Snails, Synapses and Smokers
... news and views conclusions about the agonist-binding site. First, it is defined by several discontinuous regions of amino-acid sequence, known as loops. The main loops are A–C on the asubunit and D on the g- or d-subunit, so the agonist-binding site spans an interface between subunits. Loops E and ...
... news and views conclusions about the agonist-binding site. First, it is defined by several discontinuous regions of amino-acid sequence, known as loops. The main loops are A–C on the asubunit and D on the g- or d-subunit, so the agonist-binding site spans an interface between subunits. Loops E and ...
INTERPRO An integrated resource of protein families
... The Sch9 protein kinase regulates Hsp90dependent signal transduction activity in the budding yeast Saccharomyces cerevisiae. This interaction was suppressed by decreased signaling through the protein kinase A (PKA) signal transduction pathway. Text is unstructured –needs to be divided into entities ...
... The Sch9 protein kinase regulates Hsp90dependent signal transduction activity in the budding yeast Saccharomyces cerevisiae. This interaction was suppressed by decreased signaling through the protein kinase A (PKA) signal transduction pathway. Text is unstructured –needs to be divided into entities ...
Journal of Bacteriology
... protein is exposed to the periplasmic side of the outer membrane and thus that the amino terminus of the PhoE protein part of the hybrid molecule faces the periplasm. However, an alternative possibility should be considered, i.e., the first residue of the PhoE protein part could be on the outside su ...
... protein is exposed to the periplasmic side of the outer membrane and thus that the amino terminus of the PhoE protein part of the hybrid molecule faces the periplasm. However, an alternative possibility should be considered, i.e., the first residue of the PhoE protein part could be on the outside su ...
Abstract
... identified with ESI Q-TOF MS/MS. Of this protein spot, three peptides are found to match a germin-like protein 6 (AAC04837, Fig. 5). The germin-like protein 6 was reported to be related to the oxalate oxidase of wheat and barley (Membre and Bernier, 1998), but its function is still unknown. We name ...
... identified with ESI Q-TOF MS/MS. Of this protein spot, three peptides are found to match a germin-like protein 6 (AAC04837, Fig. 5). The germin-like protein 6 was reported to be related to the oxalate oxidase of wheat and barley (Membre and Bernier, 1998), but its function is still unknown. We name ...
PDF - Oxford Academic - Oxford University Press
... encoding the C-terminal two thirds of the Rad31 protein, was replaced by the ura4 gene by the method described by Barbet et al. (16). Since this construct also removed 1.2 kb of sequence 3′ to the rad31 gene and potentially disrupted other coding sequences a second construct was prepared by cloning ...
... encoding the C-terminal two thirds of the Rad31 protein, was replaced by the ura4 gene by the method described by Barbet et al. (16). Since this construct also removed 1.2 kb of sequence 3′ to the rad31 gene and potentially disrupted other coding sequences a second construct was prepared by cloning ...
Chlamydomonas reinhardtii strains carrying the stb1-1
... The original mutant strains I73 (sta4-1) and I97 (sta4-2) were transformed with the complete PHOB genomic fragment amplified by PCR and cloned in the pSL18 plasmid (see methods). The paromomycin resistant clones were screened by zymogram (a). Three complementated strains were obtained from 23 resist ...
... The original mutant strains I73 (sta4-1) and I97 (sta4-2) were transformed with the complete PHOB genomic fragment amplified by PCR and cloned in the pSL18 plasmid (see methods). The paromomycin resistant clones were screened by zymogram (a). Three complementated strains were obtained from 23 resist ...
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... detergents are removed. 1.3.4 Integral proteins usually have one or more domains rich in hydrophobic amino acid residues. 1.3.5 Transmembrane domains of a protein can be predicted with reasonable accuracy through hydropathy plotting. ...
... detergents are removed. 1.3.4 Integral proteins usually have one or more domains rich in hydrophobic amino acid residues. 1.3.5 Transmembrane domains of a protein can be predicted with reasonable accuracy through hydropathy plotting. ...
pARA and pKAN-R
... naturally in bacterial cells. The plasmids used in molecular biology have been modified through genetic engineering to facilitate gene cloning and protein production (gene expression) in bacteria. Antibiotic resistant genes have been engineered into these plasmids and function as selectable markers— ...
... naturally in bacterial cells. The plasmids used in molecular biology have been modified through genetic engineering to facilitate gene cloning and protein production (gene expression) in bacteria. Antibiotic resistant genes have been engineered into these plasmids and function as selectable markers— ...
Protein Synthesis: Translation
... 2) A special protein binds to the stop codon at the A site. 3) The newly-formed polypeptide is released. The tRNAs are released. The two ribosome subunits separate. ...
... 2) A special protein binds to the stop codon at the A site. 3) The newly-formed polypeptide is released. The tRNAs are released. The two ribosome subunits separate. ...
viewpoint - Lindquist Lab
... basic concepts in immunology and revive, at least in part, the template theory—obviously the tertiary structure and function of a protein is not determined solely by its amino-acid sequence (Bussard, 2003). Similarly, Lindquist’s work on the role of [PS1+] in adapting to new environmental conditions ...
... basic concepts in immunology and revive, at least in part, the template theory—obviously the tertiary structure and function of a protein is not determined solely by its amino-acid sequence (Bussard, 2003). Similarly, Lindquist’s work on the role of [PS1+] in adapting to new environmental conditions ...
Making Plastic - South Dakota School of Mines and Technology
... Altered shape Denaturation Loss of biological activity ...
... Altered shape Denaturation Loss of biological activity ...
Genome Biology and
... – Target genes are highly enriched for functions related to DNA replication, budding and the cell cycle – In vivo binding sites are highly enriched for sequences matching the defined consensus binding sites ...
... – Target genes are highly enriched for functions related to DNA replication, budding and the cell cycle – In vivo binding sites are highly enriched for sequences matching the defined consensus binding sites ...
Update on “Death by Veganism” by Nina Planck
... tubers, because they contain all the essential amino acids needed for life in the right ratio. This is not true of plant proteins, which are inferior in quantity and quality — even soy. The scientific truth is: Proteins function as structural materials which build the scaffoldings that maintain cell ...
... tubers, because they contain all the essential amino acids needed for life in the right ratio. This is not true of plant proteins, which are inferior in quantity and quality — even soy. The scientific truth is: Proteins function as structural materials which build the scaffoldings that maintain cell ...
Identification of genes and proteins involved in the
... With this aim in view, we used a proteomic strategy to investigate the regulatory cellular network involved in the adaptation to a high concentration of arsenic in Caenibacter arsenoxydans strain ULPAs1 [5], an arsenic resistant βproteobacterium. Proteome expression profiling constitutes an attracti ...
... With this aim in view, we used a proteomic strategy to investigate the regulatory cellular network involved in the adaptation to a high concentration of arsenic in Caenibacter arsenoxydans strain ULPAs1 [5], an arsenic resistant βproteobacterium. Proteome expression profiling constitutes an attracti ...
Exploring a Protein Structure in the RCSB PDB: Major
... with the students. Note that there are a few PDB entries listed throughout the feature. For example, PDB entry 1igt can be linked from ...
... with the students. Note that there are a few PDB entries listed throughout the feature. For example, PDB entry 1igt can be linked from ...
Solid Tumour Section Soft tissue tumors:
... Macroscopic findings: the tumour presents as lobulated or multinodular mass, generally well circumscribed by a distinct fibrous capsule. The size of the tumour at the time of diagnosis may vary from 1 to about 20 cm (mean size: about 7 cm). Histology: typically, tumour nodules are composed of round ...
... Macroscopic findings: the tumour presents as lobulated or multinodular mass, generally well circumscribed by a distinct fibrous capsule. The size of the tumour at the time of diagnosis may vary from 1 to about 20 cm (mean size: about 7 cm). Histology: typically, tumour nodules are composed of round ...
Gene Section RPL26 (ribosomal protein L26) Atlas of Genetics and Cytogenetics
... (rRNAs) and approximately 80 ribosomal proteins, ribosomal protein L26 is associated with the 60S subunit of the ribosome. The ratio of rRNAs to ribosomal proteins is tightly regulated within the cell. An excess or reduction in either component can disrupt ribosome assembly. In a recent study invest ...
... (rRNAs) and approximately 80 ribosomal proteins, ribosomal protein L26 is associated with the 60S subunit of the ribosome. The ratio of rRNAs to ribosomal proteins is tightly regulated within the cell. An excess or reduction in either component can disrupt ribosome assembly. In a recent study invest ...
bio12_sm_02_2
... chemicals used in cellular communication. Attachment and recognition proteins act as attachment points for structural elements such as the cytoskeleton or as recognition sites for foreign substances such as microbes. 10. They both detect molecules and perform an action in response. They both recogni ...
... chemicals used in cellular communication. Attachment and recognition proteins act as attachment points for structural elements such as the cytoskeleton or as recognition sites for foreign substances such as microbes. 10. They both detect molecules and perform an action in response. They both recogni ...
Biology Biochemistry
... o Long chains of amino acids are called __________________________________. Amino acids are all composed of the same _____________, _________________ and central __________________ structure. The difference between amino acid monomers is due to each amino acid having a different ____________________ ...
... o Long chains of amino acids are called __________________________________. Amino acids are all composed of the same _____________, _________________ and central __________________ structure. The difference between amino acid monomers is due to each amino acid having a different ____________________ ...
Research group: MariZyme
... Streptcoccus pyogenes bacteria4. The bacteria were preincubated with 10 and 20 U/ml concentrations of Penzyme (Fig.1) followed by incubation on cell monolayers. The results demonstrated that Penzyme reduces cell adhesion of all the bacteria tested. Penzyme showed high efficacy against MRSA adhesion. ...
... Streptcoccus pyogenes bacteria4. The bacteria were preincubated with 10 and 20 U/ml concentrations of Penzyme (Fig.1) followed by incubation on cell monolayers. The results demonstrated that Penzyme reduces cell adhesion of all the bacteria tested. Penzyme showed high efficacy against MRSA adhesion. ...
Functional analysis of the Drosophila Dnop5 gene using targeted RNA interference
... expression of Dnop5 throughout development and better study the function of this protein. We generated transformant lines carrying the transgene UAS- Dnop5.IR. This construct led to the synthesis of double-stranded RNA under the control of the GAL4-UAS (Figure 2A). Induction of the Dnop5 dsRNA synth ...
... expression of Dnop5 throughout development and better study the function of this protein. We generated transformant lines carrying the transgene UAS- Dnop5.IR. This construct led to the synthesis of double-stranded RNA under the control of the GAL4-UAS (Figure 2A). Induction of the Dnop5 dsRNA synth ...
Molecules of Life
... array held in place by hydrogen bonds (dotted lines) between different parts of the polypeptide chain. ...
... array held in place by hydrogen bonds (dotted lines) between different parts of the polypeptide chain. ...
Ch4Carbonand5Macromolecules
... • Polar and non-polar amino acids are relevant to the bonds formed between R groups. • Students should know that most organisms use the same 20 amino acids in the same genetic code although there are some exceptions. Specific examples could be used for illustration. ...
... • Polar and non-polar amino acids are relevant to the bonds formed between R groups. • Students should know that most organisms use the same 20 amino acids in the same genetic code although there are some exceptions. Specific examples could be used for illustration. ...
Document
... array held in place by hydrogen bonds (dotted lines) between different parts of the polypeptide chain. ...
... array held in place by hydrogen bonds (dotted lines) between different parts of the polypeptide chain. ...
Gene discovery within the planctomycete division of the domain
... Sequence tags from G. obscuriglobus and Pi. marina that represent putative protein-coding genes were identified by comparison of individual clone nucleotide sequence translated in all reading frames against protein-sequence databases using the BLASTX algorithm (Tables 1,2). Only sequence matches wit ...
... Sequence tags from G. obscuriglobus and Pi. marina that represent putative protein-coding genes were identified by comparison of individual clone nucleotide sequence translated in all reading frames against protein-sequence databases using the BLASTX algorithm (Tables 1,2). Only sequence matches wit ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.