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Antiporter-lika proteinsubenheter i andningskedjans Komplex I
Antiporter-lika proteinsubenheter i andningskedjans Komplex I

... responsible for salt balance and for maintaining a neutral cytoplasmic pH at alkaline growth conditions. Since NuoL, NuoM and NuoN show similarities to that kind of antiporters, they are most likely involved in the proton transport machinery. NuoL is more similar to MrpA and NuoM and NuoN are more s ...
Slide 1
Slide 1

... • Capsid- Protein coat that encapsidates the virus. • Nucleocapsid-Capsid with genome inside (plus anything else that may be inside like enzymes and other viral proteins for some viruses). Capsid functions 1. Protect genome from outside environment (May include damaging UV-light, shearing forces, nu ...
BIOCHEMISTRY - Mexico Central School District
BIOCHEMISTRY - Mexico Central School District

... Examples: insulin, hemoglobin, and enzymes. ...
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... Lipids do not dissolve in water but do dissolve in oils Candy, red meats, fried foods, dairy products ...
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... The Golgi apparatus is a stack of flattened membrane sacs, but they are not interconnected like ER stacks. Golgi receives, modifies and segregates different proteins. a. Some of the proteins modified and sorted by the Golgi are parts of membranes (such as channel proteins or receptor molecules), som ...
Presentation - University of Evansville Faculty Web sites
Presentation - University of Evansville Faculty Web sites

... The Golgi apparatus is a stack of flattened membrane sacs, but they are not interconnected like ER stacks. Golgi receives, modifies and segregates different proteins. a. Some of the proteins modified and sorted by the Golgi are parts of membranes (such as channel proteins or receptor molecules), som ...
Gene Section LYL1 (lymphoblastic leukemia derived sequence 1) in Oncology and Haematology
Gene Section LYL1 (lymphoblastic leukemia derived sequence 1) in Oncology and Haematology

... bone marrow cells in the majority of cases of acute myeloblastic leukemia (AML) or myelodysplastic syndrome when compared to normal bone marrow. This study also showed that LYL1 was highly expressed in most AML cell lines and in CD34(+) AML cells. ...
PowerPoint
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... There are two populations of membrane proteins. Integral proteins ‫ ُمندَمج‬penetrate the hydrophobic core of the lipid bilayer (transmembrane protein). The integral proteins has a middle area, hydrophobic regions with surface area, in contact with the nonpolar amino acids. And aqueous environment, ...
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Protein Synthesis

... What is a Protein? • Proteins are made of 20 different amino acids • The sequence (pattern) of amino acids will vary between each protein • The sequence of an amino acid will tell its shape, how to fold and its function (job) ...
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poster - Computer Science and Engineering

... RNA molecules play diverse functional and structural roles in cells: ...
Controlling Gene Expression
Controlling Gene Expression

... There are four levels of control: ◦ transcriptional (controls transcription from DNA to mRNA) ◦ posttranscriptional (controls the removal of introns) ◦ translational (controls rate that mRNA is activated through ribosomes) ◦ posttranslational (affects the rate proteins can leave the cell) ...
12. Chau Vu.- Treacher Collins Syndrome
12. Chau Vu.- Treacher Collins Syndrome

...  AddiIonal  eye  abnormaliIes  that  can  lead  to  vision  loss.      absent,  small,  or  unusually  formed  ears.      Defects  in  the  middle  ear  cause  hearing  loss  in  about  half  of  cases.      usually  have  normal ...
ASE FS21 GM handout (DOC 756Kb)
ASE FS21 GM handout (DOC 756Kb)

... What you have just done is a simple exercise in bioinformatics. Using a lot more information and a lot more computing power you could predict the function of a protein from only knowing the DNA sequence. This is one of the uses of the DNA ...
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... • QRT-PCR data support the previous hypothesis that AFND is caused by dysregulation of the hedgehog pathway ...
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... link and fold together to form a 3-dimensional protein • Proteins differ in number and sequence of aa • Protein structure determines their function ...
Chemical biology beyond binary codes
Chemical biology beyond binary codes

... dimer of the Phe36Met mutant and most interestingly, the interaction is between one of the `effector' loops (necessary for binding to the FK506^FKBP12 target calcineurin) and the FK506 binding site [1]. The FKBP-Met36 mutant could be used in an alternative, negative dimerization system, complementar ...
Gene Section HSPA8 (heat shock 70kDa protein 8) in Oncology and Haematology
Gene Section HSPA8 (heat shock 70kDa protein 8) in Oncology and Haematology

... includes other three members: the HSP70, the glucose-regulated protein 78 (GRP78), and HSP75. Human HSC70 shares 85% amino acid similarity with HSP70 (Ali et al., 2003). They have similar functions and interact with each other in an ATP-dependent manner. HSC70 can form a stable complex with newly sy ...
“Doing science is like doing puzzles,” according to Dr
“Doing science is like doing puzzles,” according to Dr

... to observe only one component: we need to observe how many parts are integrated and work together. It is the same with genes and their system of operation. In the past, scientists were able to study only one gene at a time, but by working with yeast and then later with human cells, Dr. Snyder develo ...
Solid Tumour Section Soft tissue chondroma with t(3;12)(q27;q15) in Oncology and Haematology
Solid Tumour Section Soft tissue chondroma with t(3;12)(q27;q15) in Oncology and Haematology

... and 3 LIM domains in its C-terminal. Exons 3-7 encode the proline-rich domain. Exon 8 encodes the LIM1 domain and exon 9 encodes the LIM2 domain. Exon 10 and parts of exon 11 encode the LIM3 domain. The LPP protein is a member of the zyxin family (also referred to as 'group 3') of LIM domain protein ...
Scheme of work for Chapter 7, Nucleic acids and proteins
Scheme of work for Chapter 7, Nucleic acids and proteins

... Extension: Q5 Support: Q6 ...
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B1: Cell Structure

... 1. What does the cell theory state? – All living things are made up of cells – The cell is also the functional unit of life – All living cells come from pre-existing cells ...
Bioinformatics and Personal Health/Intro computer lab
Bioinformatics and Personal Health/Intro computer lab

... transcriptional repressors. When the hormone GA is absent the GRAS domain binds transcription factors, inactivating them. When GA is present the DELLA domain binds the protein GID1. This binding causes the DELLA protein to be tagged for degradation (using ubiquitination). With DELLA proteins degrade ...
Plasma Proteins - neutralposture
Plasma Proteins - neutralposture

... It is about 25 mm Hg, & 80% of it is contributed by albumin. ii. According to Starling’s hypothesis, at the capillary end the BP or hydrostatic pressure expels water out, & effective osmotic pressure (EOP) takes water into the ...
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MHC II Function - Andrew Pierce -

... RFX (trimer of RFXANK, RFX5 and RFXAP) CREB (cAMP response element binding protein) NF-Y (trimer of A, B and C subunits) OCAB (“octamer” binding protein) CIITA – MHCII Transactivator; acts as transcriptional “integrator” BRG1 – Brahma-related gene 1; ATPase involved in remodeling nucleosome structur ...
Leukaemia Section t(14;15)(q32;q11-13) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(14;15)(q32;q11-13) Atlas of Genetics and Cytogenetics in Oncology and Haematology

... expression in lymphoid tissues, whereas BCL8 expression is not normally found in hematopoietic tissues. ...
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Protein moonlighting



Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.
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