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Axonal of Kinesin in the Chain Isoforms
Axonal of Kinesin in the Chain Isoforms

... hexokinase. These results suggest that KHC-A is enriched on small tubulovesicular structures like synaptic vesicles and that at least one form of KHC-B is predominantly on mitochondria. Biochemical specialization may target kinesins to appropriate organelles and facilitate differential regulation of ...
Zinc transporters that regulate vacuolar zinc storage in
Zinc transporters that regulate vacuolar zinc storage in

... which belong to the ZIP family of metal transporters. Under zinc limitation, ZRT1 and ZRT2 transcription is induced by the Zap1p transcriptional activator. We describe here a new component of zinc homeostasis, vacuolar zinc storage, that is also regulated by Zap1p. Zinc-replete cells accumulate zinc ...
SURGERY OF THE LACRIMAL DRAINAGE SYSTEM
SURGERY OF THE LACRIMAL DRAINAGE SYSTEM

... elevator, moving towards the sharp lacrimal crest and then down into the lacrimal fossa, still separating the periosteum from the bone.Take great care to keep the periosteal elevator always just under the periosteum and right on the surface of the bone. The lacrimal crest can have quite a sharp angl ...
Three distinct ribosome assemblies modulated by translation are the
Three distinct ribosome assemblies modulated by translation are the

... Here we took advantage of atomic force microscopy (AFM), which has the unique capacity to resolve both single RNA molecules (Hansma et al., 2004) and ribosomes (Yoshida et al., 1997; Mikamo et al., 2005; Mikamo-Satoh et al., 2009). Highlight results from AFM imaging include the visualization of sing ...
Identification and analysis of new phloem proteins from
Identification and analysis of new phloem proteins from

Effect of bile salts on the DNA and membrane integrity of enteric
Effect of bile salts on the DNA and membrane integrity of enteric

... pathogenic potential of an enteric bacterium is directly related to its ability to grow in the presence of bile salts. However, to determine if this hypothesis is true the mechanisms by which bacteria are able to grow in bile salt environments need to be ...
Cell cycle checkpoints in Caenorhabditis elegans
Cell cycle checkpoints in Caenorhabditis elegans

... Figure 24. par-5 is necessary for IR-induced response. .......................................................... 58 Figure 25. par-2, par-3 and mpk-1 are dispensable for the S-phase checkpoint. .................... 60 Figure 26. par-5 is required for replication stress-induced cell cycle delay in t ...
Airway surface liquid pH in well-differentiated airway - AJP-Cell
Airway surface liquid pH in well-differentiated airway - AJP-Cell

... In some experiments, amiloride (10 mg/kg of 1 mM solution) was injected intraperitoneally 30 min before anesthesia, and 2.7 ␮g of amiloride (dispersed in perfluorocarbon) was instilled into trachea together with BCECF-dextran. ASL pH was measured 10 min after the perfluorocarbon instillation. Mice w ...
Control of Pre-mRNA Splicing by the General Splicing Factors
Control of Pre-mRNA Splicing by the General Splicing Factors

... to the importance of splicing for normal cellular function. The splicing process is made more complex by the fact that many premRNAs can be spliced in more than one way to give mature transcripts coding for proteins with distinct functions. Such alternative splicing greatly expands the coding capaci ...
Direct Interaction between Survivin and Smac/DIABLO Is Essential
Direct Interaction between Survivin and Smac/DIABLO Is Essential

... vitro and does not inhibit caspase-3 activity. Wang and colleagues identified a novel mitochondrial-associated protein Smac/DIABLO that was able to interact with IAPs (20, 21) and may help explain the inhibitory function of Survivin. Smac/DIABLO is a mitochondria protein but is released into the cyt ...
mexCD-oprJ aeruginosa
mexCD-oprJ aeruginosa

... Figure 4-6: NfxB and EsrC interact in the presence and absence of CHX-mediated envelope stress .........61   Figure 4-7: Screening for NfxB variants demonstrating a loss of interaction with EsrC .............................63   Figure 4-8: Expression of EsrC and mutant NfxB proteins in E. coli ...
- Wiley Online Library
- Wiley Online Library

... involves self-limiting gastrointestinal symptoms in otherwise healthy individuals but can also develop into more systemic conditions, primarily affecting the brain as well as the fetus in pregnant women (Allerberger and Wagner, 2010). In such severe invasive cases, mortality rates of up to 30% have ...
Auxin coordinates cell division and cell fate specification during
Auxin coordinates cell division and cell fate specification during

... In the above paragraphs we referred to some of the possible signalling pathways that could link auxin to the molecular regulation of cell cycle. However, on top of this complexity, it could be that some auxin responses are confined to certain stages of the cell cycle or in other words that cells mig ...
Auxin coordinates cell division and cell fate specification during
Auxin coordinates cell division and cell fate specification during

... In the above paragraphs we referred to some of the possible signalling pathways that could link auxin to the molecular regulation of cell cycle. However, on top of this complexity, it could be that some auxin responses are confined to certain stages of the cell cycle or in other words that cells mig ...
Self-Incompatibility-induced Programmed Cell
Self-Incompatibility-induced Programmed Cell

... Dangl, 1996; van Doorn, 2011; van Doorn et al., 2011). There is considerable biochemical evidence for the involvement of caspase-like activities in plant PCD (van Doorn and Woltering, 2005). For example, Vacuolar Processing Enzyme (VPE) has YVADase (caspase-1-like) activity (Hatsugai et al., 2004; R ...
collagen in odontogenic tumours
collagen in odontogenic tumours

CE - University of Pittsburgh
CE - University of Pittsburgh

... • HDL may transfer some cholesterol esters to other lipoproteins. • Some remain associated with HDL, which may be taken up by liver & degraded. • HDL thus transports cholesterol from tissues & other lipoproteins to the liver, which can excrete excess cholesterol as bile acids. • High blood levels of ...
Downloaded - The Journal of Cell Biology
Downloaded - The Journal of Cell Biology

... cell migration and axon outgrowth (for review see Anastasiadis and Reynolds, 2000). The JM region may modulate adhesion by serving as the binding site for regulatory proteins. One candidate, p120ctn (henceforth p120), was identified by scientists studying the effects on cell adhesion of the oncogeni ...
Auxin transport routes in plant development
Auxin transport routes in plant development

... Other proteins that play a role in auxin efflux are plant orthologs of the mammalian ATP-binding cassette subfamily B (ABCB)-type transporters of the multidrug resistance/phosphoglycoprotein (ABCB/MDR/PGP) protein family (Noh et al., 2001; Verrier et al., 2008). Some of these (ABCB1, ABCB4 and ABCB1 ...
Schubert, C. M., R. Lin, C. J. de Vries, R. H. A.
Schubert, C. M., R. Lin, C. J. de Vries, R. H. A.

... genes can disrupt the localization of all PAR proteins (Etemad-Moghadam et al., 1995; Boyd et al., 1996; Tabuse et al., 1998; Hung and Kemphues, 1999). Mutations in the par genes also cause marked defects in many, or all, of the subsequent asymmetries observed between wild-type blastomeres after cel ...
Plant hormones and growth regulators
Plant hormones and growth regulators

... growth, whereas reducing its concentration promoted cell and tissue elongation (Bennet-Clark, 1956 ; Tagawa and Bonner, 1957 ). Strong support for the Ca2+/pectate interaction came from a quantitative examination of the cation exchange capacity of the coleoptile cell wall, which was shown to be due ...
Utilization and Transport of Mannitol in Olea
Utilization and Transport of Mannitol in Olea

... a 250 and 500 mM NaCl pulse, whereas extensive loss of cell viability was observed in sucrose-grown cells. OeMaT1 transcripts increased throughout maturation of olive fruits, suggesting that an OeMaT is involved in the accumulation of mannitol during ripening of olive. Thus, mannitol transport and c ...
Glycosyltransferases and Transpeptidases/Penicillin-Binding
Glycosyltransferases and Transpeptidases/Penicillin-Binding

... “miraculous” penicillin antibiotic that inactivates these enzymes. Since the discovery of penicillin “miraculous” penicillin antibiotic that inactivates these enzymes. Since the discovery of penicillin and and its wide utilization in medicine in the 1940s, several new classes and generations of rela ...
Live Imaging of Drosophila Brain Neuroblasts Reveals a Role for
Live Imaging of Drosophila Brain Neuroblasts Reveals a Role for

... Lis1 is required for nuclear migration in fungi, cell cycle progression in mammals, and the formation of a folded cerebral cortex in humans. Lis1 binds dynactin and the dynein motor complex, but the role of Lis1 in many dynein/dynactindependent processes is not clearly understood. Here we generate a ...
Nuclear export signal located within the DNAbinding domain of the
Nuclear export signal located within the DNAbinding domain of the

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Endomembrane system

The endomembrane system is composed of the different membranes that are suspended in the cytoplasm within a eukaryotic cell. These membranes divide the cell into functional and structural compartments, or organelles. In eukaryotes the organelles of the endomembrane system include: the nuclear membrane, the endoplasmic reticulum, the Golgi apparatus, lysosomes, vesicles, endosomes and the cell membrane. The system is defined more accurately as the set of membranes that form a single functional and developmental unit, either being connected directly, or exchanging material through vesicle transport. Importantly, the endomembrane system does not include the membranes of mitochondria or chloroplasts.The nuclear membrane contains two lipid bilayers that encompass the contents of the nucleus. The endoplasmic reticulum (ER) is a synthesis and transport organelle that branches into the cytoplasm in plant and animal cells. The Golgi apparatus is a series of multiple compartments where molecules are packaged for delivery to other cell components or for secretion from the cell. Vacuoles, which are found in both plant and animal cells (though much bigger in plant cells), are responsible for maintaining the shape and structure of the cell as well as storing waste products. A vesicle is a relatively small, membrane-enclosed sac that stores or transports substances. The cell membrane, is a protective barrier that regulates what enters and leaves the cell. There is also an organelle known as the Spitzenkörper that is only found in fungi, and is connected with hyphal tip growth.In prokaryotes endomembranes are rare, although in many photosynthetic bacteria the plasma membrane is highly folded and most of the cell cytoplasm is filled with layers of light-gathering membrane. These light-gathering membranes may even form enclosed structures called chlorosomes in green sulfur bacteria.The organelles of the endomembrane system are related through direct contact or by the transfer of membrane segments as vesicles. Despite these relationships, the various membranes are not identical in structure and function. The thickness, molecular composition, and metabolic behavior of a membrane are not fixed, they may be modified several times during the membrane's life. One unifying characteristic the membranes share is a lipid bilayer, with proteins attached to either side or traversing them.
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