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Guidance cues involved in the development of the peripheral
Guidance cues involved in the development of the peripheral

... 3. Development of the enteric nervous system The vast majority of enteric neurons and glial cells arise from neural crest cells that emigrate from the post-otic hindbrain adjacent to somites 1– 7 (Yntema and Hammond, 1954; Le Douarin and Teillet, 1973). Vagal neural crest cells enter the foregut, an ...
A Critical Role for Egr-1 Characterization of CD44 Induction by IL-1:
A Critical Role for Egr-1 Characterization of CD44 Induction by IL-1:

... (8). Furthermore, three studies have shown that an anti-CD44 Ab, IM7, has antiinflammatory effects in several in vivo models of inflammation (15–17). Finally, binding of low m.w. fragments of hyaluronic acid (HA) to alveolar macrophages via CD44 elicits the expression of a number of proinflammatory ...
Function Antigens but with Altered Cytokine Secretion Cells To
Function Antigens but with Altered Cytokine Secretion Cells To

... Dendritic cells (DCs) are directly activated by pathogen-associated molecular patterns (PAMPs) and undergo maturation. Mature DCs express high levels of MHC class II molecules (“signal 1”), upregulate T cell costimulatory receptors (“signal 2”), and secrete “signal 3” cytokines (e.g., IL-12). Mature ...
The influence of chronic stress on T cell immunity
The influence of chronic stress on T cell immunity

... system is not operating autonomously but influences and is influenced by the central nervous system (CNS) through a complex, interacting network of nerves, hormones, and neuropeptides. This interaction is thought to serve as a mechanism to fine-tune many immune responses, for instance to prevent the ...
PCR product Lane L2 : Purified PCR product Lane L3 : Undigested
PCR product Lane L2 : Purified PCR product Lane L3 : Undigested

... with microbes and infection free wound healing was observed in responds to incisions  The active principle was isolated and characterized (Zasloff et al., 1987) ...
programmed cell death in plant
programmed cell death in plant

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Oct-4 controls cell-cycle progression of embryonic stem cells

... c The Authors Journal compilation  c 2010 Biochemical Society ...
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Amyotrophic Lateral Sclerosis SOD1
Amyotrophic Lateral Sclerosis SOD1

... To isolate total-protein extracts, cells in serum-free medium were harvested in ice-cold RIPA buffer (PBS, 1% Nonidet P-40, 0.5% sodium deoxycholate, 0.1% SDS) added to protease inhibitor mixture (Sigma-Aldrich). Lysates were kept on ice for 30 min and then centrifuged for 10 min at 14,000 3 g at 4˚ ...
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Archaea - The Ancient Oddities

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FEMS Microbiology Ecology
FEMS Microbiology Ecology

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Trafficking of the human transferrin receptor in plant cells: effects of

... homodimers and internalized BRI1–SERK3 heterodimers. Endocytic trafficking of other receptor-like kinases such as CLV1 (CLAVATA 1) and SRK may be expected because their kinase domains interact with an endosomal sorting nexin (Vanoosthuyse et al., 2003). On the other hand, biotin and biotinylated mar ...
Control of convergent yolk syncytial layer nuclear movement in
Control of convergent yolk syncytial layer nuclear movement in

... morphogenesis is required for blastoderm epiboly. Finally, the YSL has been proposed to induce fibronectin expression in the overlying embryonic tissue, which is important for heart progenitor cell migration during gastrulation and somitogenesis stages (Sakaguchi et al., 2006). The YSL is formed by ...
Development of angiosperm seed is a complex process
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... Proanthocyanidins are apparently released from the endothelial cells and impregnate walls the inner three cell layers during this period (Fig. 2E). ...
Growth-modulating molecules are associated with invading
Growth-modulating molecules are associated with invading

6 systems biology of cell organization
6 systems biology of cell organization

... So let’s suppose that a researcher could somehow synthesize the genome of a species and produce all of its RNA molecules and proteins. That would be an amazing feat! If the genome, proteins, and RNAs were combined in a test tube with other small molecules that are needed for energy and as building b ...
toxins
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... Clostridium botulinum and Clostridium tetani secrete very potent neurotoxins, which are responsible for neurological disorders in humans and animals, botulism and tetanus, respectively. Several recent reviews detail the structure and mode of action of neurotoxins [39–45]. C. tetani forms a homogeneo ...
Inflammation 1
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... - are the most common and medically important causes of inflammation - the microbial products are sensed by the family of Toll-like receptors (TLRs) - engagement of these receptors triggers signalling pathways that stimulate the production of various mediators. • Foreign bodies (splinters, dirt, sut ...
machinery pre-mRNA in sensing defects in the spliceosomal Mdm4
machinery pre-mRNA in sensing defects in the spliceosomal Mdm4

Abscisic acid
Abscisic acid

... impaired ABA response and reduced drought resistance. They found two copies of PYR1 fit snugly together in plant cells, and they are receptors for ABA. Each copy of the PYR1 molecule has an internal open space like the inside of a tin can, and when a ABA molecule comes along, it fits into one of the ...
Control of convergent yolk syncytial layer nuclear movement in
Control of convergent yolk syncytial layer nuclear movement in

... morphogenesis is required for blastoderm epiboly. Finally, the YSL has been proposed to induce fibronectin expression in the overlying embryonic tissue, which is important for heart progenitor cell migration during gastrulation and somitogenesis stages (Sakaguchi et al., 2006). The YSL is formed by ...
Xpf suppresses mutagenic consequences of bacterial phagocytosis
Xpf suppresses mutagenic consequences of bacterial phagocytosis

... molecules such as hypochlorus acid and reactive oxygen species, which are known to be highly mutagenic (Knaapen et al., 2006). It is thus conceivable that the mutagen forms part of an amoebal immune response to bacteria. An intriguing observation is that bacteria differ in their potency to inhibit g ...
Precursor of human adenovirus core polypeptide Mu targets the
Precursor of human adenovirus core polypeptide Mu targets the

... Fig. 1. Identification of regions of Mu protein involved in nuclear and nucleolar targeting. (A) Schematic showing the regions of preMu protein fused to EGFP. On the left, each protein is identified by the amino acids from the full-length preMu protein sequence, expressed N-terminal to the EGFP sequ ...
Molecular and Cellular Mechanisms Whereby the Apical Ectodermal
Molecular and Cellular Mechanisms Whereby the Apical Ectodermal

... Developmental biology is becoming an increasingly important area of study, with research only scratching the surface of the many complex processes involved in the process of making an ordered form. There are many facets of developmental biology; some focusing on cellular mechanisms and behavior with ...
Construction and applications of yellow fever virus replicons
Construction and applications of yellow fever virus replicons

... Fig. 1. Organization of the YFV genome and replicon constructs. (A) Schematic representation of the YFV genome with open boxes denoting regions coding for the structural (white) and nonstructural (light gray) proteins that are translated as a polyprotein. The 5Vand 3Vuntranslated regions (UTRs) are ...
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Amitosis

Amitosis (a- + mitosis) is absence of mitosis, the usual form of cell division in the cells of eukaryotes. There are several senses in which eukaryotic cells can be amitotic. One refers to capability for non-mitotic division and the other refers to lack of capability for division. In one sense of the word, which is now mostly obsolete, amitosis is cell division in eukaryotic cells that happens without the usual features of mitosis as seen on microscopy, namely, without nuclear envelope breakdown and without formation of mitotic spindle and condensed chromosomes as far as microscopy can detect. However, most examples of cell division formerly thought to belong to this supposedly ""non-mitotic"" class, such as the division of unicellular eukaryotes, are today recognized as belonging to a class of mitosis called closed mitosis. A spectrum of mitotic activity can be categorized as open, semi-closed, and closed mitosis, depending on the fate of the nuclear envelope. An exception is the division of ciliate macronucleus, which is not mitotic, and the reference to this process as amitosis may be the only legitimate use of the ""non-mitotic division"" sense of the term today. In animals and plants which normally have open mitosis, the microscopic picture described in the 19th century as amitosis most likely corresponded to apoptosis, a process of programmed cell death associated with fragmentation of the nucleus and cytoplasm. Relatedly, even in the late 19th century cytologists mentioned that in larger life forms, amitosis is a ""forerunner of degeneration"".Another sense of amitotic refers to cells of certain tissues that are usually no longer capable of mitosis once the organism has matured into adulthood. In humans this is true of various muscle and nerve tissue types; if the existing ones are damaged, they cannot be replaced with new ones of equal capability. For example, cardiac muscle destroyed by heart attack and nerves destroyed by piercing trauma usually cannot regenerate. In contrast, skin cells are capable of mitosis throughout adulthood; old skin cells that die and slough off are replaced with new ones. Human liver tissue also has a sort of dormant regenerative ability; it is usually not needed or expressed but can be elicited if needed.
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