here - Genetics
... o r more base-pair positions, and since any of four different base-pairs may occupy any one position, the number of possible mutant alleles is very large. It is important that each mutant allele of a particular locus be given a unique designation; e.g., by the use of serial numbers as suffixes. Use ...
... o r more base-pair positions, and since any of four different base-pairs may occupy any one position, the number of possible mutant alleles is very large. It is important that each mutant allele of a particular locus be given a unique designation; e.g., by the use of serial numbers as suffixes. Use ...
Journal of Molecular Microbiology and Biotechnology
... mycosubtilin biosynthesis gene cluster devoted to synthesis of an iturin-like compound, is situated at the same location [Duitman et al., 1999], suggesting that additional NRPS operons could be integrated in different ways in this area either as an insertion or as a substitution of existing NRPS ope ...
... mycosubtilin biosynthesis gene cluster devoted to synthesis of an iturin-like compound, is situated at the same location [Duitman et al., 1999], suggesting that additional NRPS operons could be integrated in different ways in this area either as an insertion or as a substitution of existing NRPS ope ...
Studying Gene Frequencies in a Population of Domestic Cats
... to study inheritance. The plant he chose showed clearly discernable traits; ones that were governed by what we now call “simple Mendelian genetics”: two alleles, one dominant, and the other recessive. For the same reasons that Mendel’s peas were an ideal subject, the domestic cat is an excellent mod ...
... to study inheritance. The plant he chose showed clearly discernable traits; ones that were governed by what we now call “simple Mendelian genetics”: two alleles, one dominant, and the other recessive. For the same reasons that Mendel’s peas were an ideal subject, the domestic cat is an excellent mod ...
Assuring agricultural and food safety of genetically modified
... on the producers’ work force and capital, the costs that will be incurred in separating the GM crops from the non-GM, as well as in determining the then yet unknown environmental impact of the GM crops. The value attached to these financial implications was set at $16 million annually (Dixelius et a ...
... on the producers’ work force and capital, the costs that will be incurred in separating the GM crops from the non-GM, as well as in determining the then yet unknown environmental impact of the GM crops. The value attached to these financial implications was set at $16 million annually (Dixelius et a ...
russell-silver syndrome
... bridge and a small jaw). Other variable features may be seen in children with RSS (see For More Information). Some individuals with RSS will have many of the possible characteristics associated with RSS while others will have very few. ...
... bridge and a small jaw). Other variable features may be seen in children with RSS (see For More Information). Some individuals with RSS will have many of the possible characteristics associated with RSS while others will have very few. ...
Laws of Inheritance
... parent and the two copies of each gene (and chromosome) are restored. For cases in which a single gene controls a single characteristic, a diploid organism has two genetic copies that may or may not encode the same version of that characteristic. For example, one individual may carry a gene that det ...
... parent and the two copies of each gene (and chromosome) are restored. For cases in which a single gene controls a single characteristic, a diploid organism has two genetic copies that may or may not encode the same version of that characteristic. For example, one individual may carry a gene that det ...
Saccharomyces Genome Database provides mutant phenotype data.
... phenotypes are termed ‘experiment types’ and fall into two major categories: classical genetics and large-scale survey. Small-scale experiments that focus on one or a few genes are recorded as ‘classical genetics’. ‘Large-scale survey’ denotes experiments that have been designed typically with some ...
... phenotypes are termed ‘experiment types’ and fall into two major categories: classical genetics and large-scale survey. Small-scale experiments that focus on one or a few genes are recorded as ‘classical genetics’. ‘Large-scale survey’ denotes experiments that have been designed typically with some ...
Yeast and Genetic Studies
... Even before this was a possibility, genetics played a key role in understanding many basic cellular processes. If you wanted to study olfaction but you had not identified any of the proteins involved, how could you begin? Because one gene corresponds to one protein and the genotype of an organism is ...
... Even before this was a possibility, genetics played a key role in understanding many basic cellular processes. If you wanted to study olfaction but you had not identified any of the proteins involved, how could you begin? Because one gene corresponds to one protein and the genotype of an organism is ...
The Rate and Tract Length of Gene Conversion between
... technical problem is that, in a simple experimental design with a single selected marker, an estimated rate may include both gene conversion and unequal crossing-over because they have an identical outcome. Such a rate cannot be fairly compared with an estimate from a more sophisticated experiment, ...
... technical problem is that, in a simple experimental design with a single selected marker, an estimated rate may include both gene conversion and unequal crossing-over because they have an identical outcome. Such a rate cannot be fairly compared with an estimate from a more sophisticated experiment, ...
Supplemental Table 1 and Figure Legends
... Panel A. Pair plots showing correlations between selected samples: Gene expression intensities obtained from samples containing 100 ng of RNA extracted from MDA-MB-468 cells considered as benchmarks and correlated with intensities obtained in profiles using decreasing RNA inputs, respectively 10 ng, ...
... Panel A. Pair plots showing correlations between selected samples: Gene expression intensities obtained from samples containing 100 ng of RNA extracted from MDA-MB-468 cells considered as benchmarks and correlated with intensities obtained in profiles using decreasing RNA inputs, respectively 10 ng, ...
Chapter 4 - Genetic Principles
... are examples of environmental effects. Environmental effects on economically important traits are controlled through management techniques such as nutrition and health programs. For the purposes of this manual, the focus will be on the genetic component of the phenotype. The genetic component of all l ...
... are examples of environmental effects. Environmental effects on economically important traits are controlled through management techniques such as nutrition and health programs. For the purposes of this manual, the focus will be on the genetic component of the phenotype. The genetic component of all l ...
Legends for Tables S1 to S3 and Figures S1 to S5
... quantification for 14 cell lines are shown. The column of BCL-2 IHC result values shows IHC scores for replicate cell pellet samples in all but MOLP-8, for which only 1 sample was available. Cell lines KMS-34, KMS-11 and Amo-1 are internal BCL-2 IHC staining references for 1+, 2+ and 3+ signal, resp ...
... quantification for 14 cell lines are shown. The column of BCL-2 IHC result values shows IHC scores for replicate cell pellet samples in all but MOLP-8, for which only 1 sample was available. Cell lines KMS-34, KMS-11 and Amo-1 are internal BCL-2 IHC staining references for 1+, 2+ and 3+ signal, resp ...
The role of Cdx genes in the mammalian gut
... However, this review is principally concerned with their role in the gut. Much insight into the function of a gene may be obtained by studying the morphology of mice in which it has been inactivated by homologous recombination.9 Knockout of the Cdx1 gene10 produced anterior homeotic shifts (that is, ...
... However, this review is principally concerned with their role in the gut. Much insight into the function of a gene may be obtained by studying the morphology of mice in which it has been inactivated by homologous recombination.9 Knockout of the Cdx1 gene10 produced anterior homeotic shifts (that is, ...
Birth of fertile bimaternal offspring following
... (WT) embryos and the phESC-derived bimaternal embryo, but all 3 paternally methylated DMRs (H19-, IGand Rasgrf1-DMRs) were significantly hypomethylated in the bimaternal embryo compared with WT embryos (Figure 1B). Consistently, transcriptome analysis showed that only 8 of all imprinted genes had mo ...
... (WT) embryos and the phESC-derived bimaternal embryo, but all 3 paternally methylated DMRs (H19-, IGand Rasgrf1-DMRs) were significantly hypomethylated in the bimaternal embryo compared with WT embryos (Figure 1B). Consistently, transcriptome analysis showed that only 8 of all imprinted genes had mo ...
... percentage of bootstrap support after 500 replicates. For construction of the tree, we used only the MYB domains; for c-MYB, we also excluded repeat 1 of its MYB domain, because this repeat is not found in the plant proteins. (B) Alignment of the MYB domain of AN2 and proteins controlling anthocyani ...
Document
... Rescue of phenotype Mutations in same gene in different alleles Tau mutation in circadian rhythm © 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey 07458 ...
... Rescue of phenotype Mutations in same gene in different alleles Tau mutation in circadian rhythm © 2005 Prentice Hall Inc. / A Pearson Education Company / Upper Saddle River, New Jersey 07458 ...
Document
... Morgan’s Experimental Evidence: Scientific Inquiry • The first solid evidence associating a specific gene with a specific chromosome came from Thomas Hunt Morgan, an embryologist • Morgan’s experiments with fruit flies provided convincing evidence that chromosomes are the location of Mendel’s herit ...
... Morgan’s Experimental Evidence: Scientific Inquiry • The first solid evidence associating a specific gene with a specific chromosome came from Thomas Hunt Morgan, an embryologist • Morgan’s experiments with fruit flies provided convincing evidence that chromosomes are the location of Mendel’s herit ...
On epistasis: why it is unimportant in polygenic directional selection References
... large number of loci involved. The three studies identified a total of 54 loci (Visscher 2008). Since there was almost no overlap in the three studies, the great majority of loci must have not yet been identified. These 54 loci accounted for about 9 per cent of the genetic variance; hence the total ...
... large number of loci involved. The three studies identified a total of 54 loci (Visscher 2008). Since there was almost no overlap in the three studies, the great majority of loci must have not yet been identified. These 54 loci accounted for about 9 per cent of the genetic variance; hence the total ...
DNA Replication/Transcription/RNA Splicing
... Sites of Ongoing Transcription The intranuclear position of many genes has been correlated with their activity state, suggesting that migration to functional subcompartments may influence gene expression. Indeed, nascent RNA production and RNA polymerase II seem to be localized into discrete foci or ...
... Sites of Ongoing Transcription The intranuclear position of many genes has been correlated with their activity state, suggesting that migration to functional subcompartments may influence gene expression. Indeed, nascent RNA production and RNA polymerase II seem to be localized into discrete foci or ...
Molecular Genetics of Alcohol-Related Brain Damage
... Several mechanisms have been implicated in the pathogenesis of thiamine deficiency such as oxidative stress, glutamatemediated excitotoxicity and focal lactic acidosis. Hazell and colleagues extensively studied the role of glutamate neurotoxicity triggered by thiamine deficiency. Their findings show ...
... Several mechanisms have been implicated in the pathogenesis of thiamine deficiency such as oxidative stress, glutamatemediated excitotoxicity and focal lactic acidosis. Hazell and colleagues extensively studied the role of glutamate neurotoxicity triggered by thiamine deficiency. Their findings show ...
ELMER: An R/Bioconductor Tool Inferring Regulatory Element
... individual studies. The one tailed t-test was used to rule out the null hypothesis: µexperiment ≥ µcontrol, where µexperiment is the mean methylation within the lowest experiment quintile and µcontrol is the mean within the lowest control quintile. Raw p-values were adjusted for multiple hypothesis ...
... individual studies. The one tailed t-test was used to rule out the null hypothesis: µexperiment ≥ µcontrol, where µexperiment is the mean methylation within the lowest experiment quintile and µcontrol is the mean within the lowest control quintile. Raw p-values were adjusted for multiple hypothesis ...
New Insight into the Main Metabolic Regulation of Escherichia Coli
... the dilution rate on gene transcript levels, where it indicates that in accordance with the increased dilution rate (or the specific glucose consumption rate), the transcript levels of ptsG, ptsH, and pfkA are increased, where cra transcript level decreased and crp as well as mlc decreased according ...
... the dilution rate on gene transcript levels, where it indicates that in accordance with the increased dilution rate (or the specific glucose consumption rate), the transcript levels of ptsG, ptsH, and pfkA are increased, where cra transcript level decreased and crp as well as mlc decreased according ...
inheritance jeopardy
... antlers, and the recessive phenotype is short stunted antlers. With respect to the gene for coat pattern (letter P), the recessive phenotype is a white chest spot, and the dominant phenotype is no spot. A moose with the genotype Ggpp will have this phenotype. ...
... antlers, and the recessive phenotype is short stunted antlers. With respect to the gene for coat pattern (letter P), the recessive phenotype is a white chest spot, and the dominant phenotype is no spot. A moose with the genotype Ggpp will have this phenotype. ...
Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function. These profiles can, for example, distinguish between cells that are actively dividing, or show how the cells react to a particular treatment. Many experiments of this sort measure an entire genome simultaneously, that is, every gene present in a particular cell.DNA microarray technology measures the relative activity of previously identified target genes. Sequence based techniques, like serial analysis of gene expression (SAGE, SuperSAGE) are also used for gene expression profiling. SuperSAGE is especially accurate and can measure any active gene, not just a predefined set. The advent of next-generation sequencing has made sequence based expression analysis an increasingly popular, ""digital"" alternative to microarrays called RNA-Seq. However, microarrays are far more common, accounting for 17,000 PubMed articles by 2006.