Neurokinin B Signaling in the Female Rat: a Novel
... to suppress the GnRH pulse generator, in a dynorphin A (Dyn)-dependent fashion, under hypoestrogenic conditions, and Dyn has been well documented to mediate several stress-related central regulatory functions. We hypothesized that the NKB/Dyn signaling cascade is required for stressinduced suppressi ...
... to suppress the GnRH pulse generator, in a dynorphin A (Dyn)-dependent fashion, under hypoestrogenic conditions, and Dyn has been well documented to mediate several stress-related central regulatory functions. We hypothesized that the NKB/Dyn signaling cascade is required for stressinduced suppressi ...
10276005
... Diarrheal Disease Research, Bangladesh (icddr, b). Without her support, enthusiasm, insight and guidance, this work would have never been accomplished. I'm truly indebted to her for allowing me to work in her well equipped laboratory. I would like to express my immense gratitude to Professor Naiyyum ...
... Diarrheal Disease Research, Bangladesh (icddr, b). Without her support, enthusiasm, insight and guidance, this work would have never been accomplished. I'm truly indebted to her for allowing me to work in her well equipped laboratory. I would like to express my immense gratitude to Professor Naiyyum ...
Reprint - Immune Tolerance Network
... model of autoimmune diabetes and autoimmune pancreatitis, we have observed complete protection against islet destruction using islet antigen-specific Tregs, whereas autoimmune attack of the surrounding exocrine pancreas progressed without hindrance (Meagher et al. 2008). In the transplant setting, t ...
... model of autoimmune diabetes and autoimmune pancreatitis, we have observed complete protection against islet destruction using islet antigen-specific Tregs, whereas autoimmune attack of the surrounding exocrine pancreas progressed without hindrance (Meagher et al. 2008). In the transplant setting, t ...
NEUTROPHIL GRANULE PROTEINS:
... release of granule proteins the PMN communicates with the endothelium, monocytes, dendritic cells, and lymphocytes and is thereby critically involved in the fine tuning of the host defense system. This thesis aimed at elucidating mechanisms by which the PMN and its granule proteins recruit, activate ...
... release of granule proteins the PMN communicates with the endothelium, monocytes, dendritic cells, and lymphocytes and is thereby critically involved in the fine tuning of the host defense system. This thesis aimed at elucidating mechanisms by which the PMN and its granule proteins recruit, activate ...
Research Plan - Manitoba HIV Research Group Home Page
... to infection and disease caused by microbial agents is a characteristic of all populations. Among susceptible individuals exposed to an infection, not all become infected and among infected individuals, not all develop disease. It seems logical that such variability in susceptibility to infection an ...
... to infection and disease caused by microbial agents is a characteristic of all populations. Among susceptible individuals exposed to an infection, not all become infected and among infected individuals, not all develop disease. It seems logical that such variability in susceptibility to infection an ...
R educed atherosclerosis in interleukin
... clerotic mice to disease-prone ones, protects the latter from developing severe disease. Interestingly, relative protection can also be obtained by immunization with candidate antigens such as oxidized low-density lipoprotein and heat shock protein 60. ¨ CD41 T cells Th1 differentiation is induced w ...
... clerotic mice to disease-prone ones, protects the latter from developing severe disease. Interestingly, relative protection can also be obtained by immunization with candidate antigens such as oxidized low-density lipoprotein and heat shock protein 60. ¨ CD41 T cells Th1 differentiation is induced w ...
Kuby`s Immunology
... chimera animal in immunological studies? Explain how the control of MHC restriction is the genetic basis for the functional specificity of T cells. ...
... chimera animal in immunological studies? Explain how the control of MHC restriction is the genetic basis for the functional specificity of T cells. ...
Chapter 28. Vitamin D: Production, Metabolism, Mechanism of
... calcium and phosphate flux across three target tissues: bone, gut, and kidney. The mechanisms by which 1,2S(OH),D, operates in these tissues will be described in more detail below. However, the receptor for 1,2S(OH),D, (VDR) is widespread and not limited to these classic target tissues. Indeed, the ...
... calcium and phosphate flux across three target tissues: bone, gut, and kidney. The mechanisms by which 1,2S(OH),D, operates in these tissues will be described in more detail below. However, the receptor for 1,2S(OH),D, (VDR) is widespread and not limited to these classic target tissues. Indeed, the ...
Vitamin D and tuberculosis
... oil7 and from exposure to sun or radiation was used to treat tuberculosis.13,15 Several recent studies in different populations have associated a deficiency in vitamin D with increased risk of tuberculosis.16–21 In a recent metaanalysis by Nnoaham and Clarke,21 a pooled effect size of vitamin D was est ...
... oil7 and from exposure to sun or radiation was used to treat tuberculosis.13,15 Several recent studies in different populations have associated a deficiency in vitamin D with increased risk of tuberculosis.16–21 In a recent metaanalysis by Nnoaham and Clarke,21 a pooled effect size of vitamin D was est ...
Antibody
... cell receptor (BCR). The BCR is only found on the lock and key. surface of B cells and facilitates the activation of these cells and their subsequent differentiation into either antibody factories called plasma cells, or memory B cells that will survive in the body and remember that same antigen so ...
... cell receptor (BCR). The BCR is only found on the lock and key. surface of B cells and facilitates the activation of these cells and their subsequent differentiation into either antibody factories called plasma cells, or memory B cells that will survive in the body and remember that same antigen so ...
Independent of IL-4 Development of Lupus in BXSB Mice Is
... Th2-type responses have also been associated with the development of SLE. Increases in number of IL-4-producing cells have been found in some lupus-susceptible strains (30, 31); treatment with blocking anti-IL-4 Ab or soluble IL-4R reduced autoantibody production and nephritis in (NZB 3 NZW)F1 and M ...
... Th2-type responses have also been associated with the development of SLE. Increases in number of IL-4-producing cells have been found in some lupus-susceptible strains (30, 31); treatment with blocking anti-IL-4 Ab or soluble IL-4R reduced autoantibody production and nephritis in (NZB 3 NZW)F1 and M ...
Immunogenic Consensus Sequence T Helper Epitopes for a Pan
... CD4+ T cells can mediate vaccine-induced immunity to experimental melioidosis [9]. These studies suggest CD4+ T cell recognition of processed and secreted proteins from live bacteria are crucial for disease protection. These results also suggest that the type of immune response generated in vivo is ...
... CD4+ T cells can mediate vaccine-induced immunity to experimental melioidosis [9]. These studies suggest CD4+ T cell recognition of processed and secreted proteins from live bacteria are crucial for disease protection. These results also suggest that the type of immune response generated in vivo is ...
Wiskott-Aldrich syndrome protein–mediated actin dynamics control
... Conversely to patients, we found that the frequency and absolute numbers of PDCA-1+/Siglec-H+/B220+ cells were higher both in spleen and LNs of WKO mice (Fig. 3 A). To understand the origin of increased cell numbers, we performed an in vivo BrdU labeling experiment by feeding WT and WKO mice for 7 d ...
... Conversely to patients, we found that the frequency and absolute numbers of PDCA-1+/Siglec-H+/B220+ cells were higher both in spleen and LNs of WKO mice (Fig. 3 A). To understand the origin of increased cell numbers, we performed an in vivo BrdU labeling experiment by feeding WT and WKO mice for 7 d ...
Isotype-switched immunoglobulin G antibodies to HIV Gag proteins
... If antibodies to HIV proteins contribute to control of HIV replication, they are likely to be higher in HIV controllers who do not carry „protective‟ HLA-B alleles. Twenty of the 32 (62.5%) HIV controllers carried a „protective‟ HLA-B allele (B*57, B*52, B*27 or B*14+Cw0802) as defined in the Intern ...
... If antibodies to HIV proteins contribute to control of HIV replication, they are likely to be higher in HIV controllers who do not carry „protective‟ HLA-B alleles. Twenty of the 32 (62.5%) HIV controllers carried a „protective‟ HLA-B allele (B*57, B*52, B*27 or B*14+Cw0802) as defined in the Intern ...
Short English summery Thesis OuTline
... lesions. It has been suggested that in MS lesions foamy macrophages have a AA phenotype, since they expressed little pro-inflammatory cytokines and iNOS. In vitro, myelin ingestion was found to inhibit the lipopolysaccharide (LPS) response. We hypothesized that activation of liver X receptor (LXR) b ...
... lesions. It has been suggested that in MS lesions foamy macrophages have a AA phenotype, since they expressed little pro-inflammatory cytokines and iNOS. In vitro, myelin ingestion was found to inhibit the lipopolysaccharide (LPS) response. We hypothesized that activation of liver X receptor (LXR) b ...
Disruption of Dendritic Cell Instruction Virus and Its Avirulent Vaccine
... responses. Innate lymphocytes, which are already active before the onset of adaptive T cell responses, are crucial for DC maturation. For example, CD1c-restricted gd T cells can drive DC differentiation toward a Th1-polarizing program (13). This bidirectional interaction between innate lymphocytes a ...
... responses. Innate lymphocytes, which are already active before the onset of adaptive T cell responses, are crucial for DC maturation. For example, CD1c-restricted gd T cells can drive DC differentiation toward a Th1-polarizing program (13). This bidirectional interaction between innate lymphocytes a ...
The beginning of connectomics: a commentary on White
... When he first began to turn his attention to the nervous system, Brenner felt he needed to find a suitable experimental organism. Among current models, one popular, well-studied choice, the fruit fly Drosophila melanogaster, had good genetics and interesting behaviour but seemed too complex as its n ...
... When he first began to turn his attention to the nervous system, Brenner felt he needed to find a suitable experimental organism. Among current models, one popular, well-studied choice, the fruit fly Drosophila melanogaster, had good genetics and interesting behaviour but seemed too complex as its n ...
Endometrial dendritic cell populations during the normal menstrual
... directly and indirectly with many other types of leukocytes, including T cells, B cells, natural killer cells and macrophages, thereby shaping the immune response in its entirety (Banchereau and Steinman, 1998). Despite the importance of DCs as antigen-presenting cells, there is a scarcity of resear ...
... directly and indirectly with many other types of leukocytes, including T cells, B cells, natural killer cells and macrophages, thereby shaping the immune response in its entirety (Banchereau and Steinman, 1998). Despite the importance of DCs as antigen-presenting cells, there is a scarcity of resear ...
4 results 28.06.13
... The crude ethanolic extract and its four fractions [hexane (F1), chloroform (F2), n-butanol (F3) and aqueous (F4)] prepared from the twigs of AS were assessed in BALB/c mice for their immunomodulatory activities after administering at 3.0, 10 and 30 mg/kg doses. The observations made on these test s ...
... The crude ethanolic extract and its four fractions [hexane (F1), chloroform (F2), n-butanol (F3) and aqueous (F4)] prepared from the twigs of AS were assessed in BALB/c mice for their immunomodulatory activities after administering at 3.0, 10 and 30 mg/kg doses. The observations made on these test s ...
Advanced Tests
... • 3. Severe reduction in serum IgG and IgA with increased IgM and normal numbers of B cells (a) AID deficiency(b) UNG deficiency • 4. Isotype or light chain deficiencies with normal numbers of B cells (a) Ig heavy chain deletions (b) κ Chain deficiency (c) Isolated IgG subclass deficiency (d) IgA wi ...
... • 3. Severe reduction in serum IgG and IgA with increased IgM and normal numbers of B cells (a) AID deficiency(b) UNG deficiency • 4. Isotype or light chain deficiencies with normal numbers of B cells (a) Ig heavy chain deletions (b) κ Chain deficiency (c) Isolated IgG subclass deficiency (d) IgA wi ...
Inflammation and cancer: interweaving microRNA, free radical
... protein coding genes and non-coding microRNA genes) to promote neoplastic transformation. While much remains to be deciphered, the understanding of the connection between inflammation and cancer is rapidly improving. Whether an inflammatory immune response is pro- or antitumorigenic is a delicate ba ...
... protein coding genes and non-coding microRNA genes) to promote neoplastic transformation. While much remains to be deciphered, the understanding of the connection between inflammation and cancer is rapidly improving. Whether an inflammatory immune response is pro- or antitumorigenic is a delicate ba ...
Nature Medicine 10, 1307
... certainly come to the fore as key players in the guise of dendritic cells (DCs), which are thought to orchestrate the extent and quality of antigen-specific immune responses. An entirely new appreciation has emerged of natural killer (NK) cells, previously given short shrift because of their lack of ...
... certainly come to the fore as key players in the guise of dendritic cells (DCs), which are thought to orchestrate the extent and quality of antigen-specific immune responses. An entirely new appreciation has emerged of natural killer (NK) cells, previously given short shrift because of their lack of ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.