Solid Tumour Section Thyroid: Papillary carcinoma with inv(7)(q21q34) in Oncology and Haematology
... tumor of thyroid follicular cell origin and is the most common thyroid malignancy, constituting about 80% of all cases. The only known etiologic factor for this type of tumor is exposure to ionizing radiation, although the history of radiation exposure is found in less than 10% of all cases. In the ...
... tumor of thyroid follicular cell origin and is the most common thyroid malignancy, constituting about 80% of all cases. The only known etiologic factor for this type of tumor is exposure to ionizing radiation, although the history of radiation exposure is found in less than 10% of all cases. In the ...
Recent advances in technology for measuring and manipulating cell
... dimensions about two orders of magnitude closer than colocalization via standard optical imaging resolution. FRET is detectable by quenching of the donor emission, sensitized emission from the acceptor, decreased excited-state lifetime, or increased resistance to bleaching of the donor. Within the k ...
... dimensions about two orders of magnitude closer than colocalization via standard optical imaging resolution. FRET is detectable by quenching of the donor emission, sensitized emission from the acceptor, decreased excited-state lifetime, or increased resistance to bleaching of the donor. Within the k ...
Inner nuclear membrane protein transport is mediated by multiple
... The contradictions in the studies published to date indicate that the targeting of INM proteins is much more complex than first assumed. Either a heretofore unclear mechanism exists that can somehow account for all these data or multiple translocation mechanisms exist and each individual INM protein ...
... The contradictions in the studies published to date indicate that the targeting of INM proteins is much more complex than first assumed. Either a heretofore unclear mechanism exists that can somehow account for all these data or multiple translocation mechanisms exist and each individual INM protein ...
Lecture 4: Mutant Characterization I Mutation types (and molecular
... Homework#1 will be posted today! ...
... Homework#1 will be posted today! ...
Document
... # These centrifuges are run in batch to isolate small volumes of biological macromolecules or cells. ...
... # These centrifuges are run in batch to isolate small volumes of biological macromolecules or cells. ...
Review Article
... required to maintain the activity of adenylate cyclase, encoded by CDC35, at levels sufficient to overcome the hydrolysis of cAMP by phosphodiesterase (Nikawa et al., 1987). The Ras proteins themselves serve as a focal point for the regulation of adenylate cyclase, being positively regulated by the ...
... required to maintain the activity of adenylate cyclase, encoded by CDC35, at levels sufficient to overcome the hydrolysis of cAMP by phosphodiesterase (Nikawa et al., 1987). The Ras proteins themselves serve as a focal point for the regulation of adenylate cyclase, being positively regulated by the ...
Human Cytomegalovirus UL34 Early and late Proteins Are Essential
... There is no UL34 binding site within the major immediate early gene, and in studies utilizing transient expression assays, UL34 has no activating or repressing effect on the mIE promoter [9]. Consequently, the reduction in IE2 transcript levels seen in the absence of UL34 proteins suggests that UL34 ...
... There is no UL34 binding site within the major immediate early gene, and in studies utilizing transient expression assays, UL34 has no activating or repressing effect on the mIE promoter [9]. Consequently, the reduction in IE2 transcript levels seen in the absence of UL34 proteins suggests that UL34 ...
final_report_columns
... deficits. These deficits represent substitutions that would have occurred if the element were neutral DNA, but did not occur because the element has been under functional constraint. These deficits are refered as "Rejected Substitutions". Rejected substitutions are a natural measure of constraint th ...
... deficits. These deficits represent substitutions that would have occurred if the element were neutral DNA, but did not occur because the element has been under functional constraint. These deficits are refered as "Rejected Substitutions". Rejected substitutions are a natural measure of constraint th ...
The Methylosome, a 20S Complex Containing JBP1 and pICln
... transferred to the SMN complex in vitro. Together with previous results, these data indicate that methylation of Sm proteins by the methylosome directs Sm proteins to the SMN complex for assembly into snRNP core particles and suggest that the methylosome can regulate snRNP assembly. ters Sm proteins ...
... transferred to the SMN complex in vitro. Together with previous results, these data indicate that methylation of Sm proteins by the methylosome directs Sm proteins to the SMN complex for assembly into snRNP core particles and suggest that the methylosome can regulate snRNP assembly. ters Sm proteins ...
Journal of Molecular Biology
... uptake of inorganic phosphate, phosphorylated compounds and of some other negatively charged solutes (Overbeeke & Lugtenberg, 1982; Korteland et al , 1982; H. Nikaido, E. Y. Rosenberg & ,I. Foulds, unpublished results) a property for which a recognition site for such compounds on the PhoE protein (O ...
... uptake of inorganic phosphate, phosphorylated compounds and of some other negatively charged solutes (Overbeeke & Lugtenberg, 1982; Korteland et al , 1982; H. Nikaido, E. Y. Rosenberg & ,I. Foulds, unpublished results) a property for which a recognition site for such compounds on the PhoE protein (O ...
Role of plectin in cytoskeleton organization and dynamics
... antibodies, for instance due to the expression of differentially spliced transcripts, or contain the protein in a form in which the epitopes of the antibodies tested were inaccessible. The widespread expression of plectin has been confirmed by RNase protection assays using cDNA representative of a v ...
... antibodies, for instance due to the expression of differentially spliced transcripts, or contain the protein in a form in which the epitopes of the antibodies tested were inaccessible. The widespread expression of plectin has been confirmed by RNase protection assays using cDNA representative of a v ...
Mutations in the CFTR protein
... example, no consideration was paid to frameshifts, mutations into stop codons, mutations causing promoter or splicing errors, or large deletions or insertions. Rather, single amino acid substitutions, insertions, and deletions were examined to find the exact area of the protein that is important fo ...
... example, no consideration was paid to frameshifts, mutations into stop codons, mutations causing promoter or splicing errors, or large deletions or insertions. Rather, single amino acid substitutions, insertions, and deletions were examined to find the exact area of the protein that is important fo ...
ID helix-loop-helix proteins - Journal of Cell Science
... The helix-loop-helix (HLH) family of transcription factors comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrat ...
... The helix-loop-helix (HLH) family of transcription factors comprises >200 members, which have been identified in organisms from yeast to man (reviewed in Littlewood and Evan, 1995; Massari and Murre, 2000). In metazoa, HLH proteins function in the coordinate regulation of gene expression, orchestrat ...
Protein aggregation in bacteria: the thin boundary
... amorphous. This observation does not dismiss the fact that IBs might indeed have an amyloid structure, because even amyloids do not incorporate their entire polypeptide length into the highly packed b-sheet structure as seen in yeast prions (Morgan et al., 2008). The secondary structure content anal ...
... amorphous. This observation does not dismiss the fact that IBs might indeed have an amyloid structure, because even amyloids do not incorporate their entire polypeptide length into the highly packed b-sheet structure as seen in yeast prions (Morgan et al., 2008). The secondary structure content anal ...
Protein Localization Analysis of Essential Genes in Prokaryotes
... genes is becoming an increasingly appealing issue not only because it will shed new light on the understanding of life at its simplest level, but also because it has much significance in practical use such as pharmaceutics and synthetic biology5–7. An intuitive way to identify an essential gene is t ...
... genes is becoming an increasingly appealing issue not only because it will shed new light on the understanding of life at its simplest level, but also because it has much significance in practical use such as pharmaceutics and synthetic biology5–7. An intuitive way to identify an essential gene is t ...
Nuclear Localization and Interaction with COP1 Are Required for
... phenotype, and therefore argue that the localization of BBX24 in the nucleus is essential to fulfill its function in the light-dependent hypocotyl elongation. As already mentioned, BBX24 confers tolerance to yeast cells growing on lithium chloride (LiCl) media (Lippuner et al., 1996). To verify into ...
... phenotype, and therefore argue that the localization of BBX24 in the nucleus is essential to fulfill its function in the light-dependent hypocotyl elongation. As already mentioned, BBX24 confers tolerance to yeast cells growing on lithium chloride (LiCl) media (Lippuner et al., 1996). To verify into ...
Section 16.2
... 16.1 Prokaryotes Regulate Gene Expression in Response to Environmental Conditions 16.2 Lactose Metabolism in E. coli Is Regulated by an Inducible System ...
... 16.1 Prokaryotes Regulate Gene Expression in Response to Environmental Conditions 16.2 Lactose Metabolism in E. coli Is Regulated by an Inducible System ...
pptx - Fenyo Lab
... •Genomic, proteome studies typically use a reference database to model the general population, masking patient specific variation ...
... •Genomic, proteome studies typically use a reference database to model the general population, masking patient specific variation ...
Structure and function of tomato disease resistance proteins van
... limited number of R proteins acts extracellularly and they contain a predicted extracellular LRR (eLRR) domain at their N-terminus. This eLRR is connected via a transmembrane domain to a variable cytoplasmic C-terminal region. When the cytoplasmic domain contains a protein kinase domain the R protei ...
... limited number of R proteins acts extracellularly and they contain a predicted extracellular LRR (eLRR) domain at their N-terminus. This eLRR is connected via a transmembrane domain to a variable cytoplasmic C-terminal region. When the cytoplasmic domain contains a protein kinase domain the R protei ...
7.06 Cell Biology EXAM #3 KEY
... active signal peptidase, so the N-terminal sequence that is usually cut off from signal peptidase cannot be cut off. This means that there will be extra amino acids on the N terminus of signal peptidase, which may interfere with its folding. Second, the cytoplasm is a very different environment than ...
... active signal peptidase, so the N-terminal sequence that is usually cut off from signal peptidase cannot be cut off. This means that there will be extra amino acids on the N terminus of signal peptidase, which may interfere with its folding. Second, the cytoplasm is a very different environment than ...
A Lipid Droplet Protein of Nannochloropsis with
... shown in Figure 3, E to H, even though the two lines did not show LD size reduction to the same extent. Whereas line R5-5 produced embryos with no oversized LDs, in line R3-4, smaller LDs were found interspersed with larger LDs. This result can be explained by lower expression levels of the LDSPHis ...
... shown in Figure 3, E to H, even though the two lines did not show LD size reduction to the same extent. Whereas line R5-5 produced embryos with no oversized LDs, in line R3-4, smaller LDs were found interspersed with larger LDs. This result can be explained by lower expression levels of the LDSPHis ...
Interpro - European Bioinformatics Institute
... – what are these proteins; to what family do they belong? – what is their function; how can we explain this in structural terms? ...
... – what are these proteins; to what family do they belong? – what is their function; how can we explain this in structural terms? ...
A New Method to Detect Related Function Among Proteins
... Approaches operating independent of bound ligands have been described by Fischer et al.41 and Rosen et al.42 They use geometric hashing for similarity searching, but different parameters are used to describe the binding site. Fischer et al. use SURFNET spheres43 to generate a negative image of the a ...
... Approaches operating independent of bound ligands have been described by Fischer et al.41 and Rosen et al.42 They use geometric hashing for similarity searching, but different parameters are used to describe the binding site. Fischer et al. use SURFNET spheres43 to generate a negative image of the a ...
Identification and Characterization of a Novel Human Testis
... physiology, most probably in the process of spermatogenesis or spermiogenesis. © 2001 Academic Press Key Words: kinase substrates; testis-specific genes; gene mapping; gene characterization; TSKS; testisspecific kinase substrate; RRAS; IRF3; testicular cancer. ...
... physiology, most probably in the process of spermatogenesis or spermiogenesis. © 2001 Academic Press Key Words: kinase substrates; testis-specific genes; gene mapping; gene characterization; TSKS; testisspecific kinase substrate; RRAS; IRF3; testicular cancer. ...
NMR spectroscopy brings invisible protein states into
... rotations about unhindered dihedral angles16, to substantial chain displacements17. In some favorable cases such picosecond to nanosecond dynamics can be inferred from temperature factors derived from crystal structures18 or often more rigorously from NMR spin relaxation properties19–22. In addition ...
... rotations about unhindered dihedral angles16, to substantial chain displacements17. In some favorable cases such picosecond to nanosecond dynamics can be inferred from temperature factors derived from crystal structures18 or often more rigorously from NMR spin relaxation properties19–22. In addition ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.