The STAT family
... The dimer is kept together by reciprocal SH2- TyrP interactions between the SH2 domain in one monomer and the phosphorylated Tyr in the other. The SH2 domain in each monomer is closely linked to the core DBD and is itself close to DNA, and is assumed also to contribute to DNA-binding. N-terminal coi ...
... The dimer is kept together by reciprocal SH2- TyrP interactions between the SH2 domain in one monomer and the phosphorylated Tyr in the other. The SH2 domain in each monomer is closely linked to the core DBD and is itself close to DNA, and is assumed also to contribute to DNA-binding. N-terminal coi ...
Like-acetylglucosaminyltransferase (LARGE)
... placement point mutations of each of the Thr residues (Thr-317, -319, -328, -329, and -322) in DGFc334 (Fig. S1B). Surprisingly, none of the single point mutations resulted in a dramatic change in LARGE-dependent glycosylation, although T317A and T319A each showed a slight reduction of both IIH6 rea ...
... placement point mutations of each of the Thr residues (Thr-317, -319, -328, -329, and -322) in DGFc334 (Fig. S1B). Surprisingly, none of the single point mutations resulted in a dramatic change in LARGE-dependent glycosylation, although T317A and T319A each showed a slight reduction of both IIH6 rea ...
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... Cellulose is the main structural component of plant cell wall and thus the most abundant carbohydrate in nature. However, extracting the energy from this abundant source is limited by its recalcitrant nature. The hydrolysis of plant cell wall requires synergystic action of different enzymes, includi ...
... Cellulose is the main structural component of plant cell wall and thus the most abundant carbohydrate in nature. However, extracting the energy from this abundant source is limited by its recalcitrant nature. The hydrolysis of plant cell wall requires synergystic action of different enzymes, includi ...
In Silico Salinispora Dinesh Kumar K. Waheeta Hopper
... residues (Table 1). The Hydroxyl group of arenicolide A interacted with oxygen of Tyr64, carbonyl group of Ser11 and carbonyl group of Asn12 ( Fig. 3 ) in the EGF binding region. Carbonyl group of arenimycin B interacted with carbonyl group of Gly410 and carbonyl group of Gln408 (Fig. 4) in the doma ...
... residues (Table 1). The Hydroxyl group of arenicolide A interacted with oxygen of Tyr64, carbonyl group of Ser11 and carbonyl group of Asn12 ( Fig. 3 ) in the EGF binding region. Carbonyl group of arenimycin B interacted with carbonyl group of Gly410 and carbonyl group of Gln408 (Fig. 4) in the doma ...
Elements of Systemic..
... are polymers of amino acids. Classified by their physical size, proteins are nanoparticles (definition: 1– 100 nm). Each protein polymer – also known as a polypeptide – consists of a sequence formed from 20 possible L-α-amino acids, also referred to as residues. For chains under 40 residues the term ...
... are polymers of amino acids. Classified by their physical size, proteins are nanoparticles (definition: 1– 100 nm). Each protein polymer – also known as a polypeptide – consists of a sequence formed from 20 possible L-α-amino acids, also referred to as residues. For chains under 40 residues the term ...
Saito et al, 2009 - The EMBO Journal
... The separation (scission) of clathrin-coated vesicles from the plasma membrane requires the dynamin GTPase. How dynamin cuts the neck of a clathrin-coated vesicle is not clear; however, it is well established that dynamin is recruited to the membrane in a GTP-bound form and nucleotide hydrolysis par ...
... The separation (scission) of clathrin-coated vesicles from the plasma membrane requires the dynamin GTPase. How dynamin cuts the neck of a clathrin-coated vesicle is not clear; however, it is well established that dynamin is recruited to the membrane in a GTP-bound form and nucleotide hydrolysis par ...
ASAP1 Antibody (Center)
... Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. ...
... Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. ...
Myosin binding proteins - Journal of Cell Science
... The precise functions of the MyBPs are uncertain. In the case of MyBP-C, evidence exists for a role in myofibril assembly and the regulation of contraction. When purified myosin is polymerized in vitro at physiological stoichiometries with MyBP-C, the resulting thick filaments are slightly longer an ...
... The precise functions of the MyBPs are uncertain. In the case of MyBP-C, evidence exists for a role in myofibril assembly and the regulation of contraction. When purified myosin is polymerized in vitro at physiological stoichiometries with MyBP-C, the resulting thick filaments are slightly longer an ...
Protein synthesis
... methionine usually encoded by AUG. • Alternative initiation codon such as GUG are used in bacteria. • İn most bacteria protein synthesis is initiated with a modified methionine(N-formyl methionine),whereas unmodified methionine initiate prot.synt.in eucaryotes ...
... methionine usually encoded by AUG. • Alternative initiation codon such as GUG are used in bacteria. • İn most bacteria protein synthesis is initiated with a modified methionine(N-formyl methionine),whereas unmodified methionine initiate prot.synt.in eucaryotes ...
nerve agents - 20 Years of OPCW
... reactivation. Such oximes are commonly used as therapeutics in case of nerve agent poisoning. They include compounds such as 2-PAM (Pralidoxime), Obidoxime, HI-6, MMB-4 and TMB-4. Pralidoxime ...
... reactivation. Such oximes are commonly used as therapeutics in case of nerve agent poisoning. They include compounds such as 2-PAM (Pralidoxime), Obidoxime, HI-6, MMB-4 and TMB-4. Pralidoxime ...
Knox, Kirstin : An Introduction To Motif Based Functional Classification of Large Protein Families
... focus exclusively on members of one branch or the other, then the presence of a common, less statistically significant motif in members of the two different branches will be missed. The nonrecursive graph model, on the other hand, creates a nonhierarchical structure that can represent relationships ...
... focus exclusively on members of one branch or the other, then the presence of a common, less statistically significant motif in members of the two different branches will be missed. The nonrecursive graph model, on the other hand, creates a nonhierarchical structure that can represent relationships ...
Functional Anthology of Intrinsic Disorder. 1. Biological Processes
... domains with poorly packed side chains are included in our view of intrinsic disorder.6 More detailed analysis of extended disordered proteins/regions revealed that they can be further divided into two groups, random coil-like and pre-molten globule-like conformations.7 Recently, more than 150 prote ...
... domains with poorly packed side chains are included in our view of intrinsic disorder.6 More detailed analysis of extended disordered proteins/regions revealed that they can be further divided into two groups, random coil-like and pre-molten globule-like conformations.7 Recently, more than 150 prote ...
Protein conformational changes induced by adsorption onto material
... where the internal energy of the protein conformation is large, adsorption onto materials should not affect considerably the protein shape. On the contrary, when the internal energy of the protein is lower, more energy can be gained in the interaction with the material. Free energy takes into accoun ...
... where the internal energy of the protein conformation is large, adsorption onto materials should not affect considerably the protein shape. On the contrary, when the internal energy of the protein is lower, more energy can be gained in the interaction with the material. Free energy takes into accoun ...
SpeeDB: fast structural protein searches
... cation–p interactions. Burley and Petsko (1985) analyzed a total of 34 crystal structures of proteins for aromatic–aromatic interactions and identified that on average, 61% of phenylalanine, 54% of tyrosine and 59% of tryptophan residues are involved in aromatic– aromatic interactions. They also fou ...
... cation–p interactions. Burley and Petsko (1985) analyzed a total of 34 crystal structures of proteins for aromatic–aromatic interactions and identified that on average, 61% of phenylalanine, 54% of tyrosine and 59% of tryptophan residues are involved in aromatic– aromatic interactions. They also fou ...
Box 1 - Open Biology
... another stil mutant, with a transgenic insertion, stil hi1262Tg-/- displayed a similar but less severe phenotype. Mutations in ASPM are the most common cause of human primary microcephaly (9). ASPM is located at chromosomal position 1q31, has an open reading frame of 10,906bp and contains 30 exons. ...
... another stil mutant, with a transgenic insertion, stil hi1262Tg-/- displayed a similar but less severe phenotype. Mutations in ASPM are the most common cause of human primary microcephaly (9). ASPM is located at chromosomal position 1q31, has an open reading frame of 10,906bp and contains 30 exons. ...
Membrane Protein Sorting in the Yeast Secretory Pathway
... contains the 1.2-kbp EcoRI-BamHI HIS3 fragment (Sikorski and Hieter, 1989) in place of the L3-kbp BstEII-KpnI portion of the coding region of DAP2 (Roberts et al., 1989). The c~-factor signal sequence was fused to the lumenal domain of DPAP B as follows: a Sail linker was inserted at the Hincll site ...
... contains the 1.2-kbp EcoRI-BamHI HIS3 fragment (Sikorski and Hieter, 1989) in place of the L3-kbp BstEII-KpnI portion of the coding region of DAP2 (Roberts et al., 1989). The c~-factor signal sequence was fused to the lumenal domain of DPAP B as follows: a Sail linker was inserted at the Hincll site ...
Building the Tree of Life
... their own kingdom, named Protista. Then yeasts and molds, along with mushrooms, were placed in their own kingdom, Fungi. Later still, scientists realized that bacteria lack the nuclei, mitochondria, and chloroplasts found in other forms of life. All prokaryotes (bacteria) were placed in yet another ...
... their own kingdom, named Protista. Then yeasts and molds, along with mushrooms, were placed in their own kingdom, Fungi. Later still, scientists realized that bacteria lack the nuclei, mitochondria, and chloroplasts found in other forms of life. All prokaryotes (bacteria) were placed in yet another ...
1 Evolutionary conservation and emerging functional diversity of the
... Being sessile, plants have to deal with complex environmental cues including a variety of stresses. They are evolved with specific mechanisms which help them regulate their cellular proteome with the changing external environment (Kosova et al. 2011; Kurepa et al. 2009). Molecular chaperones are a d ...
... Being sessile, plants have to deal with complex environmental cues including a variety of stresses. They are evolved with specific mechanisms which help them regulate their cellular proteome with the changing external environment (Kosova et al. 2011; Kurepa et al. 2009). Molecular chaperones are a d ...
Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.