BCL-6 Negatively Regulates Expression of the NF- p50 Subunit B1 p105/
... of NF-B (19 –21). In the macrophage/osteoclast lineage, a homodimeric cytokine, CSF-1, is the primary regulator of survival, proliferation, and differentiation (reviewed in Ref. 22). Major events triggered by engagement of the CSF-1 receptor, c-Fms, include activation of STAT1, STAT3, the MAPK, and ...
... of NF-B (19 –21). In the macrophage/osteoclast lineage, a homodimeric cytokine, CSF-1, is the primary regulator of survival, proliferation, and differentiation (reviewed in Ref. 22). Major events triggered by engagement of the CSF-1 receptor, c-Fms, include activation of STAT1, STAT3, the MAPK, and ...
Comprehensive Analysis of Human Cytomegalovirus MicroRNA
... and cellular factors involved in signaling and cell cycle [15]. In the present work expression and kinetics of 16 mature HCMV miRNAs were examined in different cell culture systems representing permissive, semi-permissive, and quiescent/latent-like infections. THP-1 acute monocytic leukemia cells [1 ...
... and cellular factors involved in signaling and cell cycle [15]. In the present work expression and kinetics of 16 mature HCMV miRNAs were examined in different cell culture systems representing permissive, semi-permissive, and quiescent/latent-like infections. THP-1 acute monocytic leukemia cells [1 ...
Neuronal Growth Cone Retraction Relies Upon Proneurotrophin
... Fig. S5: Decrease of Rac- but not RhoA activity induces growth cone collapse. Fig. S6: Fascin and p75NTR form a complex in embryonic brain lysates. Author contributions: K.D., T.K. and D.S.S. performed experiments and analyzed data, K.D., R.E.M., B.A.E., T.A.N., M.V.C. and B.L.H. designed experiment ...
... Fig. S5: Decrease of Rac- but not RhoA activity induces growth cone collapse. Fig. S6: Fascin and p75NTR form a complex in embryonic brain lysates. Author contributions: K.D., T.K. and D.S.S. performed experiments and analyzed data, K.D., R.E.M., B.A.E., T.A.N., M.V.C. and B.L.H. designed experiment ...
Caenorhabditis elegans lin-3
... carries a G-to-A transition in the first nucleotide of exon 8 of lin-3 and is predicted to mutate an arginine to a lysine at amino acid 347 of LIN-3 (Figure 1B). The n4951 mutant carries a G-to-A transition that results in a nonsense mutation predicted to truncate LIN-3 after only 26 amino acids, be ...
... carries a G-to-A transition in the first nucleotide of exon 8 of lin-3 and is predicted to mutate an arginine to a lysine at amino acid 347 of LIN-3 (Figure 1B). The n4951 mutant carries a G-to-A transition that results in a nonsense mutation predicted to truncate LIN-3 after only 26 amino acids, be ...
Muscle tissues Muscle tissue
... • Skeletal muscle or "voluntary muscle" is anchored by tendons (or by aponeuroses at a few places) to bone and is used to effect skeletal movement such as locomotion and in maintaining posture. • Though this postural control is generally maintained as an unconscious reflex (see proprioception), the ...
... • Skeletal muscle or "voluntary muscle" is anchored by tendons (or by aponeuroses at a few places) to bone and is used to effect skeletal movement such as locomotion and in maintaining posture. • Though this postural control is generally maintained as an unconscious reflex (see proprioception), the ...
The lysosome as a command-and-control center for cellular
... activators of mTORC1 (Hara et al., 1998; Wang et al., 1998) upstream of the Rag GTPases (Sancak et al., 2008). Of note, arginine, an amino acid crucial for mammalian embryogenesis and early development, is highly concentrated in rat liver lysosomes ...
... activators of mTORC1 (Hara et al., 1998; Wang et al., 1998) upstream of the Rag GTPases (Sancak et al., 2008). Of note, arginine, an amino acid crucial for mammalian embryogenesis and early development, is highly concentrated in rat liver lysosomes ...
... characterized in normal individuals for a number of distinct phenotypic and functional features that, in general, support the hypothesis of a confined immunological compartment. In fact, lung lymphocytes display the very late activation-1 (VLA-1) surface antigens [1] at a much higher rate than early ...
Micronuclei and the Cytoplasm of Growing Tetrahymena Contain a
... acetylated with a macronuclear acetylase (Fig. 1), we were interested to see whether purified micronuclei contain any extractable activity that could acetylate macronuclear histones. Macronuclear histone (both DNA free and chromatin) was chosen as an initial substrate for these experiments (as oppos ...
... acetylated with a macronuclear acetylase (Fig. 1), we were interested to see whether purified micronuclei contain any extractable activity that could acetylate macronuclear histones. Macronuclear histone (both DNA free and chromatin) was chosen as an initial substrate for these experiments (as oppos ...
The lysosome as a command-and-control center for cellular
... activators of mTORC1 (Hara et al., 1998; Wang et al., 1998) upstream of the Rag GTPases (Sancak et al., 2008). Of note, arginine, an amino acid crucial for mammalian embryogenesis and early development, is highly concentrated in rat liver lysosomes ...
... activators of mTORC1 (Hara et al., 1998; Wang et al., 1998) upstream of the Rag GTPases (Sancak et al., 2008). Of note, arginine, an amino acid crucial for mammalian embryogenesis and early development, is highly concentrated in rat liver lysosomes ...
Biochemical bases of appearance and texture changes in fresh
... results in colorless products, while the oxidation reaction is relatively rapid and the resultant quinones are colored. Subsequent reactions of the quinones lead to melanin accumulation, which is the brown or black pigment associated with “browning” in plant tissues. The specific reaction sequence w ...
... results in colorless products, while the oxidation reaction is relatively rapid and the resultant quinones are colored. Subsequent reactions of the quinones lead to melanin accumulation, which is the brown or black pigment associated with “browning” in plant tissues. The specific reaction sequence w ...
High density lipoprotein-associated lysosphingolipids reduce E
... and the amount of E-selectin in cell lysates was determined using Eselectin-specific immunoassay system as described under Materials and methods. Shown are results from three to five independent experiments. (C, D) Cells were collected by trypsinization, fixed, and analyzed by flow cytometry with FITC-c ...
... and the amount of E-selectin in cell lysates was determined using Eselectin-specific immunoassay system as described under Materials and methods. Shown are results from three to five independent experiments. (C, D) Cells were collected by trypsinization, fixed, and analyzed by flow cytometry with FITC-c ...
Plant Soil
... there are two other very important plant-microbe interactions that involve some type of molecular signaling: the nitrogen-fixing symbiosis between Frankia and actinorhizal plants, and the phosphate-acquiring mycorrhizal associations that exist between a number of diverse fungi and a broad spectrum o ...
... there are two other very important plant-microbe interactions that involve some type of molecular signaling: the nitrogen-fixing symbiosis between Frankia and actinorhizal plants, and the phosphate-acquiring mycorrhizal associations that exist between a number of diverse fungi and a broad spectrum o ...
Allergen-Sensitization Increases Mast
... increased by lipopolysaccharide exposure in a temporal pattern that coincides with the peak of tumor necrosis factor-α secretion [13]. A study in the interleukin-3-dependent MC line MC9 demonstrated that stimulation with stem cell factor, interleukin-3, and interleukin-10 induced high levels of SNAP ...
... increased by lipopolysaccharide exposure in a temporal pattern that coincides with the peak of tumor necrosis factor-α secretion [13]. A study in the interleukin-3-dependent MC line MC9 demonstrated that stimulation with stem cell factor, interleukin-3, and interleukin-10 induced high levels of SNAP ...
cytoplasm nucleus and the A specific subset of
... out of the nucleus, probably bound to mRNA, remains associated with poly(A)+ RNA in the cytoplasm, and is reimported into the nucleus after dissociating from the RNA. The fact that hnRNP A1 is bound to mRNA in both cellular compartments suggested that shuttling hnRNP proteins may be involved in the ...
... out of the nucleus, probably bound to mRNA, remains associated with poly(A)+ RNA in the cytoplasm, and is reimported into the nucleus after dissociating from the RNA. The fact that hnRNP A1 is bound to mRNA in both cellular compartments suggested that shuttling hnRNP proteins may be involved in the ...
The Functional Influence of Burst and Tonic Firing Mode on Synaptic
... Figure 1. Properties of synaptic connections between PGN and thalamocortical neurons. A, Schematic diagram of the recording arrangement for recordings in B–E is shown. The PGN neuron was activated via the intracellular injection of a depolarizing current pulse while recording from a recipient thalam ...
... Figure 1. Properties of synaptic connections between PGN and thalamocortical neurons. A, Schematic diagram of the recording arrangement for recordings in B–E is shown. The PGN neuron was activated via the intracellular injection of a depolarizing current pulse while recording from a recipient thalam ...
The subunit of voltage sensitive Ca 2+ channels is a single
... Abstract The membrane topology of a2/6 subunit was investigated utilizing electrophysiological functional assay and specific anti-a2 antibodies. (a) cRNA encoding a deleted a216 subunit was coinjected with a l C subunit of the L-type calcium channel into Xenopus oocytes. The truncated form, lacking ...
... Abstract The membrane topology of a2/6 subunit was investigated utilizing electrophysiological functional assay and specific anti-a2 antibodies. (a) cRNA encoding a deleted a216 subunit was coinjected with a l C subunit of the L-type calcium channel into Xenopus oocytes. The truncated form, lacking ...
Muscle precursor cells isolated from aged rats exhibit
... Improving muscle precursor cell (MPC, muscle-specific stem cells) function during aging has been implicated as a key therapeutic target for improving age-related skeletal muscle loss. MPC dysfunction during aging can be attributed to both the aging MPC population and the changing environment in skel ...
... Improving muscle precursor cell (MPC, muscle-specific stem cells) function during aging has been implicated as a key therapeutic target for improving age-related skeletal muscle loss. MPC dysfunction during aging can be attributed to both the aging MPC population and the changing environment in skel ...
Communications between Mitochondria, the Nucleus, Vacuoles
... In the cytosol of chronologically “young” yeast progressing through D and PD growth phases, the non-reducing disaccharide trehalose is synthesized from glucose (Goldberg et al., 2009b; Kyryakov et al., 2012). The rate of such synthesis sustains cellular trehalose homeostasis and is modulated by the ...
... In the cytosol of chronologically “young” yeast progressing through D and PD growth phases, the non-reducing disaccharide trehalose is synthesized from glucose (Goldberg et al., 2009b; Kyryakov et al., 2012). The rate of such synthesis sustains cellular trehalose homeostasis and is modulated by the ...
Discovery of genes with highly restricted expression
... expression patterns of characterized genes. In the body wall, pannier (pan), twist (twi) and BarH1, which are enriched in the body-wall sample (Table 1), are known to be highly expressed in the presumptive body wall (Bate et al., 1991; Ramain et al., 1993; Sato et al., 1999). In the wing, knot (kn), ...
... expression patterns of characterized genes. In the body wall, pannier (pan), twist (twi) and BarH1, which are enriched in the body-wall sample (Table 1), are known to be highly expressed in the presumptive body wall (Bate et al., 1991; Ramain et al., 1993; Sato et al., 1999). In the wing, knot (kn), ...
Regulation of the Eukaryotic Redox-State through - diss.fu
... Cells which use aerobic metabolism gain more ATP per mole glucose, but also have to face the toxic side effects of oxygen. The mitochondrial electron transport chain is always somewhat “leaky”, leading to direct one-electron transfer to molecular oxygen and to the formation of the superoxide anion r ...
... Cells which use aerobic metabolism gain more ATP per mole glucose, but also have to face the toxic side effects of oxygen. The mitochondrial electron transport chain is always somewhat “leaky”, leading to direct one-electron transfer to molecular oxygen and to the formation of the superoxide anion r ...
Diarch Symmetry of the Vascular Bundle in
... cells displayed meristematic features with frequently three or more vacuoles and a dense cytoplasm containing numerous electron-dense ribosomes (Fig. 1A). At the phloem pole, all pericycle cells presented a single and large central vacuole and a parietal cytoplasm with less ribosomes, characteristic ...
... cells displayed meristematic features with frequently three or more vacuoles and a dense cytoplasm containing numerous electron-dense ribosomes (Fig. 1A). At the phloem pole, all pericycle cells presented a single and large central vacuole and a parietal cytoplasm with less ribosomes, characteristic ...
What is new in tympanoplasty? - Romanian Journal of Rhinology
... the laboratory to clinical application is always a challenge. Although, of course, it is important to be pragmatic about what will really help patients. Perhaps we can all hope for a future in which 3D printing of the tympanic membrane is feasible. Conflicts of interests: None Contribution of author ...
... the laboratory to clinical application is always a challenge. Although, of course, it is important to be pragmatic about what will really help patients. Perhaps we can all hope for a future in which 3D printing of the tympanic membrane is feasible. Conflicts of interests: None Contribution of author ...
Scrapie infected tissues
... oftensurrounded or emperipolesed by PrPd expressing FDC dendrites. At this terminal stage of differentiation, these cells are known as plasma cells. Less mature B cells still with dilated endoplasmic reticulum similar to the maturity seen on the right side were found in the secondary follicles of bo ...
... oftensurrounded or emperipolesed by PrPd expressing FDC dendrites. At this terminal stage of differentiation, these cells are known as plasma cells. Less mature B cells still with dilated endoplasmic reticulum similar to the maturity seen on the right side were found in the secondary follicles of bo ...