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Guidleine on potency testing of cell based immunotherapy medicinal
Guidleine on potency testing of cell based immunotherapy medicinal

11 May 2017 17:07 E.S.T. ASGCT Posters 2017
11 May 2017 17:07 E.S.T. ASGCT Posters 2017

... TALEN has revolutionized biological research and has broad-based therapeutic applications. However, for clinical use, it is essential to understand the totality of genome-modifying effects of these nucleases as deleterious off-target mutations may create cells with oncogenic potential or impaired fu ...
Oxidative Stress: Antagonistic Signaling for
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... resistance to oxidative stress-induced cell death is critical. However, such outcomes should not be regarded as a success (for acclimation) or a failure (for death). This may be so from a cellular perspective, but at the level of the organ or organism the processes of cell death and acclimation are ...
A conserved sequence in calmodulin regulated spectrinassociated
A conserved sequence in calmodulin regulated spectrinassociated

... extending newly formed axons. Among these are microtubules (Lafont et al. 1993) and proteins that interact with them as assembly factors (e.g. Gordon-Weeks 2004), motors (e.g. Ahmad et al. 2000; Hirokawa and Takemura 2004) or cross-linkers (e.g. Dehmelt and Halpain 2004). Recently, we characterised ...
Gain of function in the immune system caused by a ryanodine
Gain of function in the immune system caused by a ryanodine

... RyR1 cDNA from wild-type mice (WT) yields the uncut band of about 376 bp, whereas digestion of the cDNA from heterozygous mice (HET RYR1Y522S) yields two bands of 276 bp and 100 bp plus the uncut 376 bp band from the wild-type allele. (B) The resting [Ca2+] of DCs from HET RYR1Y522S mice is signific ...
Full Text  - The Journal of Immunology
Full Text - The Journal of Immunology

... factors, 5637 human bladder epithelial cells were infected with K12 E. coli expressing (AAEC185/pSH2) or not expressing (AAEC185) type 1 pili and the IL-6 concentration in the supernatants was determined. TMP-SMZ, a bacteriostatic antibiotic frequently used in the treatment of UTIs, was always coinc ...
Nuclear and Nucleolar Localization by the N
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... nuclear localization (Figure 3A and 3B) and neither displayed nucleolar localization. These data imply that nucleolin binding region (residue 166-210) alone is not sufficient for the nucleolar localization of the enzyme. To further characterize the nucleolin binding region and localization, we const ...
Federal and State legislative activity March 15, 2017 CTIA
Federal and State legislative activity March 15, 2017 CTIA

... – at increasing levels – access to wireless products and services. This is demonstrated by the fact the number of wireless subscribers in Florida has grown 17% since 2010, amounting to over 20.2 million subscribers. 1 In fact, 99% of Floridians use wireless.2 These demands from the wireless industry ...
Use of the BacTiter-Glo™ Microbial Cell Viability Assay to Study
Use of the BacTiter-Glo™ Microbial Cell Viability Assay to Study

... a review, see reference 1). Each step is characterized by the involvement of a distinct surface organelle. Flagella mediate reversible attachment, type 1 pili mediate irreversible attachment, and capsules allow the formation of the mature biofilm. The synthesis of each organelle requires the coordin ...
Prm1p, a Pheromone-regulated Multispanning Membrane Protein
Prm1p, a Pheromone-regulated Multispanning Membrane Protein

... assembles from subunits associated with different bilayers— their final structures bear remarkable similarities (Weber et al., 1998). In each case, the assembled fusase has domains in- ...
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Slide 1
Slide 1

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ch_06_clicker_questions
ch_06_clicker_questions

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Transcriptomic analysis of stage 1 versus advanced adult granulosa
Transcriptomic analysis of stage 1 versus advanced adult granulosa

... changes were assessed for 4 genes, selected on the basis of their fold change and p-value, by quantitative RT-PCR (Figure 3) using an overlapping but non-identical group of tumors (Table 1): microibrillar-associated protein 5 (MFAP5) which was signiicantly more highly expressed in the stage 3 group; ...
Cell Membrane - holyoke
Cell Membrane - holyoke

... When something can move through a cell membrane without using any energy (like diffusion) it is called ___________ transport. ...
hormone
hormone

... Copyright © 2002 Pearson Education, Inc., publishing as Benjamin Cummings ...
The cell biology of bone metabolism
The cell biology of bone metabolism

... matrix, size, structure, geometry and density all combine to determine the bone’s overall mechanical properties. Defects in these parameters will result in diseases such as osteoporosis, Paget’s disease of bone, osteopetrosis and osteogenesis imperfecta. In order for the strength of the bone to be m ...
Isolates of Vaccinia Virus Strains, Smallpox Vaccines, and Zoonotic
Isolates of Vaccinia Virus Strains, Smallpox Vaccines, and Zoonotic

... was the live vaccine used to eradicate smallpox. In the absence of smallpox, VACV is being stockpiled in several countries against a potential nefarious release of variola virus, the causative agent of this now historic disease. Furthermore, smallpox vaccination provided protection against a range o ...
Rat embryonic ectoderm as renal isograft - Development
Rat embryonic ectoderm as renal isograft - Development

... the Miillerian ducts in the male mouse embryos, may involve this mechanism (Trelstad, Hayashi, Hayashi & Donahoe, 1982; Paranko, Pelliniemi & Foidart, 1984). On the other hand, the formation of mesenchyme through an analogoue of the primitive streak is always attained when the early mouse embryo (or ...
Growth of a Tryptophanase-producing Thermophile
Growth of a Tryptophanase-producing Thermophile

... membrane filter placed on the surface of Trp-PEP agar medium and incubated at 60 "C for 24 h. The total cell numbers of S . thermophilum strain T and Bacillus strain S in the mixed culture were determined in a PetroffHausser counting chamber by phase contrast microscopy ( x 1000 magnification). Sepa ...
Cover (Outside).qxd
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... Laboulbeniales are known from Carabidae including Laboulbenia Montagne & Robin with several hundred ground beetle-infesting species. Host specificity and mechanisms of parasite transfer of many taxa, especially those from tropical regions, are still unclear. There are few specific studies of these p ...
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Basophils are inept at promoting human Th17 responses

... HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. ...
Anatomy and Physiology
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... Question 10 Explanation:a. Caudal – inferior; away from the head end or toward the lower part of a structure or the body. b. Distal farther from the origin of a body part or the point of attachment of a limb to the body trunk c. Proximal – closer to the origin of a body part or the point of attachme ...
Swimming behavior of the monotrichous bacterium Pseudomonas
Swimming behavior of the monotrichous bacterium Pseudomonas

... & El-Masry, 1989; Kanda et al., 2011). Pseudomonas putida PRS2000 generally have five to seven flagella (Harwood et al., 1989). The number of flagella on P. fluorescens SBW25 cells is probably similar to that of P. aeruginosa, which often carry a single flagellum (E.P. Greenberg and R. Ramphal, pers ...
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Amitosis

Amitosis (a- + mitosis) is absence of mitosis, the usual form of cell division in the cells of eukaryotes. There are several senses in which eukaryotic cells can be amitotic. One refers to capability for non-mitotic division and the other refers to lack of capability for division. In one sense of the word, which is now mostly obsolete, amitosis is cell division in eukaryotic cells that happens without the usual features of mitosis as seen on microscopy, namely, without nuclear envelope breakdown and without formation of mitotic spindle and condensed chromosomes as far as microscopy can detect. However, most examples of cell division formerly thought to belong to this supposedly ""non-mitotic"" class, such as the division of unicellular eukaryotes, are today recognized as belonging to a class of mitosis called closed mitosis. A spectrum of mitotic activity can be categorized as open, semi-closed, and closed mitosis, depending on the fate of the nuclear envelope. An exception is the division of ciliate macronucleus, which is not mitotic, and the reference to this process as amitosis may be the only legitimate use of the ""non-mitotic division"" sense of the term today. In animals and plants which normally have open mitosis, the microscopic picture described in the 19th century as amitosis most likely corresponded to apoptosis, a process of programmed cell death associated with fragmentation of the nucleus and cytoplasm. Relatedly, even in the late 19th century cytologists mentioned that in larger life forms, amitosis is a ""forerunner of degeneration"".Another sense of amitotic refers to cells of certain tissues that are usually no longer capable of mitosis once the organism has matured into adulthood. In humans this is true of various muscle and nerve tissue types; if the existing ones are damaged, they cannot be replaced with new ones of equal capability. For example, cardiac muscle destroyed by heart attack and nerves destroyed by piercing trauma usually cannot regenerate. In contrast, skin cells are capable of mitosis throughout adulthood; old skin cells that die and slough off are replaced with new ones. Human liver tissue also has a sort of dormant regenerative ability; it is usually not needed or expressed but can be elicited if needed.
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