Regulatory T-lymphocytes in asthma REVIEW A.J.M. van Oosterhout* and N. Bloksma
... A major issue in the study of Treg subsets is the lack of discriminative cell-surface markers (fig. 1). CD25 expression has been linked to the subpopulation of nTreg cells. However, CD25 is a general activation marker of T-cells and CD4+CD25+ cells may, therefore, contain recently activated conventi ...
... A major issue in the study of Treg subsets is the lack of discriminative cell-surface markers (fig. 1). CD25 expression has been linked to the subpopulation of nTreg cells. However, CD25 is a general activation marker of T-cells and CD4+CD25+ cells may, therefore, contain recently activated conventi ...
Document
... the body's cells, recognizing and eliminating tumor cells and virusinfected cells by release of proteins, cutting holes and by other means. a. Cytotoxic T cells become activated when an antigen binds to its receptors. Memory T cells provide a no-delay response to any future exposure to the same anti ...
... the body's cells, recognizing and eliminating tumor cells and virusinfected cells by release of proteins, cutting holes and by other means. a. Cytotoxic T cells become activated when an antigen binds to its receptors. Memory T cells provide a no-delay response to any future exposure to the same anti ...
Lymphatic/Immune System
... the body's cells, recognizing and eliminating tumor cells and virusinfected cells by release of proteins, cutting holes and by other means. a. Cytotoxic T cells become activated when an antigen binds to its receptors. Memory T cells provide a no-delay response to any future exposure to the same anti ...
... the body's cells, recognizing and eliminating tumor cells and virusinfected cells by release of proteins, cutting holes and by other means. a. Cytotoxic T cells become activated when an antigen binds to its receptors. Memory T cells provide a no-delay response to any future exposure to the same anti ...
Identification of novel CTL epitopes of CMV-pp65
... Stanford, CA), pLBPC/pp65, or pLBPC/EGFP, was packaged in the Phoenix gibbon ape leukemia virus (GALV) cell line21 (a gift from H.-P. Kiem, Fred Hutchinson Cancer Research Center; and from G. Nolan, Stanford University, Stanford, CA) using FuGENE 6 (Roche Diagnostics, Mannheim, Germany). CD40-B cell ...
... Stanford, CA), pLBPC/pp65, or pLBPC/EGFP, was packaged in the Phoenix gibbon ape leukemia virus (GALV) cell line21 (a gift from H.-P. Kiem, Fred Hutchinson Cancer Research Center; and from G. Nolan, Stanford University, Stanford, CA) using FuGENE 6 (Roche Diagnostics, Mannheim, Germany). CD40-B cell ...
Lactobacilli- and Staphylococcus aureus mediated
... The human gastro-intestinal tract is in direct contact with the external environment. It continuously encounters dietary products, environmental antigens, pathogens and commensal microbes. Given the huge antigenic load, a balance needs to be maintained between immunogenic and tolerogenic immune resp ...
... The human gastro-intestinal tract is in direct contact with the external environment. It continuously encounters dietary products, environmental antigens, pathogens and commensal microbes. Given the huge antigenic load, a balance needs to be maintained between immunogenic and tolerogenic immune resp ...
INTERPLAY BETWEEN HELICOBACTER PYLORI AND THE
... immune response, whereas MHC class I restricted CD8 T cells are not essential. Further experiments showed the presence of IL-12 (36) and IL-18 (37) in the gastric mucosa. Both of these cytokines are responsible for directing gastric T lymphocytes to Th1 mediated response. Experimental data in animal ...
... immune response, whereas MHC class I restricted CD8 T cells are not essential. Further experiments showed the presence of IL-12 (36) and IL-18 (37) in the gastric mucosa. Both of these cytokines are responsible for directing gastric T lymphocytes to Th1 mediated response. Experimental data in animal ...
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... Blood circulating from the intestines to the liver is rich in bacterial products, environmental toxins, and food antigens. To effectively and quickly defend against potentially toxic agents without launching harmful immune responses, the liver relies on its strong innate immune system. This comprise ...
... Blood circulating from the intestines to the liver is rich in bacterial products, environmental toxins, and food antigens. To effectively and quickly defend against potentially toxic agents without launching harmful immune responses, the liver relies on its strong innate immune system. This comprise ...
Wheat Amylase Trypsin Inhibitors as Nutritional Activators of Innate
... monocytes, DCs, and polymorphonuclear leukocytes that by means of their pattern-recognition receptors, such as TLRs, induce the release of proinflammatory cytokines and chemokines, resulting in recruitment and activation of additional inflammatory cells (Medzhitov, 2007). Thus, peptides p31-43 or p3 ...
... monocytes, DCs, and polymorphonuclear leukocytes that by means of their pattern-recognition receptors, such as TLRs, induce the release of proinflammatory cytokines and chemokines, resulting in recruitment and activation of additional inflammatory cells (Medzhitov, 2007). Thus, peptides p31-43 or p3 ...
Antibody
... antigens (in general identical) and, therefore, recognize specific foreign objects. This region of the antibody is called the Fab (fragment, antigen binding) region. It is composed of one constant and one variable domain from each heavy and light chain of the antibody.[21] The paratope is shaped at ...
... antigens (in general identical) and, therefore, recognize specific foreign objects. This region of the antibody is called the Fab (fragment, antigen binding) region. It is composed of one constant and one variable domain from each heavy and light chain of the antibody.[21] The paratope is shaped at ...
Epithelial antimicrobial peptides and proteins: their role in
... epithelial cells and by cells of the submucosal glands. The relative contribution of these sources and the contribution of the various cell types of the surface epithelium to polypeptide synthesis are not known. In vitro epithelial cell culture studies and results from bronchial xenografts generated ...
... epithelial cells and by cells of the submucosal glands. The relative contribution of these sources and the contribution of the various cell types of the surface epithelium to polypeptide synthesis are not known. In vitro epithelial cell culture studies and results from bronchial xenografts generated ...
Vaccines, Depression and Neurodegeneration After Age 50
... It has been found that insertion of viral fragments, not even the whole virus, is sufficient to trigger the brain's microglial system and subsequent excitotoxicity, leading to progressive brain degeneration. This is accepted to be the mechanism by which the HIV virus causes dementia in a great numbe ...
... It has been found that insertion of viral fragments, not even the whole virus, is sufficient to trigger the brain's microglial system and subsequent excitotoxicity, leading to progressive brain degeneration. This is accepted to be the mechanism by which the HIV virus causes dementia in a great numbe ...
Vaccinia-Expressed Human Papillomavirus 16 and 18 E6 and E7 as
... (20, 24, 25). It consists of the fused E6 and E7 open reading frames of HPV-16 and HPV-18, each under the control of a vaccinia promoter within the Wyeth strain of vaccinia virus. The E7 gene in both cases was modified by mutation of the retinoblastoma gene product binding sequence so that there can ...
... (20, 24, 25). It consists of the fused E6 and E7 open reading frames of HPV-16 and HPV-18, each under the control of a vaccinia promoter within the Wyeth strain of vaccinia virus. The E7 gene in both cases was modified by mutation of the retinoblastoma gene product binding sequence so that there can ...
Developing and characterizing a salmonid intestinal
... Histocompatibility (MH) class II α and ß. When MH activity was examined at the protein level, the cell lines showed constitutive expression of MH class I proteins, but not for MH class II molecules. RTS11, a rainbow trout spleen monocyte/ macrophage-like cell line, was the only line to express all M ...
... Histocompatibility (MH) class II α and ß. When MH activity was examined at the protein level, the cell lines showed constitutive expression of MH class I proteins, but not for MH class II molecules. RTS11, a rainbow trout spleen monocyte/ macrophage-like cell line, was the only line to express all M ...
CD8 T cell activation predominate early immune
... Attention has focused on the role of oxidized low-density lipoprotein (LDL) [15]. LDL particles become oxidized by various enzymes and oxygen metabolites when entrapped in the extra cellular matrix of the artery wall [16]. Oxidized LDL is targeted by both IgM and IgG autoantibodies [17] and as much ...
... Attention has focused on the role of oxidized low-density lipoprotein (LDL) [15]. LDL particles become oxidized by various enzymes and oxygen metabolites when entrapped in the extra cellular matrix of the artery wall [16]. Oxidized LDL is targeted by both IgM and IgG autoantibodies [17] and as much ...
Poster
... to avoid detection by T-lymphocytes and Natural Killer (NK) cells in the human immune system by producing a protein, U21, that binds to class I MHC molecules and prevents their transport to the cytoplasmic membrane. Since the function of class I MHC is to present peptides from intracellular pathogen ...
... to avoid detection by T-lymphocytes and Natural Killer (NK) cells in the human immune system by producing a protein, U21, that binds to class I MHC molecules and prevents their transport to the cytoplasmic membrane. Since the function of class I MHC is to present peptides from intracellular pathogen ...
Negative Regulation of Toll-Like Receptor Signaling by
... Toll-like receptors (TLRs) trigger the production of inflammatory cytokines and shape adaptive and innate immunity to pathogens. We report the identification of B cell leukemia (Bcl)–3 as an essential negative regulator of TLR signaling. By blocking ubiquitination of p50, a member of the nuclear fac ...
... Toll-like receptors (TLRs) trigger the production of inflammatory cytokines and shape adaptive and innate immunity to pathogens. We report the identification of B cell leukemia (Bcl)–3 as an essential negative regulator of TLR signaling. By blocking ubiquitination of p50, a member of the nuclear fac ...
34130-Review
... pro/pre-B cells. This cell death signal is regulated mainly via a specific soluble stromal cell-dependent death signal that is presumably regulated by its responsive AhR gene, CYP1A1[10,30,39,40]. Later, the authors of the same study reported that the addition of a precise and competitive inhibitor ...
... pro/pre-B cells. This cell death signal is regulated mainly via a specific soluble stromal cell-dependent death signal that is presumably regulated by its responsive AhR gene, CYP1A1[10,30,39,40]. Later, the authors of the same study reported that the addition of a precise and competitive inhibitor ...
Phenotypic Markers Distinguished by Their Cytokine Profiles and T
... cells from LCMV-infected mice (at day 8 p.i.). No IFN-g production by virus-specific CD81 T cells was observed.) The nonbiotinylated splenocytes were recovered by collecting 100 ml of supernatant which was immediately added to wells containing 4 3 105 peptide-coated or uncoated fibroblast APCs (prew ...
... cells from LCMV-infected mice (at day 8 p.i.). No IFN-g production by virus-specific CD81 T cells was observed.) The nonbiotinylated splenocytes were recovered by collecting 100 ml of supernatant which was immediately added to wells containing 4 3 105 peptide-coated or uncoated fibroblast APCs (prew ...
Immune Recruitment and Therapeutic Synergy: Keys to Optimizing
... Potential interactions of the host immune system with OVs and tumors are summarized in Tables 2 and 3. These interactions are complex and illustrate how the host immune response can be focused on the virus (antiviral immunity), or the tumor (antitumor immunity). The development of antitumor immunity ...
... Potential interactions of the host immune system with OVs and tumors are summarized in Tables 2 and 3. These interactions are complex and illustrate how the host immune response can be focused on the virus (antiviral immunity), or the tumor (antitumor immunity). The development of antitumor immunity ...
innovative development strategies and applications for bispecific
... of monoclonal antibodies. By targeting two different receptors on the same cell or by targeting two ligands, the bispecific antibody can block two signaling pathways involved in cancer cell proliferation and the inflammatory response. This multi-targeted approach is highly effective in destroying tu ...
... of monoclonal antibodies. By targeting two different receptors on the same cell or by targeting two ligands, the bispecific antibody can block two signaling pathways involved in cancer cell proliferation and the inflammatory response. This multi-targeted approach is highly effective in destroying tu ...
Presentation Slides - Hairy Cell Leukemia Foundation
... rate and duration after each successive course of purine analogue - Bone marrow toxicity and immune suppression after multiple courses of chemotherapy ...
... rate and duration after each successive course of purine analogue - Bone marrow toxicity and immune suppression after multiple courses of chemotherapy ...
a case of hashimoto`s thyroiditis with autoimmune haemolytic anaemia
... activation of T cells or B cells or both, resulting in a spectrum of diseases that can target specific organs or affect the body systemically.[8]The initiation of autoimmune events in Hashimoto's thyroiditis may be caused by a molecular mimicry mechanism, abnormal antigen-specific induction of T cel ...
... activation of T cells or B cells or both, resulting in a spectrum of diseases that can target specific organs or affect the body systemically.[8]The initiation of autoimmune events in Hashimoto's thyroiditis may be caused by a molecular mimicry mechanism, abnormal antigen-specific induction of T cel ...
Candida Infections: An Update on Host Immune Defenses and Anti
... played by Als proteins in host–fungus interactions. Als3 is a major component of the hyphal cell wall, but not for the yeast phase[22]. Deletion of C. albicans ALS3 results in striking adhesion and biofilm formation defects. ALS3 is also required for C. albicans cell binding to E-cadherin on epithel ...
... played by Als proteins in host–fungus interactions. Als3 is a major component of the hyphal cell wall, but not for the yeast phase[22]. Deletion of C. albicans ALS3 results in striking adhesion and biofilm formation defects. ALS3 is also required for C. albicans cell binding to E-cadherin on epithel ...
Impact of IgA Constant Domain on HIV
... thought to be pivotal in preventing transmission. HIV-specific IgA, but not IgG, has been detected in the genital tract, seminal fluid, urethral swabs, urine, and vaginal wash samples of HIV-negative sex workers and HIV-status discordant couples. Purified mucosal and plasma IgA from some individuals ...
... thought to be pivotal in preventing transmission. HIV-specific IgA, but not IgG, has been detected in the genital tract, seminal fluid, urethral swabs, urine, and vaginal wash samples of HIV-negative sex workers and HIV-status discordant couples. Purified mucosal and plasma IgA from some individuals ...