The immune response to resistive breathing REVIEW
... diaphragm, secondary to the resistive loading, observed represents relatively abundant mRNA tissue levels, since cytokines were detected using a multi-probe ribonuclease protection assay [15], which does not amplify the RNA signal and is less sensitive than the commonly used technique to detect RNA, ...
... diaphragm, secondary to the resistive loading, observed represents relatively abundant mRNA tissue levels, since cytokines were detected using a multi-probe ribonuclease protection assay [15], which does not amplify the RNA signal and is less sensitive than the commonly used technique to detect RNA, ...
Immune System Pathways of the Innate and Adaptive Functions of
... resultant peptides can be presented by MHC I, a process referred to as cross-presentation (34). There is debate regarding the cellular compartment in which Ags are processed for cross-presentation (34, 50). Vesicular bodies into which Ag is internalized, such as endosomes or phagosomes, may become s ...
... resultant peptides can be presented by MHC I, a process referred to as cross-presentation (34). There is debate regarding the cellular compartment in which Ags are processed for cross-presentation (34, 50). Vesicular bodies into which Ag is internalized, such as endosomes or phagosomes, may become s ...
Chemokines as Drug Targets in Type 1 Diabetes
... Abstract: Acute or chronic inflammation is thought to play a major role in the etiology and/or pathogenesis of autoimmune disease. Often viral infections are the initial cause for a local inflammatory reaction resulting in tissue infiltration by activated leukocytes. The activation and trafficking o ...
... Abstract: Acute or chronic inflammation is thought to play a major role in the etiology and/or pathogenesis of autoimmune disease. Often viral infections are the initial cause for a local inflammatory reaction resulting in tissue infiltration by activated leukocytes. The activation and trafficking o ...
Chapter 15 the autonomic nervous system -
... The ENS is capable of autonomous functions such as the coordination of reflexes; although it receives considerable innervation from the autonomic nervous system, it can and does operate independently of the brain and the spinal cord. Its study is the focus of neurogastroenterology. ENS function can ...
... The ENS is capable of autonomous functions such as the coordination of reflexes; although it receives considerable innervation from the autonomic nervous system, it can and does operate independently of the brain and the spinal cord. Its study is the focus of neurogastroenterology. ENS function can ...
PD-1/PD-L1 Immune Checkpoint Blockade in Non–Small Cell Lung
... Rationale for Immunotherapy in NSCLC It is well established that the immune system is capable of recognizing and destroying tumor cells through T-cell activity.11,12 The presence of tumor-infiltrating T-cells has been correlated with better clinical outcomes,13-15 and suppression of the immune syste ...
... Rationale for Immunotherapy in NSCLC It is well established that the immune system is capable of recognizing and destroying tumor cells through T-cell activity.11,12 The presence of tumor-infiltrating T-cells has been correlated with better clinical outcomes,13-15 and suppression of the immune syste ...
Antigen Responses to a Secondary T-Independent T
... a greater impact of malaria than infection alone. In these regions, it is common for people to have subpatent malaria infection (7), and therefore, it is important to understand how an established malaria infection could inhibit immunity to a newly acquired infection or vaccine. Evidence for a role ...
... a greater impact of malaria than infection alone. In these regions, it is common for people to have subpatent malaria infection (7), and therefore, it is important to understand how an established malaria infection could inhibit immunity to a newly acquired infection or vaccine. Evidence for a role ...
Flagellated Pathogen Exhibit Impaired CD4 T Cell Responses to a
... resistant to some flagellated pathogens (14), but also more susceptible to others (16). In addition to this well-studied interaction of flagellin with host innate immune responses, flagellin also happens to be a protein Ag that is specifically targeted by the adaptive immune system during bacterial ...
... resistant to some flagellated pathogens (14), but also more susceptible to others (16). In addition to this well-studied interaction of flagellin with host innate immune responses, flagellin also happens to be a protein Ag that is specifically targeted by the adaptive immune system during bacterial ...
Tesi unita 08 - Padua@Research
... survives within the host despite the immune response, thus giving a chronic disease, remains an unexplored issue. In the present study, we investigated the role of a T. pallidum protein, called antigen 4D or TpF1 in the pathogenesis of syphilis. TpF1 is an oligomeric protein of 190 kDa localised in ...
... survives within the host despite the immune response, thus giving a chronic disease, remains an unexplored issue. In the present study, we investigated the role of a T. pallidum protein, called antigen 4D or TpF1 in the pathogenesis of syphilis. TpF1 is an oligomeric protein of 190 kDa localised in ...
Blockade of ASC but not NLRP3 Inhibits DC Proliferation and T cell
... alloantigen recognition and allograft rejection. We found that deletion of ASC significantly inhibited DC and T cell alloresponses, whereas deletion of NLRP3 had no effect. Despite the significant in vitro findings, there was no effect of the deletion of NLRP3 or ASC on allogeneic skin graft rejecti ...
... alloantigen recognition and allograft rejection. We found that deletion of ASC significantly inhibited DC and T cell alloresponses, whereas deletion of NLRP3 had no effect. Despite the significant in vitro findings, there was no effect of the deletion of NLRP3 or ASC on allogeneic skin graft rejecti ...
NIH Public Access
... Under normal gestational conditions (e.g., full-term gestation and vaginal delivery), the newborn infant leaves a germ-free intrauterine environment to enter a highly contaminated external world. During sequential periods within the first year of life, the infant colonizes its intestine with approxi ...
... Under normal gestational conditions (e.g., full-term gestation and vaginal delivery), the newborn infant leaves a germ-free intrauterine environment to enter a highly contaminated external world. During sequential periods within the first year of life, the infant colonizes its intestine with approxi ...
Chapter 15 the autonomic nervous system -
... The ENS is capable of autonomous functions such as the coordination of reflexes; although it receives considerable innervation from the autonomic nervous system, it can and does operate independently of the brain and the spinal cord. Its study is the focus of neurogastroenterology. ENS function can ...
... The ENS is capable of autonomous functions such as the coordination of reflexes; although it receives considerable innervation from the autonomic nervous system, it can and does operate independently of the brain and the spinal cord. Its study is the focus of neurogastroenterology. ENS function can ...
Chagas disease: a role for autoimmunity?
... disease was proposed (reviewed in Ref. [6]). Various technical advances helped to further explore the role of immune dysfunction in Chagas disease, resulting in the evolution of hypotheses on the mechanisms by which antiself immune responses could be generated, including polyclonal activation, molec ...
... disease was proposed (reviewed in Ref. [6]). Various technical advances helped to further explore the role of immune dysfunction in Chagas disease, resulting in the evolution of hypotheses on the mechanisms by which antiself immune responses could be generated, including polyclonal activation, molec ...
Invest Ophthalmol Vis Sci 1999 - Weizmann Institute of Science
... patients.3–5 However, none of these findings proves an autoimmune pathogenesis. Indeed, several findings seem to argue against a role for circulating autoantibodies in the immunopathology of idiopathic keratitis. First, the presence of corneal autoantibodies is not restricted to patients with idiopa ...
... patients.3–5 However, none of these findings proves an autoimmune pathogenesis. Indeed, several findings seem to argue against a role for circulating autoantibodies in the immunopathology of idiopathic keratitis. First, the presence of corneal autoantibodies is not restricted to patients with idiopa ...
Smart cell assays for immuno-oncology
... ICAM-1 KO and anti–LFA-1 integrin blockade inhibit the formation of T cell activation clusters Long-term, automated, image-based analysis enable direct phenotypic measurements challenging by other technologies ...
... ICAM-1 KO and anti–LFA-1 integrin blockade inhibit the formation of T cell activation clusters Long-term, automated, image-based analysis enable direct phenotypic measurements challenging by other technologies ...
complement - Micro-Rao
... C3b and C4b act as opsonins on the surface of microorganisms and promote phagocytosis. ...
... C3b and C4b act as opsonins on the surface of microorganisms and promote phagocytosis. ...
Islet inflammation in human type 1 diabetes
... autolysis such that the state of preservation of the tissue may be less than optimal when it is recovered. This may be offset by the rapid processing of an organ at the time of donation in heartbeating donors, but such glands are rarely available from patients with recent-onset T1D. Figure 1 illustr ...
... autolysis such that the state of preservation of the tissue may be less than optimal when it is recovered. This may be offset by the rapid processing of an organ at the time of donation in heartbeating donors, but such glands are rarely available from patients with recent-onset T1D. Figure 1 illustr ...
Chapter 8 Practice Tes1
... 9. putting on your coat when it is cold outside is a behavior that is maintained by: A. discrimination learning B. punishment C. negative reinforcement D. classical conditioning E. positive reinforcement 10. On an intermittent reinforcement schedule, reinforcement is given: A. in very small ...
... 9. putting on your coat when it is cold outside is a behavior that is maintained by: A. discrimination learning B. punishment C. negative reinforcement D. classical conditioning E. positive reinforcement 10. On an intermittent reinforcement schedule, reinforcement is given: A. in very small ...
CBS_Apr_7_05
... by the polytope are correctly processed and presented. •Cleavage by the proteasome in the cytosol, translocation into the ER by the TAP complex, as well as binding to MHC class I should be taken into account in an integrative manner. •The design of a polytope can be done in an effective way by modif ...
... by the polytope are correctly processed and presented. •Cleavage by the proteasome in the cytosol, translocation into the ER by the TAP complex, as well as binding to MHC class I should be taken into account in an integrative manner. •The design of a polytope can be done in an effective way by modif ...
Useful Links - Essentials of Clinical Immunology
... Useful information about tuberculosis world-wide; teaching and patient information aids. ...
... Useful information about tuberculosis world-wide; teaching and patient information aids. ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.