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H37-R38 - Uplift Mighty Prep
H37-R38 - Uplift Mighty Prep

... BIOLOGY – Ch 38(Circulatory and Respiratory systems) ________________________________________________________________________ Cardiovascular system – connects the muscle and organs of the body through an extensive system of vessels that transport blood. Blood vessels (Refer to picture in packet) Lym ...
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Outline - Membranes 1. Fluid Mosaic Model of Membrane Structure

... Moving Molecules into or out of Cells - Overview of Types of Transport I. Passive Transport 1. Always “down” a concentration gradient 2. Always involves proteins called A. Channels B. Carriers ...
BIO 181 Unity of Life I - Coconino Community College
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< 1 ... 1014 1015 1016 1017 1018 1019 1020 1021 1022 ... 1638 >

Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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