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Making an Effort to Listen: Mechanical Amplification in the Ear
Making an Effort to Listen: Mechanical Amplification in the Ear

... bears a tonotopic map. In mammals, birds, and many reptiles, low frequencies are represented at the apex of the cochlea and high pitches at the base; lizards display more varied and complex tonotopic patterning. The sharpness of tuning in a normal cochlea reflects the narrow range of frequencies tha ...
Opposite and redundant roles of the two Drosophila perilipins in
Opposite and redundant roles of the two Drosophila perilipins in

... proteins and the evolutionarily conserved regulation of HSL translocation by perilipins. Key words: PLIN1, PLIN2, HSL, Lipid droplet, Lipolysis ...
β-catenin: a key mediator of Wnt signaling Karl
β-catenin: a key mediator of Wnt signaling Karl

DC-derived exosomes bear molecules involved in
DC-derived exosomes bear molecules involved in

... lines weakly 10,13 and fail to stimulate naïve T cells 9,11. This impaired naïve T cell stimulatory ability of exosomes has been attributed to their low T cell receptor-cross-linking capacity (inadequate for naïve T cell activation) and their small size and membrane composition exosomes increase the ...
237-747-1-SP - International Journal of Applied Research in
237-747-1-SP - International Journal of Applied Research in

... The antiviral activity of C. colocynthis/SNPs and the corresponding AEs of different plant organs were tested by measuring the cytopathic effect (CPE). Briefly; Vero cells were plated in a 96-well plate (8 mm diameter; Falcon Plastics) at a density of 10,000 cells/well in Dulbecco's Modified Eagle's ...
SECHENOV MEDICAL ACADEMY, MOSCOW Department of
SECHENOV MEDICAL ACADEMY, MOSCOW Department of

... These granules are the storage sites of Ca++ and Mg++ ions. Functions of mitochondria. Mitochondria are energy producers of cells. Energy is produced by the Krebs cycle and oxidative phosphorylation. Mitochondria also oxidize and synthesize fatty acids, concentrate ferritin, and accumulate cations i ...
Differential assembly of polypeptides of the light
Differential assembly of polypeptides of the light

... The photosynthetic units of the facultative photoheterotroph Rhodobacter sphaeroides, a member of the a-3 subclass of Proteobacteria, contain two integral membrane light-harvesting complexes, designated as LH1 and LH2, which function as core and peripheral antennae, respectively. Radiant energy harv ...
Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1
Coordination of Genomic RNA Packaging with Viral Assembly in HIV-1

... Although distinct from HIV-1 in overall structure, the packaging signal region of another lentivirus, FIV, also adopts two conformations that regulate the balance between translation, dimerization and packaging [6]. The more distantly related gammaretrovirus, MoMuLV, also utilizes a structural switc ...
Daughter-Specific Transcription Factors Regulate Cell Size Control
Daughter-Specific Transcription Factors Regulate Cell Size Control

Responses to Cell Loss Become Restricted as the Supporting Cells
Responses to Cell Loss Become Restricted as the Supporting Cells

... Figure 2. LatA treatments did not produce detectable changes in the size of the reinforced F-actin bands in adult mouse utricles. A, Confocal images of sensory epithelia (SE) that were cultured with 5 ␮M LatA or vehicle control for 1, 12, or 24 h and then fixed and labeled with fluorescent phalloidi ...
Exocytosis acts as a modulator of the ILT4
Exocytosis acts as a modulator of the ILT4

... eutrophils constitute more than 50% of circulating leukocytes in humans and play a major role in host defense against invading pathogens. The release of chemotactic signals from inflamed or infected tissues triggers neutrophil migration from the bloodstream to inflammatory foci (1). They thus recogniz ...
The Aspergillus fumigatus cspA Gene Encoding a Repeat
The Aspergillus fumigatus cspA Gene Encoding a Repeat

1 - The Mostowy Lab
1 - The Mostowy Lab

... Autophagy: bacterial friend or foe? Autophagy is an intracellular degradation process by which cytosolic materials are delivered to a lysosomal compartment (Figure 1). The ‘canonical’ autophagy pathway involves the initiation and elongation of double-membrane phagophores that close upon themselves t ...
Bound by Fate: Reactive Oxygen Species in
Bound by Fate: Reactive Oxygen Species in

Calcium oscillations in higher plants Nicola H Evans*, Martin R
Calcium oscillations in higher plants Nicola H Evans*, Martin R

... calcium-permeable channels were involved in the generation of [Ca2+]ext-induced oscillations in [Ca2+]cyt (i.e. oscillations induced by the concentration of calcium ions outside the cell) in this cell type. Other evidence highlighting the importance of plasma membrane calcium-permeable channels has ...
The Fusion Core Complex of the Peste des Petits Ruminants Virus Is
The Fusion Core Complex of the Peste des Petits Ruminants Virus Is

... and viral envelopes. The PPRV F protein does not require the HN protein to bring about biological fusion, a property shown by the paramyxovirus SV5, while the other members in the Paramyxoviridae family require the fusion promotion function mediated by HN or H protein (1-13). The F proteinmediated f ...
In vivo quantification of peroxisome tethering to chloroplasts in
In vivo quantification of peroxisome tethering to chloroplasts in

... School of Earth Sciences, University of Bristol, Wills Memorial Building, Central Laser Facility, Science and Technology Facilities Council, Research ...
Actin Dynamics in Muscle Cells
Actin Dynamics in Muscle Cells

... organelles inside the cells. The microfilaments are essential in the contraction, motility, cytokinesis, and endocytosis. Intermediate filaments are the tool of integration of the signals (mechanical stress) within two distinct compartments: nuclear-inner nucleus envelope (via lamins) and the cytoplas ...
Ornithodoros savignyi CHAPTER 2  SIGNALING PATHWAYS REGULATING PROTEIN SECRETION FROM
Ornithodoros savignyi CHAPTER 2 SIGNALING PATHWAYS REGULATING PROTEIN SECRETION FROM

... SDS-PAGE analysis of the secreted proteins showed variable results in response to different agonists. The highest number of proteins was detected from ticks in the earliest stages of feeding. In some ticks, proteins were identified at one collection time but not at another time in secretions from th ...
Mechanisms of dorsal-ventral axis determination in
Mechanisms of dorsal-ventral axis determination in

... the putative Toll ligand might be initially produced and distributed in a way that would determine the shape of the nuclear dorsal protein gradient. This process would not require additional steps of pattern formation. If, on the other hand, only a weak dorsal-ventral asymmetry were present in the v ...
Cooperation between the RING+B1-B2 and coiled-coil
Cooperation between the RING+B1-B2 and coiled-coil

... The RING ®nger motif, the B-boxes and the coiled-coil regions are retained in the PML/RARa protein. PML is a nuclear phosphoprotein (Chang et al., 1995) and is localized to speci®c matrix-associated subdomains called nuclear bodies (PML-NB), also known as POD (PML oncogenic domains), ND10 (Nuclear D ...
Nitric oxide is essential for vesicle formation and
Nitric oxide is essential for vesicle formation and

Sirtuins at a Glance - Journal of Cell Science
Sirtuins at a Glance - Journal of Cell Science

... are highly conserved from bacteria to human and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; Kaeberlein et al., 1999). Since then, sirtuins have been shown to also regulate longevity in other lower organisms, such as flies and worms (Tissenbaum and Guarente, 2001 ...
Transcriptional regulation of mammalian autophagy at a glance
Transcriptional regulation of mammalian autophagy at a glance

ภาพนิ่ง 1
ภาพนิ่ง 1

... germination and vivipary ABA added to the culture ...
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Endomembrane system

The endomembrane system is composed of the different membranes that are suspended in the cytoplasm within a eukaryotic cell. These membranes divide the cell into functional and structural compartments, or organelles. In eukaryotes the organelles of the endomembrane system include: the nuclear membrane, the endoplasmic reticulum, the Golgi apparatus, lysosomes, vesicles, endosomes and the cell membrane. The system is defined more accurately as the set of membranes that form a single functional and developmental unit, either being connected directly, or exchanging material through vesicle transport. Importantly, the endomembrane system does not include the membranes of mitochondria or chloroplasts.The nuclear membrane contains two lipid bilayers that encompass the contents of the nucleus. The endoplasmic reticulum (ER) is a synthesis and transport organelle that branches into the cytoplasm in plant and animal cells. The Golgi apparatus is a series of multiple compartments where molecules are packaged for delivery to other cell components or for secretion from the cell. Vacuoles, which are found in both plant and animal cells (though much bigger in plant cells), are responsible for maintaining the shape and structure of the cell as well as storing waste products. A vesicle is a relatively small, membrane-enclosed sac that stores or transports substances. The cell membrane, is a protective barrier that regulates what enters and leaves the cell. There is also an organelle known as the Spitzenkörper that is only found in fungi, and is connected with hyphal tip growth.In prokaryotes endomembranes are rare, although in many photosynthetic bacteria the plasma membrane is highly folded and most of the cell cytoplasm is filled with layers of light-gathering membrane. These light-gathering membranes may even form enclosed structures called chlorosomes in green sulfur bacteria.The organelles of the endomembrane system are related through direct contact or by the transfer of membrane segments as vesicles. Despite these relationships, the various membranes are not identical in structure and function. The thickness, molecular composition, and metabolic behavior of a membrane are not fixed, they may be modified several times during the membrane's life. One unifying characteristic the membranes share is a lipid bilayer, with proteins attached to either side or traversing them.
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