The role of senescent cells in ageing
... exposure to histone deacetylase inhibitors triggers senescence via a p21dependent mechanism29. A key target of epigenetic stressors that promote senescence may be the INK4a/ARF locus, which in proliferating cells is repressed by polycomb group-mediated H3K27 methylation and H2AK119 ubiquitination30. ...
... exposure to histone deacetylase inhibitors triggers senescence via a p21dependent mechanism29. A key target of epigenetic stressors that promote senescence may be the INK4a/ARF locus, which in proliferating cells is repressed by polycomb group-mediated H3K27 methylation and H2AK119 ubiquitination30. ...
The Timing of Response Onset and Offset in Macaque
... receptive field adequately activate all of these cell types (EnrothCugell and Robson, 1966; Movshon et al., 1978), but here we present them in rapid, random succession with their canonical opposites to facilitate the precise estimation of timing. In the retina and LGN, there is probably no strong op ...
... receptive field adequately activate all of these cell types (EnrothCugell and Robson, 1966; Movshon et al., 1978), but here we present them in rapid, random succession with their canonical opposites to facilitate the precise estimation of timing. In the retina and LGN, there is probably no strong op ...
In July 2004, The Training Program Director`s Core Curriculum and
... b. Epitope recognition and immunoglobulin production ..................................................... 48 c. Maturation of B lymphocytes........................................................................................... 49 d. Maturation of the antibody response........................... ...
... b. Epitope recognition and immunoglobulin production ..................................................... 48 c. Maturation of B lymphocytes........................................................................................... 49 d. Maturation of the antibody response........................... ...
Prospects of new vaccines for resurgent and emergent diseases
... the disease13. Live vaccines offer the advantage that they do not require adjuvants and can stimulate potent cellular and humoral immune responses. Cellular immunity is likely to be important for protection against many resurgent and emergent diseases, including AIDS and malaria. Thus, live vaccines ...
... the disease13. Live vaccines offer the advantage that they do not require adjuvants and can stimulate potent cellular and humoral immune responses. Cellular immunity is likely to be important for protection against many resurgent and emergent diseases, including AIDS and malaria. Thus, live vaccines ...
the avian thrombocyte is a specialized immune cell
... Thrombocytes are the most abundant circulating cells next to red blood cells in avian blood. Avian thrombocytes are homologous in function to mammalian platelets. Avian thrombocytes and the mammalian platelet are widely recognized contributors to inflammatory responses upon stimulation with various ...
... Thrombocytes are the most abundant circulating cells next to red blood cells in avian blood. Avian thrombocytes are homologous in function to mammalian platelets. Avian thrombocytes and the mammalian platelet are widely recognized contributors to inflammatory responses upon stimulation with various ...
Delivery strategies to enhance oral vaccination against
... In the developed world, diarrhoeal diseases account for significant morbidity whereas in the developing world, where sanitation systems are often sub-optimal, it is associated with high levels of mortality [1], especially in children under 5 years of age who are most at risk at contracting and succum ...
... In the developed world, diarrhoeal diseases account for significant morbidity whereas in the developing world, where sanitation systems are often sub-optimal, it is associated with high levels of mortality [1], especially in children under 5 years of age who are most at risk at contracting and succum ...
Synapse
... stereotypy, and rearing in Long-Evans and Sprague-Dawley rats were compared. A single cocaine injection (molar equivalent of 60 µmol/kg cocaethylene, intraperitoneal) elicited a robust series of motor output behaviors, including locomotion, stereotypy, and rearing over a 30-minute testing period in ...
... stereotypy, and rearing in Long-Evans and Sprague-Dawley rats were compared. A single cocaine injection (molar equivalent of 60 µmol/kg cocaethylene, intraperitoneal) elicited a robust series of motor output behaviors, including locomotion, stereotypy, and rearing over a 30-minute testing period in ...
VacA`s Induction of VacA-Containing Vacuoles (VCVs) and Their
... It is known that in order to exert its many effects, VacA must be internalized via endocytosis. VacA–target binding has been associated with the larger p55 subunit, but it has also been shown that both the p33 and the p55 subunits are required for internalization [15]. Since the formation of vacuole ...
... It is known that in order to exert its many effects, VacA must be internalized via endocytosis. VacA–target binding has been associated with the larger p55 subunit, but it has also been shown that both the p33 and the p55 subunits are required for internalization [15]. Since the formation of vacuole ...
post-peer-review-non-publishers
... evidence indicating that individual SCN cells are capable of reporting the average light intensity across the whole visual field. As a result of these local irradiance coding properties, our data establish that photic integration is primarily mediated at the level of the SCN network and suggest that ...
... evidence indicating that individual SCN cells are capable of reporting the average light intensity across the whole visual field. As a result of these local irradiance coding properties, our data establish that photic integration is primarily mediated at the level of the SCN network and suggest that ...
pre-service teacher-generated analogies for function concepts
... use of analogy, however, mostly did not appear in the lesson plans. The courses were presented in three different sequences: 1) analogies, definition or rules, and solving examples, 2) definition or rules, analogies, solving examples, and 3) definition or rules, and solving examples. This indicates ...
... use of analogy, however, mostly did not appear in the lesson plans. The courses were presented in three different sequences: 1) analogies, definition or rules, and solving examples, 2) definition or rules, analogies, solving examples, and 3) definition or rules, and solving examples. This indicates ...
CHAPTER ONE
... loss. For this, drugs with antispasmodic, antimotility, antioxidative, anti-secretory/pro-absorptive and/or antiinflammatory properties (depending on the causative agents) may be used to treat diarrhoeal (Wynn and Fougere, 2007). The issue of antimicrobial therapy for self-limiting and non-infectiou ...
... loss. For this, drugs with antispasmodic, antimotility, antioxidative, anti-secretory/pro-absorptive and/or antiinflammatory properties (depending on the causative agents) may be used to treat diarrhoeal (Wynn and Fougere, 2007). The issue of antimicrobial therapy for self-limiting and non-infectiou ...
Infect Immun. 2011 Feb;79(2):688-94. Epub 2010 Nov 22.
... Type I interferons (IFNs) comprise a small family of cytokines, including beta IFN (IFN-!), that signal through the type I IFN receptor (IFNAR) and exert pleiotropic effects on the immune system (27). In addition to their role in induction of an antiviral state (6), type I IFNs have many systemic ef ...
... Type I interferons (IFNs) comprise a small family of cytokines, including beta IFN (IFN-!), that signal through the type I IFN receptor (IFNAR) and exert pleiotropic effects on the immune system (27). In addition to their role in induction of an antiviral state (6), type I IFNs have many systemic ef ...
Distinct or Gradually Changing Spatial and Nonspatial
... out a continuous theta oscillation. Moreover, the nature of theta oscillation in the bat’s dorsal hippocampus was intermittent (Ulanovsky and Moss, 2007), much like the intermittent theta reported by Royer et al. (2010) in the rat ventral hippocampus. The existence of place cells without continuous ...
... out a continuous theta oscillation. Moreover, the nature of theta oscillation in the bat’s dorsal hippocampus was intermittent (Ulanovsky and Moss, 2007), much like the intermittent theta reported by Royer et al. (2010) in the rat ventral hippocampus. The existence of place cells without continuous ...
3A - India Environment Portal
... New Delhi: As a thick blanket of smog smothers the city every morning, pollution experts are not only pointing to the usual suspects — nitrogen oxides (Nox) and ozone — this time. It’s the rising concentration of lesser-known volatile organic compounds (VOCs) like benzene, toluene, xylene, styrene a ...
... New Delhi: As a thick blanket of smog smothers the city every morning, pollution experts are not only pointing to the usual suspects — nitrogen oxides (Nox) and ozone — this time. It’s the rising concentration of lesser-known volatile organic compounds (VOCs) like benzene, toluene, xylene, styrene a ...
Licentiate thesis from the Department of Immunology,
... In vitro analyses of the responses of murine and human macrophages to M. tuberculosis infection indicate that these cells produce a robust proinflammatory response through the activity of TLR agonists (stimulators of the host's TLRs) that are abundant on the surface of the bacteria. These components ...
... In vitro analyses of the responses of murine and human macrophages to M. tuberculosis infection indicate that these cells produce a robust proinflammatory response through the activity of TLR agonists (stimulators of the host's TLRs) that are abundant on the surface of the bacteria. These components ...
3. Connections of the Hypothalamus
... Visual inputs may reach the hypothalamus via a direct retinal projection. In all mammalian species, including humans, some retinal fibers leave the optic chiasm and pass dorsally into the hypothalamus, where they innervate the suprachiasmatic nuclei, the endogeneous circadian clock. A second visual ...
... Visual inputs may reach the hypothalamus via a direct retinal projection. In all mammalian species, including humans, some retinal fibers leave the optic chiasm and pass dorsally into the hypothalamus, where they innervate the suprachiasmatic nuclei, the endogeneous circadian clock. A second visual ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.