Thioaptamer decoy targeting of AP-1 proteins influences cytokine
... and enhance the induction of cytokines IL-6, IL-8 and TNF-a, while reducing the binding to AP-1 promoter elements. Administration of XBY-S2 to Pichinde virus-infected guinea pigs resulted in a significant reduction in Pichinde virus-induced mortality and enhanced the expression of cytokines from pri ...
... and enhance the induction of cytokines IL-6, IL-8 and TNF-a, while reducing the binding to AP-1 promoter elements. Administration of XBY-S2 to Pichinde virus-infected guinea pigs resulted in a significant reduction in Pichinde virus-induced mortality and enhanced the expression of cytokines from pri ...
Biological Theories of Aging
... Age-Related Changes in Hormonal Axis • Loss of sex hormones with age ↓ muscle mass and muscle strength • Testosterone levels gradually decline at ~ 1% a year after age 30. By about age 70, the decrease can be as much as 50%. • Testosterone replacement in men ↑ lean muscle mass, but resistance exerc ...
... Age-Related Changes in Hormonal Axis • Loss of sex hormones with age ↓ muscle mass and muscle strength • Testosterone levels gradually decline at ~ 1% a year after age 30. By about age 70, the decrease can be as much as 50%. • Testosterone replacement in men ↑ lean muscle mass, but resistance exerc ...
presentation
... What are known epigenetic modifiers of microglia behavior? Maternal exposures (diet, pollution, narcotics) Prior inflammation ...
... What are known epigenetic modifiers of microglia behavior? Maternal exposures (diet, pollution, narcotics) Prior inflammation ...
7th Grade Science Objectives
... analyze and interpret data. • Read and comprehend scientific text to learn about the human body systems. • Use scientific language in oral and written communication to present scientific information. • Explain and expand upon the knowledge of the human body system to real-life situations. Electricit ...
... analyze and interpret data. • Read and comprehend scientific text to learn about the human body systems. • Use scientific language in oral and written communication to present scientific information. • Explain and expand upon the knowledge of the human body system to real-life situations. Electricit ...
THE EMOTIOGENIC BRAIN STRUCTURES IN CONDITIONING
... AM. Hence, the activation of the structures of the emotiogenic control system of memory creates a spatial-temporal organization of brain structures that promotes the appearance of the effector conditioned response. Through what mechanisms does the emotiogenic control system act on memory? There are ...
... AM. Hence, the activation of the structures of the emotiogenic control system of memory creates a spatial-temporal organization of brain structures that promotes the appearance of the effector conditioned response. Through what mechanisms does the emotiogenic control system act on memory? There are ...
Document
... some very important functions. One important function of the hypothalamus is the control of body temperature. The hypothalamus acts as a "thermostat" by sensing changes in body temperature and then sending signals to adjust the temperature. For example, if you are too hot, the hypothalamus detects t ...
... some very important functions. One important function of the hypothalamus is the control of body temperature. The hypothalamus acts as a "thermostat" by sensing changes in body temperature and then sending signals to adjust the temperature. For example, if you are too hot, the hypothalamus detects t ...
Diehl - Buffalo Ontology Site
... • 295 annotations generated for a variety of gene products involved in response to S aureus and other pathogens, including NOD2, TLR2, TLR4, IL10, CD36, Scd1, and others. • Anatomical details, cell type ID, taxon IDs, and specific strain information collected where appropriate. • Some annotations ar ...
... • 295 annotations generated for a variety of gene products involved in response to S aureus and other pathogens, including NOD2, TLR2, TLR4, IL10, CD36, Scd1, and others. • Anatomical details, cell type ID, taxon IDs, and specific strain information collected where appropriate. • Some annotations ar ...
NEB-on-gene-expression_RMIS-5756
... changing systemic concentrations of metabolic cues. GnRH neurons, present in the hypothalamus, represent the final output pathway of the neural network that integrates a multitude of internal and environmental cues to regulate the secretion of LH and FSH from the anterior pituitary gland. However, l ...
... changing systemic concentrations of metabolic cues. GnRH neurons, present in the hypothalamus, represent the final output pathway of the neural network that integrates a multitude of internal and environmental cues to regulate the secretion of LH and FSH from the anterior pituitary gland. However, l ...
Biology of Select Zoonotic Protozoan Infections
... and infectious sporozoites which actively penetrate the intestinal epithelium. The exact site of intestinal epithelium invasion varies between species of Eimeria, and may also vary within a species depending on the age of the host. In the case of E. tenella, the sporozoites invade the caeca, whereas ...
... and infectious sporozoites which actively penetrate the intestinal epithelium. The exact site of intestinal epithelium invasion varies between species of Eimeria, and may also vary within a species depending on the age of the host. In the case of E. tenella, the sporozoites invade the caeca, whereas ...
Immunity-Related Genes and Gene Families in Anopheles gambiae
... fully sequenced and extensively annotated genome, which has been compared with the Anopheles genome (4). Insect immune reactions do not belong to adaptive immunity (which occurs only in chordates) but to the ancient defense system of innate immunity, which is relied upon by the vast majority of meta ...
... fully sequenced and extensively annotated genome, which has been compared with the Anopheles genome (4). Insect immune reactions do not belong to adaptive immunity (which occurs only in chordates) but to the ancient defense system of innate immunity, which is relied upon by the vast majority of meta ...
About Chronic Myeloid Leukemia What Is Chronic Myeloid Leukemia?
... up lymphoid tissue, a major part of the immune system. Lymphoid tissue is found in lymph nodes, the thymus gland, the spleen, the tonsils and adenoids, and is scattered throughout the digestive and respiratory systems and the bone marrow. The 2 major types of lymphocytes are known as B lymphocytes ( ...
... up lymphoid tissue, a major part of the immune system. Lymphoid tissue is found in lymph nodes, the thymus gland, the spleen, the tonsils and adenoids, and is scattered throughout the digestive and respiratory systems and the bone marrow. The 2 major types of lymphocytes are known as B lymphocytes ( ...
The Nervous System - Liberty Union High School District
... system and controls unconscious impulses such as the heartbeat. The sympathetic and parasympathetic systems work opposite of one another. For example, the sympathetic system speeds up the heart rate while the parasympathetic system slows down the heart rate. ...
... system and controls unconscious impulses such as the heartbeat. The sympathetic and parasympathetic systems work opposite of one another. For example, the sympathetic system speeds up the heart rate while the parasympathetic system slows down the heart rate. ...
Hepatitis B virus: from immunobiology to
... of infection [4,9,21,22]. (iii) In uPA (urokinase-type plasminogen activator)/SCID (severe combined immunodeficiency) mice harbouring human hepatocytes, baseline levels of human ISGs (interferon-stimulated genes) were slightly increased in HBVinfected animals when compared with uninfected mice [23]. ...
... of infection [4,9,21,22]. (iii) In uPA (urokinase-type plasminogen activator)/SCID (severe combined immunodeficiency) mice harbouring human hepatocytes, baseline levels of human ISGs (interferon-stimulated genes) were slightly increased in HBVinfected animals when compared with uninfected mice [23]. ...
Effects of deviating the Th2-response in murine mercury
... treatment with rIL-12 and a-IL-4 for modulating the Th1/Th2balance in HgIA. The rationale for this therapy was to deplete existing CD4+ cells and subsequently deviate developing Th0 cells into Th1 cells. However, this regimen abolished the induction of ANoA (data not shown), indicating that the deve ...
... treatment with rIL-12 and a-IL-4 for modulating the Th1/Th2balance in HgIA. The rationale for this therapy was to deplete existing CD4+ cells and subsequently deviate developing Th0 cells into Th1 cells. However, this regimen abolished the induction of ANoA (data not shown), indicating that the deve ...
Cytokine function of heat shock proteins - AJP
... function of HSPs with broad biological significance. The induction of proinflammatory cytokines by Hsp60 and Hsp70 may contribute to the pathogenesis of autoimmune diseases and chronic inflammation (55). Chlamydial Hsp60 frequently colocalizes with human Hsp60 in macrophages of atherosclerotic plaqu ...
... function of HSPs with broad biological significance. The induction of proinflammatory cytokines by Hsp60 and Hsp70 may contribute to the pathogenesis of autoimmune diseases and chronic inflammation (55). Chlamydial Hsp60 frequently colocalizes with human Hsp60 in macrophages of atherosclerotic plaqu ...
cell-mediated cytotoxicity during rejection and
... Antlsera and Antibodies.--Enhancing antisera (EAS) were prepared in Le adult rats that were grafted with skin two times and infused with spleen cells two times from BN donors. Complete details of preparation are presented in references 27 and 28. 0.3 ml of Le anti-BN (LABN) EAS or of normal Le serum ...
... Antlsera and Antibodies.--Enhancing antisera (EAS) were prepared in Le adult rats that were grafted with skin two times and infused with spleen cells two times from BN donors. Complete details of preparation are presented in references 27 and 28. 0.3 ml of Le anti-BN (LABN) EAS or of normal Le serum ...
1 - Sur Lab
... (A) A cortical slice is interfaced with a chip, and simultaneous patch-clamp is achieved on a layer 2/3 pyramidal cell, as visualized at 2.5x. Scale bars: 200 μm. Stimulating a pin during current clamp near the patched cell results in single action potentials (B), which are abolished with 1μm TTX (C ...
... (A) A cortical slice is interfaced with a chip, and simultaneous patch-clamp is achieved on a layer 2/3 pyramidal cell, as visualized at 2.5x. Scale bars: 200 μm. Stimulating a pin during current clamp near the patched cell results in single action potentials (B), which are abolished with 1μm TTX (C ...
EBV, the Human Host, and the 7TM Receptors
... the case for the most upregulated 7TM receptor EBI2 (EBV-induced gene 2 or GPR183). Whereas some regulated genes have been suggested to be involved in the EBV life cycle, others could also be important for the antiviral immune defense. As many of these 7TM receptors and ligands have been shown to be ...
... the case for the most upregulated 7TM receptor EBI2 (EBV-induced gene 2 or GPR183). Whereas some regulated genes have been suggested to be involved in the EBV life cycle, others could also be important for the antiviral immune defense. As many of these 7TM receptors and ligands have been shown to be ...
Targeting TLR-4 with a novel pharmaceutical grade plant derived
... situations. In accordance with the formal “Instruction of Medical Use―, one medical indication for Immunomax® is the stimulation of immune defense during the treatment of different infectious diseases (http://www.gepon.ru/immax_intro.htm). Thus, we hypothesized that the immunostimulatory activi ...
... situations. In accordance with the formal “Instruction of Medical Use―, one medical indication for Immunomax® is the stimulation of immune defense during the treatment of different infectious diseases (http://www.gepon.ru/immax_intro.htm). Thus, we hypothesized that the immunostimulatory activi ...
Monoclonal Antibodies
... a) HIV antigen is attached to the plate. b) Patients serum passed over the plate. Any HIV antibody in the patients serum will attached to the antigen already on the plate. c) A second antibody which is specific to the HIV antibody is passed over the plate. This antibody will attach to the concentra ...
... a) HIV antigen is attached to the plate. b) Patients serum passed over the plate. Any HIV antibody in the patients serum will attached to the antigen already on the plate. c) A second antibody which is specific to the HIV antibody is passed over the plate. This antibody will attach to the concentra ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.