Module name Bioinformatics Module code B
... Total number of non-contact hours – 15 Number of ECTS points for non-contact hours – 0.5 Total number of ECTS points for the module - 1 Continuous evaluation of the computer classes The course will familiarize students with the bioinformatics tools for searching DNA/ protein sequence databases and p ...
... Total number of non-contact hours – 15 Number of ECTS points for non-contact hours – 0.5 Total number of ECTS points for the module - 1 Continuous evaluation of the computer classes The course will familiarize students with the bioinformatics tools for searching DNA/ protein sequence databases and p ...
Getting the inside running on enzymes
... understanding how communication networks in proteins support the transmission of signals between different sites on an enzyme molecule. “The key focus of the research is about fundamentally understanding the network and how it evolved. Can we design a protein to be regulated in a similar way because ...
... understanding how communication networks in proteins support the transmission of signals between different sites on an enzyme molecule. “The key focus of the research is about fundamentally understanding the network and how it evolved. Can we design a protein to be regulated in a similar way because ...
Ch. 13 Section Assessment Answers
... 23. Yes, a mutation could produce a protein with a new or altered function that might be useful to an organism in a changing environment. 24. A chromosomal mutation that occurs during meiosis will be carried by some of the organism’s gametes and possibly to the organism’s offspring. A mutation that ...
... 23. Yes, a mutation could produce a protein with a new or altered function that might be useful to an organism in a changing environment. 24. A chromosomal mutation that occurs during meiosis will be carried by some of the organism’s gametes and possibly to the organism’s offspring. A mutation that ...
here
... In the α,β-hydrolase family, a triad of amino acids (histodine, aspartate and serine) are conserved. They occur in the active site in close proximity to one another, where they interact to allow Serine to act as a nucleophile. This triad is present in MhpC, but it is unknown whether it has the same ...
... In the α,β-hydrolase family, a triad of amino acids (histodine, aspartate and serine) are conserved. They occur in the active site in close proximity to one another, where they interact to allow Serine to act as a nucleophile. This triad is present in MhpC, but it is unknown whether it has the same ...
LEGO PROTEIN SYNTHESIS (25 pts)
... PURPOSE: Your cells come in all shapes and sizes. Different types of cell make different proteins according to the jobs they have to do. For example, only red blood cells contain the protein hemoglobin which carries oxygen around your body. Similarly, only cells in your eyes make proteins for detect ...
... PURPOSE: Your cells come in all shapes and sizes. Different types of cell make different proteins according to the jobs they have to do. For example, only red blood cells contain the protein hemoglobin which carries oxygen around your body. Similarly, only cells in your eyes make proteins for detect ...
DNA/Protein structure-function analysis and prediction - IBIVU
... 3D domain swapping definitions. A: Closed monomers are comprised of tertiary or secondary structural domains (represented by a circle and square) linked by polypeptide linkers (hinge loops). The interface between domains in the closed monomer is referred to as the C- (closed) interface. Closed monom ...
... 3D domain swapping definitions. A: Closed monomers are comprised of tertiary or secondary structural domains (represented by a circle and square) linked by polypeptide linkers (hinge loops). The interface between domains in the closed monomer is referred to as the C- (closed) interface. Closed monom ...
Ch. 18 Regulation of Gene Expression
... found in clusters that have their own promoter and individually transcribed some are found on different chromosomes expression depends on a combination of elements that recognize control elements and bind to them, so all genes are transcribed at the same time ...
... found in clusters that have their own promoter and individually transcribed some are found on different chromosomes expression depends on a combination of elements that recognize control elements and bind to them, so all genes are transcribed at the same time ...
Pathogen Genomics COURSE
... 3.3) The two major outliers appear to suggest that “membrane” proteins and “adhesins” may be important for pathogenesis of E. coli O157:H7. You can use the “Query” function in TaxPlot to highlight other membrane proteins and adhesins in the plot. Q6: Are there other membrane proteins and adhesins t ...
... 3.3) The two major outliers appear to suggest that “membrane” proteins and “adhesins” may be important for pathogenesis of E. coli O157:H7. You can use the “Query” function in TaxPlot to highlight other membrane proteins and adhesins in the plot. Q6: Are there other membrane proteins and adhesins t ...
Transcription/Translation
... histone proteins is referred to as heterochromatin in contrast to the more diffuse euchromatin. • Genes contained in the heterochromatin regions of a chromosome are usually not expressed because the packaging of DNA into nucleosomes can make DNA physically inaccessible to RNA polymerase for transcri ...
... histone proteins is referred to as heterochromatin in contrast to the more diffuse euchromatin. • Genes contained in the heterochromatin regions of a chromosome are usually not expressed because the packaging of DNA into nucleosomes can make DNA physically inaccessible to RNA polymerase for transcri ...
Human Proteome advertising miniposter (PDF)
... part of the foreign target, the antigen. The unique properties of antibodies are used in a wide range of therapeutic and research applications. This poster describes some of the most common techniques. ...
... part of the foreign target, the antigen. The unique properties of antibodies are used in a wide range of therapeutic and research applications. This poster describes some of the most common techniques. ...
Instructions for Mem-mEN Web-server
... Membrane proteins, which interact with the membranes of a cell or an organelle, play essential roles in a variety of vital biological processes. Because membrane proteins mediate many interactions between cells and extracellular surroundings as well as between the cytosol and membrane-bound organell ...
... Membrane proteins, which interact with the membranes of a cell or an organelle, play essential roles in a variety of vital biological processes. Because membrane proteins mediate many interactions between cells and extracellular surroundings as well as between the cytosol and membrane-bound organell ...
发现次级代谢途径特异性转录调控因子
... Figure A demonstrates that binding ability relies on the DNA-binding domain, and is independent of the PAS domain. Figure B demonstrates that truncated forms of the protein have significantly higher affinity. ...
... Figure A demonstrates that binding ability relies on the DNA-binding domain, and is independent of the PAS domain. Figure B demonstrates that truncated forms of the protein have significantly higher affinity. ...
Expression and purification of huntingtin domain
... with 300 mM imidazole (E). Samples collected throughout the prep were analysed by 4-20 % Tris-Glycine SDSPAGE. No obvious band for the protein is seen in the elution fraction on the SDS-PAGE (expected MW ~ 40.1 kDa). To verify whether protein was expressed in the BVES production, 3 mL samples (saved ...
... with 300 mM imidazole (E). Samples collected throughout the prep were analysed by 4-20 % Tris-Glycine SDSPAGE. No obvious band for the protein is seen in the elution fraction on the SDS-PAGE (expected MW ~ 40.1 kDa). To verify whether protein was expressed in the BVES production, 3 mL samples (saved ...
Genomics
... interaction among proteins can be determined for a particular living system. Proteomics can also be applied to map protein modification to determine the difference between a wild type and a genetically modified organism. It is also used to study protein-protein interactions involved in plant defense ...
... interaction among proteins can be determined for a particular living system. Proteomics can also be applied to map protein modification to determine the difference between a wild type and a genetically modified organism. It is also used to study protein-protein interactions involved in plant defense ...
Ενδοκυττάρια ∆ιαµερίσµατα, ∆ιαλογή και µεταφορά πρωτεινών
... presequence and negative patches of receptors along the import pathway: The Acid chain hypothesis- Gradation of affinities leads the presequence along the import pathway ...
... presequence and negative patches of receptors along the import pathway: The Acid chain hypothesis- Gradation of affinities leads the presequence along the import pathway ...
FERM domain proteins
... Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members, K Takeuchi et al, J Cell Bio 125:1371-1384(1994) ...
... Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members, K Takeuchi et al, J Cell Bio 125:1371-1384(1994) ...
Automate Function Prediction
... – BLAST2GO (http://www.blast2go.com/b2ghome) – GOTCHA (http://www.compbio.dundee.ac.uk/gotcha/gotcha.php) – ARGOT(http://www.medcomp.medicina.unipd.it/Argot2/form.php) – PFP (http://kiharalab.org/web/pfp.php) ...
... – BLAST2GO (http://www.blast2go.com/b2ghome) – GOTCHA (http://www.compbio.dundee.ac.uk/gotcha/gotcha.php) – ARGOT(http://www.medcomp.medicina.unipd.it/Argot2/form.php) – PFP (http://kiharalab.org/web/pfp.php) ...
α2 protein during Drosophila oogenesis
... The in vitro generated mutant, where the CAS-binding residues (responsible for the recyclization of Importin-α protein from nucleus) were targeted, was trapped into the nuclei and completely depleted from the cytoplasm of each cells of egg chambers. This observation unequivocally verify that during ...
... The in vitro generated mutant, where the CAS-binding residues (responsible for the recyclization of Importin-α protein from nucleus) were targeted, was trapped into the nuclei and completely depleted from the cytoplasm of each cells of egg chambers. This observation unequivocally verify that during ...
0_GO - Theoretical Systems Biology
... chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.” ...
... chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.” ...
Intracellular Compartments and Protein Sorting
... Signal sequence often at C-terminus Some proteins with sequence near N-terminus Peroxins (receptors, docking proteins) participate in transport Inherited defects in peroxin genes such as Zellweger syndrome ...
... Signal sequence often at C-terminus Some proteins with sequence near N-terminus Peroxins (receptors, docking proteins) participate in transport Inherited defects in peroxin genes such as Zellweger syndrome ...
Chemistry of Living Things revised
... reaction they catalyze. • In organisms, _____________ allow the chemical reactions of ______________ to take place more efficiently than they otherwise would at body temperature. • For example, amino acids are produced from protein digestion. The enzymes needed for this reaction are not changed but ...
... reaction they catalyze. • In organisms, _____________ allow the chemical reactions of ______________ to take place more efficiently than they otherwise would at body temperature. • For example, amino acids are produced from protein digestion. The enzymes needed for this reaction are not changed but ...
Evolution of protein targeting via endomembrane system to primary
... algae, and green plants engulfed cyanobacteria, which then were transformed into primary plastids with two envelope membranes. Gene transfer from the cyanobacterial genome to the host nucleus fostered the integration of the endosymbiont and the host but it is still not clear how protein products of ...
... algae, and green plants engulfed cyanobacteria, which then were transformed into primary plastids with two envelope membranes. Gene transfer from the cyanobacterial genome to the host nucleus fostered the integration of the endosymbiont and the host but it is still not clear how protein products of ...
Lecture#5 - Introduction to gene regulation and operons in
... Inducers - specific substrates that induced the appearance of specific enzymes (new synthesis of the enzymes). beta-galactosidase could be induced with several types of beta-galactosides – IPTG – Fig The enzyme is not normally present in absence of an inducer. ...
... Inducers - specific substrates that induced the appearance of specific enzymes (new synthesis of the enzymes). beta-galactosidase could be induced with several types of beta-galactosides – IPTG – Fig The enzyme is not normally present in absence of an inducer. ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.