
... mice (2–5). Many but not all of these receptors have been assigned a role in the initial detection of, and response to, specific pathogen-associated molecules (PAMs). In macrophages and neutrophils, this drives innate immune responses, such as inflammation and induction of microbicidal activity, whe ...
Immature Myeloid Cells Promote Tumor Formation Via Non
... mature cells. There is a substantial expansion of IMC in cancer and many other pathological conditions which is associated with pathologic activation of these cells. As a result, these cells acquire the ability to suppress immune responses and are termed Myeloid-derived Suppressor Cells (MDSCs). Alt ...
... mature cells. There is a substantial expansion of IMC in cancer and many other pathological conditions which is associated with pathologic activation of these cells. As a result, these cells acquire the ability to suppress immune responses and are termed Myeloid-derived Suppressor Cells (MDSCs). Alt ...
The Pathogenesis of Rheumatoid Arthritis
... shared epitope, confer particular susceptibility.6 These findings suggest that some predisposing T-cell repertoire selection, antigen presentation, or alteration in peptide affinity has a role in promoting autoreactive adaptive immune responses. Other possible explanations for the link between rheum ...
... shared epitope, confer particular susceptibility.6 These findings suggest that some predisposing T-cell repertoire selection, antigen presentation, or alteration in peptide affinity has a role in promoting autoreactive adaptive immune responses. Other possible explanations for the link between rheum ...
Flyer: Cell Therapy Systems
... Whether you’re developing cell-based vaccines, genetically modified T cells, or other immunity-based cell therapy strategies, Gibco CTS tools and reagents support all aspects of your work—from bench to clinic and beyond into commercial applications. The CTS products provide specialized products to i ...
... Whether you’re developing cell-based vaccines, genetically modified T cells, or other immunity-based cell therapy strategies, Gibco CTS tools and reagents support all aspects of your work—from bench to clinic and beyond into commercial applications. The CTS products provide specialized products to i ...
Oncology Animal Models - Charles River Laboratories
... Nomenclature: CAnN.Cg-Foxn1nu/Crl Strain Code: 194 (homozygous), 195 (heterozygous) Origin: Developed through crosses and backcrosses between BALB/cABom-nu and BALB/cAnNCrj-nu at Charles River Japan. Pedigreed pregnant females of CAnN.Cg-Foxn1nu/Crl were received from Charles River Japan in 1985. Th ...
... Nomenclature: CAnN.Cg-Foxn1nu/Crl Strain Code: 194 (homozygous), 195 (heterozygous) Origin: Developed through crosses and backcrosses between BALB/cABom-nu and BALB/cAnNCrj-nu at Charles River Japan. Pedigreed pregnant females of CAnN.Cg-Foxn1nu/Crl were received from Charles River Japan in 1985. Th ...
Detection of antibodies to common antigens of pathogenic and
... antibodies to common antigens. The greatest difference was seen in the prevalence of antibody to the N . meningitidis B,15P1.16 35-Kda antigen which was more frequently present in sera from carriers than from non-carriers (p = 0.1). Fig. 2C and D shows a comparison of the reactivity of antibodies in ...
... antibodies to common antigens. The greatest difference was seen in the prevalence of antibody to the N . meningitidis B,15P1.16 35-Kda antigen which was more frequently present in sera from carriers than from non-carriers (p = 0.1). Fig. 2C and D shows a comparison of the reactivity of antibodies in ...
Signal Transduction (Medical Biotechnology)
... 1. I.1 Introduction, overview of extracellular signaling Soluble mediators transmit information through the extracellular space over various distances in cell-to cell communication. In local (short distance) cell signaling, some cells may be in direct contact with each other in order to communicate. ...
... 1. I.1 Introduction, overview of extracellular signaling Soluble mediators transmit information through the extracellular space over various distances in cell-to cell communication. In local (short distance) cell signaling, some cells may be in direct contact with each other in order to communicate. ...
Printable Version - Chinese Shar
... Diagnosis: There is no specific diagnostic test for FSF at this time. Diagnosis is based on the clinical sign of episodic fever in a Shar-Pei. I think every Shar-Pei that dies should be autopsied to determine the cause of death, but this is even more critical in cases involving FSF. Renal amyloidosi ...
... Diagnosis: There is no specific diagnostic test for FSF at this time. Diagnosis is based on the clinical sign of episodic fever in a Shar-Pei. I think every Shar-Pei that dies should be autopsied to determine the cause of death, but this is even more critical in cases involving FSF. Renal amyloidosi ...
Analysis of the roles of Interleukin 15 and CD4+ T cells specific of a
... availability in spite of your tight schedule, for all regular meetings and discussions that we had. Thank you for having given me a large autonomy and your precious advice at moments when I particularly needed it. Thanks for the time you devoted for improving of our manuscripts and correction of thi ...
... availability in spite of your tight schedule, for all regular meetings and discussions that we had. Thank you for having given me a large autonomy and your precious advice at moments when I particularly needed it. Thanks for the time you devoted for improving of our manuscripts and correction of thi ...
THE FORGOTTEN THYMUS
... against foreign substances. We can define its action as a defense against non-self substances which are potentially harmful." (Chaffee, page 304) "The immune response can be defined as the body's ability to recognize materials that are foreign to it and the ability to make specific responses to thes ...
... against foreign substances. We can define its action as a defense against non-self substances which are potentially harmful." (Chaffee, page 304) "The immune response can be defined as the body's ability to recognize materials that are foreign to it and the ability to make specific responses to thes ...
Effects of Whole Yeast Cell Product Supplementation in Chickens
... or 0.1% whole yeast cell product and challenged with live coccidial oocysts after 21 days of whole yeast feeding. Whole yeast cell product supplementation did not significantly alter body weight or feed consumption post-challenge. Supplementation with whole yeast cell product decreased intestinal co ...
... or 0.1% whole yeast cell product and challenged with live coccidial oocysts after 21 days of whole yeast feeding. Whole yeast cell product supplementation did not significantly alter body weight or feed consumption post-challenge. Supplementation with whole yeast cell product decreased intestinal co ...
Extracellular vesicles: biology and emerging therapeutic opportunities
... formed by the inward budding of the multivesicular body (MVB) membrane. Cargo sorting into exosomes involves the endosomal sorting complex required for transport (ESCRT) and other associated proteins such as programmed cell death 6 interacting protein (PDCD6IP; also known as ALIX) and tumour suscep ...
... formed by the inward budding of the multivesicular body (MVB) membrane. Cargo sorting into exosomes involves the endosomal sorting complex required for transport (ESCRT) and other associated proteins such as programmed cell death 6 interacting protein (PDCD6IP; also known as ALIX) and tumour suscep ...
Distinct and Separable Roles of the Complement System in Factor H
... were in the form of iC3b and C3dg, whereas active C3b remained in Cfh⫺/⫺ recipients of wild-type bone marrow. These data show that plasma Cfh limits complement activation in the circulation and other accessible sites such as the glomerulus, whereas platelet Cfh is responsible for immune complex proc ...
... were in the form of iC3b and C3dg, whereas active C3b remained in Cfh⫺/⫺ recipients of wild-type bone marrow. These data show that plasma Cfh limits complement activation in the circulation and other accessible sites such as the glomerulus, whereas platelet Cfh is responsible for immune complex proc ...
Bioassay-Validated Recombinant Cytokines
... all tissues and plays an important role in a variety of normal and pathological processes, including development, wound healing, and neoplastic transformation. FGFb is mitogenic for many cell types, both epithelial and mesenchymal. It shows potent angiogenic activity and has been implicated in tumor ...
... all tissues and plays an important role in a variety of normal and pathological processes, including development, wound healing, and neoplastic transformation. FGFb is mitogenic for many cell types, both epithelial and mesenchymal. It shows potent angiogenic activity and has been implicated in tumor ...
STATE OF THE SCIENCE REPORT
... Biomaterials have been used for thousands of years. Over 2000 years ago, the Romans, Chinese, and Aztecs were already using gold for dentistry. Wooden teeth and glass eyes are other historical examples of biomaterials. Modern medical applications of biomaterials include dental fillings, contacts ...
... Biomaterials have been used for thousands of years. Over 2000 years ago, the Romans, Chinese, and Aztecs were already using gold for dentistry. Wooden teeth and glass eyes are other historical examples of biomaterials. Modern medical applications of biomaterials include dental fillings, contacts ...
In July 2004, The Training Program Director`s Core Curriculum and
... a. B cell activation – cytokines and signal transduction ...................................................... 46 b. Epitope recognition and immunoglobulin production ..................................................... 48 c. Maturation of B lymphocytes............................................. ...
... a. B cell activation – cytokines and signal transduction ...................................................... 46 b. Epitope recognition and immunoglobulin production ..................................................... 48 c. Maturation of B lymphocytes............................................. ...
4. Treatment of pyoderma gangrenosum usually involves systemic
... and the trunk [4]. The varied appearance of these ulcers has led to their recent clinical classification, which includes four prototypic forms of pyoderma gangrenosum: ulcerative, pustular, bullous and vegetative. Only the last of these classifications has no common association with underlying syste ...
... and the trunk [4]. The varied appearance of these ulcers has led to their recent clinical classification, which includes four prototypic forms of pyoderma gangrenosum: ulcerative, pustular, bullous and vegetative. Only the last of these classifications has no common association with underlying syste ...