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08_PopulationGenetics
08_PopulationGenetics

... 1. If the frequency of two alleles in a gene pool is 90% A and 10% a, what is the frequency of individuals in the population with the genotype Aa? ...
Modifier genes in Huntington`s desease - Ruhr
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... The main goal of the study was finding new AO associations in carefully chosen candidate genes which are involved in mitochondrial functions and partially, evaluating previously reported associations. Three previously reported SNPs from the ADORA2A, HAP1 and OGG1 genes were analysed. No association ...
q 2 - University of Evansville Faculty Web sites
q 2 - University of Evansville Faculty Web sites

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... Explain Mendel’s principle of dominance. What is the gene that is not expressed called? What do upper and lower case symbolize? What do heterozygous and homozygous mean, in terms of letters?  Make a Punnett square showing a cross between 2 heterozygous purple flower pea plants. HINT: Purple is domi ...
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... Crossing Over leads to genetic variation. Homologous chromosomes contain the same genetic information, they code for the same trait. Ex: eye color. Random Assortment of Chromosomes states that chromosomes are __________ assorted to create __________ cells. Thus your sex cells contain chromosomes fr ...
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... • Much of this pattern of variation is largely shaped by the genetic drift of effectively neutral alleles (the marker alleles) • Hence, molecular variation is a snap-shot of the neutral variation – All loci equally influenced by demography ...
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... accurate enough, there won't be two individuals with the same measurement. In such a popu­ lation variation is said to be continuous with individuals having the average expression most common. Characters of this nature which show a continuous range of variability from one extreme to the other are re ...
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... Geologists theorize that a geologic “hot spot” of upwelling magma has been drifting westward for the past 20 million years, gradually forming the islands as it moves. Thus the MOST EASTERN island, LANZAROTE, is the oldest, while the smaller western island, HIERRO, is the youngest (about 0.8 million ...
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Natural selection - Mercer Island School District
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J.J. Bryan, V.L. Vance, M. Bauchet, C.L. Mouritsen

... , USA residents with Northern and Western Europe ancestry from the CEPH collection and TSI-Toscani in Italia); Asia (CHB – Han Chinese in Beijing, China; CHD –Denver, USA residents with Han Chinese ancestry from the CEPH collection; JPT-Japanese in Tokyo, Japan); India Subcontinent (GIH - Gujarati I ...
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Human genetic variation



Human genetic variation is the genetic differences both within and among populations. There may be multiple variants of any given gene in the human population (genes), leading to polymorphism. Many genes are not polymorphic, meaning that only a single allele is present in the population: the gene is then said to be fixed. On average, in terms of DNA sequence all humans are 99.9% similar to any other humans.No two humans are genetically identical. Even monozygotic twins, who develop from one zygote, have infrequent genetic differences due to mutations occurring during development and gene copy-number variation. Differences between individuals, even closely related individuals, are the key to techniques such as genetic fingerprinting. Alleles occur at different frequencies in different human populations, with populations that are more geographically and ancestrally remote tending to differ more.Causes of differences between individuals include the exchange of genes during meiosis and various mutational events. There are at least two reasons why genetic variation exists between populations. Natural selection may confer an adaptive advantage to individuals in a specific environment if an allele provides a competitive advantage. Alleles under selection are likely to occur only in those geographic regions where they confer an advantage. The second main cause of genetic variation is due to the high degree of neutrality of most mutations. Most mutations do not appear to have any selective effect one way or the other on the organism. The main cause is genetic drift, this is the effect of random changes in the gene pool. In humans, founder effect and past small population size (increasing the likelihood of genetic drift) may have had an important influence in neutral differences between populations. The theory that humans recently migrated out of Africa supports this.The study of human genetic variation has both evolutionary significance and medical applications. It can help scientists understand ancient human population migrations as well as how different human groups are biologically related to one another. For medicine, study of human genetic variation may be important because some disease-causing alleles occur more often in people from specific geographic regions. New findings show that each human has on average 60 new mutations compared to their parents.Apart from mutations, many genes that may have aided humans in ancient times plague humans today. For example, it is suspected that genes that allow humans to more efficiently process food are those that make people susceptible to obesity and diabetes today.
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