Dr. Elisar Barbar`s Lab - Oregon State University
... • A large multi-subunit molecular motor protein – Heavy chains contain the ATP and microtubule binding sites • Cytoplasmic dynein is responsible for transporting cellular cargo to the minus end of microtubules (i.e. toward the centrosome) ...
... • A large multi-subunit molecular motor protein – Heavy chains contain the ATP and microtubule binding sites • Cytoplasmic dynein is responsible for transporting cellular cargo to the minus end of microtubules (i.e. toward the centrosome) ...
lecture13_06
... and (E) wound healing and tissue remodeling. These clusters also contain named genes not involved in these processes and numerous uncharacterized genes. ...
... and (E) wound healing and tissue remodeling. These clusters also contain named genes not involved in these processes and numerous uncharacterized genes. ...
Key concepts_chromatin
... left-handed turns about an octamer of histones, two each of four types: H2A, H2B, H3 and H4. H2A and H2B form heterodimers, while H3 and H4 form a tetramer. Some of the histones exist in variant forms, and all are subject to a number of possible posttranslational modifications. This allows an enormo ...
... left-handed turns about an octamer of histones, two each of four types: H2A, H2B, H3 and H4. H2A and H2B form heterodimers, while H3 and H4 form a tetramer. Some of the histones exist in variant forms, and all are subject to a number of possible posttranslational modifications. This allows an enormo ...
Hortmon and Udenfriend (I969 Anal. ... Fisher, C. R. Anilinonophthalene rulfonote ...
... gels much easier to remove from the electrophoreris cell. With both-mcdificotionr, equal volumes of O.M)025% riboflavin (freshly prepored from a 10X stock stored in the dark under refrigeration) were substituted for penulfote, and photopolymerization was allowed to take place for 20 min. with two I5 ...
... gels much easier to remove from the electrophoreris cell. With both-mcdificotionr, equal volumes of O.M)025% riboflavin (freshly prepored from a 10X stock stored in the dark under refrigeration) were substituted for penulfote, and photopolymerization was allowed to take place for 20 min. with two I5 ...
CS "Autism and epilepsy"
... Marta Biagioli of Cibio will receive 120,000 dollars in research funding over three years from two American foundations for an innovative idea based on the use of a non-codifying RNA class that for decades has been regarded as a byproduct of cellular metabolism. These molecules stimulate the product ...
... Marta Biagioli of Cibio will receive 120,000 dollars in research funding over three years from two American foundations for an innovative idea based on the use of a non-codifying RNA class that for decades has been regarded as a byproduct of cellular metabolism. These molecules stimulate the product ...
A novel probe to identify biochemical signals of cells at cell
... interface, while <1 implicated it was from the apical portion. These proteins were analyzed by gene ontology, confirming the subcellular location of interfacial proteins were ECM, stress fibers and membrane proteins. DISCUSSION: We successfully identified proteins located at cell-material interface ...
... interface, while <1 implicated it was from the apical portion. These proteins were analyzed by gene ontology, confirming the subcellular location of interfacial proteins were ECM, stress fibers and membrane proteins. DISCUSSION: We successfully identified proteins located at cell-material interface ...
Get the PDF version of this article
... multi-step cumulative process involving alterations in 4 to 12 genes such as MCC, TGF-ß, Rb and Myc. The LOH pathway begins with the sporadic or inherited loss of the APC gene, which causes the colonic epithelium to become hyperproliferative and form an early adenoma. (FAP follows the LOH pathway). ...
... multi-step cumulative process involving alterations in 4 to 12 genes such as MCC, TGF-ß, Rb and Myc. The LOH pathway begins with the sporadic or inherited loss of the APC gene, which causes the colonic epithelium to become hyperproliferative and form an early adenoma. (FAP follows the LOH pathway). ...
Detection of protein-protein interactions
... • Target plasmid directs transcription of the Nterminal domain of RNA polymerase α –subunit • The target gene is fused in-frame to RNAPα at its the 3' end. • A promoter controls transcription ...
... • Target plasmid directs transcription of the Nterminal domain of RNA polymerase α –subunit • The target gene is fused in-frame to RNAPα at its the 3' end. • A promoter controls transcription ...
Chapter 12
... trigger histone degradation, depending on number of ubiquitin proteins added to each histone. – General transcription factors assemble at the core promoter and serve as the foundation for RNA polymerase activation. – Activator and repressor proteins are transcription factors that control the activit ...
... trigger histone degradation, depending on number of ubiquitin proteins added to each histone. – General transcription factors assemble at the core promoter and serve as the foundation for RNA polymerase activation. – Activator and repressor proteins are transcription factors that control the activit ...
Leukaemia Section inv(19)(p13q13) TCF3/TFPT, t(19;19)(p13;q13) TCF3/TFPT Atlas of Genetics and Cytogenetics
... There is no clinical data in the only paper describing the fusion TCF3-TFPT, nor cytogenetic indications (Brambillasca et al., 1999); inv(19)(p13q13) has also be found in 3 cases of hairy cell leukemia (Haglund et al., 1994); the genes involved in these three patients are unknown; this inv(19) is li ...
... There is no clinical data in the only paper describing the fusion TCF3-TFPT, nor cytogenetic indications (Brambillasca et al., 1999); inv(19)(p13q13) has also be found in 3 cases of hairy cell leukemia (Haglund et al., 1994); the genes involved in these three patients are unknown; this inv(19) is li ...
Cell Structures and Functions
... • In plants, made of the polysaccharide cellulose as well as the proteins pectin and lignin. Actually 2 layers, depending on the cell function, the thicknesses of each vary. – Contain openings lined with membrane called Plasmodesmata, that allow things to enter the cell. • In fungi, made of nitrogen ...
... • In plants, made of the polysaccharide cellulose as well as the proteins pectin and lignin. Actually 2 layers, depending on the cell function, the thicknesses of each vary. – Contain openings lined with membrane called Plasmodesmata, that allow things to enter the cell. • In fungi, made of nitrogen ...
Gene Section RNF11 (ring finger protein 11) Atlas of Genetics and Cytogenetics
... anchoring via acylation is necessary in order for RNF11 to be post-translationally modified by the addition of several ubiquitin moieties (Santonico et al., 2010). Four serine (Ser) residues have been identified as murine RNF11 phosphorylation sites (Ser7, Ser14, Ser25, Ser54) with differences betwe ...
... anchoring via acylation is necessary in order for RNF11 to be post-translationally modified by the addition of several ubiquitin moieties (Santonico et al., 2010). Four serine (Ser) residues have been identified as murine RNF11 phosphorylation sites (Ser7, Ser14, Ser25, Ser54) with differences betwe ...
Introduction Quality Protein Maize (QPM) contains nearly twice as
... Introduction Quality Protein Maize (QPM) contains nearly twice as much usable protein as other maize grown in Kenya. The majority of people in Kenya depend on maize as their principal daily food, for weaning babies, and for feeding livestock. Unfortunately normal maize has one significant flaw, it l ...
... Introduction Quality Protein Maize (QPM) contains nearly twice as much usable protein as other maize grown in Kenya. The majority of people in Kenya depend on maize as their principal daily food, for weaning babies, and for feeding livestock. Unfortunately normal maize has one significant flaw, it l ...
Comparative Genomics
... Synteny exercise Go to the Synteny view in the location tab. 1. How many chromosomes in dog have syntenic regions to human chromosome 6? 2. Click „15 downstream genes‟. Are there missing dog homologues to the human gene ...
... Synteny exercise Go to the Synteny view in the location tab. 1. How many chromosomes in dog have syntenic regions to human chromosome 6? 2. Click „15 downstream genes‟. Are there missing dog homologues to the human gene ...
Just 15 years ago, the idea that proteins might be functional without
... as well. Forman-Kay also cautions that NMR studies of isolated disordered sequences, excised from larger proteins, may not reveal the whole story, and have led people to think that all disordered proteins ...
... as well. Forman-Kay also cautions that NMR studies of isolated disordered sequences, excised from larger proteins, may not reveal the whole story, and have led people to think that all disordered proteins ...
BIO 132: Genes and People
... Week 7 and 8: Illustrating how changes to the DNA sequence may or may not change the proteins made and therefore affect the traits of the next generation i.e. initiation of disease In class group assignment Topic 10: Cytogenetics Week 11: discussion of how chromosome ...
... Week 7 and 8: Illustrating how changes to the DNA sequence may or may not change the proteins made and therefore affect the traits of the next generation i.e. initiation of disease In class group assignment Topic 10: Cytogenetics Week 11: discussion of how chromosome ...
Proteins - davis.k12.ut.us
... Protein is made of chemical compounds called AMINO ACIDS There are 22 different amino acids, all but 9 are made in the body. The 9 must come from food sources. ...
... Protein is made of chemical compounds called AMINO ACIDS There are 22 different amino acids, all but 9 are made in the body. The 9 must come from food sources. ...
STUDYING PROTEIN DYNAMICS USING NMR Martin
... measurements (see CvHeijenoort1.pdf). Further examples will be encountered in the afternoon practical session. Residual dipolar couplings (RDCs) have emerged as a powerful addition to these techniques. The sensitivity of RDCs to the relative orientation of a pair of coupled spins has led to their ro ...
... measurements (see CvHeijenoort1.pdf). Further examples will be encountered in the afternoon practical session. Residual dipolar couplings (RDCs) have emerged as a powerful addition to these techniques. The sensitivity of RDCs to the relative orientation of a pair of coupled spins has led to their ro ...
7.27_genetics_lectur..
... Why we care if a medically significant trait shows a Mendelian inheritance pattern • Providing genetic counseling information for patients • Locating gene for medically important trait through positional cloning ...
... Why we care if a medically significant trait shows a Mendelian inheritance pattern • Providing genetic counseling information for patients • Locating gene for medically important trait through positional cloning ...
Protein regulation: The statistical theory of
... made through the use of NMR spectroscopy, which provides a variety of tools for characterizing the structure and dynamics of proteins3–6. Particularly attractive in this context is the use of chemical shifts, because these parameters can be measured with great accuracy and under a wide variety of di ...
... made through the use of NMR spectroscopy, which provides a variety of tools for characterizing the structure and dynamics of proteins3–6. Particularly attractive in this context is the use of chemical shifts, because these parameters can be measured with great accuracy and under a wide variety of di ...
Gene function
... Other types of RNA sequences also are important for development and regulation of gene expression (e.g., miRNAs, siRNA). Non-coding DNA sequences also function importantly in gene regulation (e.g., binding sites for transcription etc.). Ultimately, the # of genes in not so important. This # is remar ...
... Other types of RNA sequences also are important for development and regulation of gene expression (e.g., miRNAs, siRNA). Non-coding DNA sequences also function importantly in gene regulation (e.g., binding sites for transcription etc.). Ultimately, the # of genes in not so important. This # is remar ...
PP076 Allergenicity assessment strategy for novel food proteins and
... use of the “weight-of-evidence approach” for food derived from GM plants were consulted. Results: A new conceptual strategy is developed for assessing the allergenicity of novel proteins (Figure 1). Discussion: Allergenicity risk assessment might pose some major difficulties in case of approval of n ...
... use of the “weight-of-evidence approach” for food derived from GM plants were consulted. Results: A new conceptual strategy is developed for assessing the allergenicity of novel proteins (Figure 1). Discussion: Allergenicity risk assessment might pose some major difficulties in case of approval of n ...
ProSEC 300S
... Proteins are complex molecules that contain ionic as well as hydrophobic and hydrophilic amino acids. Proteins are monodisperse (contain species of a single molecular weight) but are often analyzed as complex mixtures with components that range in size from small to extremely large. ...
... Proteins are complex molecules that contain ionic as well as hydrophobic and hydrophilic amino acids. Proteins are monodisperse (contain species of a single molecular weight) but are often analyzed as complex mixtures with components that range in size from small to extremely large. ...
View/Open - JEWLScholar@MTSU
... •Not all genes in the genome are expressed in every cell. •Regulation of gene expression can occur at many levels including transcription, splicing, nuclear export, RNA decay, and translation. •Alternative mRNA splicing, which is a common gene regulation mechanism in eukaryotes, occurs when one gene ...
... •Not all genes in the genome are expressed in every cell. •Regulation of gene expression can occur at many levels including transcription, splicing, nuclear export, RNA decay, and translation. •Alternative mRNA splicing, which is a common gene regulation mechanism in eukaryotes, occurs when one gene ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.