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... the final QC checkpoints, a protein must typically have reached a correctly folded conformation. This is generally the so-called ‘native’ conformation that corresponds to the most energetically favourable state. In the case of proteins with several subunits, proper oligomeric assembly is usually nec ...
... the final QC checkpoints, a protein must typically have reached a correctly folded conformation. This is generally the so-called ‘native’ conformation that corresponds to the most energetically favourable state. In the case of proteins with several subunits, proper oligomeric assembly is usually nec ...
Description of the KDD-Cup 2004 Protein Data
... template structure) using the five similarity measures mentioned above (reference Jaroslaw Meller and Ron Elber, "Linear Optimization and a double Statistical Filter for protein threading protocols", Proteins, Structure, Function and Genetics, 45,241-261(2001) 27-31 Scores of Local threading feature ...
... template structure) using the five similarity measures mentioned above (reference Jaroslaw Meller and Ron Elber, "Linear Optimization and a double Statistical Filter for protein threading protocols", Proteins, Structure, Function and Genetics, 45,241-261(2001) 27-31 Scores of Local threading feature ...
- BioTek Instruments
... structural support to proteins acting as enzymes for modulating signal transduction pathways, such as kinases, proteases and phosphatases; to transmembrane proteins that allow for extracellular interactions, such as GPCRs and ion channels. Although almost all proteins are made from the same set of 2 ...
... structural support to proteins acting as enzymes for modulating signal transduction pathways, such as kinases, proteases and phosphatases; to transmembrane proteins that allow for extracellular interactions, such as GPCRs and ion channels. Although almost all proteins are made from the same set of 2 ...
Membrane Transport - Austin Publishing Group
... chloroplasts. Most currently known porins are trimers, in which each subunit is composed of 12 to 18 membrane spanning beta strands that are amphipathic. The alternating hydrophobichydrophilic amino acids lead to a water filled core that provides a hydrophilic passageway for the movement of ions or ...
... chloroplasts. Most currently known porins are trimers, in which each subunit is composed of 12 to 18 membrane spanning beta strands that are amphipathic. The alternating hydrophobichydrophilic amino acids lead to a water filled core that provides a hydrophilic passageway for the movement of ions or ...
The role of protein–protein interactions in the intracellular traffic of
... different isoforms of 14-3-3 (σ, β, θ and ζ) were found to interact with TASK-1 [88]. Screening of a human heart cDNA library with the last 16 amino acids of human TASK-1 independently yielded 14-3-3β as an interacting protein [76]. Progressive truncation of the C-terminus from the proximal side sho ...
... different isoforms of 14-3-3 (σ, β, θ and ζ) were found to interact with TASK-1 [88]. Screening of a human heart cDNA library with the last 16 amino acids of human TASK-1 independently yielded 14-3-3β as an interacting protein [76]. Progressive truncation of the C-terminus from the proximal side sho ...
The Methylosome, a 20S Complex Containing JBP1 and pICln
... to the sDMA-modified forms of SmD1 and SmD3, suggesting that protein methylation may be a general mechanism for regulating protein-protein interaction (21). Proteins were shown to contain dimethylarginines over 30 years ago (42, 43), yet knowledge of the molecular functions of protein arginine methy ...
... to the sDMA-modified forms of SmD1 and SmD3, suggesting that protein methylation may be a general mechanism for regulating protein-protein interaction (21). Proteins were shown to contain dimethylarginines over 30 years ago (42, 43), yet knowledge of the molecular functions of protein arginine methy ...
the RbDe web service - Oxford Academic
... the lack of better structural information, the term snake-like diagram has been coined, inspired by the layout of the sequence that spans the membrane several times. The automation of the rendering of snake-like diagrams, for proteins whose topology was similar to that of G proteincoupled receptors ...
... the lack of better structural information, the term snake-like diagram has been coined, inspired by the layout of the sequence that spans the membrane several times. The automation of the rendering of snake-like diagrams, for proteins whose topology was similar to that of G proteincoupled receptors ...
The Plant Journal
... Calmodulin is a regulatory protein activated during Ca2+ signalling. We have isolated a cDNA, designated LeCBDGK (Lycopersicon esculentum calmodulin-binding diacylglycerol kinase) encoding a novel calmodulin-binding protein with sequence similarity to diacylglycerol kinases from animals. Diacylglyce ...
... Calmodulin is a regulatory protein activated during Ca2+ signalling. We have isolated a cDNA, designated LeCBDGK (Lycopersicon esculentum calmodulin-binding diacylglycerol kinase) encoding a novel calmodulin-binding protein with sequence similarity to diacylglycerol kinases from animals. Diacylglyce ...
Protein microarrays
... DNA microarray and oligonucleotide genechips have emerged as powerful tools for gene expression profiling on a genomic scale and for establishing functional relationships between the large number of genes involved in distinct cellular processes [1-4]. In addition to detection of DNA copy-number and ...
... DNA microarray and oligonucleotide genechips have emerged as powerful tools for gene expression profiling on a genomic scale and for establishing functional relationships between the large number of genes involved in distinct cellular processes [1-4]. In addition to detection of DNA copy-number and ...
Career of Tom Muir
... ■ First example of protein splicing by small molecule ■ MBP and His are model protein ■ No structural or sequence restrictions to exteins ...
... ■ First example of protein splicing by small molecule ■ MBP and His are model protein ■ No structural or sequence restrictions to exteins ...
Chapter18_Section03_edit
... • Eukarya, which is composed of protists, fungi, plants, and animals. • Bacteria, which corresponds to the kingdom Eubacteria. • Archaea, which corresponds to the kingdom Archaebacteria. ...
... • Eukarya, which is composed of protists, fungi, plants, and animals. • Bacteria, which corresponds to the kingdom Eubacteria. • Archaea, which corresponds to the kingdom Archaebacteria. ...
S1. Comparison of complex functions in MCL-GO
... are conserved in their biological processes in E. coli than yeast. Conversely fewer superfamilies are conserved in molecular function and cellular component in E. coli than yeast. Notice that the numbers are correlated with organismal complexity. The results suggest that more complex organisms have ...
... are conserved in their biological processes in E. coli than yeast. Conversely fewer superfamilies are conserved in molecular function and cellular component in E. coli than yeast. Notice that the numbers are correlated with organismal complexity. The results suggest that more complex organisms have ...
Relationships between amino acid sequence and backbone torsion
... most probably do not show in the first graph, because in general, proteins are dominated by the regular secondary structures of ␣-helices and -strands. So the regions for these structures are observed to be more populated when one considers all conformations of Ala. As seen from the second graph, Al ...
... most probably do not show in the first graph, because in general, proteins are dominated by the regular secondary structures of ␣-helices and -strands. So the regions for these structures are observed to be more populated when one considers all conformations of Ala. As seen from the second graph, Al ...
Leukaemia Section t(11;14)(q23;q32) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... karyotype with -7 and i(17q), the ALL case also had a complex karyotype, with +12. ...
... karyotype with -7 and i(17q), the ALL case also had a complex karyotype, with +12. ...
7 Putting genetics into optogenetics: knocking out proteins with light
... [17, 18, 19, 20]. This is most likely due to the mechanism of degradation. The destabilizing domain becomes unfolded when the molecule is removed [18, 19, 21, 22], or even more usefully becomes unfolded when the small molecule is added [17]. The unfolded protein is then likely to be recognized by ch ...
... [17, 18, 19, 20]. This is most likely due to the mechanism of degradation. The destabilizing domain becomes unfolded when the molecule is removed [18, 19, 21, 22], or even more usefully becomes unfolded when the small molecule is added [17]. The unfolded protein is then likely to be recognized by ch ...
The Bcl-3 oncoprotein acts as a bridging factor between NF
... conditions. In contrast, expression of the other Bcl-3 interacting proteins led to a pronounced increase in Bcl-3-associated p50 dimers. The strongest increase in p50 DNA-binding activity was achieved by Jab1, followed by Pirin and Tip60. Thus, expression of Jab1, Tip60 or Pirin enhance association ...
... conditions. In contrast, expression of the other Bcl-3 interacting proteins led to a pronounced increase in Bcl-3-associated p50 dimers. The strongest increase in p50 DNA-binding activity was achieved by Jab1, followed by Pirin and Tip60. Thus, expression of Jab1, Tip60 or Pirin enhance association ...
Western Blot part 2_v2 - University of San Diego Home Pages
... paper. This type of detection gives very sharp bands with low background staining of the membrane. This is one of the easiest methods for western blot detection. There are two disadvantages to this method: the signal or bands fade over time when exposed to light, and second, it is not as sensitive a ...
... paper. This type of detection gives very sharp bands with low background staining of the membrane. This is one of the easiest methods for western blot detection. There are two disadvantages to this method: the signal or bands fade over time when exposed to light, and second, it is not as sensitive a ...
Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.