Database resources of the National Center for Biotechnology
... one record to another, a new `Links' pull-down menu now appears in the top right-hand corner of Entrez displays. The records retrieved by an Entrez search can be displayed in a wide variety of formats and downloaded singly or in batches. A new redirection control allows results to be sent directly t ...
... one record to another, a new `Links' pull-down menu now appears in the top right-hand corner of Entrez displays. The records retrieved by an Entrez search can be displayed in a wide variety of formats and downloaded singly or in batches. A new redirection control allows results to be sent directly t ...
A whole-genome assembly of the domestic cow, Bos taurus
... Another indicator of assembly completeness, and also of its potential for annotation, is the extent to which known gene sequences can be mapped onto it. We aligned 8,689 independently validated full-length cow mRNA sequences to the two assemblies, using spliced alignment mapping tools (see Materials ...
... Another indicator of assembly completeness, and also of its potential for annotation, is the extent to which known gene sequences can be mapped onto it. We aligned 8,689 independently validated full-length cow mRNA sequences to the two assemblies, using spliced alignment mapping tools (see Materials ...
Fact Sheet 52|HAEMOPHILIA WHAT IS HAEMOPHILIA
... properly. This variation is called a mutation or pathogenic variant, and means that the product produced by the gene, called a protein, is impaired or even absent. Gene mutations may be inherited from a parent, or occur for the first time in an individual. Once you have a gene mutation however, it m ...
... properly. This variation is called a mutation or pathogenic variant, and means that the product produced by the gene, called a protein, is impaired or even absent. Gene mutations may be inherited from a parent, or occur for the first time in an individual. Once you have a gene mutation however, it m ...
Genetic Diseases (cont.)
... • Control manufacture of protein synthesis • An allele is a specific version of a given gene Chromosomes • During mitosis, the DNA that makes up the chromosomes is replicated and distributed to daughter cells • 46 chromosomes in humans – 22 autosome pairs – One sex chromosome pair Copyright © 2015 W ...
... • Control manufacture of protein synthesis • An allele is a specific version of a given gene Chromosomes • During mitosis, the DNA that makes up the chromosomes is replicated and distributed to daughter cells • 46 chromosomes in humans – 22 autosome pairs – One sex chromosome pair Copyright © 2015 W ...
Chromosomal breakpoint positions suggest a direct role for radiation
... properties, but was not sucient for transformation (Santoro et al., 1993). However, malignant phenotype was obtained by cotransfection with H-RAS or K-RAS oncogenes. An alternative to the direct pathway is that radiation does not act directly to produce the RET/PTC3 fusion, but instead may cause pe ...
... properties, but was not sucient for transformation (Santoro et al., 1993). However, malignant phenotype was obtained by cotransfection with H-RAS or K-RAS oncogenes. An alternative to the direct pathway is that radiation does not act directly to produce the RET/PTC3 fusion, but instead may cause pe ...
Polycomb Group silencers collaborate with Notch pathway to cause
... HpaII will not cut at its recognition sequence if it contains a methylated cytosine (mCCGG), both MspI and HpaII digestion will be blocked if both cytosines are methylated (mCmCGG). ...
... HpaII will not cut at its recognition sequence if it contains a methylated cytosine (mCCGG), both MspI and HpaII digestion will be blocked if both cytosines are methylated (mCmCGG). ...
Direct Sequence Analysis of the 14q+ and 18q
... gene has been conserved without any of the short duplications or deletions noted by others.'.'' Analysis of mcr junctions in bcl-2. A similar analysis was performed using oligonucleotide primers for the mcr region of bcl-2. In a particular patient it was possible to sequence both the 14q+ and 18q- j ...
... gene has been conserved without any of the short duplications or deletions noted by others.'.'' Analysis of mcr junctions in bcl-2. A similar analysis was performed using oligonucleotide primers for the mcr region of bcl-2. In a particular patient it was possible to sequence both the 14q+ and 18q- j ...
DNA recognition code of transcription factors
... function and morphology. The truth is manifestly otherwise. A group of proteins, transcription factors, selects the information used in cells by specifically binding to 'regulatory' DNA sequences. Among other effects, this causes the differentiation of cells. These factors act as the final messenger ...
... function and morphology. The truth is manifestly otherwise. A group of proteins, transcription factors, selects the information used in cells by specifically binding to 'regulatory' DNA sequences. Among other effects, this causes the differentiation of cells. These factors act as the final messenger ...
Section D - Prokaryotic and Eukaryotic Chromosome Structure
... • Open reading frames (ORFs) are suspected coding regions starting with ATG and end with TGA,TAA or TAG identified by computer. • When the ORF is known to encode a certain protein, it is usually referred as a coding region. ...
... • Open reading frames (ORFs) are suspected coding regions starting with ATG and end with TGA,TAA or TAG identified by computer. • When the ORF is known to encode a certain protein, it is usually referred as a coding region. ...
Evolution of Steroid Receptors
... Fig. 4. Evolution of specific aldosterone-MR signaling by molecular exploitation. (A) Synthesis pathway for corticosteroid hormones. Ligands for the ancestral CR and extant MRs are underlined; cortisol, the ligand for the tetrapod GR, is overlined. The terminal addition of aldosterone is in green. ...
... Fig. 4. Evolution of specific aldosterone-MR signaling by molecular exploitation. (A) Synthesis pathway for corticosteroid hormones. Ligands for the ancestral CR and extant MRs are underlined; cortisol, the ligand for the tetrapod GR, is overlined. The terminal addition of aldosterone is in green. ...
First mutation in the red blood cell-specific
... Utrecht), in a patient previously diagnosed with HK deficiency. To our knowledge, these three patients are the only ones in which the molecular basis has been studied. In all three cases mutations were located in that part of the gene that encodes both HK-R and HK-1. The erythroid-specific promoter ...
... Utrecht), in a patient previously diagnosed with HK deficiency. To our knowledge, these three patients are the only ones in which the molecular basis has been studied. In all three cases mutations were located in that part of the gene that encodes both HK-R and HK-1. The erythroid-specific promoter ...
NCEA Level 1 Science (90948) 2014 Assessment Schedule
... present for tongue rolling to be expressed. Both of 6’s children are a nontongue rollers, which means they must have both recessive alleles and be tt. Because they get one allele from each parent, and individual 5 can pass on only a recessive allele, this means that 6 must have passed on the other r ...
... present for tongue rolling to be expressed. Both of 6’s children are a nontongue rollers, which means they must have both recessive alleles and be tt. Because they get one allele from each parent, and individual 5 can pass on only a recessive allele, this means that 6 must have passed on the other r ...
A Survey of Human Traits
... • Alternate form of a gene for a trait – Blue or Brown are alleles for eye color – Allele may be dominant or recessive (B or b) ...
... • Alternate form of a gene for a trait – Blue or Brown are alleles for eye color – Allele may be dominant or recessive (B or b) ...
Molecular analysis of putative genetic factors affecting BSE
... calculated from the sample and when this information was is taken into account significant segregation distortion, i.e. unequal transmission probabilities of alleles within a locus, was significant for 3 loci BM315, INRA107 and INRA36 on Chr 5, 10 and 20, respectively. Although the Transmission Dist ...
... calculated from the sample and when this information was is taken into account significant segregation distortion, i.e. unequal transmission probabilities of alleles within a locus, was significant for 3 loci BM315, INRA107 and INRA36 on Chr 5, 10 and 20, respectively. Although the Transmission Dist ...
Clustering short time series gene expression data
... – For example, if c=2 then between successive time points a gene can go up either one or two units, stay the same, or go down one or two units. – For n time points, this strategy results in (2c+1)n-1 distinct profiles. – Our method relies on correlation, ‘one unit’ may be defined differently for dif ...
... – For example, if c=2 then between successive time points a gene can go up either one or two units, stay the same, or go down one or two units. – For n time points, this strategy results in (2c+1)n-1 distinct profiles. – Our method relies on correlation, ‘one unit’ may be defined differently for dif ...
A Survey of Human Traits
... – Blue or Brown are alleles for eye color – Allele may be dominant or recessive (B or b) ...
... – Blue or Brown are alleles for eye color – Allele may be dominant or recessive (B or b) ...
VI. The relationship between genotype and phenotype is rarely simple
... Conclusions: From these types of experiments and observations, Mendel concluded that since the inheritable factor for white flowers was not lost in the F1 generation, it must have been masked by the presence of the purple-flower factor. Mendel's factors are now called genes; and in Mendel's terms, p ...
... Conclusions: From these types of experiments and observations, Mendel concluded that since the inheritable factor for white flowers was not lost in the F1 generation, it must have been masked by the presence of the purple-flower factor. Mendel's factors are now called genes; and in Mendel's terms, p ...
I. Molecular mechanism for polyunsaturated fatty acid regulation of
... and 35% of the PUFA control can be attributed to the proximal and distal elements, respectively. Interestingly, the proximal PUFA response region of the fatty acid synthase gene has characteristics that are very similar to the PUFA response region of the S14 gene (⫺220 to ⫺80), whereas the distal PU ...
... and 35% of the PUFA control can be attributed to the proximal and distal elements, respectively. Interestingly, the proximal PUFA response region of the fatty acid synthase gene has characteristics that are very similar to the PUFA response region of the S14 gene (⫺220 to ⫺80), whereas the distal PU ...
Construction of nanA mutants
... of nanA were amplified using primers SP1693_Janus1 vs SP1693_Janus2, and primers SP1693_Janus3 vs SP1693_Janus4, respectively, generating approx. 1 kb PCR products in each case. The 1500 bp Janus Cassette was amplified with primers Janus KpnF and Janus SacIR. The PCR products generated from the 3 in ...
... of nanA were amplified using primers SP1693_Janus1 vs SP1693_Janus2, and primers SP1693_Janus3 vs SP1693_Janus4, respectively, generating approx. 1 kb PCR products in each case. The 1500 bp Janus Cassette was amplified with primers Janus KpnF and Janus SacIR. The PCR products generated from the 3 in ...
The PTC Gene - Wilbur World of Science
... evolved as a mechanism to prevent early humans from eating poisonous plants. Humans have about 30 genes that code for bitter taste receptors. Each receptor can interact with several compounds, allowing people to taste a wide variety of bitter substances. ...
... evolved as a mechanism to prevent early humans from eating poisonous plants. Humans have about 30 genes that code for bitter taste receptors. Each receptor can interact with several compounds, allowing people to taste a wide variety of bitter substances. ...
NCEA Level 1 Science (90948) 2014
... present for tongue rolling to be expressed. Both of 6’s children are a nontongue rollers, which means they must have both recessive alleles and be tt. Because they get one allele from each parent, and individual 5 can pass on only a recessive allele, this means that 6 must have passed on the other r ...
... present for tongue rolling to be expressed. Both of 6’s children are a nontongue rollers, which means they must have both recessive alleles and be tt. Because they get one allele from each parent, and individual 5 can pass on only a recessive allele, this means that 6 must have passed on the other r ...
DNA-Catalyzed Covalent Modification of Amino Acid Side Chains in
... (deoxyribozymes) that modify side chains of peptide substrates, with the long-term goal of achieving DNA-catalyzed covalent protein modification. We recently described several deoxyribozymes that modify tyrosine (Tyr) or serine (Ser) side chains by catalyzing their reaction with 50 -triphosphorylated ...
... (deoxyribozymes) that modify side chains of peptide substrates, with the long-term goal of achieving DNA-catalyzed covalent protein modification. We recently described several deoxyribozymes that modify tyrosine (Tyr) or serine (Ser) side chains by catalyzing their reaction with 50 -triphosphorylated ...
Genetic Traits
... Traits are passed down from parent to offspring through genetic material in cells called deoxyribonucleic acid (DNA). Therefore, the DNA that an individual inherits determines his or her characteristics. Within cells, molecules of DNA form structures called chromosomes. The instructions for specific ...
... Traits are passed down from parent to offspring through genetic material in cells called deoxyribonucleic acid (DNA). Therefore, the DNA that an individual inherits determines his or her characteristics. Within cells, molecules of DNA form structures called chromosomes. The instructions for specific ...
primer on genetic epidemiology
... heritability with consideration of shared and non-shared environment effects by collecting diverse environmental variables [32]. Recently, Yang et al. has developed a GCTA model, a tool that estimates heritability using genome-wide association study (GWAS) data and unrelated individuals for both qua ...
... heritability with consideration of shared and non-shared environment effects by collecting diverse environmental variables [32]. Recently, Yang et al. has developed a GCTA model, a tool that estimates heritability using genome-wide association study (GWAS) data and unrelated individuals for both qua ...
Determinants of pathogenic@ and avirulence in plant pathogenic
... test plants that happen to have a corresponding R gene, and it will enable direct investigation of Avr targeting signals and secretion mechanisms. For example, chaperone-independent targeting information in two Yop proteins has been shown to reside in the mRNA encoding the amino terminus of the prot ...
... test plants that happen to have a corresponding R gene, and it will enable direct investigation of Avr targeting signals and secretion mechanisms. For example, chaperone-independent targeting information in two Yop proteins has been shown to reside in the mRNA encoding the amino terminus of the prot ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.