Scientific Category: VASCULAR BIOLOGY CEACAM1 myeloid cells
... Local inflammation during cutaneous leishmaniasis is accompanied by accumulation of CD11b+ cells at the site of the infection. A functional role for these monocytic cells in local angiogenesis in leishmaniasis has not been described so far. Here, we show that CD11b+ cells express high levels of the ...
... Local inflammation during cutaneous leishmaniasis is accompanied by accumulation of CD11b+ cells at the site of the infection. A functional role for these monocytic cells in local angiogenesis in leishmaniasis has not been described so far. Here, we show that CD11b+ cells express high levels of the ...
Gene, environment, microbiome and mucosal immune tolerance in
... Mucosal structure and function There are a variety of mucosal sites in humans, including the eye, respiratory tract, gastrointestinal tract and genitourinary tract, as well as mammary glands and serosal sites such as the pleural and peritoneal cavities [1416]. In addition, there are multiple subsit ...
... Mucosal structure and function There are a variety of mucosal sites in humans, including the eye, respiratory tract, gastrointestinal tract and genitourinary tract, as well as mammary glands and serosal sites such as the pleural and peritoneal cavities [1416]. In addition, there are multiple subsit ...
Periodontal Disease and Cancer
... The diminished immune activity not only may explain the connection between obesity and heightened cancer risk, it also suggests that obesity might reduce the effectiveness of common vaccines, such as flu and tetanus. According to Connie Rogers, Ph.D., MPH, a research fellow at the Laboratory of Tumo ...
... The diminished immune activity not only may explain the connection between obesity and heightened cancer risk, it also suggests that obesity might reduce the effectiveness of common vaccines, such as flu and tetanus. According to Connie Rogers, Ph.D., MPH, a research fellow at the Laboratory of Tumo ...
Enteric glia: A new player in inflammatory bowel
... altered and, following injury and inflammation, these activated cells undergo a dynamic process associated with an increased proliferation and a pro-inflammatory phenotype.45,47,48 Enteroglial activation is characterized by the over-release of neurotrophins, growth factors, and cytokines that, in tu ...
... altered and, following injury and inflammation, these activated cells undergo a dynamic process associated with an increased proliferation and a pro-inflammatory phenotype.45,47,48 Enteroglial activation is characterized by the over-release of neurotrophins, growth factors, and cytokines that, in tu ...
Biased to Th2 Secondary Responses Primary Effector Responses In
... mediated by alloantigen-reactive, IL-4-producing cells (7, 8). Tolerance to alloantigens in the newborn may then be achieved by the suppressive effects of Th2 cells on Th1 cell-mediated immunity. Second, it was reported recently (9, 10) that priming with Ag during the neonatal period leads to second ...
... mediated by alloantigen-reactive, IL-4-producing cells (7, 8). Tolerance to alloantigens in the newborn may then be achieved by the suppressive effects of Th2 cells on Th1 cell-mediated immunity. Second, it was reported recently (9, 10) that priming with Ag during the neonatal period leads to second ...
Unit B3 - Using Biology
... Step 4: The progesterone then maintains the lining of the uterus and inhibits production of FSH and LH. When the level of progesterone falls (and there’s a low oestrogen level) the lining breaks down. This allows FSH to be produced and the process starts again. If the woman is pregnant then progeste ...
... Step 4: The progesterone then maintains the lining of the uterus and inhibits production of FSH and LH. When the level of progesterone falls (and there’s a low oestrogen level) the lining breaks down. This allows FSH to be produced and the process starts again. If the woman is pregnant then progeste ...
Immune components of bovine colostrum and milk
... A wide variety of components linked to the innate immune response have been identified in colostrum and milk. These include neutrophils, macrophages, complement, oligosaccharides, gangliosides, reactive oxygen species, acute-phase proteins, immunomodulatory factors (including many different pro- and ...
... A wide variety of components linked to the innate immune response have been identified in colostrum and milk. These include neutrophils, macrophages, complement, oligosaccharides, gangliosides, reactive oxygen species, acute-phase proteins, immunomodulatory factors (including many different pro- and ...
Bloodless revolution
... bowel disorders and other chronic diseases such as arthritis, eczema and rhinitis (Book et al. 2003). Could ‘fat wrapping’, the distinctive but as yet unexplained feature of Crohn’s disease, be adipose tissue’s long-term response to persistent signals from its client immune cells for important fatty ...
... bowel disorders and other chronic diseases such as arthritis, eczema and rhinitis (Book et al. 2003). Could ‘fat wrapping’, the distinctive but as yet unexplained feature of Crohn’s disease, be adipose tissue’s long-term response to persistent signals from its client immune cells for important fatty ...
Laboratory of Viral Immunology
... HIV-R women will have high levels of immune CTL, CD4+ T cell responses in PBMC (Fowke et al.) activation to fight infection Mucosal CTL responses (Kaul et al.) Qualitatively distinct responses strong proliferation, weak IFNg (Alimonti et al.) ▫ Genetic basis for resistance ...
... HIV-R women will have high levels of immune CTL, CD4+ T cell responses in PBMC (Fowke et al.) activation to fight infection Mucosal CTL responses (Kaul et al.) Qualitatively distinct responses strong proliferation, weak IFNg (Alimonti et al.) ▫ Genetic basis for resistance ...
Possible Applications Basic overview
... by dendritic cells in vitro and by direct administration with antigens in vivo. In animal models of human diseases, TCT attenuated acute graft-versus host disease and slowed the onset and clinical signs of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. ...
... by dendritic cells in vitro and by direct administration with antigens in vivo. In animal models of human diseases, TCT attenuated acute graft-versus host disease and slowed the onset and clinical signs of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis. ...
Recognition of viruses by cytoplasmic sensors
... inflammasome activation was dependent on the presence of viral genomic dsDNA, lending support to the idea that NALP3 may directly or indirectly serve as a PRR for DNA-based pathogens to trigger inflammation [32]. RNA viruses also have the potential to activate inflammasomes, as influenza A virus was ...
... inflammasome activation was dependent on the presence of viral genomic dsDNA, lending support to the idea that NALP3 may directly or indirectly serve as a PRR for DNA-based pathogens to trigger inflammation [32]. RNA viruses also have the potential to activate inflammasomes, as influenza A virus was ...
Booster Vaccinations against Cancer Are Critical
... efficacy. In particular, whether how and how frequently a patient should be boosted remains to be defined. Here, we have assessed the ability of dendritic cell (DC)-based vaccines to induce a long-lasting tumorspecific CTL response in either prophylactic or therapeutic settings by taking advantage of t ...
... efficacy. In particular, whether how and how frequently a patient should be boosted remains to be defined. Here, we have assessed the ability of dendritic cell (DC)-based vaccines to induce a long-lasting tumorspecific CTL response in either prophylactic or therapeutic settings by taking advantage of t ...
The western painted turtle genome, a model for the
... least 210 million years [3] and is characterized by a number of unique morphological and physiological features. Besides their distinctive shell, turtles have extremely long lifespans, are often reproductively active at very advanced ages, often determine sex by the temperature at which eggs incubat ...
... least 210 million years [3] and is characterized by a number of unique morphological and physiological features. Besides their distinctive shell, turtles have extremely long lifespans, are often reproductively active at very advanced ages, often determine sex by the temperature at which eggs incubat ...
Genetic background affects susceptibility in nonfatal pneumococcal bronchopneumonia J.A. Preston , K.W. Beagley
... that links the outcome of infectious disease to variations in the intensity of inflammatory responses that are determined by host characteristics such as gene polymorphisms [19– 21]. Thus susceptibility to pneumococcal diseases such as bronchopneumonia may result from host genetic factors, and the g ...
... that links the outcome of infectious disease to variations in the intensity of inflammatory responses that are determined by host characteristics such as gene polymorphisms [19– 21]. Thus susceptibility to pneumococcal diseases such as bronchopneumonia may result from host genetic factors, and the g ...
HIV/AIDS: What People with Substance Use Disorders Need to
... – Lower viral load associated with decreased infectivity ...
... – Lower viral load associated with decreased infectivity ...
Humoral and cellular immune responses induced by the urease
... insecticidal mechanism of action is still not well understood. Jaburetox is a recombinant peptide derived from one of the isoforms of Canavalia ensiformis (Jack Bean) urease that presents biotechnological interest since it is toxic to insects of different orders. Previous studies of our group using ...
... insecticidal mechanism of action is still not well understood. Jaburetox is a recombinant peptide derived from one of the isoforms of Canavalia ensiformis (Jack Bean) urease that presents biotechnological interest since it is toxic to insects of different orders. Previous studies of our group using ...
Poster
... thrombin/thrombomodulin complex is higher, such as in small blood vessels. EPCR allows this close contact to occur anywhere in the bloodstream, specifically in larger vessels, and greatly facilitates the molecular interaction. ...
... thrombin/thrombomodulin complex is higher, such as in small blood vessels. EPCR allows this close contact to occur anywhere in the bloodstream, specifically in larger vessels, and greatly facilitates the molecular interaction. ...
Gut flora in health and disease
... By contrast, the large intestine contains a complex high densities of living bacteria. Some of these bacteria are potential pathogens and can be a source of infection and sepsis under some circumstances for instance when the integrity of the bowel barrier is physically or functionally breached. How ...
... By contrast, the large intestine contains a complex high densities of living bacteria. Some of these bacteria are potential pathogens and can be a source of infection and sepsis under some circumstances for instance when the integrity of the bowel barrier is physically or functionally breached. How ...
Acute effects of tobacco smoke on human
... noted that other particles, such as allergens or infectious agents, do not lead to selective recruitment of this DC subpopulation into human airways [17, 18]. Therefore, tobacco smoke appears to be a unique stimulus for mDC recruitment. It is remarkable that recruitment of mDCs into the airways coul ...
... noted that other particles, such as allergens or infectious agents, do not lead to selective recruitment of this DC subpopulation into human airways [17, 18]. Therefore, tobacco smoke appears to be a unique stimulus for mDC recruitment. It is remarkable that recruitment of mDCs into the airways coul ...
High Temperature Affects Cytokine Release by Human Peripheral
... heat shock factor-1 serving as a trigger for development of heat shock response with subsequent production of inflammatory cytokines by immune cells. Heat shock proteins are produced intracellular, but under stress conditions they are unconstrained from the cells and initiate the production of infla ...
... heat shock factor-1 serving as a trigger for development of heat shock response with subsequent production of inflammatory cytokines by immune cells. Heat shock proteins are produced intracellular, but under stress conditions they are unconstrained from the cells and initiate the production of infla ...
Review Article - clinicalevidence
... component typically require concentrations of 1–10 g/mL, which is several logs higher than the concentrations of LPS required for activating macrophages. This may either mean that PepG is not an important initiator of inflammation or that only a part of the PepG structure is responsible for its pro ...
... component typically require concentrations of 1–10 g/mL, which is several logs higher than the concentrations of LPS required for activating macrophages. This may either mean that PepG is not an important initiator of inflammation or that only a part of the PepG structure is responsible for its pro ...
Immunology
... The T-cell receptor is closely associated with the CD3, a complex of polypeptide chains involved in signal transduction forming the TCR-CD3 membrane complex. CD3 is a complex of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (), a h ...
... The T-cell receptor is closely associated with the CD3, a complex of polypeptide chains involved in signal transduction forming the TCR-CD3 membrane complex. CD3 is a complex of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (), a h ...
live blood analysis
... WBC’s. They comprise 35% of the total white blood cell count. They look very similar to Monocytes but they are smaller. They are formed in the bone marrow or lymph tissues and are approximately the same size as RBC’s. It is hard to distinguish between a B & T cell. They are not very reflective in Da ...
... WBC’s. They comprise 35% of the total white blood cell count. They look very similar to Monocytes but they are smaller. They are formed in the bone marrow or lymph tissues and are approximately the same size as RBC’s. It is hard to distinguish between a B & T cell. They are not very reflective in Da ...
