Cenp-A Presence in Drosophila - Institute of Molecular Life Sciences
... chromosomes. These information strings are precisely transmitted to daughter cells during mitotic and meiotic cell divisions, but only if the centromere, a specialized chromosomal region, is functional. The centromere region within chromosomes of many species—including humans and the fly Drosophila ...
... chromosomes. These information strings are precisely transmitted to daughter cells during mitotic and meiotic cell divisions, but only if the centromere, a specialized chromosomal region, is functional. The centromere region within chromosomes of many species—including humans and the fly Drosophila ...
FUNCTIONAL CONSEQUENCES OF THE DIRECT PHYSICAL CBP/p300
... 2.2.2 E2A is Involved in Later Stages of B-Cell Development ................................ 11 2.3 Regulation of E2A Activity..................................................................................... 11 2.3.1 Regulation of E2A by Dimerization with Other bHLH Proteins .................... ...
... 2.2.2 E2A is Involved in Later Stages of B-Cell Development ................................ 11 2.3 Regulation of E2A Activity..................................................................................... 11 2.3.1 Regulation of E2A by Dimerization with Other bHLH Proteins .................... ...
МІНІСТЕРСТВО ОХОРОНИ ЗДОРОВ`Я УКРАЇНИ
... chemically on one of its constituents; the liver and pancreas, two large glands in the abdomen, the secretions of which, in addition to that of numerous minute glands in the walls of the alimentary canal, assist in the process of digestion. Alimentary canal embryo is laid in the form of primary int ...
... chemically on one of its constituents; the liver and pancreas, two large glands in the abdomen, the secretions of which, in addition to that of numerous minute glands in the walls of the alimentary canal, assist in the process of digestion. Alimentary canal embryo is laid in the form of primary int ...
Heterozygous LmnadelK32 mice develop dilated
... ubiquitous proteins of the type V intermediate filament family. They assemble in highly organized structures and, together with B-type lamins, form a meshwork beneath the inner nuclear membrane: the nuclear lamina (9). The physiological roles of lamin A/C are not yet fully understood. Their numerous ...
... ubiquitous proteins of the type V intermediate filament family. They assemble in highly organized structures and, together with B-type lamins, form a meshwork beneath the inner nuclear membrane: the nuclear lamina (9). The physiological roles of lamin A/C are not yet fully understood. Their numerous ...
Bioinformatics analysis of FRG1
... 2010). All fascin family of proteins actively participate in actin bundling by forming homodimers and heterodimers, thus creating multiple actin-binding sites necessary for actin bundling (Edwards & Bryan 1995; Kureishy et al. 2002). Immunostaining of C. elegans endogenous FRG1 showed that it is pre ...
... 2010). All fascin family of proteins actively participate in actin bundling by forming homodimers and heterodimers, thus creating multiple actin-binding sites necessary for actin bundling (Edwards & Bryan 1995; Kureishy et al. 2002). Immunostaining of C. elegans endogenous FRG1 showed that it is pre ...
The Epigenetic Pathways to Ribosomal DNA Silencing
... FIG 2 rDNA-silencing components in yeast and mammals. (A) Two main rDNA-silencing complexes, RENT and Tof2-Lrs4/Csm1, are found in yeast. The RENT complex is composed of Net1, Sir2, and Cdc14 proteins. Human and mouse NoRCs are composed of TIP5 and SNF2h, while the eNoSC is composed of SIRT1, NML, a ...
... FIG 2 rDNA-silencing components in yeast and mammals. (A) Two main rDNA-silencing complexes, RENT and Tof2-Lrs4/Csm1, are found in yeast. The RENT complex is composed of Net1, Sir2, and Cdc14 proteins. Human and mouse NoRCs are composed of TIP5 and SNF2h, while the eNoSC is composed of SIRT1, NML, a ...
Complex Degradation Processes Lead to Non
... activity at the various steps of degradation. Moreover, the particular form of the lifetime distribution for each species of mRNA depends on the specific mechanisms that are responsible for its degradation. A species of mRNA that is mostly degraded by the action of an endonuclease, for instance, wil ...
... activity at the various steps of degradation. Moreover, the particular form of the lifetime distribution for each species of mRNA depends on the specific mechanisms that are responsible for its degradation. A species of mRNA that is mostly degraded by the action of an endonuclease, for instance, wil ...
Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF
... The nuclear factor NF-kB is a pleiotropic transcription factor whose activation results in inflammation, viral replication, and growth modulation. Due to its role in pathogenesis, NF-kB is considered a key target for drug development. In the present report we show that sanguinarine (a benzophenanthr ...
... The nuclear factor NF-kB is a pleiotropic transcription factor whose activation results in inflammation, viral replication, and growth modulation. Due to its role in pathogenesis, NF-kB is considered a key target for drug development. In the present report we show that sanguinarine (a benzophenanthr ...
Roles of Long Non-coding RNAs in X
... Other than gene silencing, coating of the Xi by Xist is the first documented cytological event during initiation of XCI in the mouse, and is seen as early as the four-cell stage of development (Okamoto et al. 2005). Xist stabilization and coating of the Xi is also observed at the onset of random XCI ...
... Other than gene silencing, coating of the Xi by Xist is the first documented cytological event during initiation of XCI in the mouse, and is seen as early as the four-cell stage of development (Okamoto et al. 2005). Xist stabilization and coating of the Xi is also observed at the onset of random XCI ...
Specific Organization of Golgi Apparatus in Plant Cells
... of the stacks to form a ribbon; therefore, the disperse state of the Golgi apparatus needs to be supported, but it also can exist “by default”. We believe that the dispersed state of the Golgi apparatus in plants is supported, on one hand, by dynamic connections of the Golgi apparatus stacks with th ...
... of the stacks to form a ribbon; therefore, the disperse state of the Golgi apparatus needs to be supported, but it also can exist “by default”. We believe that the dispersed state of the Golgi apparatus in plants is supported, on one hand, by dynamic connections of the Golgi apparatus stacks with th ...
Review The cellular functions of clathrin
... Received 12 December 2005; received after revision 21 March 2006; accepted 29 March 2006 Abstract. Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathri ...
... Received 12 December 2005; received after revision 21 March 2006; accepted 29 March 2006 Abstract. Membranes and proteins are moved around the cell in small vesicles. A protein coat aids the budding of such vesicles from donor membranes. The major type of coat used by the cell is composed of clathri ...
... the ER (the vacuum cleaner model; Boevink et al., 1998). In this view, vesicles are thought to bud out from the ER, so Golgi bodies must continually move to collect them. A second model is that Golgi stack movement allows the Golgi to move between fixed ER exit sites (the stop-and-go model; Nebenfüh ...
TETRASPORE is required for male meiotic
... analysis of mutants defective in some of these processes (Kaul, 1988; Regan and Moffatt, 1990; Aarts et al., 1993; Dawson et al., 1993; Chaudhury et al., 1994; Preuss et al., 1994; Chen and ...
... analysis of mutants defective in some of these processes (Kaul, 1988; Regan and Moffatt, 1990; Aarts et al., 1993; Dawson et al., 1993; Chaudhury et al., 1994; Preuss et al., 1994; Chen and ...
Deep Insight Section Mechanisms and regulation of autophagy in mammalian cells
... unfolded polypeptides across the lysosomal membrane. KFERQ-like motifs are found mainly in cytosolic proteins, and it is estimated that about 30% of cytosolic proteins contain this motif. CMA performs several general functions, such as the elimination of oxidazed proteins and the removal of misfolde ...
... unfolded polypeptides across the lysosomal membrane. KFERQ-like motifs are found mainly in cytosolic proteins, and it is estimated that about 30% of cytosolic proteins contain this motif. CMA performs several general functions, such as the elimination of oxidazed proteins and the removal of misfolde ...
Class II Histone Deacetylases Are Directly Recruited by BCL6
... genes has been identified by DNA microarray screening in lymphocytes. BCL6 was found to repress a number of genes involved in B cell activation and terminal differentiation, inflammation, and cell cycle regulation (12). Earlier studies have shaded light on the molecular mechanisms by which BCL6 nega ...
... genes has been identified by DNA microarray screening in lymphocytes. BCL6 was found to repress a number of genes involved in B cell activation and terminal differentiation, inflammation, and cell cycle regulation (12). Earlier studies have shaded light on the molecular mechanisms by which BCL6 nega ...
What recent ribosome structures have revealed
... Thermus thermophilus3 published in 2000 were the basis for the phasing and/or molecular interpretation of every subsequent structure of the ribosome or its subunits. Such structures include low-resolution structures of the 70S ribosome by crystallography4 or cryoelectron microscopy (cryoEM)5, the st ...
... Thermus thermophilus3 published in 2000 were the basis for the phasing and/or molecular interpretation of every subsequent structure of the ribosome or its subunits. Such structures include low-resolution structures of the 70S ribosome by crystallography4 or cryoelectron microscopy (cryoEM)5, the st ...
Interrelations between translation and general mRNA degradation in
... Interrelations between translation and general mRNA degradation in yeast Susanne Huch and Tracy Nissan∗ Messenger RNA (mRNA) degradation is an important element of gene expression that can be modulated by alterations in translation, such as reductions in initiation or elongation rates. Reducing tran ...
... Interrelations between translation and general mRNA degradation in yeast Susanne Huch and Tracy Nissan∗ Messenger RNA (mRNA) degradation is an important element of gene expression that can be modulated by alterations in translation, such as reductions in initiation or elongation rates. Reducing tran ...
Translocation of Structural P Proteins in the Phloem
... Figure 5. RT-PCR Gel Blot Analyses of Cucurbita PP1 and PP2 mRNAs from Intergeneric Grafts of Cucumis sativus Scions on Cucurbita maxima or Cucurbita ficifolia Stocks. RT-PCR products generated from total RNA with 59 and 39 primers that flank the protein coding sequences of genes encoding PP1 and PP ...
... Figure 5. RT-PCR Gel Blot Analyses of Cucurbita PP1 and PP2 mRNAs from Intergeneric Grafts of Cucumis sativus Scions on Cucurbita maxima or Cucurbita ficifolia Stocks. RT-PCR products generated from total RNA with 59 and 39 primers that flank the protein coding sequences of genes encoding PP1 and PP ...
Identification and characterization of regulatory factors and
... 3.1.7 The chaperone Hfq induces CsrC and CsrB synthesis and activates rovA expression..................................................................................................83 3.1.8 Analysis of the csrC promoter region ..................................................................88 ...
... 3.1.7 The chaperone Hfq induces CsrC and CsrB synthesis and activates rovA expression..................................................................................................83 3.1.8 Analysis of the csrC promoter region ..................................................................88 ...
Golgins and GTPases, giving identity and structure to the Golgi
... This doesn’t mean that they are unimportant. Rather, it probably indicates that the Golgi is structurally adapted in different species to meet the specific needs of different cell types. For example, the recent finding that GM130 is not required for mammalian cell viability at 34.5 8C, but is essent ...
... This doesn’t mean that they are unimportant. Rather, it probably indicates that the Golgi is structurally adapted in different species to meet the specific needs of different cell types. For example, the recent finding that GM130 is not required for mammalian cell viability at 34.5 8C, but is essent ...
Cell nucleus
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel) is a membrane-enclosed organelle found in eukaryotic cells. Eukaryotes usually have a single nucleus, but a few cell types have no nuclei, and a few others have many.Cell nuclei contain most of the cell's genetic material, organized as multiple long linear DNA molecules in complex with a large variety of proteins, such as histones, to form chromosomes. The genes within these chromosomes are the cell's nuclear genome. The function of the nucleus is to maintain the integrity of these genes and to control the activities of the cell by regulating gene expression—the nucleus is, therefore, the control center of the cell. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm, and the nucleoskeleton (which includes nuclear lamina), a network within the nucleus that adds mechanical support, much like the cytoskeleton, which supports the cell as a whole.Because the nuclear membrane is impermeable to large molecules, nuclear pores are required that regulate nuclear transport of molecules across the envelope. The pores cross both nuclear membranes, providing a channel through which larger molecules must be actively transported by carrier proteins while allowing free movement of small molecules and ions. Movement of large molecules such as proteins and RNA through the pores is required for both gene expression and the maintenance of chromosomes. The interior of the nucleus does not contain any membrane-bound sub compartments, its contents are not uniform, and a number of sub-nuclear bodies exist, made up of unique proteins, RNA molecules, and particular parts of the chromosomes. The best-known of these is the nucleolus, which is mainly involved in the assembly of ribosomes. After being produced in the nucleolus, ribosomes are exported to the cytoplasm where they translate mRNA.