Hereditary neutropenia - University of Washington
... the rare Hermansky– Pudlak syndrome type 2 (HPS2) in humans – only three families with a total of four children have been described [28 –30] – as well as the pearl mouse and ruby Drosophila strains (Figure 3). Hermansky – Pudlak syndromes are heterogeneous autosomal-recessive disorders that cause cu ...
... the rare Hermansky– Pudlak syndrome type 2 (HPS2) in humans – only three families with a total of four children have been described [28 –30] – as well as the pearl mouse and ruby Drosophila strains (Figure 3). Hermansky – Pudlak syndromes are heterogeneous autosomal-recessive disorders that cause cu ...
articles
... are still poorly understood. Here we provide evidence that distinct cellular steps of EMT occur sequentially during gastrulation. Basement membrane (BM) breakdown is the first recognizable step and is controlled by loss of basally localized RhoA activity and its activator neuroepithelial-transformin ...
... are still poorly understood. Here we provide evidence that distinct cellular steps of EMT occur sequentially during gastrulation. Basement membrane (BM) breakdown is the first recognizable step and is controlled by loss of basally localized RhoA activity and its activator neuroepithelial-transformin ...
Sister Chromatid Cohesion Control and Aneuploidy
... structure for cohesin complexes. A heterodimer shaped by the interactions of the hinge regions from SMC1 and SMC3 form the ring arrangement. The N- and C-termini regions of SCC1/RAD21 kleisin subunit interact with the head domains from SMC3 and SMC1, respectively, closing the ring. The SCC3/SA/STAG ...
... structure for cohesin complexes. A heterodimer shaped by the interactions of the hinge regions from SMC1 and SMC3 form the ring arrangement. The N- and C-termini regions of SCC1/RAD21 kleisin subunit interact with the head domains from SMC3 and SMC1, respectively, closing the ring. The SCC3/SA/STAG ...
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... Thus, the data available from such in vivo experimentation are, by themselves, inconclusive. However, an in vitro system not only provides the advantage of isolating the regenerating systems from the direct effects of the deranged metabolic conditions, but also makes it feasible to study the direct ...
... Thus, the data available from such in vivo experimentation are, by themselves, inconclusive. However, an in vitro system not only provides the advantage of isolating the regenerating systems from the direct effects of the deranged metabolic conditions, but also makes it feasible to study the direct ...
Regulation of DNA replication during development
... dwarfism characterized by several developmental abnormalities (Gorlin, 1992). MGS follows an autosomal recessive mode of inheritance with differing degrees of severity and until recently no genes or loci had been found to be associated with this syndrome. A series of elegant studies, however, has no ...
... dwarfism characterized by several developmental abnormalities (Gorlin, 1992). MGS follows an autosomal recessive mode of inheritance with differing degrees of severity and until recently no genes or loci had been found to be associated with this syndrome. A series of elegant studies, however, has no ...
Get PDF - Wiley Online Library
... 2000). Although convergence is occurring during epiboly, the mechanistic relationships between the two processes are not understood. However, these movements must be somewhat interdependent, as epiboly is slowed in frogs by treatments that block convergence (Hikasa et al., 2002). Here, we document t ...
... 2000). Although convergence is occurring during epiboly, the mechanistic relationships between the two processes are not understood. However, these movements must be somewhat interdependent, as epiboly is slowed in frogs by treatments that block convergence (Hikasa et al., 2002). Here, we document t ...
Nervous Tissue - Essex County College Faculty Web Server
... Refractory Period of Action Potential • Period of time during which neuron can not generate another action potential • Absolute refractory period – even very strong stimulus will not begin another AP – inactivated Na+ channels must return to the resting state before they can be reopened – large fib ...
... Refractory Period of Action Potential • Period of time during which neuron can not generate another action potential • Absolute refractory period – even very strong stimulus will not begin another AP – inactivated Na+ channels must return to the resting state before they can be reopened – large fib ...
Recovery of the resurrection plant Craterostigma wilmsii from
... taken for this protection to be instituted is thought to preclude recovery after rapid drying. Thus the response of C. wilmsii plants to rapid dehydration was investigated. The effect of rapid drying on sucrose accumulation was determined and the cellular ultrastructure was investigated during natur ...
... taken for this protection to be instituted is thought to preclude recovery after rapid drying. Thus the response of C. wilmsii plants to rapid dehydration was investigated. The effect of rapid drying on sucrose accumulation was determined and the cellular ultrastructure was investigated during natur ...
In vitro skin models to study epithelial regeneration from the hair
... permanent cover but, availability can be restricted due to sparse donor sites which can lead to pain and scar formation. The latter are temporary, subject to rejection, and pose a risk of viral transmission. Utilisation of keratinocyte sheets in the treatment of burns has also been documented [2]. H ...
... permanent cover but, availability can be restricted due to sparse donor sites which can lead to pain and scar formation. The latter are temporary, subject to rejection, and pose a risk of viral transmission. Utilisation of keratinocyte sheets in the treatment of burns has also been documented [2]. H ...
Use of Phenylboronic Acids to Investigate Boron
... Boronates (i.e. boronic acids) are a structurally similar but diverse class of molecules that can form reversible ester bonds with cis-diols in a manner functionally identical to borates (Bergold and Scouten, 1983; Springsteen and Wang, 2002). Boronates, however, contain only one pair of hydroxyl mo ...
... Boronates (i.e. boronic acids) are a structurally similar but diverse class of molecules that can form reversible ester bonds with cis-diols in a manner functionally identical to borates (Bergold and Scouten, 1983; Springsteen and Wang, 2002). Boronates, however, contain only one pair of hydroxyl mo ...
Lectures 1 and 2
... Glycobiology is an integrative science, crossing all subfields of chemistry, biology and medicine. Chemical analysis and biochemistry dominated the field in the early part of the century. ...
... Glycobiology is an integrative science, crossing all subfields of chemistry, biology and medicine. Chemical analysis and biochemistry dominated the field in the early part of the century. ...
Study of moss vacuoles and functional
... Compartment) and lytic vacuoles (LV) or protein storage vacuole (PSV). This model is based on different studies and was described in Vitale„s review (Vitale and Raikhel 1999). However this ...
... Compartment) and lytic vacuoles (LV) or protein storage vacuole (PSV). This model is based on different studies and was described in Vitale„s review (Vitale and Raikhel 1999). However this ...
Robust mechanisms of ventral furrow invagination require the
... as a model system for this analysis for two reasons. First, it is one of the best-studied morphogenetic processes in biology. Second, ventral furrow formation is a comparatively simple but important mechanical process which, as the first largescale morphogenetic movement in the fly embryo, begins as ...
... as a model system for this analysis for two reasons. First, it is one of the best-studied morphogenetic processes in biology. Second, ventral furrow formation is a comparatively simple but important mechanical process which, as the first largescale morphogenetic movement in the fly embryo, begins as ...
... deep and anteriorwards to begin eye folding (Fig. 1B-D,F-H, Fig. 3G). Coincidently, telencephalon and the anterior-lateral eye field fold towards the midline, which positions them above medial and posterior eye cells (Fig. 1B,F). This creates a neuropore within the dorsal seam of the neural tube nea ...
Computational optogenetics: A novel continuum framework for the
... The human heart propels over 7000 l of blood through the body daily, beating more than 40 million times a year. It is a remarkably efficient, durable, and reliable mechanical pump, precisely regulated by spatially and temporally varying electrical and chemical fields. Disturbed conduction and uncoordi ...
... The human heart propels over 7000 l of blood through the body daily, beating more than 40 million times a year. It is a remarkably efficient, durable, and reliable mechanical pump, precisely regulated by spatially and temporally varying electrical and chemical fields. Disturbed conduction and uncoordi ...
Journal of Bacteriology
... (x400 magnification). Attachment was ranked from class 1 (no attached bacteria) to class 4 (many attached bacteria forming a caplike aggregate on top of the root hair). The percentage of root hairs of each class was calculated. The variability of this test is about 5% and depends largely on the cond ...
... (x400 magnification). Attachment was ranked from class 1 (no attached bacteria) to class 4 (many attached bacteria forming a caplike aggregate on top of the root hair). The percentage of root hairs of each class was calculated. The variability of this test is about 5% and depends largely on the cond ...
Highly pathogenic avian influenza virus infection in chickens but not
... influenza (HPAI) H5N1 virus infection causes severe disease in humans with a fatality rate of about 60% [2]. Most human influenza pandemics of the 20th century had been caused by influenza A viruses (IAVs) that originated, either wholly or in part, from avian influenza A viruses [3]. Ducks and wate ...
... influenza (HPAI) H5N1 virus infection causes severe disease in humans with a fatality rate of about 60% [2]. Most human influenza pandemics of the 20th century had been caused by influenza A viruses (IAVs) that originated, either wholly or in part, from avian influenza A viruses [3]. Ducks and wate ...
Copyright Information of the Article Published Online
... peroxisomes and mitochondria are present, with the actual number depending on the metabolic needs of the cells. The shape and the interconnection among and between these organelles also change depending on the metabolic environment[25]. ...
... peroxisomes and mitochondria are present, with the actual number depending on the metabolic needs of the cells. The shape and the interconnection among and between these organelles also change depending on the metabolic environment[25]. ...
Shh signalling and cell death in limb development
... Fig. 1. Shh expression and cell death following grafts of polarising region cells (A-H) or Shh beads (I-L) to the posterior margin. (A) Graft of polarising region cells to posterior margin of a stage 20 wing bud. Embryo collected immediately after the operation and subjected to in situ hybridisation ...
... Fig. 1. Shh expression and cell death following grafts of polarising region cells (A-H) or Shh beads (I-L) to the posterior margin. (A) Graft of polarising region cells to posterior margin of a stage 20 wing bud. Embryo collected immediately after the operation and subjected to in situ hybridisation ...
Lats kinase is involved in the intestinal apical
... orb6, a Lats kinase homolog, is known to be involved in the maintenance of cell polarity (Verde et al., 1998). cbk1, the budding yeast homolog of Lats kinase, regulates polarized cell growth (Bidlingmaier et al., 2001). Several reports also suggest that Lats kinase is involved in information process ...
... orb6, a Lats kinase homolog, is known to be involved in the maintenance of cell polarity (Verde et al., 1998). cbk1, the budding yeast homolog of Lats kinase, regulates polarized cell growth (Bidlingmaier et al., 2001). Several reports also suggest that Lats kinase is involved in information process ...
Plant and animal cells
... Structure of cellulose • Like starch, cellulose is composed of a long chain of at least 500 glucose molecules. Cellulose is thus a polysaccharide. Several of these polysaccharide chains are arranged in parallel arrays to form cellulose microfibrils. • The individual polysaccharide chains are bound ...
... Structure of cellulose • Like starch, cellulose is composed of a long chain of at least 500 glucose molecules. Cellulose is thus a polysaccharide. Several of these polysaccharide chains are arranged in parallel arrays to form cellulose microfibrils. • The individual polysaccharide chains are bound ...
Capturing protein interactions in the secretory pathway of living cells
... fragment 2 was fused to the C terminus of MCFD2 and albumin as well as to the N terminus of catZ (Fig. 1B). C-terminal tagging of catZ was not possible, because it interferes with ERGIC-53 binding (C. Appenzeller and H.-P.H., unpublished data). Fluorometric analysis detected YFP fragment complementa ...
... fragment 2 was fused to the C terminus of MCFD2 and albumin as well as to the N terminus of catZ (Fig. 1B). C-terminal tagging of catZ was not possible, because it interferes with ERGIC-53 binding (C. Appenzeller and H.-P.H., unpublished data). Fluorometric analysis detected YFP fragment complementa ...
Dazl regulates mouse embryonic germ cell development
... into the oocyte cytoplasm, the nuclear lamina is disassembled and the sperm chromatin then undergoes extensive de-condensation (McLay and Clarke, 2003). Nuclear membranes then reform around the chromosomes and both maternal and paternal pronuclei move towards the center of the oocyte, undergoing DNA ...
... into the oocyte cytoplasm, the nuclear lamina is disassembled and the sperm chromatin then undergoes extensive de-condensation (McLay and Clarke, 2003). Nuclear membranes then reform around the chromosomes and both maternal and paternal pronuclei move towards the center of the oocyte, undergoing DNA ...
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... system. A monoclonal antibody to acetylated α-tubulin (ACT; Sigma) was used to stain axons in embryos of different stages. Tracings of nerves from representative segments were fused into a single image that depicts the major events during T. rude axogenesis. The time line indicates the approximate c ...
... system. A monoclonal antibody to acetylated α-tubulin (ACT; Sigma) was used to stain axons in embryos of different stages. Tracings of nerves from representative segments were fused into a single image that depicts the major events during T. rude axogenesis. The time line indicates the approximate c ...
BCL-6 Negatively Regulates Expression of the NF- p50 Subunit B1 p105/
... of NF-B (19 –21). In the macrophage/osteoclast lineage, a homodimeric cytokine, CSF-1, is the primary regulator of survival, proliferation, and differentiation (reviewed in Ref. 22). Major events triggered by engagement of the CSF-1 receptor, c-Fms, include activation of STAT1, STAT3, the MAPK, and ...
... of NF-B (19 –21). In the macrophage/osteoclast lineage, a homodimeric cytokine, CSF-1, is the primary regulator of survival, proliferation, and differentiation (reviewed in Ref. 22). Major events triggered by engagement of the CSF-1 receptor, c-Fms, include activation of STAT1, STAT3, the MAPK, and ...