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CH 13: Regulation of Gene Expression
CH 13: Regulation of Gene Expression

... regulate _______________ which genes are expressed and which needs are not, depending on the cell’s _________. – If specific proteins are not needed all of the time, it waste would be a ___________ of energy for the cell to continually make them • Review… – What did we call the sequence of DNA that ...
Biological Explanations powerpoint
Biological Explanations powerpoint

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Nerve activates contraction

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PP - Cloudfront.net
PP - Cloudfront.net

... The two forms of a gene really don’t interact. It is just that the dominant gene codes for an enzyme producing a certain trait and the recessive allele does not. Two dominant alleles will form more enzyme, let’s say, than a heterozygote. A dominant allele does not mean it is more frequent in the pop ...
NORMAL MONOGENIC HUMAN TRAITS
NORMAL MONOGENIC HUMAN TRAITS

... tested serologically (by the reaction of agglutination). The phenotype is determined by the presence of 4 types of erythrocyte antigens (H, A1, A2, B) = agglutinogens (Ag) and 4 types of plasma antibodies (Ab) (anti-H, anti-A1, anti-A2, anti-B) = agglutinins. So, agglutinogens are present in the cel ...
INCLUSION BODY MYOPATHIES
INCLUSION BODY MYOPATHIES

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Chromosomes and Fertilization
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The Sexual Nature of the Eukaryote Genome
The Sexual Nature of the Eukaryote Genome

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chapter 24: genetics and genomics
chapter 24: genetics and genomics

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chapter 24: genetics and genomics
chapter 24: genetics and genomics

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... for a disorder, but do not have the disorder (Heterozygous) • Genetic disorders – any disease / disorder that has a genetic basis • Polygenic – characteristics that are influenced by several genes – Examples: • Skin color – six genes • Other examples – eye color, height, hair color ...
Finding the Lost Treasure of NGS Data
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... Identification using RNAseq Data • Traditionally, somatic mutations are detected using Sanger sequencing or RT-PCR by comparing paired tumor and normal samples. One obvious limitation of such methods is that we have to limit our search to a certain genomic region of interest. • With the maturity of ...
B1.7 Genes - Pearson Schools and FE Colleges
B1.7 Genes - Pearson Schools and FE Colleges

... using a DNA test. In this test, the DNA from each person is taken and chopped into pieces. The pieces are separated and form a pattern of bands. Each person’s DNA produces a different pattern but there will be similarities in the patterns for closely related people. The diagram shows the pattern of ...
Monday, Oct - Fall Pima 100
Monday, Oct - Fall Pima 100

... 3. What does the author mean when she states “we are at the beginning of a personalgenomics revolution..”? 4. Wojcicki’s husband Sergey Brin carries a gene that puts him at risk for Parkinson’s disease and there is 50% chance that their child will inherit this gene. Do you feel that this couple shou ...
Assignment Sheet
Assignment Sheet

... 12. Sickle Cell Anemia is a recessive disorder. Describe how what this condition does and how it occurs. This disorder is caused by a single base substitution and results in an altered hemoglobin protein. This causes the red blood cells to sickle. They are sticky, do not carry oxygen as effectively ...
Sequences 5` to Translation Start Regulate
Sequences 5` to Translation Start Regulate

... Studies that define the c/s-acting elements in 5' promoter regions generally use deletion analysis of the pertinent sequences (Morelli et al., 1985; Nagy et al., 1985; Timko et al., 1985); however, this type of analysis can give misleading results if duplicated sequence elements are involved. We cho ...
Appendix_1_SimpleNomenclature(plain)
Appendix_1_SimpleNomenclature(plain)

... genetic model is a diagram of the logic that you propose for inheritance. For instance, if you cross a true-breeding purple plant with a true-breeding white plant (e.g. see Figure 2 on page 2; cross the outer two plants) you will get a heterozygote (the middle plant in Figure 2, also shown at left). ...
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Gene expression profiling



In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.
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