SBT-production - Webarchiv ETHZ / Webarchive ETH
... Conclusion and outlook One tkt gene is first target for proteomic switch. Thermodynamic analysis can be used to rank the proteomic switch ...
... Conclusion and outlook One tkt gene is first target for proteomic switch. Thermodynamic analysis can be used to rank the proteomic switch ...
Document
... system, surrogate host Model system for cellular eukaryotic functions (animal or plant): Intracellular signal transduction DNA repair, replication, cell cycle transcription chromosome biology protein transport water transport etc. Protein-protein interactions Global transcriptional regulation Drug t ...
... system, surrogate host Model system for cellular eukaryotic functions (animal or plant): Intracellular signal transduction DNA repair, replication, cell cycle transcription chromosome biology protein transport water transport etc. Protein-protein interactions Global transcriptional regulation Drug t ...
Evolution of the Actin Gene Family in Testate Lobose Amoebae
... A. vulgaris are independent genetic lineages. Furthermore, we characterized multiple actin gene copies from all lineages. Analyses of the resulting sequences reveal numerous diverse actin genes, which differ mostly by synonymous substitutions. We estimate that the actin gene family contains 40–50 pa ...
... A. vulgaris are independent genetic lineages. Furthermore, we characterized multiple actin gene copies from all lineages. Analyses of the resulting sequences reveal numerous diverse actin genes, which differ mostly by synonymous substitutions. We estimate that the actin gene family contains 40–50 pa ...
Supplementary Information (doc 408K)
... heterozygous genotype in a particular gene if they had inherited at least two different variants within that gene on each parental chromosome (Figure S1). The false positive rate of compound heterozygous genotype calls in probands is likely to be extremely low given all variants contributing to thes ...
... heterozygous genotype in a particular gene if they had inherited at least two different variants within that gene on each parental chromosome (Figure S1). The false positive rate of compound heterozygous genotype calls in probands is likely to be extremely low given all variants contributing to thes ...
Touring Ensembl: A practical guide to genome browsing Open Access
... at the 5' end of the IL2 transcript and flanking sequence [12-14]. Within only 200 bp upstream of the translational start site, binding sites for proteins such as NF-κB, AP-1, and NFAT (nuclear factor of activated T-cells), DNase I hypersensitive sites and a TATA box can all be found. These regions ...
... at the 5' end of the IL2 transcript and flanking sequence [12-14]. Within only 200 bp upstream of the translational start site, binding sites for proteins such as NF-κB, AP-1, and NFAT (nuclear factor of activated T-cells), DNase I hypersensitive sites and a TATA box can all be found. These regions ...
Recent highlights of the China Rice Functional Genomics Program
... traits, we have developed a platform for genetic improvements of key agronomic traits including a robust transformation technology and controllable expression systems. This can be illustrated by using an antisense Waxy gene and its promoter, to produce stable transgenic lines with a range of reduced ...
... traits, we have developed a platform for genetic improvements of key agronomic traits including a robust transformation technology and controllable expression systems. This can be illustrated by using an antisense Waxy gene and its promoter, to produce stable transgenic lines with a range of reduced ...
here - Genomes Unzipped
... Li et al.[1] sequenced cDNA from lymphoblastoid cell lines derived from 27 individuals whose genomes have been sequenced at low coverage [2], and identified 10,210 sites of mismatches between an individual’s mRNA and DNA sequences (RDD sites, for RNA-DNA difference). RDD sites included all possible ...
... Li et al.[1] sequenced cDNA from lymphoblastoid cell lines derived from 27 individuals whose genomes have been sequenced at low coverage [2], and identified 10,210 sites of mismatches between an individual’s mRNA and DNA sequences (RDD sites, for RNA-DNA difference). RDD sites included all possible ...
Interpreting the Genetic Code
... The net effect of wobble base pairing is to reduce the number of tRNAs that must be produced by a cell In reality cells do not make 61 different tRNAs, one for each codon Many tRNAs have anticodons that anneal to several different codons\ Codons are known for which there are more than one tRNA, alth ...
... The net effect of wobble base pairing is to reduce the number of tRNAs that must be produced by a cell In reality cells do not make 61 different tRNAs, one for each codon Many tRNAs have anticodons that anneal to several different codons\ Codons are known for which there are more than one tRNA, alth ...
Transgenic Tobacco Plants with Bacillus thuringiensis 8
... which leads to osmotic imbalance and cell lysis (Hofmann et ai., 1988; Slatin et ai., 1990; English et al., 1991; English and Slatin, 1992). Among insecticidal protein genes, lepidopteran specific genes, cryJA class, are mostly well characterized (Adang et al., 1985; Thorne et al., 1986; Schnepf et ...
... which leads to osmotic imbalance and cell lysis (Hofmann et ai., 1988; Slatin et ai., 1990; English et al., 1991; English and Slatin, 1992). Among insecticidal protein genes, lepidopteran specific genes, cryJA class, are mostly well characterized (Adang et al., 1985; Thorne et al., 1986; Schnepf et ...
Regulation of 6sg expression site transcription and switching in
... second 6sg into an active ES, and concluded that parasites expressing two Vsgs have no intrinsic growth disadvantage in vivo or in vitro [55]. ...
... second 6sg into an active ES, and concluded that parasites expressing two Vsgs have no intrinsic growth disadvantage in vivo or in vitro [55]. ...
Semiconservative Replication in the Quasispecies Model
... p(σ, σ ′ )p((σ, σ ′ ), (σ ′′ , σ̄ ′′ )). Write σ = b1 . . . bL , σ = b′1 . . . b′L , and σ” = b1 ” . . . bL ”. Let l ≡ HD(σ, σ”). Let us consider some i for which bi = bi ”. Then b′i can take on any value, for if b′i = b̄i ”, then no repair is necessary, and we obtain bi → (bi ”, b̄i ”). If b′i 6= b ...
... p(σ, σ ′ )p((σ, σ ′ ), (σ ′′ , σ̄ ′′ )). Write σ = b1 . . . bL , σ = b′1 . . . b′L , and σ” = b1 ” . . . bL ”. Let l ≡ HD(σ, σ”). Let us consider some i for which bi = bi ”. Then b′i can take on any value, for if b′i = b̄i ”, then no repair is necessary, and we obtain bi → (bi ”, b̄i ”). If b′i 6= b ...
The importance of alternative splicing in the drug discovery process
... Antisense oligonucleotides can be designed to inhibit study the function of the gene. However, it turned out that abnormal, disease-causing splicing. Such an approach was not all the gene is shut down and a residual binding activused to correct an aberrant splicing of the cystic fibrosis ity remains ...
... Antisense oligonucleotides can be designed to inhibit study the function of the gene. However, it turned out that abnormal, disease-causing splicing. Such an approach was not all the gene is shut down and a residual binding activused to correct an aberrant splicing of the cystic fibrosis ity remains ...
Close relationship between non-viral retroposons in Drosophila
... Cx 2 Cx 4 Hx 4 C motif, and two adjacent imperfect ones (fig. 7a) are found within G-orfl, a 241 amino acid long orf that partially overlaps G-orf2 (figs. 2 and 3). In fig. 7b the G-orfl region encompassing the cysteine-rich motifs is aligned with the homologous regions in F-orf 1 and Iorfl. The hom ...
... Cx 2 Cx 4 Hx 4 C motif, and two adjacent imperfect ones (fig. 7a) are found within G-orfl, a 241 amino acid long orf that partially overlaps G-orf2 (figs. 2 and 3). In fig. 7b the G-orfl region encompassing the cysteine-rich motifs is aligned with the homologous regions in F-orf 1 and Iorfl. The hom ...
Supplementary Figure Legends (doc 52K)
... these hydrocarbons in incubations with the corresponding unlabelled substrates as measured by HPLC (naphthalene and phenanthrene) or GCMS (n-hexadecane) (squares). (a) phenanthrene; (b) naphthalene; (c) n-hexadecane. The endpoint for these SIP incubations was determined to be 5 days. Each data point ...
... these hydrocarbons in incubations with the corresponding unlabelled substrates as measured by HPLC (naphthalene and phenanthrene) or GCMS (n-hexadecane) (squares). (a) phenanthrene; (b) naphthalene; (c) n-hexadecane. The endpoint for these SIP incubations was determined to be 5 days. Each data point ...
Interpreting the Genetic Code
... Reassignment of Stop Codons Changes in stop codon meaning must have occurred after meanings were “frozen” in other organisms, alternatively organisms that exhibit them must have evolved from organisms that never shared the universal genetic code All changes in stop codons must include three changes ...
... Reassignment of Stop Codons Changes in stop codon meaning must have occurred after meanings were “frozen” in other organisms, alternatively organisms that exhibit them must have evolved from organisms that never shared the universal genetic code All changes in stop codons must include three changes ...
Patterns of Inheritance Family Studies
... Heterogeneity can also occur at the allelic level. In the majority of single-gene disorders (e.g., β-thalassemia) a large number of different mutations have been identified as being responsible (p. 160). There are individuals who have two different mutations at the same locus and are known as compou ...
... Heterogeneity can also occur at the allelic level. In the majority of single-gene disorders (e.g., β-thalassemia) a large number of different mutations have been identified as being responsible (p. 160). There are individuals who have two different mutations at the same locus and are known as compou ...
The Experiments of Gregor Mendel
... determined by factors that are passed from one parental generation to the next. Scientists call the factors that are passed from parent to offspring genes. ...
... determined by factors that are passed from one parental generation to the next. Scientists call the factors that are passed from parent to offspring genes. ...
to Sample Chapter
... The law of dominance is the first law of inheritance where each character is controlled by a pair of factors and when it is a pair of dissimilar factors i.e. Tt only the one which is dominant i.e. (T)-Tall is expressed and the other i.e.(t)- dwarf is completely suppressed. Thus there is a complete d ...
... The law of dominance is the first law of inheritance where each character is controlled by a pair of factors and when it is a pair of dissimilar factors i.e. Tt only the one which is dominant i.e. (T)-Tall is expressed and the other i.e.(t)- dwarf is completely suppressed. Thus there is a complete d ...
The Dawn of Genetics
... What did the F1’s look like? • Mendel found that 100% percent of the F1’s were tall. • This is where the terms dominant and recessive came from. Mendel concluded that tall was dominant over short. • Mendel concluded that heredity is not just a blending of traits. Instead one trait will be dominant ...
... What did the F1’s look like? • Mendel found that 100% percent of the F1’s were tall. • This is where the terms dominant and recessive came from. Mendel concluded that tall was dominant over short. • Mendel concluded that heredity is not just a blending of traits. Instead one trait will be dominant ...
Gene Section FANCF (Fanconi anemia, complementation group F)
... FANCC join the complex; phosphorylation of FANCA would induce its translocation into the nucleus.This FA complex translocates into the nucleus, where FANCE and FANCF are present; FANCE and FANCF join the complex. The FA complex subsequently interacts with FANCD2 by monoubiquitination of FANCD2 durin ...
... FANCC join the complex; phosphorylation of FANCA would induce its translocation into the nucleus.This FA complex translocates into the nucleus, where FANCE and FANCF are present; FANCE and FANCF join the complex. The FA complex subsequently interacts with FANCD2 by monoubiquitination of FANCD2 durin ...
Pole Region-Dependent Repression of the Drosophila Gap Gene
... mutant phenotype (Scott and O’Farrell, 1986), the role of gap genes in the segmentation process is less apparent. In comparison to the large gap seen in the amorphic Kf embryos, the expression domain of Kr in wild-type embryos is relatively small. This suggests that it is Kfdependent activity rather ...
... mutant phenotype (Scott and O’Farrell, 1986), the role of gap genes in the segmentation process is less apparent. In comparison to the large gap seen in the amorphic Kf embryos, the expression domain of Kr in wild-type embryos is relatively small. This suggests that it is Kfdependent activity rather ...
Gene transfer in bacteria - McGraw Hill Higher Education
... Hartwell et al., 4th edition, Chapter 14 ...
... Hartwell et al., 4th edition, Chapter 14 ...
What are the chances?
... Background: Genetic disorders are abnormal conditions that are inherited through genes or chromosomes. Some genetic disorders are caused by mutations in the DNA of genes. Others are caused by changes in the overall structure or number of chromosomes. Cystic fibrosis is a genetic disorder in which th ...
... Background: Genetic disorders are abnormal conditions that are inherited through genes or chromosomes. Some genetic disorders are caused by mutations in the DNA of genes. Others are caused by changes in the overall structure or number of chromosomes. Cystic fibrosis is a genetic disorder in which th ...
Gene
A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity. The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. Most biological traits are under the influence of polygenes (many different genes) as well as the gene–environment interactions. Some genetic traits are instantly visible, such as eye colour or number of limbs, and some are not, such as blood type, risk for specific diseases, or the thousands of basic biochemical processes that comprise life.Genes can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. These alleles encode slightly different versions of a protein, which cause different phenotype traits. Colloquial usage of the term ""having a gene"" (e.g., ""good genes,"" ""hair colour gene"") typically refers to having a different allele of the gene. Genes evolve due to natural selection or survival of the fittest of the alleles.The concept of a gene continues to be refined as new phenomena are discovered. For example, regulatory regions of a gene can be far removed from its coding regions, and coding regions can be split into several exons. Some viruses store their genome in RNA instead of DNA and some gene products are functional non-coding RNAs. Therefore, a broad, modern working definition of a gene is any discrete locus of heritable, genomic sequence which affect an organism's traits by being expressed as a functional product or by regulation of gene expression.