Homework 3 - Haixu Tang`s Homepage
... ----------------------------------- Mini Group Project # 2 ---------------------------------------Mini group project # 2 is sequential to the HW Section 1. 30 points Membrane proteins compromise a large fraction of eukaryotic proteins, and carry out many important protein functions as ion transport ...
... ----------------------------------- Mini Group Project # 2 ---------------------------------------Mini group project # 2 is sequential to the HW Section 1. 30 points Membrane proteins compromise a large fraction of eukaryotic proteins, and carry out many important protein functions as ion transport ...
Part Two – Lecture I
... stranded DNA occurs, the hydrogen bonds open, the duplex unwinds, and the strand separate No covalent bonds break so that the ...
... stranded DNA occurs, the hydrogen bonds open, the duplex unwinds, and the strand separate No covalent bonds break so that the ...
Activation of cellular proto-oncogenes to oncogenes How was active
... Disease initiation by transcriptional deregulation: Burkitt’s lymphoma and MYC Burkitt’s lymphoma is a B cell malignancy endemic in the malarial belt and common in immunosuppressed populations. Virtually all patients associated with BL have a common chromosomal breakpoint at t(8;14)(q24;q32) which ...
... Disease initiation by transcriptional deregulation: Burkitt’s lymphoma and MYC Burkitt’s lymphoma is a B cell malignancy endemic in the malarial belt and common in immunosuppressed populations. Virtually all patients associated with BL have a common chromosomal breakpoint at t(8;14)(q24;q32) which ...
plainumWhey protein
... PLATINUM Whey Protein MUSCLE EPITOME™ Platinum Whey Protein is great tasting high quality non-fat protein blend is an ideal way to meet up your protein requirement throughout the day. It provides a full 25g of protein per serving, plus essential nutrients to assist with your fitness goals, to help s ...
... PLATINUM Whey Protein MUSCLE EPITOME™ Platinum Whey Protein is great tasting high quality non-fat protein blend is an ideal way to meet up your protein requirement throughout the day. It provides a full 25g of protein per serving, plus essential nutrients to assist with your fitness goals, to help s ...
Powerpoint
... • Ho Y, Gruhler A, et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature ...
... • Ho Y, Gruhler A, et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature ...
StudentsLecture 2(ribosome modification).
... Lysosomes have several types of digestive functions: 1. Fuse with food vacuoles to release molecules such as amino acids for example and leave the lysosome to be reused by the cell 2. Help destroy harmful bacteria (breakdown the bacterial wall inside of white blood cells), serve as recycling center ...
... Lysosomes have several types of digestive functions: 1. Fuse with food vacuoles to release molecules such as amino acids for example and leave the lysosome to be reused by the cell 2. Help destroy harmful bacteria (breakdown the bacterial wall inside of white blood cells), serve as recycling center ...
The Biocreative Task in SEER
... Gene Entity Pitfalls • Language is complex Stably transfected human kidney 293 cells expressing the wild type rat LH / CG receptor ( rLHR ) or receptors with C-terminal tails truncated at residues 653 , 631 , or 628 (designated rLHR-t653 , rLHR-t631 , and rLHR-t628 ) were used to probe the importan ...
... Gene Entity Pitfalls • Language is complex Stably transfected human kidney 293 cells expressing the wild type rat LH / CG receptor ( rLHR ) or receptors with C-terminal tails truncated at residues 653 , 631 , or 628 (designated rLHR-t653 , rLHR-t631 , and rLHR-t628 ) were used to probe the importan ...
Pfam
... • Proteins in a family descend from a common ancestor (homology) and typically have similar three-dimensional structures, functions, and significant sequence similarity. While it is difficult to evaluate the significance of functional or structural similarity, there is a fairly well developed framew ...
... • Proteins in a family descend from a common ancestor (homology) and typically have similar three-dimensional structures, functions, and significant sequence similarity. While it is difficult to evaluate the significance of functional or structural similarity, there is a fairly well developed framew ...
Controlling Gene Expression
... ◦ Pre-transcriptional ◦ transcriptional (controls transcription from DNA to mRNA) ◦ posttranscriptional (controls the removal of introns) ◦ translational (controls rate that mRNA is activated through ribosomes) ◦ posttranslational (affects the rate proteins can leave the cell) ...
... ◦ Pre-transcriptional ◦ transcriptional (controls transcription from DNA to mRNA) ◦ posttranscriptional (controls the removal of introns) ◦ translational (controls rate that mRNA is activated through ribosomes) ◦ posttranslational (affects the rate proteins can leave the cell) ...
slide - KOCSEA
... Network Vulnerability Random attack: repeatedly disrupt a randomly selected node Degree-based hub attack: repeatedly disrupt the highest degree node Structural hub attack: repeatedly disrupt the node with the highest hub confidence For each iteration, observes the largest component ...
... Network Vulnerability Random attack: repeatedly disrupt a randomly selected node Degree-based hub attack: repeatedly disrupt the highest degree node Structural hub attack: repeatedly disrupt the node with the highest hub confidence For each iteration, observes the largest component ...
Background on Protein and Interactions
... gland. It regulates cell growth by binding to a protein called a growth hormone receptor. ...
... gland. It regulates cell growth by binding to a protein called a growth hormone receptor. ...
Open questions - in brief: Beyond -omics, missing organisms
... There has been a recent proliferation of publications that describe the identification of intracellular cytosol-based multi-protein complexes in various organisms that can act as functional modules for diverse biochemical activities. The method of choice is generally a form of affinity purification ...
... There has been a recent proliferation of publications that describe the identification of intracellular cytosol-based multi-protein complexes in various organisms that can act as functional modules for diverse biochemical activities. The method of choice is generally a form of affinity purification ...
File
... Initiator regions contain a purine-rich sequence called the Shine-Dalgarno sequence about 10 nucleotides 5’ of the initiator codon The Shine-Dalgarno sequence interacts with a complementary region on the 3’ end of 16S RNA ...
... Initiator regions contain a purine-rich sequence called the Shine-Dalgarno sequence about 10 nucleotides 5’ of the initiator codon The Shine-Dalgarno sequence interacts with a complementary region on the 3’ end of 16S RNA ...
posterexample2
... The unwounded leaves of both wild type and mutant had low expression levels of lipoxygease 2, allene oxide synthase, OPDA reductase 3 and low induction of the JA responsive gene, PDF1.2. The JAZ1 gene that encodes for a protein that repress genes in the JA pathway was elevated in the unwounded tissu ...
... The unwounded leaves of both wild type and mutant had low expression levels of lipoxygease 2, allene oxide synthase, OPDA reductase 3 and low induction of the JA responsive gene, PDF1.2. The JAZ1 gene that encodes for a protein that repress genes in the JA pathway was elevated in the unwounded tissu ...
Leukaemia Section t(7;9)(q34;q32) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... vitro substrate for MAP kinases such as ERK1. TAL2 polypeptides interact in vivo with the E2A gene products to form HLH heterodimers that bind DNA, the result is the E2A inactivation. The E2A products are transcriptional factors implicated in the B and T cell development. TAL2 product was also shown ...
... vitro substrate for MAP kinases such as ERK1. TAL2 polypeptides interact in vivo with the E2A gene products to form HLH heterodimers that bind DNA, the result is the E2A inactivation. The E2A products are transcriptional factors implicated in the B and T cell development. TAL2 product was also shown ...
Week 2
... – The excess protein amounts are sensed by the molecular mechanism that triggers the expression of specific proteins that labels the excess proteins for degradation – The proteins marked for degradation are taken to the lysosome by the molecular transport mechanisms – In the lysosome, polypeptide ch ...
... – The excess protein amounts are sensed by the molecular mechanism that triggers the expression of specific proteins that labels the excess proteins for degradation – The proteins marked for degradation are taken to the lysosome by the molecular transport mechanisms – In the lysosome, polypeptide ch ...
Digestion of Biomolecules
... Hydrolysis Reactions • Proteins amino acids – Proteases, peptidases ...
... Hydrolysis Reactions • Proteins amino acids – Proteases, peptidases ...
Biological networks and network motifs
... If X* regulates Y, the net production rate of gene Y is dY f X * Y ...
... If X* regulates Y, the net production rate of gene Y is dY f X * Y ...
High-throughput screening and semi
... screening of eukaryotic proteins The Center for Eukaryotic Structural Genomics (CESG) has developed a rapid small-scale high-throughput screen for identifying positively expressed cloned genes isolated from Arabidopsis thaliana, rice, human, yeast, and mouse. We have screened expression of over 2,50 ...
... screening of eukaryotic proteins The Center for Eukaryotic Structural Genomics (CESG) has developed a rapid small-scale high-throughput screen for identifying positively expressed cloned genes isolated from Arabidopsis thaliana, rice, human, yeast, and mouse. We have screened expression of over 2,50 ...
The Power of Protein - Jackson County Sheriff
... When we think protein, we think beef or pork. They have about 15-20 grams in a 3-ounce serving (the size of a deck of cards). But beef and pork can have 10+ grams of artery-clogging saturated fat in a 3-ounce serving, too. ...
... When we think protein, we think beef or pork. They have about 15-20 grams in a 3-ounce serving (the size of a deck of cards). But beef and pork can have 10+ grams of artery-clogging saturated fat in a 3-ounce serving, too. ...
Molecules of Life – Part 2
... Proteins (A. K.A. Polypeptides) and Enzymes (Enzymes are a type of protein.) A. Proteins make up greater than 50% of an organisms dry weight (referred to as biomass). B. This is another important example of the theme: Structure = Function. (These are very large 3-D Molecules.) C. The monomer “buildi ...
... Proteins (A. K.A. Polypeptides) and Enzymes (Enzymes are a type of protein.) A. Proteins make up greater than 50% of an organisms dry weight (referred to as biomass). B. This is another important example of the theme: Structure = Function. (These are very large 3-D Molecules.) C. The monomer “buildi ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.