Relevance of sexual dimorphism to regulatory T cells: estradiol
... Mechanisms accounting for gender dimorphism during immune responses are still poorly understood. Since invariant natural killer T (iNKT) cells exert important regulatory functions through their capacity to produce both T helper 1 (Th1) and Th2 cytokines, we addressed the question of whether these ac ...
... Mechanisms accounting for gender dimorphism during immune responses are still poorly understood. Since invariant natural killer T (iNKT) cells exert important regulatory functions through their capacity to produce both T helper 1 (Th1) and Th2 cytokines, we addressed the question of whether these ac ...
Effects of supplementation with tocotrienol-rich fraction on
... 1997a, b) and Brown Norway rats (Gu et al., 1999). However, the effects of tocotrienol on the human immune system following immunization have not been investigated. Activated T cells can differentiate into effector T cells showing distinct patterns of cytokine production. The T-helper-1 (TH1) cells, ...
... 1997a, b) and Brown Norway rats (Gu et al., 1999). However, the effects of tocotrienol on the human immune system following immunization have not been investigated. Activated T cells can differentiate into effector T cells showing distinct patterns of cytokine production. The T-helper-1 (TH1) cells, ...
Overskrift Navn, etternavn
... slow and inefficient. On the spore-producing medium CMC for 62h, only 100 macroconidia could be found in ΔFgStuA, in contrast to 1x106 in the wildtype. The mutant macroconidia also germinate at a slower rate than wildype, about 4h later at 25C in liquid complete medium (CM). B. The chitin binding ...
... slow and inefficient. On the spore-producing medium CMC for 62h, only 100 macroconidia could be found in ΔFgStuA, in contrast to 1x106 in the wildtype. The mutant macroconidia also germinate at a slower rate than wildype, about 4h later at 25C in liquid complete medium (CM). B. The chitin binding ...
Stress
... The benefits of meaningful work in enhancing self-esteem outweigh the costs Among both men and women, those who balance vocational, marital, and parental roles generally are healthier and happier than those who function in only one or two of these roles What matters most is not the number of roles a ...
... The benefits of meaningful work in enhancing self-esteem outweigh the costs Among both men and women, those who balance vocational, marital, and parental roles generally are healthier and happier than those who function in only one or two of these roles What matters most is not the number of roles a ...
IDENTICAL PEPTIDES RECOGNIZED BY MHC CLASS I
... Several lines of evidence suggest that the mechanism of T cell recognition of antigen is similar in both class I and class II MHC-restricted systems. First, the TCR molecules that recognize antigen in the context of either the class I or class II MHC molecules are assembled from the same set of germ ...
... Several lines of evidence suggest that the mechanism of T cell recognition of antigen is similar in both class I and class II MHC-restricted systems. First, the TCR molecules that recognize antigen in the context of either the class I or class II MHC molecules are assembled from the same set of germ ...
Immunogenicity of Pluripotent Stem Cells and Their
... estimated 1% to 10% of the T cell pool can react with intact allogeneic HLA during direct T cell allorecognition. As with any other tissue type, histocompatibility appears to be an important factor in the rejection of undifferentiated ES cells. ES cell rejection is accelerated when MHC molecules are ...
... estimated 1% to 10% of the T cell pool can react with intact allogeneic HLA during direct T cell allorecognition. As with any other tissue type, histocompatibility appears to be an important factor in the rejection of undifferentiated ES cells. ES cell rejection is accelerated when MHC molecules are ...
CD4 T cells promote tissue inflammation via CD40 signaling without
... mice.4,6 Thus, the question arises of how T cells function in this innate immunity-dominated response and in the absence of exogenous Ag stimulation? T cells may function in an Ag-independent manner by secreting cytokines and up-regulating costimulatory molecules. The role of T cell– derived CD28, C ...
... mice.4,6 Thus, the question arises of how T cells function in this innate immunity-dominated response and in the absence of exogenous Ag stimulation? T cells may function in an Ag-independent manner by secreting cytokines and up-regulating costimulatory molecules. The role of T cell– derived CD28, C ...
Document
... • Hint of a possible immune correlate • 60 vaccinated volunteers who remained HIV uninfected: high CD4+ T-cell epitopes (peptides 44 and 49) in V2 loop of gp120. • Peptide 44 targets integrin α4β7 a receptor on CD4+ T-cells in cervix and rectum that is highly susceptible to HIV infection • James A ...
... • Hint of a possible immune correlate • 60 vaccinated volunteers who remained HIV uninfected: high CD4+ T-cell epitopes (peptides 44 and 49) in V2 loop of gp120. • Peptide 44 targets integrin α4β7 a receptor on CD4+ T-cells in cervix and rectum that is highly susceptible to HIV infection • James A ...
NIH Public Access - IUPUI ScholarWorks
... lung is most likely achieved by direct infection of RDC. Different DC subsets in both mice and humans differ in susceptibility to IAV infection. In case of IAV H1N1 PR/8 infection in mice, CD103+ RDCs, unlike CD11bhi RDCs, are highly susceptible to infection with this strain in vivo (Hao et al. 2008 ...
... lung is most likely achieved by direct infection of RDC. Different DC subsets in both mice and humans differ in susceptibility to IAV infection. In case of IAV H1N1 PR/8 infection in mice, CD103+ RDCs, unlike CD11bhi RDCs, are highly susceptible to infection with this strain in vivo (Hao et al. 2008 ...
PowerPoint
... Passively acquired antibody conserved during the neonatal period due to slow catabolism by the fetus. Infants exposed to an infectious process in utero or shortly after birth may produce small amounts of IgM detectable by sensitive techniques, but rarely form RBC antibodies of either class during th ...
... Passively acquired antibody conserved during the neonatal period due to slow catabolism by the fetus. Infants exposed to an infectious process in utero or shortly after birth may produce small amounts of IgM detectable by sensitive techniques, but rarely form RBC antibodies of either class during th ...
Endotoxin can induce MyD88-deficient dendritic cells to support Th2
... immunity. A TLR-associated adapter protein, MyD88, is essential for cytokine production induced by TLR. However, in response to a TLR4 ligand, lipopolysaccharide (LPS), MyD88-de®cient (MyD88±/±) DC can up-regulate co-stimulatory molecule expression and enhance their T cell stimulatory activity, indi ...
... immunity. A TLR-associated adapter protein, MyD88, is essential for cytokine production induced by TLR. However, in response to a TLR4 ligand, lipopolysaccharide (LPS), MyD88-de®cient (MyD88±/±) DC can up-regulate co-stimulatory molecule expression and enhance their T cell stimulatory activity, indi ...
Great events in history of transplantation
... Drug levels are frequently measured for dosage and toxicity, but levels are not highly predictive of actual immunosuppressive effect. Drug levels are reflected for 5 to 10 days because of a long half life. Side effects: nephrotoxicity caused by afferent arteriolar constriction and manifested by olig ...
... Drug levels are frequently measured for dosage and toxicity, but levels are not highly predictive of actual immunosuppressive effect. Drug levels are reflected for 5 to 10 days because of a long half life. Side effects: nephrotoxicity caused by afferent arteriolar constriction and manifested by olig ...
New Insights on the Pathogenesis of Invasive Cryptococcus neoformans
... antibodies are effective against disseminated cryptococcosis. Transgenic mice expressing human antibodies can develop a protective antibody response to GXM mimetopes and acquire immunity to Cn [9•]. However, the role of antibody is complicated. B-cell–deficient mice have decreased survival time and ...
... antibodies are effective against disseminated cryptococcosis. Transgenic mice expressing human antibodies can develop a protective antibody response to GXM mimetopes and acquire immunity to Cn [9•]. However, the role of antibody is complicated. B-cell–deficient mice have decreased survival time and ...
The Jekyll and Hyde Functions of Caspases
... alternative cellular functions independent of cell death. Exciting recent developments have focused on uncovering nonapoptotic roles of caspases ranging from immune regulation to spermatogenesis, in highly specialized cellular frameworks. Introduction Apoptosis is a highly regulated form of cell dea ...
... alternative cellular functions independent of cell death. Exciting recent developments have focused on uncovering nonapoptotic roles of caspases ranging from immune regulation to spermatogenesis, in highly specialized cellular frameworks. Introduction Apoptosis is a highly regulated form of cell dea ...
Emergent Group Dynamics Governed by Regulatory Cells Produce
... briefly expands in response to the amount of antigen present before committing to a fixed program. We point out that the antigen-dependent and antigen-independent parts of the model from Antia et al. (2003) occur in the opposite order of the more common notion that a developmental program precedes a ...
... briefly expands in response to the amount of antigen present before committing to a fixed program. We point out that the antigen-dependent and antigen-independent parts of the model from Antia et al. (2003) occur in the opposite order of the more common notion that a developmental program precedes a ...
INTRAVENOuS HYDROGEN PEROxIDE
... tabolism, enzymatic reactions and hormonal levels. Secondly it is a powerful oxidizing agent used by the immune system to kill off harmful bacteria, viruses and other pathogens. The use of Intravenous Hydrogen Peroxide is extremely safe and assists in correcting cellular metabolism as well as ...
... tabolism, enzymatic reactions and hormonal levels. Secondly it is a powerful oxidizing agent used by the immune system to kill off harmful bacteria, viruses and other pathogens. The use of Intravenous Hydrogen Peroxide is extremely safe and assists in correcting cellular metabolism as well as ...
Viral Pathogenesis - E-Learning per i corsi di Studi in Biologia
... Acute infection followed by chronic infection: •initial productive infection with viremia •virus not cleared completely by immune system •continuous, low-level productive infection •may be "smoldering" infection (productive infection by small fraction of cells) •example: human immunodeficiency viru ...
... Acute infection followed by chronic infection: •initial productive infection with viremia •virus not cleared completely by immune system •continuous, low-level productive infection •may be "smoldering" infection (productive infection by small fraction of cells) •example: human immunodeficiency viru ...
Recurrent respiratory papillomatosis: pathogenesis to treatment
... to represent the type of replication that occurs in nondifferentiated basal cells [18,19]. Part of the mechanism of episomal maintenance has been recently clarified. The viral gene E2 binds the viral genome to host chromosomal DNA so that it is segregated and maintained during mitosis [20••]. When k ...
... to represent the type of replication that occurs in nondifferentiated basal cells [18,19]. Part of the mechanism of episomal maintenance has been recently clarified. The viral gene E2 binds the viral genome to host chromosomal DNA so that it is segregated and maintained during mitosis [20••]. When k ...
Document
... • If you inject a monoclonal antibody into a genetically identical recipient then anti-idiotypic antibodies are generated • No anti-isotypic and no anti-allotypic Abs will be generated ...
... • If you inject a monoclonal antibody into a genetically identical recipient then anti-idiotypic antibodies are generated • No anti-isotypic and no anti-allotypic Abs will be generated ...
PATHOGENESIS OF AN EMERGING PATHOGEN – CRIMEAN
... the release of tumor necrosis factor (TNF), IL-6 and IL-10. Interestingly, conditioned media from CCHFV-infected moDCs activated ECs as indicated by enhanced intercellular adhesion molecule 1 (ICAM-1) expression. This effect was shown to be dependent on TNF. The work presented in this thesis provide ...
... the release of tumor necrosis factor (TNF), IL-6 and IL-10. Interestingly, conditioned media from CCHFV-infected moDCs activated ECs as indicated by enhanced intercellular adhesion molecule 1 (ICAM-1) expression. This effect was shown to be dependent on TNF. The work presented in this thesis provide ...
Effects of intracellular and extracellular heat shock proteins on anti
... Cytotoxic lymphocyte clones ......................................................................................................................34 ...
... Cytotoxic lymphocyte clones ......................................................................................................................34 ...
Dendritic Cell Biology - Wiley-VCH
... phocytes differentiate along many different lines and with important consequences: distinct types of effector cells, long term clonal expansion, and memory. The single term “maturation” clearly cannot specify the many different responses that dendritic cells exhibit when they encounter endogenous (C ...
... phocytes differentiate along many different lines and with important consequences: distinct types of effector cells, long term clonal expansion, and memory. The single term “maturation” clearly cannot specify the many different responses that dendritic cells exhibit when they encounter endogenous (C ...
Microglial Phagocytosis of FibrillarЯ
... 2003). When the experiments were conducted at 4°C, stimulation of phagocytosis was not detected (data not shown). The reverse A peptide, A42–1, as well as nonfibrillar A25–35, were unable to stimulate phagocytosis, demonstrating that only fibrillar A peptides can elicit this response (Fig. 1G). ...
... 2003). When the experiments were conducted at 4°C, stimulation of phagocytosis was not detected (data not shown). The reverse A peptide, A42–1, as well as nonfibrillar A25–35, were unable to stimulate phagocytosis, demonstrating that only fibrillar A peptides can elicit this response (Fig. 1G). ...
