OX40 ligand newly expressed on bronchiolar progenitors mediates
... are not simply a repeat of what has been published before, which claimed that OX40-OX40L interactions drive an exacerbated T cell response to flu virus that causes pathology (Humphreys et al, JEM, 2003). Although the data as presented look convincing, this experiment was apparently only 1 experiment ...
... are not simply a repeat of what has been published before, which claimed that OX40-OX40L interactions drive an exacerbated T cell response to flu virus that causes pathology (Humphreys et al, JEM, 2003). Although the data as presented look convincing, this experiment was apparently only 1 experiment ...
Le Mercier I et al, 2013
... pDC contributes to autoimmune diseases (10). In contrast to immune activation, pDC were also shown to suppress or limit inflammatory responses to allo-Ag, allergens or oral Ag (1114). In human breast cancer, we previously reported that pDC infiltrating the primary tumor represent an independent prog ...
... pDC contributes to autoimmune diseases (10). In contrast to immune activation, pDC were also shown to suppress or limit inflammatory responses to allo-Ag, allergens or oral Ag (1114). In human breast cancer, we previously reported that pDC infiltrating the primary tumor represent an independent prog ...
Viral Pathogenesis
... Acute infection followed by chronic infection: •initial productive infection with viremia •virus not cleared completely by immune system •continuous, low-level productive infection •may be "smoldering" infection (productive infection by small fraction of cells) •example: human immunodeficiency viru ...
... Acute infection followed by chronic infection: •initial productive infection with viremia •virus not cleared completely by immune system •continuous, low-level productive infection •may be "smoldering" infection (productive infection by small fraction of cells) •example: human immunodeficiency viru ...
PD-1/PD-L1 Immune Checkpoint Blockade in Non–Small Cell Lung
... an increased risk of cancer.16,17 Tumor specimens from patients with resected early-stage lung cancer demonstrate an association between increased tumor infiltration with CD4 and CD8 T-cells and improved overall survival,18-20 whereas high levels of tumor-infiltrating T-regulatory cells are associat ...
... an increased risk of cancer.16,17 Tumor specimens from patients with resected early-stage lung cancer demonstrate an association between increased tumor infiltration with CD4 and CD8 T-cells and improved overall survival,18-20 whereas high levels of tumor-infiltrating T-regulatory cells are associat ...
Toll-like receptors and immune regulation: their direct and indirect
... of CD4+ CD25+ Treg cells with hsp60 or its peptide p277 before anti-CD3 mAb-induced activation significantly enhanced the ability of the CD4+ CD25+ Treg cells to down-regulate the function of CD4+CD25– or CD8+ target T cells, detected through the inhibition of target T-cell proliferation and IFN-c a ...
... of CD4+ CD25+ Treg cells with hsp60 or its peptide p277 before anti-CD3 mAb-induced activation significantly enhanced the ability of the CD4+ CD25+ Treg cells to down-regulate the function of CD4+CD25– or CD8+ target T cells, detected through the inhibition of target T-cell proliferation and IFN-c a ...
Plasma is the main regulator of Staphylococcus epidermidis biofilms
... As expected, biofilms biomass (Fig. 1A) and biofilm cells culturability (Fig. 1B) and viability (Fig. 1C) were significantly reduced in the presence of whole human blood. A more pronounced reduction, however, was observed in the culturability of biofilm cells rather than in viability. This differenc ...
... As expected, biofilms biomass (Fig. 1A) and biofilm cells culturability (Fig. 1B) and viability (Fig. 1C) were significantly reduced in the presence of whole human blood. A more pronounced reduction, however, was observed in the culturability of biofilm cells rather than in viability. This differenc ...
- Future Medicine
... early clinical development while others have been evaluated in larger clinical trials and cohorts to determine whether they can predict adverse clinical outcomes in patients on cART. Most of these biomarkers are not yet used in routine clinical practice but are currently being evaluated to understan ...
... early clinical development while others have been evaluated in larger clinical trials and cohorts to determine whether they can predict adverse clinical outcomes in patients on cART. Most of these biomarkers are not yet used in routine clinical practice but are currently being evaluated to understan ...
... The regular B-cell antigens, Ki-B 5 and L-26, could be demonstrated on all atypical blasts, including small centroblasts. The immunostaining pattern of lymphoma cells is summarized in table 1. After PCR with primers specific for heavy chain consensus sequences [15], using temperature gradient gel el ...
Adhesion Proteins PCOL 582
... resting T cells. Chemokines produced by the antigenpresenting cell (APC) and signals induced by the TCR when it recognizes antigen both act on integrins and lead to their clustering and to conformational changes that increase the affinity of the integrins for their ligands. As a result, the integrin ...
... resting T cells. Chemokines produced by the antigenpresenting cell (APC) and signals induced by the TCR when it recognizes antigen both act on integrins and lead to their clustering and to conformational changes that increase the affinity of the integrins for their ligands. As a result, the integrin ...
Immunotherapy for small-cell lung cancer: rationale and clinical
... cytokines (19,20). Chemotherapy and radiotherapy activate PRRs, which are critical for INF-I production, priming of T-cells and enhancement of ICB (18). Tumor material can act as damage-associated molecular patterns (DAMPs), that are engaged on dendritic cells and/or tumor-associated macrophages to ...
... cytokines (19,20). Chemotherapy and radiotherapy activate PRRs, which are critical for INF-I production, priming of T-cells and enhancement of ICB (18). Tumor material can act as damage-associated molecular patterns (DAMPs), that are engaged on dendritic cells and/or tumor-associated macrophages to ...
Document
... Natural history and pathology of tolerant grafts without immunosuppression is uncertain Protocol biopsies planned at 1,3, 5 years ...
... Natural history and pathology of tolerant grafts without immunosuppression is uncertain Protocol biopsies planned at 1,3, 5 years ...
Early life cytokines, viral infections and IgE
... specific antigens. B and T cells bear B-cell receptors (BcR, also called antibodies or immunoglobulins) and T-cell receptors (TcR), respectively. The BcR recognises specific epitopes on whole antigen molecules, whereas the TcR only recognise small peptide fragments (approximately 8-25 amino acids lo ...
... specific antigens. B and T cells bear B-cell receptors (BcR, also called antibodies or immunoglobulins) and T-cell receptors (TcR), respectively. The BcR recognises specific epitopes on whole antigen molecules, whereas the TcR only recognise small peptide fragments (approximately 8-25 amino acids lo ...
RNA-based vaccines - Università degli Studi di Roma "Tor Vergata"
... expression can persist for many weeks [35]. Hence, RNA vaccination better mimics antigen expression during an acute infection, which may be more conducive to induction of antigen-specific immune responses. The mechanisms of action for RNA vaccines have not been fully elucidated, but likely involve so ...
... expression can persist for many weeks [35]. Hence, RNA vaccination better mimics antigen expression during an acute infection, which may be more conducive to induction of antigen-specific immune responses. The mechanisms of action for RNA vaccines have not been fully elucidated, but likely involve so ...
The elimination of bacteria and biofilms in periodontal disease via
... causing tissue destruction in the host. Invariably, oxygen tension is low and ischemic and necrotic events occur, which benefit the bacterial colony. If antibiotics or an anti-microbial solution is released in an effort to control or eliminate the infection, the swiftness of reproduction and genetic ...
... causing tissue destruction in the host. Invariably, oxygen tension is low and ischemic and necrotic events occur, which benefit the bacterial colony. If antibiotics or an anti-microbial solution is released in an effort to control or eliminate the infection, the swiftness of reproduction and genetic ...
Telomeres and Telomerase
... All mammals have TTAGGG as the repeating telomere sequence Other organisms may have TTGGGG as their sequence When telomeres shorten too far, it may either cause altered gene expression or signal for apoptosis. ...
... All mammals have TTAGGG as the repeating telomere sequence Other organisms may have TTGGGG as their sequence When telomeres shorten too far, it may either cause altered gene expression or signal for apoptosis. ...
Heart Allograft Tolerance Regulatory Cells: Relevance to
... We hypothesize that developmental exposure to noninherited maternal Ags (NIMA) results in alloantigen-specific natural and adaptive T regulatory (TR) cells. We compared offspring exposed to maternal H-2d (NIMAd) with nonexposed controls. In vitro assays did not reveal any differences in T cell respo ...
... We hypothesize that developmental exposure to noninherited maternal Ags (NIMA) results in alloantigen-specific natural and adaptive T regulatory (TR) cells. We compared offspring exposed to maternal H-2d (NIMAd) with nonexposed controls. In vitro assays did not reveal any differences in T cell respo ...
White blood cells 1: non-malignant disorders
... further subdivided into two roughly equal compartments: a marginated pool of cells loosely adherent to vascular endothelium, and a freely circulating pool.4 Only the latter can be counted. Stress (exercise) causes a transient increase in the freely circulating pool.4 Corticosteroids promote release ...
... further subdivided into two roughly equal compartments: a marginated pool of cells loosely adherent to vascular endothelium, and a freely circulating pool.4 Only the latter can be counted. Stress (exercise) causes a transient increase in the freely circulating pool.4 Corticosteroids promote release ...
Tolerogenic Dendritic Cells Producing and Readily Migrating −
... Analysis was performed using Cytomics FC 500 Beckman Coulter, BD Canto II, and BD FACSCalibur (each experiment was repeated using at least two different FACS instruments). Data were analyzed by FlowJo (version 7.6.3; Tree Star, Ashland, OR). Islet-derived DC migration required detection of rare popu ...
... Analysis was performed using Cytomics FC 500 Beckman Coulter, BD Canto II, and BD FACSCalibur (each experiment was repeated using at least two different FACS instruments). Data were analyzed by FlowJo (version 7.6.3; Tree Star, Ashland, OR). Islet-derived DC migration required detection of rare popu ...
Stress Damages Immune System and Health
... impact of stress on the pathophysiology of herpes simplex virus type I (HSV-1) infection and Epstein-Barr virus (EBV) latency. A series of studies employing mouse models have been performed in which the effect of restraint stress on the immune responses to both primary and secondary HSV-1 infections ...
... impact of stress on the pathophysiology of herpes simplex virus type I (HSV-1) infection and Epstein-Barr virus (EBV) latency. A series of studies employing mouse models have been performed in which the effect of restraint stress on the immune responses to both primary and secondary HSV-1 infections ...
Up-regulated interleukin-4 production by peripheral T
... Th1 and Th2 cell proportions and Th1/Th2 ratio in healthy control, MN, MCNS and FSGS Figure 2 shows the results of the intracellular cytokine analysis among the four groups. The proportion of IFN- single positive Th cells (Th1 cells) was not significantly different among groups (Figure 2A), whereas ...
... Th1 and Th2 cell proportions and Th1/Th2 ratio in healthy control, MN, MCNS and FSGS Figure 2 shows the results of the intracellular cytokine analysis among the four groups. The proportion of IFN- single positive Th cells (Th1 cells) was not significantly different among groups (Figure 2A), whereas ...
synthetic bone substitute Baveno, SIB Conference, 3
... Results: biological response “Osteoimmunology: crosstalk between the immune and bone system” T. Nakashima, H. Takayanagi ; J Clin Immunol (2009) 29:555–567 ...
... Results: biological response “Osteoimmunology: crosstalk between the immune and bone system” T. Nakashima, H. Takayanagi ; J Clin Immunol (2009) 29:555–567 ...
Review Immunoglobulins in Defense, Pathogenesis, and Therapy of Fungal Diseases
... in host defense against fungi, and they have brought about a paradigm shift in our thinking on this question. Prior to the 1990s, AMI was considered to be irrelevant in host defense against fungi (for review, see Casadevall, 1995), as the experimental methods that were in use at the time were not ab ...
... in host defense against fungi, and they have brought about a paradigm shift in our thinking on this question. Prior to the 1990s, AMI was considered to be irrelevant in host defense against fungi (for review, see Casadevall, 1995), as the experimental methods that were in use at the time were not ab ...
Peer-reviewed Article PDF
... epitopes are dependent on the tertiary structure of allergen proteins, changing the tertiary structure through allergen modification, such as in peptide allergens, diminishes the binding strength of IgE to the allergen and may weaken the allergic reaction [11]. T-cell epitopes, however, were not imp ...
... epitopes are dependent on the tertiary structure of allergen proteins, changing the tertiary structure through allergen modification, such as in peptide allergens, diminishes the binding strength of IgE to the allergen and may weaken the allergic reaction [11]. T-cell epitopes, however, were not imp ...