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Poster
Poster

... No approved human treatments interact directly with MHC II yet, but mouse and human trials have shown that vaccines containing only fragments of antigens (peptide vaccines) may be able to prevent disease. Peptide vaccines are unique in that, unlike traditional vaccines in which a patient receives a ...
Impact of IgA Constant Domain on HIV
Impact of IgA Constant Domain on HIV

... thought to be pivotal in preventing transmission. HIV-specific IgA, but not IgG, has been detected in the genital tract, seminal fluid, urethral swabs, urine, and vaginal wash samples of HIV-negative sex workers and HIV-status discordant couples. Purified mucosal and plasma IgA from some individuals ...
a,
a,

... Are coded for by genes of the major histocompatibility complex (MHC) and are unique to an individual ...
WHEY PROTEINS AND IMMUNITY
WHEY PROTEINS AND IMMUNITY

... of the B cells and T cells (lymphocytes); only these cells remember how to conquer past invaders and therefore form the basis of all our vaccines.29 Specific immune defense involves two recognition strategies. The first is the humoral immune response that consists of soluble plasma proteins derived ...
投影片 1 - 國防醫學院數位學習系統
投影片 1 - 國防醫學院數位學習系統

... Complement-fixing antibodies with specificity for paternal determinants on sperm mediate infertility High levels of complement regulatory protein on reproductive system  prevent uncontrolled complement activation (e.g.: DAF, MCP,CD59) ...
NIAID/GSK Experimental Ebola Vaccine Appears Safe, Prompts
NIAID/GSK Experimental Ebola Vaccine Appears Safe, Prompts

... The investigators also analyzed the research participants’ blood to learn whether the vaccine prompted production of immune system cells called T cells. A recent study by VRC scientist Nancy J. Sullivan, Ph.D., and colleagues showed that non-human primates inoculated with the candidate NIAID/GSK vac ...
Mice that “conditionally” lack basophils, AT LAST
Mice that “conditionally” lack basophils, AT LAST

... Basophil responses during primary and secondary tick infestation. The model depicted here for the role of basophils during primary and secondary tick infestation as suggested by the data of Wada and colleagues (12). (A) Primary infestation. Upon infestation, tick antigens are likely to be taken up b ...
ADVANCED MOLECULAR THERAPIES OF THE 21ST CENTURY I
ADVANCED MOLECULAR THERAPIES OF THE 21ST CENTURY I

... About 300 million are the acute cases of malaria each ...
Chapter 9 Lymphatic System The lymphatic system is examined
Chapter 9 Lymphatic System The lymphatic system is examined

... Receive lymph from the collecting ducts Located superficially and deep in body Superficial nodes accessible to inspection and palpation Lymphocytes Central to body response to antigens B-lymphocytes produce antibodies T-lymphocytes have important role in controlling immune responses brought about by ...
Blood
Blood

... exposed to the corresponding antibodies, they agglutinate; that is, clump together. • People usually have antibodies against those red cell antigens that they lack. ...
Granule exocytosis mediates immune surveillance of senescent cells
Granule exocytosis mediates immune surveillance of senescent cells

... In order to understand how NK cells target senescent cells, we employed an in vitro cytotoxicity assay whereby normal and senescent cells are co-cultured with the NK cells.4 We incorporated as one model the human NK cell line, YT. The cells express components of both the death receptor and granule e ...
Control of neutrophil inflammation at mucosal surfaces by secreted
Control of neutrophil inflammation at mucosal surfaces by secreted

... driving inflammation and neutrophil recruitment. Other intestinal bacterial pathogens, including Shigella flexneri and enteroaggregative Escherichia coli O42 (EAEC), are also able to trigger 12-lipoxygenase and MRP2 dependent synthesis and secretion of HXA3 to drive neutrophil transepithelial migrat ...
Full Text
Full Text

... Various proteins and peptides have been approved or are being evaluated in clinical trials for treatment of cancer. Due to limited oral bioavailability of such antigens, injectable routes of administration are currently being used. Scientists have been exploring the potential of delivering vaccine a ...
LESSON 1.3 WORKBOOK Bacterial structures
LESSON 1.3 WORKBOOK Bacterial structures

... Between the inner and outer membrane of Gram-negative bacteria, in addition to the thin murein cell wall layer, there is a gel-like solution of enzymes. These enzymes can play important roles in infection. One enzyme in particular, beta-lactamase, can inactivate certain types of antibiotics like pen ...
2、role of autophagy in plant innate immunity
2、role of autophagy in plant innate immunity

... copy of AtATG7 but not with AtATG7 mutant that effect catalytic activity and autophagosome formation ...
A biologically important single nucleotide poly
A biologically important single nucleotide poly

... well documented, but the location of non-MHC susceptibility genes, which contribute two-thirds of the genetic risk for RA, are largely unknown. In support of our results TLR4 has been mapped to chromosome 9 (9q32-q33) (10), within a region that has not previously been genetically linked with RA. The ...
Emotions, Aggression and Stress
Emotions, Aggression and Stress

... Facial Expression and Emotions According to Keltner and Ekman (2000) there are eight emotions based on facial expression. Where Keltner and Ekman (2000) suggest contempt and embarrassment Plutchik (1994) included adoration and vigilance. ...
Human embryonic stem cells and therapeutic cloning
Human embryonic stem cells and therapeutic cloning

... the pluripotency of ES cells. Standard culture conditions for ES cells contain fetal bovine serum (FBS), which is not well characterized and is susceptible to variation from batch to batch. ES cells can also be maintained less effectively without feeder layer on gelatin or extracellular matrix subst ...
A minimum of two distinct heritable factors are required to explain
A minimum of two distinct heritable factors are required to explain

... now demonstrate that two are sufficient for a mathematical model to reproduce the most significant features of the data. The features of the data can be divided into three categories: statistics describing division times, statistics describing death times and those describing fate determination. Our ...
Regional Specialisation of T Cell Subsets and Apoptosis in the
Regional Specialisation of T Cell Subsets and Apoptosis in the

... sections of the intestine, such as Crohn’s disease [CD]. In the present study we aimed to provide an integrated view of the effector-regulatory balance of the mucosal immune function that occurs in healthy subjects and in patients with different inflammatory conditions, and to determine the differen ...
Inflammatory Myopathies
Inflammatory Myopathies

Transmission of a fatal clonal tumor by biting occurs carnivorous marsupial
Transmission of a fatal clonal tumor by biting occurs carnivorous marsupial

... with some populations declining by 90% (5). Although DFTD is widespread across eastern Tasmania, it has not yet been observed in northwestern populations (5). Pearse and Swift (2) proposed that DFTD cells are transferred between individuals as allografts, because tumor cells taken from different ind ...
Activation of Innate Immune Responses by Non
Activation of Innate Immune Responses by Non

antigen- antibody reactions - SOUTHERN MEDICAL UNIVERSITY
antigen- antibody reactions - SOUTHERN MEDICAL UNIVERSITY

Why bacteria matter in animal development and evolution
Why bacteria matter in animal development and evolution

... the polysaccharides in wood to acetate, which the termites absorb as their major source of nutrition. A metagenomic analysis of this bacterial community in the hindgut of a Costa Rican Nasutitermes termite species [9] uncovered the presence of a diverse set of bacterial genes for cellulose and xylan ...
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Immunomics

Immunomics is the study of immune system regulation and response to pathogens using genome-wide approaches. With the rise of genomic and proteomic technologies, scientists have been able to visualize biological networks and infer interrelationships between genes and/or proteins; recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another. Defects of the immune system such as autoimmune diseases, immunodeficiency, and malignancies can benefit from genomic insights on pathological processes. For example, analyzing the systematic variation of gene expression can relate these patterns with specific diseases and gene networks important for immune functions.Traditionally, scientists studying the immune system have had to search for antigens on an individual basis and identify the protein sequence of these antigens (“epitopes”) that would stimulate an immune response. This procedure required that antigens be isolated from whole cells, digested into smaller fragments, and tested against T- and B-cells to observe T- and B- cell responses. These classical approaches could only visualize this system as a static condition and required a large amount of time and labor.Immunomics has made this approach easier by its ability to look at the immune system as a whole and characterize it as a dynamic model. It has revealed that some of the immune system’s most distinguishing features are the continuous motility, turnover, and plasticity of its constituent cells. In addition, current genomic technologies, like microarrays, can capture immune system gene expression over time and can trace interactions of microorganisms with cells of the innate immune system. New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships.
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