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Two Domains of the Human bZIP Transcription Factor
Two Domains of the Human bZIP Transcription Factor

... shown to transactivate through the hARE response element in the NAD(P)H:quinone oxidoreductase-1 promoter (9), a site that is important for the induction of NAD(P)H:quinone oxidoreductase-1 in response to xenobiotics and antioxidants. These observations indicate a role for TCF11 in the regulation of ...
AHM1, a Novel Type of Nuclear Matrix–Localized
AHM1, a Novel Type of Nuclear Matrix–Localized

... The nuclear matrix, operationally defined, is the dynamic fibrogranular structure forming the skeletal framework that surrounds and penetrates the interphase nucleus; it has been implicated in most nuclear functions, including replication, repair, transcription, RNA processing, and RNA transport (Be ...
Nutrition for Swimmers
Nutrition for Swimmers

... • In addition to the appropriate timing of macronutrients (carbs, protein and fat) around workouts there are some other important things to keep in mind when it comes to recovering from a workout 1. Hydration - Proper hydration is important when it comes to recovering properly for many reasons • Hyd ...
the Sec7 family of guanine-nucleotide- exchange factors
the Sec7 family of guanine-nucleotide- exchange factors

... ADP-ribosylation factor (ARF) can interact weakly with membrane phospholipids when bound to GDP, whereas its GTPbound form is tightly membrane bound owing to the interaction of the amphipathic N-terminal helix with the lipid bilayer. It is likely that, in the exchange reaction, membrane interaction ...
Higher Expression Level and Lower Toxicity of Genetically Spliced
Higher Expression Level and Lower Toxicity of Genetically Spliced

Gene Section ELL (eleven nineteen lysin rich leukemia gene)
Gene Section ELL (eleven nineteen lysin rich leukemia gene)

... EAF1, a protein that shares homology with AF4, LAF4, and AF5q31. Interestingly the EAF1 interacting domain, but not the ELL elongation domain is required for transformation. ELL has also been reported to interact withp53 and inhibit its transcriptional activating activity. ...
mouse_comparison_jul..
mouse_comparison_jul..

... Novel object recognition: Decreased preference for novel objects, no change in duration of object contacts, controls made fewer contacts in LTM and RM tests ...
Top down - The Fenyo Lab
Top down - The Fenyo Lab

Intricacies and surprises of nuclear–mitochondrial co
Intricacies and surprises of nuclear–mitochondrial co

... EF-Tu (Tu stands for thermo-unstable) forms the elongation factor subfamily of GTPases together with EF-G and IF2 (initiation factor 2). All three proteins have homologues in Bacteria, Archaea and Eukarya, suggesting that they arose by gene-duplication events that predate the divergence of the Kingd ...
pMAL FAQs
pMAL FAQs

Slides
Slides

... Defined by: Present in at least 90% of species from all kingdoms. Present in at least 70% archaeal and eukaryotic species. ...
PROTEIN SEQUENCING First Sequence
PROTEIN SEQUENCING First Sequence

... • Direct sequencing is applicable to peptides that have up to about 50 residues only. • Problems which occur after lengthy reactions – Incomplete reactions – Accumulation of impurities from side reactions • Solution: use enzymes to break down the polypeptide chain into shorter fragments – Proteolyti ...
Crk: The First Identified Adaptor Protein
Crk: The First Identified Adaptor Protein

Structure and function of nucleus-vacuole junctions: outer
Structure and function of nucleus-vacuole junctions: outer

Self Menu Template (Men) - Lyn
Self Menu Template (Men) - Lyn

... and chicken (animal protein) or bread (grain) and eggs (animal protein). Coconut Milk and animal proteins are a test. In winter we always have either a cooked vegetable or a soup with lunch to aid digestion. Dinner always has cooked vegetables and a raw veg salad as raw vegetables contain enzymes. C ...
18-3
18-3

Comparative Analysis of Plant and Animal Calcium Signal
Comparative Analysis of Plant and Animal Calcium Signal

... functional genes have changed dramatically at a sequence level, we searched for calcium transport protein homologs (table 1) and performed comparative analyses at putative functional domains (figs. 1 and 2). Channels In animals, various types of VDCC complex are controlled by the cell membrane volta ...
Domain conservation in several volvocalean cell wall - UvA-DARE
Domain conservation in several volvocalean cell wall - UvA-DARE

... carry ProProXYLys repeats. However, as the number of characterized H R G P s has increased, considerable variation has been found in the canonical repeats, and there has been a growing tendency to emphasize the novelty of these variants (e.g., monocot vs. dicot extensins). Recently, Kieliszewski and ...
Structure, function and evolution of the XPD family of iron–sulfur
Structure, function and evolution of the XPD family of iron–sulfur

... that glycosylases with an iron–sulfur cluster might pass an electron on to DNA as a mechanism to test for the presence of DNA damage [25]. Since XPD has also been predicted to play a role in the detection of DNA damage during NER, this has prompted speculation that the iron–sulfur cluster might play ...
Identification of Isoforms of a Mitotic Motor in Mammalian Spermatogenesis
Identification of Isoforms of a Mitotic Motor in Mammalian Spermatogenesis

... placement, the homology of superfamily members to one another decreases dramatically outside the motor domain. The divergent ‘‘tail’’ domains of these proteins are thought to specify the cargo to which they attach and move. Although alternative messenger RNA processing is a common method for generat ...
Discrete molecular dynamics
Discrete molecular dynamics

Folding quality control in the export of proteins by the
Folding quality control in the export of proteins by the

Fast Protein Folding in the Hydrophobic
Fast Protein Folding in the Hydrophobic

... if there is an even number of elements between them. It follows from our definition of blocks that two 1’s within a block cannot be topological neighbors. Further, any pair of 1‘s take from blocks bh and b~ may be topological neighbors only when Ik – j I is odd, To see this, observe that the length ...
Development of a protein microarray using sequence
Development of a protein microarray using sequence

... Surface for protein immobilization is also important to prepare protein microarray. Several different coatings have been published, which can be divided into two types: gel-coated surfaces and non-gel-coated glass or plastic surfaces [10]. Proteins do not provide a uniform outer surface unlike DNA, a ...
Transmembrane Domain–Dependent Functional
Transmembrane Domain–Dependent Functional

... dimerization or oligomerization is mediated by specific, potentially functional protein regions of these receptors. For example, the extracellular domain plays a crucial role in EGFR dimerization[14], while the transmembrane domain of TGFβR plays a pivotal role in its activation[12]. In all of these ...
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Protein domain



A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural domains. One domain may appear in a variety of different proteins. Molecular evolution uses domains as building blocks and these may be recombined in different arrangements to create proteins with different functions. Domains vary in length from between about 25 amino acids up to 500 amino acids in length. The shortest domains such as zinc fingers are stabilized by metal ions or disulfide bridges. Domains often form functional units, such as the calcium-binding EF hand domain of calmodulin. Because they are independently stable, domains can be ""swapped"" by genetic engineering between one protein and another to make chimeric proteins.
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