Asthma and pulmonary arterial hypertension: pathogenesis? PERSPECTIVE
... attributable to NFAT activation: asthma and PAH (fig. 2). 2) Replacement therapy with VIP reverses both phenotypes. 3) The therapeutic effect of VIP in VIP-/- mice duplicates that of the VIVIT peptide [49], a selective calcineurin/NFAT pathway inhibitor. 4) These findings suggest that lack of the VI ...
... attributable to NFAT activation: asthma and PAH (fig. 2). 2) Replacement therapy with VIP reverses both phenotypes. 3) The therapeutic effect of VIP in VIP-/- mice duplicates that of the VIVIT peptide [49], a selective calcineurin/NFAT pathway inhibitor. 4) These findings suggest that lack of the VI ...
- Wiley Online Library
... but the current consensus is that early-recruited neutrophils largely deal with killing invasive microorganisms at the wound site,27 whereas macrophages are needed for clearing apoptotic neutrophils and orchestrating early wound closure events, and also emit signals that cause later scarring.27,28 B ...
... but the current consensus is that early-recruited neutrophils largely deal with killing invasive microorganisms at the wound site,27 whereas macrophages are needed for clearing apoptotic neutrophils and orchestrating early wound closure events, and also emit signals that cause later scarring.27,28 B ...
Ascorbic acid treatment, similarly to fluoxetine, reverses depressive
... and mortality (Nemeroff, 2007). The neurobiology of this condition and detailed knowledge of its etiology is not yet well established, however, it is known that major depression might originate from both environmental and genetic risk factors (Nestler et al., 2002). It has been reported that stressf ...
... and mortality (Nemeroff, 2007). The neurobiology of this condition and detailed knowledge of its etiology is not yet well established, however, it is known that major depression might originate from both environmental and genetic risk factors (Nestler et al., 2002). It has been reported that stressf ...
The role of different monocyte subsets and macrophages in asthma
... protein CCL2/MCP-1 produced by stimulated bronchial epithelial cells and rhinovirus-infected macrophages [37,38]. In addition, Th2-oriented cytokine such as human TSLP (thymic stromal lymphopoietin) that can be released by bronchial epithelial cells and is over-expressed in asthmatic patients was sh ...
... protein CCL2/MCP-1 produced by stimulated bronchial epithelial cells and rhinovirus-infected macrophages [37,38]. In addition, Th2-oriented cytokine such as human TSLP (thymic stromal lymphopoietin) that can be released by bronchial epithelial cells and is over-expressed in asthmatic patients was sh ...
Neurons in the mouse deep superior colliculus encode
... peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission. ...
... peer-reviewed) is the author/funder. All rights reserved. No reuse allowed without permission. ...
The Immunobiology of Tourette`s Disorder, Pediatric Autoimmune
... TD should be viewed as a sequela to acute chorea. After a lag of *20 years, the argument reappeared that, in at least some cases, tics and OCD are related to infectious processes. In the late 1980s, researchers noted that patients with SC often developed OCD symptoms; further inquiry revealed that p ...
... TD should be viewed as a sequela to acute chorea. After a lag of *20 years, the argument reappeared that, in at least some cases, tics and OCD are related to infectious processes. In the late 1980s, researchers noted that patients with SC often developed OCD symptoms; further inquiry revealed that p ...
Persistent accumulation of interferon-gamma- producing CD8(+)CD56(+) T cells in blood from
... prominent components of human atherosclerotic lesions2-3 and also, blood samples from patients with coronary artery disease (CAD), in particular acute coronary syndromes (ACS), show signs of T cell activation4-6. While much attention has been focused on the role of CD4+ T cells, the CD8+ T cell comp ...
... prominent components of human atherosclerotic lesions2-3 and also, blood samples from patients with coronary artery disease (CAD), in particular acute coronary syndromes (ACS), show signs of T cell activation4-6. While much attention has been focused on the role of CD4+ T cells, the CD8+ T cell comp ...
... TD should be viewed as a sequela to acute chorea. After a lag of *20 years, the argument reappeared that, in at least some cases, tics and OCD are related to infectious processes. In the late 1980s, researchers noted that patients with SC often developed OCD symptoms; further inquiry revealed that p ...
lymphatic system
... Before birth, the body makes an inventory of "self" proteins and other large molecules. b. After inventory, lymphocytes develop receptors that allow them to differentiate between nonself (foreign) and self antigens. c. Nonself antigens combine with T-cell and B-cell surface receptors and stimulate t ...
... Before birth, the body makes an inventory of "self" proteins and other large molecules. b. After inventory, lymphocytes develop receptors that allow them to differentiate between nonself (foreign) and self antigens. c. Nonself antigens combine with T-cell and B-cell surface receptors and stimulate t ...
lymphatic system
... a.Before birth, the body makes an inventory of "self" proteins and other large molecules. b. After inventory, lymphocytes develop receptors that allow them to differentiate between nonself (foreign) and self antigens. c. Nonself antigens combine with T-cell and B-cell surface receptors and stimulate ...
... a.Before birth, the body makes an inventory of "self" proteins and other large molecules. b. After inventory, lymphocytes develop receptors that allow them to differentiate between nonself (foreign) and self antigens. c. Nonself antigens combine with T-cell and B-cell surface receptors and stimulate ...
The role of peanut-specific T cell
... evidence regarding the immunological mechanisms involved in the induction, development and persistence of peanut allergy. Main findings of the study and their significance Our findings are related to the four objectives that we achieved in this study: Objective 01: Investigation of four immunologica ...
... evidence regarding the immunological mechanisms involved in the induction, development and persistence of peanut allergy. Main findings of the study and their significance Our findings are related to the four objectives that we achieved in this study: Objective 01: Investigation of four immunologica ...
Role of complement in health and disease
... History • 1889‐ Hans Ernst Buchner, first observed that bactericidal effect of the serum was destroyed by heating at 55o C for one hour. • 1894‐ Pfieffer discovered that cholera vibrios were lysed when injected intraperitoneally into specifically immunized guinea pigs (bacteriolysis in vivo o ...
... History • 1889‐ Hans Ernst Buchner, first observed that bactericidal effect of the serum was destroyed by heating at 55o C for one hour. • 1894‐ Pfieffer discovered that cholera vibrios were lysed when injected intraperitoneally into specifically immunized guinea pigs (bacteriolysis in vivo o ...
as a PDF
... the remaining gaps in these signaling pathways. Furthermore, we still have a lot to learn regarding the function of various cell types in IFN induction during in vivo infections, as well as the role type I IFNs play in host defense against different types of pathogens. In this review, we will discus ...
... the remaining gaps in these signaling pathways. Furthermore, we still have a lot to learn regarding the function of various cell types in IFN induction during in vivo infections, as well as the role type I IFNs play in host defense against different types of pathogens. In this review, we will discus ...
The source of fatty acids incorporated into proliferating lymphoid
... guinea pigs ate standard chow for the last 5 d, during which swelling of one popliteal lymph node was stimulated by repeated local injection of lipopolysaccharide. The fatty acid compositions of phospholipids in both popliteal and in several mesenteric lymph nodes, and of triacylglycerols in eleven ...
... guinea pigs ate standard chow for the last 5 d, during which swelling of one popliteal lymph node was stimulated by repeated local injection of lipopolysaccharide. The fatty acid compositions of phospholipids in both popliteal and in several mesenteric lymph nodes, and of triacylglycerols in eleven ...
1- Introduction
... A vital par of this process was meeting my main supervisor Pr Berit Smestad Paulsen, who as painstakingly supervised this dissertation. Her accessibility and commitment to this research project have made it a cherished experience for me. I am eternally grateful for the knowledge in the field of mode ...
... A vital par of this process was meeting my main supervisor Pr Berit Smestad Paulsen, who as painstakingly supervised this dissertation. Her accessibility and commitment to this research project have made it a cherished experience for me. I am eternally grateful for the knowledge in the field of mode ...
here - Aerotoxic Association
... “neuropsychological effects of long-term exposure,”61 “neurobehavioral effects,”62 and “delayed neurologic behavioral effects of subtoxic doses.”63 Our review of the literature indicated that these studies describe a nervous system disorder induced by organophosphorus compounds which involves neuron ...
... “neuropsychological effects of long-term exposure,”61 “neurobehavioral effects,”62 and “delayed neurologic behavioral effects of subtoxic doses.”63 Our review of the literature indicated that these studies describe a nervous system disorder induced by organophosphorus compounds which involves neuron ...
The role of Fc–Fc R interactions in IgG-mediated microbial
... against infectious diseases in the past, the reintroduction of antibodies as therapeutic modalities against infections has previously faced skepticism, mainly because of the highly specific nature of antibodies that normally target restricted epitopes, thereby presenting limited breadth against othe ...
... against infectious diseases in the past, the reintroduction of antibodies as therapeutic modalities against infections has previously faced skepticism, mainly because of the highly specific nature of antibodies that normally target restricted epitopes, thereby presenting limited breadth against othe ...
Pollen-Induced Oxidative Stress Influences Both Innate and
... maturation, and consequently induce adaptive immune responses. Recently, it has been shown that pollen grains and their allergenic extracts have a potent pro-oxidant activity, which induces profound oxidative stress in the lung or conjunctiva within minutes after exposure (3–5). Inhibition of this i ...
... maturation, and consequently induce adaptive immune responses. Recently, it has been shown that pollen grains and their allergenic extracts have a potent pro-oxidant activity, which induces profound oxidative stress in the lung or conjunctiva within minutes after exposure (3–5). Inhibition of this i ...
Recent Advances in Researches on Shrimp Immune Pathway
... infection, the host innate immune system activated microbial clearing pathways and cellular stress relief pathways that needed to be balanced for insufficient or excessive immune responses leading to deleterious consequences. Shrimp is an invertebrate with open circulatory system, especially prone t ...
... infection, the host innate immune system activated microbial clearing pathways and cellular stress relief pathways that needed to be balanced for insufficient or excessive immune responses leading to deleterious consequences. Shrimp is an invertebrate with open circulatory system, especially prone t ...
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes
... is clear that the transcriptional Treg signature is established very early Treg cell commitment is beginning to be better understood. Several on, with its main characteristics being already present in CD4+ single- milestones have been put down that etch a putative map of how the positive cells21. Po ...
... is clear that the transcriptional Treg signature is established very early Treg cell commitment is beginning to be better understood. Several on, with its main characteristics being already present in CD4+ single- milestones have been put down that etch a putative map of how the positive cells21. Po ...
The Role of Intracellular Neutral Lipid Hydrolases in Immune Cell
... lab colleagues, especially Silvia for always being there when a helping hand was needed, Anton for his often very helpful MacGyver skills and technical support, Nemo for fruitful discussions, Madeleine, Melly, Christina for the fun moments during lunch breaks, the hearty laughs and the cheerful comp ...
... lab colleagues, especially Silvia for always being there when a helping hand was needed, Anton for his often very helpful MacGyver skills and technical support, Nemo for fruitful discussions, Madeleine, Melly, Christina for the fun moments during lunch breaks, the hearty laughs and the cheerful comp ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.