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The Blood Brain Barrier
The Blood Brain Barrier

... either through clathrin-coated pits or caveolae. • Transcytosis of molecules at the BBB is an energy requiring/ATP-dependent transport process, both for the endocytosis of the transported molecule at the luminal side of the EC and for its transport across the EC as well as for its exocytosis at the ...
Main Differences Between IgE and IgG Allergies
Main Differences Between IgE and IgG Allergies

... antibodies wait until the next peanut exposure. When the next peanut exposure occurs the IgE antibodies signal the mast cells to release histamine and other compounds. Histamine and these other compounds are the cause of allergy symptoms like itching and inflammation. All of this usually happens wit ...
here - The Kennedy Institute of Rheumatology
here - The Kennedy Institute of Rheumatology

... The Kennedy Institute is a world-leading medical research institute that carries out basic and translational research into chronic inflammatory and degenerative diseases. Kennedy Institute scientists and clinicians identified the role of the cytokine TNF in the pathogenesis of rheumatoid arthritis, ...
Inflammation
Inflammation

Immune cellular regulation on autoantibody production in pemphigus
Immune cellular regulation on autoantibody production in pemphigus

... autoimmune diseases. Additionally, they may function as selfantigen-presenting cells. Furthermore, B cells may regulate the T-cell development and function in vivo through multiple mechanisms. In treatment of pemphigus vulgaris (PV) patients, rituximab (an anti-CD20 monoclonal antibody) has been rep ...
Table 1. Strategies and mechanisms of survival of Leishmania
Table 1. Strategies and mechanisms of survival of Leishmania

... 13. Carrera L, Gazzinelli RT, Badolato R, Hieny S, Muller W, Kuhn R, Sacks DL: Leishmania promastigotes selectively inhibit interleukin12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J. Exp. Med. 1996, 183:515–526. 14. Sartori A, Oliveira MA, Scott P, Trinchieri ...
hormones
hormones

... 4. Compare and contrast the nervous and endocrine system. • They BOTH regulate the body. • They BOTH send messages to different parts of the body. • The endocrine system releases HORMONES. The nervous system transmit IMPULSES. • Endocrine system messages are chemical. Nervous system messages are el ...
Dendritic Cells: A Basic Review
Dendritic Cells: A Basic Review

... also needs to be optimized. It may be useful for the DCs to be transfected with RNA or DNA to produce the appropriate antigen and to present it on the surface. Finally, it may be that DC immunotherapy will work better when administered in combination with cytokines or other molecules which activate ...
Lesions of the Basolateral Amygdala Disrupt Selective Aspects of
Lesions of the Basolateral Amygdala Disrupt Selective Aspects of

... resulted in the presentation of this CS than on a control lever. ...
No Slide Title
No Slide Title

... • TYPE 1 produces amines leading to eosinophil degranulation protein which is toxic to macro-parasites. IMMUNITY PARASITES ...
Pain Part 2
Pain Part 2

... could this account for some cases of episodic analgesia? ...
Minireview: Role of Glia in Neuroendocrine Function
Minireview: Role of Glia in Neuroendocrine Function

Author`s personal copy
Author`s personal copy

ICH E10
ICH E10

... from two or more factors, each one of which would not be sufficient on its own, could trigger additional studies. If additional immunotoxicity studies are not performed, ...
MODULE J – CONTROL OF VENTILATION
MODULE J – CONTROL OF VENTILATION

... B. It is associated with many vital involuntary reflexes (sneezing, coughing) and also the regulation of cardiovascular and respiratory activity. C. There are two dense bilateral groups of neurons that function to control ventilation. 1. Dorsal Respiratory Groups a. These neurons are mainly associat ...
File
File

... The brain stem connects the brain and spinal cord. The brain stem includes three regions—the midbrain, the pons, and the medulla oblongata. Each of these regions regulates the flow of information between the brain and the rest of the body. Functions such as regulation of blood pressure, heart rate, ...
Systemically dispersed innate IL-13–expressing cells in type 2
Systemically dispersed innate IL-13–expressing cells in type 2

... critically on production of the canonical type 2-associated cytokines IL-4, IL-5, and IL-13 (1, 2). Although adaptive Th2 cells and follicular T cells are important sources of these cytokines (3), various innate cells, including eosinophils, basophils, and mast cells, have also been implicated as pr ...
ch_21_lecture_presentation_b
ch_21_lecture_presentation_b

... and responses in immune system • Include interferons and interleukins • Interleukin 1 (IL-1) released by macrophages co-stimulates bound T cells to – Release interleukin 2 (IL-2) – Synthesize more IL-2 receptors © 2013 Pearson Education, Inc. ...
What is HIV?
What is HIV?

Hypothalamus and Limbic System, Lecture 2 Emotion and reward
Hypothalamus and Limbic System, Lecture 2 Emotion and reward

... • Fear conditioning can be found in a large range of animals, from rodents to rabbits to humans. • As early as the 1920s, fear conditioning was demonstrated in infants. A white rat presented to an infant does not innately elicit fear, but pairing the rat with an aversive noise, produces crying and a ...
Increased frequencies of pulmonary regulatory T-cells in latent Mycobacterium tuberculosis infection
Increased frequencies of pulmonary regulatory T-cells in latent Mycobacterium tuberculosis infection

... of active TB due to a high percentage of falsenegative results [9]. Mechanisms that govern local containment versus the development of active disease are still incompletely understood. It would be advantageous if biomarkers that correlate either with maintenance of effective immune control of the my ...
Hypothalamus and Limbic System, Lecture 2
Hypothalamus and Limbic System, Lecture 2

... found that brain stimulation to parts of the hypothalamus and related structures can act as a reinforcer. This stimulation worked independent of drive state (e.g. hunger), and has been replicated in many brain structures. A key finding in these studies is that brain stimulation activates neurons in ...
Immunosuppression via TCDD Activation of the Aryl
Immunosuppression via TCDD Activation of the Aryl

... Normal (prolonged) immune response: T Cell proliferation TCDD induces CD4+ T Cells to differentiate into CD25 expressing T Regulatory-like cells (Tregs) Tregs inhibit T Cell proliferation, leading to immune suppression ...
PDF
PDF

21 - Dr. Jerry Cronin
21 - Dr. Jerry Cronin

... and responses in immune system • Include interferons and interleukins • Interleukin 1 (IL-1) released by macrophages co-stimulates bound T cells to – Release interleukin 2 (IL-2) – Synthesize more IL-2 receptors © 2013 Pearson Education, Inc. ...
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Psychoneuroimmunology



Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.
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