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Glutamate 83 and arginine 85 of helix H3 bend are key residues for
Glutamate 83 and arginine 85 of helix H3 bend are key residues for

... only in an antiparallel manner. Thus, from a low-resolution sheet structure of Methanococcus jannaschii FtsZ, it has been proposed that two protofilaments interact through the same lateral face, in a parallel form, to produce doublestranded filaments called thick filaments, which subsequently form s ...
Class II Histone Deacetylases Are Directly Recruited by BCL6
Class II Histone Deacetylases Are Directly Recruited by BCL6

... genes has been identified by DNA microarray screening in lymphocytes. BCL6 was found to repress a number of genes involved in B cell activation and terminal differentiation, inflammation, and cell cycle regulation (12). Earlier studies have shaded light on the molecular mechanisms by which BCL6 nega ...
The Role of Carnitine System in Maintaining Muscle Homeostasis
The Role of Carnitine System in Maintaining Muscle Homeostasis

... The function of carnitine in metabolism refers to its physiological roles in intermediary metabolism as a carrier of carbon chains (Table 1), more specifically, of long-chain fatty acids for their beta-oxidation in mitochondria, and of endogenous and exogenous toxic metabolites for their elimination ...
No Slide Title
No Slide Title

... • Lysozyme digests debris from cell walls of bacteria that have already been processed by other enzymes. • Another function of lysozyme is to modulate inflammation by suppressing neutrophil chemotaxis and oxidative metabolism. ...
The contractile apparatus and mechanical properties of airway smooth muscle
The contractile apparatus and mechanical properties of airway smooth muscle

... on the lateral sides of dense bodies, often forming loops at the lateral surface [15, 38]. The intermediate filaments that surround a given dense body do not run parallel to the contractile unit and associate with the next dense body in series; but are oriented obliquely toward another dense body of ...
Endocytosis, Recycling, and Regulated Exocytosis of Glucose
Endocytosis, Recycling, and Regulated Exocytosis of Glucose

... Figure 1. Model of the transit of GLUT4 through intracellular compartments during endocytosis and exocytosis (see the text for details). GLUT4 is internalized via clathrin-mediated endocytosis (CME) or cholesterol-dependent but clathrin-independent endocytosis. Within 2 min, GLUT4 traverses early en ...
for ICD-10
for ICD-10

... The middle ear (like the ear canal) is normally filled with air. Unlike the open ear canal, however, the air of the middle ear is not in direct contact with the atmosphere outside the body. The Eustachian tube connects from the chamber of the middle ear to the back of the nasopharynx. The middle ear ...
Apical-basal patterning in Arabidopsis - Development
Apical-basal patterning in Arabidopsis - Development

View/Open - eDiss - Georg-August
View/Open - eDiss - Georg-August

... recognition receptors (PRRs). In Arabidopsis, perception of the fungal cell wall component chitin requires the LysM receptor-like kinase CERK1. CERK1 is post-translationally modified to release a soluble ectodomain derivative into the apoplast. The ectodomain fragment is likely to be generated by a ...
PDF
PDF

... seconds, with t=0 corresponding to pronuclear meeting unless stated otherwise, and scale bars represent 10 µm. See also supplementary material Movies 1 and 2. (C,D) Kymographs of the areas marked by dashed white rectangles in A and B. The white line delineates the position of the nuclear envelopes o ...
Oxidative-stress-induced nuclear to cytoplasmic relocalization is
Oxidative-stress-induced nuclear to cytoplasmic relocalization is

the projection of the midline and intralaminar nuclei of the thalamus
the projection of the midline and intralaminar nuclei of the thalamus

... the head of the caudate nucleus, the putamen, and reticular nucleus. The other principal nuclei which the dorsal margin of the nucleus accumbens have show changes are the antero-medial, dorso-medial, been completely destroyed. Immediately behind and ventro-medial, in all of which there is a this. le ...
Protein kinase C- modulates mitochondrial function and active Na
Protein kinase C- modulates mitochondrial function and active Na

... Ca2⫹-independent outward K⫹ channels on the plasma membrane (38). Subcellular redistribution is an essential feature of PKC-⑀ activation. Translocation to specific subcellular compartments is a critical step in the phosphorylation of target proteins and PKC-⑀ signaling. The mitochondrion is thought ...
REVIEWS - Unisciel
REVIEWS - Unisciel

... homologues, H- and X-proteins, all of which are composed of Ig and fibronectin domains, are located here. The functions of these proteins are unknown, but they bind to myosin and are spaced at 43-nm intervals along the filament, which is also the repeat distance of the helix that describes the myosi ...
Transmembrane Movement of Exogenous Long
Transmembrane Movement of Exogenous Long

... genes encoding two isoforms of FACS (FAA1 and FAA4), which are involved in the activation of exogenous long-chain fatty acids (51, 55, 77, 78, 90, 91), and one gene that encodes the yeast orthologue of the mammalian fatty acid transport protein (FAT1) (50, 54, 140). ...
The role of yolk syncytial layer and blastoderm movements during
The role of yolk syncytial layer and blastoderm movements during

... colleagues, who began genetic analysis in the zebrafish and established the methodological foundation allowing its use as a vertebrate model organism (Streisinger et al., 1981; Westerfield, 2000). Indeed, the zebrafish embryo offers many advantages to study embryonic development compared to other or ...
Intragenic Revertants of Yeast Invertase Variants with Secretion-Defective Leader Sequences.
Intragenic Revertants of Yeast Invertase Variants with Secretion-Defective Leader Sequences.

... the secretory pathway (C. A. Kaiser, Ph.D. thesis, Massachusetts Institute of Technology, Cambridge, 1987). Thus, these amino-terminal residues constitute a signal sequence for secretion. They are necessary for invertase secretion, since the constitutive form of invertase remains in the cytoplasm, a ...
Collagen Diversity, Synthesis and Assembly
Collagen Diversity, Synthesis and Assembly

... cross-linked to both collagens II and XI in the cartilage fibril, through lysine-derived cross-links; recent studies have shown how flexibility within the non-collagenous domains allows these cross-links to form (Eyre et al., 2004). Strongest homology within the FACITs is in the C-terminal collageno ...
Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects
Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects

... . Mitochondria produce ATP primarily by utilizing the electrochemical gradient formed by electron transfer via the electron transport chain located on the inner mitochondrial membrane. However, electron leakage from the electron transport chain and production of O2- and H2O2, which arises from dismu ...
Biology - Cellular, Molecular, Professional Emphasis (sample 4 Year Plan) 2011.doc
Biology - Cellular, Molecular, Professional Emphasis (sample 4 Year Plan) 2011.doc

... Bio 306 Neurobiology (S, odd years) (3 cr) Bio 315 Virology (S) (3 cr) Bio 321 Mycology (F) (3 cr) Bio 337 Plant Anatomy (S) (3 cr) Bio 309 General Bacteriology (5 cr) Bio 316 Developmental Biology (S) (3 cr) Bio 341 Immunology (F) (3 cr) (if not used to fill preceding requirement) Bio 350 Electron ...
Cellular Physiology of Skeletal, Cardiac, and Smooth Muscle
Cellular Physiology of Skeletal, Cardiac, and Smooth Muscle

... contraction is triggered by electrical signals from neighboring cardiacmusclecells. Theseelectricalimpulsesoriginate in the pacemaker region of the hean, the sinoatrial node (p. 489), which spontaneouslyand periodicallygeneratesaction potentials.To facilitate direct electricalcommunication betweenca ...
Cbp3–Cbp6 interacts with the yeast mitochondrial ribosomal tunnel
Cbp3–Cbp6 interacts with the yeast mitochondrial ribosomal tunnel

... much is known about how they mediate the formation of a functional bc1 complex. Protein synthesis in mitochondria is performed by organellespecific ribosomes. These ribosomes developed from the translation system of the bacterial ancestor of mitochondria. Surprisingly little is known about how these ...
Calcium: silver bullet in signaling
Calcium: silver bullet in signaling

... have several unique Ca2 + -sensing proteins and that the downstream components of Ca2 + signaling in plants have novel features and regulatory mechanisms. Although the mechanisms by which Ca2 + regulates diverse biochemical and molecular processes and eventually physiological processes in response t ...
Structural differences in two biochemically-defined
Structural differences in two biochemically-defined

... The mitochondria of cardiomyocytes consist of two spatially disparate populations: one abutting the sarcolemma, the other trapped within the contractile apparatus. Techniques that permit the separate isolation of these two populations have led to the finding that in several mammalian species the two ...
Characterization of the Nucleolar Gene Product, Treacle, in Treacher Collins Syndrome
Characterization of the Nucleolar Gene Product, Treacle, in Treacher Collins Syndrome

... weight mostly due to its high degree of phosphorylation (Meier and Blobel, 1992; Meier, 1996). To test whether treacle was phosphorylated like Nopp140, in vitro-translated treacle was incubated for 30 min at 37°C with alkaline phosphatase. Indeed, phosphatase treatment in the absence (Figure 2, lane ...
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Endomembrane system

The endomembrane system is composed of the different membranes that are suspended in the cytoplasm within a eukaryotic cell. These membranes divide the cell into functional and structural compartments, or organelles. In eukaryotes the organelles of the endomembrane system include: the nuclear membrane, the endoplasmic reticulum, the Golgi apparatus, lysosomes, vesicles, endosomes and the cell membrane. The system is defined more accurately as the set of membranes that form a single functional and developmental unit, either being connected directly, or exchanging material through vesicle transport. Importantly, the endomembrane system does not include the membranes of mitochondria or chloroplasts.The nuclear membrane contains two lipid bilayers that encompass the contents of the nucleus. The endoplasmic reticulum (ER) is a synthesis and transport organelle that branches into the cytoplasm in plant and animal cells. The Golgi apparatus is a series of multiple compartments where molecules are packaged for delivery to other cell components or for secretion from the cell. Vacuoles, which are found in both plant and animal cells (though much bigger in plant cells), are responsible for maintaining the shape and structure of the cell as well as storing waste products. A vesicle is a relatively small, membrane-enclosed sac that stores or transports substances. The cell membrane, is a protective barrier that regulates what enters and leaves the cell. There is also an organelle known as the Spitzenkörper that is only found in fungi, and is connected with hyphal tip growth.In prokaryotes endomembranes are rare, although in many photosynthetic bacteria the plasma membrane is highly folded and most of the cell cytoplasm is filled with layers of light-gathering membrane. These light-gathering membranes may even form enclosed structures called chlorosomes in green sulfur bacteria.The organelles of the endomembrane system are related through direct contact or by the transfer of membrane segments as vesicles. Despite these relationships, the various membranes are not identical in structure and function. The thickness, molecular composition, and metabolic behavior of a membrane are not fixed, they may be modified several times during the membrane's life. One unifying characteristic the membranes share is a lipid bilayer, with proteins attached to either side or traversing them.
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