Twins take the job
... Analysis of hDIS3L1 and hDIS3 protein sequences indicates that some conserved amino acids essential for the endonucleolytic activity have been substituted in the PIN domain of hDIS3L1. Biochemical studies with hDIS3 and hDIS3L1, purified from transiently transfected or stable cell lines, confirm tha ...
... Analysis of hDIS3L1 and hDIS3 protein sequences indicates that some conserved amino acids essential for the endonucleolytic activity have been substituted in the PIN domain of hDIS3L1. Biochemical studies with hDIS3 and hDIS3L1, purified from transiently transfected or stable cell lines, confirm tha ...
ATR Regulates a G2-Phase Cell-Cycle Checkpoint
... Here, we investigate the effects of an ATR T-DNA insertion allele in the plant Arabidopsis. The allele has a 6-kb insertion within the kinase domain and is presumably null. We find that the mutant plant (atr) is viable and developmentally normal in the absence of exogenous DNA-damaging treatments bu ...
... Here, we investigate the effects of an ATR T-DNA insertion allele in the plant Arabidopsis. The allele has a 6-kb insertion within the kinase domain and is presumably null. We find that the mutant plant (atr) is viable and developmentally normal in the absence of exogenous DNA-damaging treatments bu ...
PDF - ScienceAsia
... WHP 100/120 mesh) and a flame-ionization detector set at 200 °C. Helium was used as the carrier gas. The oven temperature protocol was to hold at 65 °C for 5 min, increase 5 °C/min for 16 min, hold for 3 min, then increase again for another 3 min, and finally hold at 200 °C for 5 min. The standardiz ...
... WHP 100/120 mesh) and a flame-ionization detector set at 200 °C. Helium was used as the carrier gas. The oven temperature protocol was to hold at 65 °C for 5 min, increase 5 °C/min for 16 min, hold for 3 min, then increase again for another 3 min, and finally hold at 200 °C for 5 min. The standardiz ...
Out of the Mouths of Plants: The Molecular Basis of the Evolution
... opposite the site of the most recent asymmetric division, which appears to be BASL’s main site of activity (Dong et al., 2009) (Figure 3). The ectopic overexpression of BASL confers abnormal cell polarization. Interestingly, the loss of asymmetry in a basl mutant resulted in adoption of the stomatal ...
... opposite the site of the most recent asymmetric division, which appears to be BASL’s main site of activity (Dong et al., 2009) (Figure 3). The ectopic overexpression of BASL confers abnormal cell polarization. Interestingly, the loss of asymmetry in a basl mutant resulted in adoption of the stomatal ...
Ion-channel blocker sensitivity of voltage-gated
... pharmacological approach using channel blockers typical of L-, P/Q-, N-, R- or T-types of VGCCs. Since the yeast cell wall is known to provide a barrier that inhibits reagents accessing the plasma membrane (Schindler & Davies, 1975; Gorenstein et al., 1978), the channel blockers were applied in conc ...
... pharmacological approach using channel blockers typical of L-, P/Q-, N-, R- or T-types of VGCCs. Since the yeast cell wall is known to provide a barrier that inhibits reagents accessing the plasma membrane (Schindler & Davies, 1975; Gorenstein et al., 1978), the channel blockers were applied in conc ...
Sulfated polysaccharides from marine sponges
... Marine sponges (Porifera) are ancient and simple eumetazoans. They constitute key organisms in the evolution from unicellular to multicellular animals. We now demonstrated that pure sulfated polysaccharides from marine sponges are responsible for the species-specific cell–cell interaction in these i ...
... Marine sponges (Porifera) are ancient and simple eumetazoans. They constitute key organisms in the evolution from unicellular to multicellular animals. We now demonstrated that pure sulfated polysaccharides from marine sponges are responsible for the species-specific cell–cell interaction in these i ...
Growth factors and tooth development
... embryonic teeth at various developmental stages by incubating freshly-separated tooth germs with '~qodine-Iabeled transferrin or EGF. and then processing the tissues for autoradiography. The number of transferrin receptors In embryonic teeth correlated with the proliferation rate, and the receptors ...
... embryonic teeth at various developmental stages by incubating freshly-separated tooth germs with '~qodine-Iabeled transferrin or EGF. and then processing the tissues for autoradiography. The number of transferrin receptors In embryonic teeth correlated with the proliferation rate, and the receptors ...
Microtubule-associated protein 1b is required for shaping the neural
... MT dynamics, suggest MAP1B function differs from the other MAPs [35]. MAP1B is also expressed prior to other members of this family in the nervous system [37–40], as it is observed in neuronal progenitors prior to their last mitotic division [41]. Despite this early expression and function in promot ...
... MT dynamics, suggest MAP1B function differs from the other MAPs [35]. MAP1B is also expressed prior to other members of this family in the nervous system [37–40], as it is observed in neuronal progenitors prior to their last mitotic division [41]. Despite this early expression and function in promot ...
Plant Gravitropism. Unraveling the Ups and
... Most Models Attempting to Explain Gravity Sensing Hypothesize a Role for Actin in This Process ...
... Most Models Attempting to Explain Gravity Sensing Hypothesize a Role for Actin in This Process ...
Germ Cell Speci fi cation - Molecular Biology and Genetics
... resume divisions only in the first (L1) larval stage after the larva begins feeding. Z2 and Z3 will eventually generate ~2,000 germ cells by adulthood (Kimble and White 1981). ...
... resume divisions only in the first (L1) larval stage after the larva begins feeding. Z2 and Z3 will eventually generate ~2,000 germ cells by adulthood (Kimble and White 1981). ...
Membrane Bistability in Olfactory Bulb Mitral Cells
... found between the duration of the downstate and the duration of the following upstate (Pearson, p ⬍ 10 ⫺ 5). This interaction suggests that processes occurring during the downstate influence generation of the subsequent upstate. Bistable activity may therefore be influenced by interactions among spe ...
... found between the duration of the downstate and the duration of the following upstate (Pearson, p ⬍ 10 ⫺ 5). This interaction suggests that processes occurring during the downstate influence generation of the subsequent upstate. Bistable activity may therefore be influenced by interactions among spe ...
Meiotic sex chromosome inactivation
... in the male germ line of almost all organisms possessing differentiated sex chromosomes, but its importance to developmental biologists, particularly to those studying germ cell development and infertility, is only just beginning to be understood. MSCI has also received a great deal of attention in ...
... in the male germ line of almost all organisms possessing differentiated sex chromosomes, but its importance to developmental biologists, particularly to those studying germ cell development and infertility, is only just beginning to be understood. MSCI has also received a great deal of attention in ...
ZO-3, a Novel Member of the MAGUK Protein Family Found at the
... that ZO-1 binds to occludin (15) and the Ras target AF-6 (47). Additional observations suggest that ZO-1 has the capacity to bind spectrin (15, 20), although localization of this cytoskeletal protein to the tight junction has not been documented. These observations, together with the protein-bindin ...
... that ZO-1 binds to occludin (15) and the Ras target AF-6 (47). Additional observations suggest that ZO-1 has the capacity to bind spectrin (15, 20), although localization of this cytoskeletal protein to the tight junction has not been documented. These observations, together with the protein-bindin ...
Chemical genetics discloses the importance of heme
... efterföljande klamydiainfektion kommer att tas hand av vårt immunförsvar. ...
... efterföljande klamydiainfektion kommer att tas hand av vårt immunförsvar. ...
Cadherins constitute a superfamily of transmembrane - HAL
... adherens junctions, this model is particularly of interest since it is supported by some of disparate results for adherens junctions. In particular, it is in agreement with the X-ray and electron microscopy results which demonstrate that the EC1 dimer is central to homotypic cadherin interaction. It ...
... adherens junctions, this model is particularly of interest since it is supported by some of disparate results for adherens junctions. In particular, it is in agreement with the X-ray and electron microscopy results which demonstrate that the EC1 dimer is central to homotypic cadherin interaction. It ...
The unique proline-rich domain of parotid proline
... cloned cDNAs in a pituitary cell line, AtT-20, they are stored in modest amounts in the dense core granules (Castle et al., 1992; Castle and Castle, 1993). Deletion of the N-terminal thirteen amino acid segment (transition region) from a basic PRP eliminated storage of the protein but also resulted ...
... cloned cDNAs in a pituitary cell line, AtT-20, they are stored in modest amounts in the dense core granules (Castle et al., 1992; Castle and Castle, 1993). Deletion of the N-terminal thirteen amino acid segment (transition region) from a basic PRP eliminated storage of the protein but also resulted ...
The Molecular Basis of the Evolution and Diversity of Stomatal
... polar: The meristemoid divides at angles of exactly 608 from each previous division, forming an orderly inward spiral of SLGCs with a triangular meristemoid inside (Serna et al., 2002; Pillitteri et al., 2007b). When spacing divisions occur, the satellite meristemoids always divide away from any nei ...
... polar: The meristemoid divides at angles of exactly 608 from each previous division, forming an orderly inward spiral of SLGCs with a triangular meristemoid inside (Serna et al., 2002; Pillitteri et al., 2007b). When spacing divisions occur, the satellite meristemoids always divide away from any nei ...
The cell biology of hearing - The Journal of Cell Biology
... elongate to form rows of graded height. Recent studies indicate that myosin motor proteins transport components of the actin assembly machinery to the tips of stereocilia to regulate their length. As stereocilia can reach up to 100 µm in length (Silver et al., 1998), regulated protein transport is a ...
... elongate to form rows of graded height. Recent studies indicate that myosin motor proteins transport components of the actin assembly machinery to the tips of stereocilia to regulate their length. As stereocilia can reach up to 100 µm in length (Silver et al., 1998), regulated protein transport is a ...
Multicellular trichomes in Arabidopsis - Development
... and co-workers (Hemerly et al., 1995) introduced a dominantnegative mutant of a mitotic cyclin-dependent kinase gene into transgenic tobacco plants, which resulted in plants with essentially normal morphology, but fewer and larger cells. In another study, overexpression of a mitotic B-cyclin in Arab ...
... and co-workers (Hemerly et al., 1995) introduced a dominantnegative mutant of a mitotic cyclin-dependent kinase gene into transgenic tobacco plants, which resulted in plants with essentially normal morphology, but fewer and larger cells. In another study, overexpression of a mitotic B-cyclin in Arab ...
machen2006
... in culture have constitutively active NF-B and upregulated expression and secretion of IL-8 and other inflammatory mediators (12, 23, 33a, 35, 36, 41, 54, 90, 167, 171, 174, 183, 186, 190). In some cases, these phenotypes were largely reversed in CFTR-corrected cells or in cells incubated at 25°C, ...
... in culture have constitutively active NF-B and upregulated expression and secretion of IL-8 and other inflammatory mediators (12, 23, 33a, 35, 36, 41, 54, 90, 167, 171, 174, 183, 186, 190). In some cases, these phenotypes were largely reversed in CFTR-corrected cells or in cells incubated at 25°C, ...
GRAND PRIX
... The number of organisms that can be supported by a given environment over a period of time. ...
... The number of organisms that can be supported by a given environment over a period of time. ...
Mitogen-activated protein kinase kinase 1
... (Colanzi et al., 2000), another explanation is that MEK1 facilitates, but is not required for, Golgi disassembly (Jesch et al., 2001a; Puthenveedu and Linstedt, 2001b). Results in the permeabilized cell assays are most consistent with MEK1 triggering Golgi unlinking and CDK1 triggering Golgi vesicul ...
... (Colanzi et al., 2000), another explanation is that MEK1 facilitates, but is not required for, Golgi disassembly (Jesch et al., 2001a; Puthenveedu and Linstedt, 2001b). Results in the permeabilized cell assays are most consistent with MEK1 triggering Golgi unlinking and CDK1 triggering Golgi vesicul ...
